IPEX as a Result of Mutations in FOXP3 by Hans J. J. van der Vliet, Edward E. Nieuwenhuis

“…Immunodysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a rare disorder caused by mutations in the FOXP3 gene that result in the defective development of CD4+CD25+ regulatory T cells which constitute an important T cell subset involved in immune homeostasis and protection against autoimmunity. …”
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Elusive modes of Foxp3 activity in versatile regulatory T cells by Minghong He, Yongqiang Feng

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Foxp3 Expression in Liver Correlates with the Degree but Not the Cause of Inflammation by Matthaios Speletas, Nikoletta Argentou, Georgios Germanidis, Themistoclis Vasiliadis, Konstantinos Mantzoukis, Kalliopi Patsiaoura, Pavlos Nikolaidis, Vaios Karanikas, Konstantinos Ritis, Anastasios E. Germenis

“…Patients with chronic viral hepatitis display increased expression of Foxp3 in liver, suggesting that Tregs expansion contributes to persistent infection. …”
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Fenofibrate Enhances the In Vitro Differentiation of Foxp3+ Regulatory T Cells in Mice by Zhou Zhou, Ying Liang, Yanxiang Gao, Wei Kong, Juan Feng, Xian Wang

“…Foxp3+ regulatory T cells (Tregs) play a critical role in maintaining immune self-tolerance. …”
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Immunohistochemical Expression of FOXP3+ Regulatory T Cells in Proteinuric Primary Glomerulopathies by Georgios Vlachopanos, Argyrios Georgalis, Pinelopi Korkolopoulou, Efstratios Patsouris, Harikleia Gakiopoulou

“…FOXP3+ regulatory T-cell (Tregs) detection in renal allograft biopsies has been associated with a less intense immune response. …”
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The Expression of T Cell FOXP3 and T-Bet Is Upregulated in Severe but Not Euthyroid Hashimoto’s Thyroiditis by Stana Tokić, Mario Štefanić, Ljubica Glavaš-Obrovac, Sonja Jaman, Eva Novosadová, Jana Petrkova, Zdenka Navratilova, Mirjana Suver Stević, Martin Petrek

“…In summary, severe but not euthyroid HT was associated with robust upregulation of T-bet and FOXP3 mRNA in peripheral T cells, independent of the thyroid hormone status but proportional to disease activity.…”
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Statins Increase the Frequency of Circulating CD4+FOXP3+ Regulatory T Cells in Healthy Individuals by Ana Lucía Rodríguez-Perea, Carlos J. Montoya, Sven Olek, Claire A. Chougnet, Paula A. Velilla

“…Statins have been shown to modulate the number and the suppressive function of CD4+FOXP3+ T cells (Treg) in inflammatory conditions. …”
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The Imbalance of FOXP3/GATA3 in Regulatory T Cells from the Peripheral Blood of Asthmatic Patients by Tiantian Chen, Xiaoxia Hou, Yingmeng Ni, Wei Du, Huize Han, Youchao Yu, Guochao Shi

“…Treg cells from asthmatic patients expressed more FOXP3 as well as GATA3; the expression level of GATA3 negatively correlated with FEV1%pred. …”
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A central role for Foxp3+ regulatory T cells in K-Ras-driven lung tumorigenesis. by Courtney A Granville, Regan M Memmott, Andria Balogh, Jacopo Mariotti, Shigeru Kawabata, Wei Han, Jaclyn Lopiccolo, Jason Foley, David J Liewehr, Seth M Steinberg, Daniel H Fowler, M Christine Hollander, Phillip A Dennis

“…In A/J mice inoculated with lung adenocarcinoma cells resistant to rapamycin, antibody-mediated depletion of Foxp3+ cells reduced lung tumorigenesis by 80%. Likewise, mutant K-Ras transgenic mice lacking Foxp3+ cells developed 75% fewer lung tumors than littermates with Foxp3+ cells.…”
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Nucleotide variation in Foxp3 gene and prognosis of bladder cancer: a case-control study by Qin Li, Yan Zhang, Yan Zhang, Min Su, Yaping Song, Yanyun Wang, Bin Zhou, Lin Zhang

Subjects: “…Foxp3…”
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Regulatory T Cells and Profile of FOXP3 Isoforms Expression in Peripheral Blood of Patients with Myelodysplastic Syndromes by Galina A. Dudina, Almira D. Donetskova, Marina M. Litvina, Alexander N. Mitin, Tatiana A. Mitina, Sergey A. Polyakov

“…We have investigated the frequencies of regulatory T cells and the level of FOXP3 isoforms expression in peripheral blood of patients with myelodysplastic syndromes and found the significant reduction of regulatory T cells at all stages of the disease. …”
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Comparison of IL-17 and FOXP3+ Levels in Maternal and Children Leprosy Patients in Endemic and Nonendemic Areas by Flora Ramona Sigit Prakoeswa, Faradiba Maharani, Munawaroh Fitriah, Jusak Nugraha, Hardyanto Soebono, Budi Prasetyo, Santi Martini, Dominicus Husada, Hari Basuki Notobroto, Muhammad Yulianto Listiawan, Anang Endaryanto, Cita Rosita Sigit Prakoeswa

“…A significant difference also was found in FOXP3+ levels between the group of healthy children living in endemic and those living in nonendemic areas (p=0.047), where higher FOXP3+ is observed in the healthy children living in endemic areas group.…”
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Comparative Approach to Define Increased Regulatory T Cells in Different Cancer Subtypes by Combined Assessment of CD127 and FOXP3 by Marc Beyer, Sabine Classen, Elmar Endl, Matthias Kochanek, Martin R. Weihrauch, Svenja Debey-Pascher, Percy A. Knolle, Joachim L. Schultze

“…Our data strongly support superiority of combined CD127 and FOXP3 analysis in comparison to CD25 and FOXP3 assessment for further quantification of Treg cells in malignant diseases.…”
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Protective Effect of CXCR3+CD4+CD25+Foxp3+ Regulatory T Cells in Renal Ischemia-Reperfusion Injury by Cao Jun, Li Qingshu, Wei Ke, Li Ping, Dong Jun, Luo Jie, Min Su

“…The PC61 + IRI group was established by i.p. injection of PC61 monoclonal antibody (mAb) to deplete Tregs before renal ischemia. CD4+CD25+Foxp3+ Tregs and CXCR3 on Tregs were analyzed by flow cytometry. …”
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IPEX Syndrome with Normal FOXP3 Protein Expression in Treg Cells in an Infant Presenting with Intractable Diarrhea as a Single Symptom by Ali Al Maawali, Beata Derfalvi, Johan Van Limbergen, Andrew Issekutz, Thomas Issekutz, Hasan Ghandourah, Mohsin Rashid

“…The patient had a normal percentage of Treg cells and FOXP3 protein expression, but further testing revealed a hemizygous missense mutation in the FOXP3 gene. …”
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Anti-CTLA4 treatment reduces lymphedema risk potentially through a systemic expansion of the FOXP3+ Treg population by Stefan Wolf, Matiar Madanchi, Patrick Turko, Maija Hollmén, Sonia Tugues, Julia von Atzigen, Pietro Giovanoli, Reinhard Dummer, Nicole Lindenblatt, Cornelia Halin, Michael Detmar, Mitchell Levesque, Epameinondas Gousopoulos

“…Here, we show that the modulation of CD4+FOXP3+CD25+regulatory T (Treg) cells upon anti-CTLA4 treatment protects against lymphedema development in patients with melanoma and in a mouse lymphedema model. …”
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FOXP3 as a prognostic marker and therapeutic target in immunogenic cell death modulation for clear cell renal cell carcinoma by Jian Chen, Cheng Zhu, Yan He, Liping Huang, Weizhuo Wang, Shuaishuai Huang

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Forkhead Box Protein-3 Gene Expression of Purified Human Peripheral Blood Mononuclear Cells Treated with Methicillin-Resistant Staphylococcus aureus-Somatic Antigens and Hepatitis... by Entidhar A. Hadi, Mohammad A. K. Al-Saadi, Kaiser N. Madlum

Subjects: “…foxp3 gene…”
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Lower FOXP3 mRNA Expression in First-Trimester Decidual Tissue from Uncomplicated Term Pregnancies with a Male Fetus by Tom E. C. Kieffer, Anne Laskewitz, Marijke M. Faas, Sicco A. Scherjon, Jan Jaap H. M. Erwich, Sanne J. Gordijn, Jelmer R. Prins

“…Early-pregnancy decidual mRNA expression of the regulatory T-cell marker, FOXP3, was sixfold lower (p<0.01) in pregnancies with a male fetus compared to pregnancies with a female fetus. …”
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Anti-PD-1 amplifies costimulation in melanoma-infiltrating Th1-like Foxp3+ regulatory T cells to alleviate local immunosuppression by Fernando Alvarez, Fan Huang, Sonia V Del Rincon, Mikhaël Attias, Tho-Alfakar Al-Aubodah, Roman Istomine, Paige McCallum, Abrahim Sleiman, Tamiko Nishimura, Yasser Riazalhosseini, Ciriaco A Piccirillo

“…However, 55% of patients with melanoma do not respond to treatment. As Foxp3+ regulatory T (Treg) cells play an important role in tumor-induced immunosuppression and express PD-1, we hypothesized that anti-PD-1 also increases the functions of melanoma-infiltrating Treg cells, which could be detrimental to treatment efficacy.Methods The cellular and functional dynamics of Treg cells were evaluated in C57Bl/6 Foxp3-reporter mice bearing highly immunogenic and PD-1 blockade-sensitive Yale University Mouse Melanoma Exposed to Radiation 1.7 (YUMMER1.7) tumors. …”
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