Elotuzumab Enhances CD16-Independent NK Cell-Mediated Cytotoxicity against Myeloma Cells by Upregulating Several NK Cell-Enhancing Genes by Yan-Hua Wang, Shotaro Hagiwara, Hiroshi Kazama, Yuki Iizuka, Norina Tanaka, Junji Tanaka

“…Furthermore, the augmentation of the antitumor effects of CD16-independent NK cells upon pretreatment with Elo enhanced the expression of CRTAM, TNFRSF9, EAT-2, and FOXP3 genes and reduced the expression of HSPA6. …”
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The PTP1B Inhibitor Trodusquemine (MSI-1436) Improves Glucose Uptake in Equine Metabolic Syndrome Affected Liver through Anti-Inflammatory and Antifibrotic Activity by Lynda Bourebaba, Anna Serwotka-Suszczak, Nabila Bourebaba, Magdalena Zyzak, Krzysztof Marycz

“…Moreover, MSI-1436 enhanced the anti-inflammatory profile of livers by elevating the expression of IL-10 and IL-4 and activating CD4+CD25+Foxp3+ regulatory T cells in treated PBMC. Similarly, the inhibitor attenuated fibrogenic pathways in the liver by downregulating TGF-β/NOX1/4 axis and associated MMP-2/9 overactivation. …”
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Shrimp allergen extract immunotherapy induces prolonged immune tolerance in a gastro-food allergy mouse model. by Honey Dzikri Marhaeny, Lutfiatur Rohmah, Yusuf Alif Pratama, Salsabilla Madudari Kasatu, Andang Miatmoko, Rafi Addimaysqi, Geert van den Bogaart, Franz Y Ho, Muhammad Taher, Junaidi Khotib

“…As the results, we found that SAE immunotherapy reduced systemic allergy symptom scores, serum IL-4 levels, IL-4 and FcεR1α mRNA relative expression, and mast cell degranulation in ileum tissue in allergic mice while increasing Foxp3 and IL-10 mRNA relative expression. Notably, we observed an increased ratio of IL-10 to IL-4 mRNA expression, demonstrating the efficacy of SAE immunotherapy in promoting desensitization. …”
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PD-L1 Expression and CD8+ T Cell Infiltration Predict a Favorable Prognosis in Advanced Gastric Cancer by Yangyang Wang, Chunchao Zhu, Wei Song, Jun Li, Gang Zhao, Hui Cao

“…In contrast, a high density of FOXP3+ T cells in AGCs indicated a poor prognosis. …”
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Tumor-derived colorectal cancer organoids induce a unique Treg cell population by directing CD4+ T cell differentiation by Sonia Aristin Revilla, Cynthia L. Frederiks, Stefan Prekovic, Enric Mocholi, Onno Kranenburg, Paul J. Coffer

“…To assess how CRC tumors directly modulate Treg cell differentiation, we developed an in vitro co-culture system using CD4+ T cells from Foxp3eGFP mice and CRC tumor-derived organoids. Co-culture resulted in a significant increase in Treg cell numbers. …”
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The Parenteral Vitamin C Improves Sepsis and Sepsis-Induced Multiple Organ Dysfunction Syndrome via Preventing Cellular Immunosuppression by Yu-Lei Gao, Bin Lu, Jian-Hua Zhai, Yan-Cun Liu, Hai-Xia Qi, Ying Yao, Yan-Fen Chai, Song-Tao Shou

“…The negative immunoregulation of Tregs was inhibited, mainly including inhibiting the expression of forkhead helix transcription factor- (Foxp-) 3, cytotoxic T lymphocyte associated antigen- (CTLA-) 4, membrane associated transforming growth factor-β (TGF-βm+), and the secretion of inhibitory cytokines [including TGF-β and interleukin- (IL-) 10], as well as CD4+ T cells-mediated cellular immunosuppression which was improved by parenteral Vit C in WT and Gulo−/− septic mice. …”
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Evaluation of Clinical and Immunological Responses: A 2-Year Follow-Up Study in Children with Allergic Rhinitis due to House Dust Mite by Heleen Moed, Roy Gerth van Wijk, Rudi W. Hendriks, J. C. van der Wouden

“…The following variables were compared: clinical symptoms, allergen skin tests, specific IgE, T-cell proliferation, IL-5, IL-13, IFN-gamma, IL-10, TGF-beta, CD4+CD25hi cells, and Foxp3 expression. Results. Allergic symptoms had decreased after two years. …”
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IL-10 and ARG-1 Concentrations in Bone Marrow and Peripheral Blood of Metastatic Neuroblastoma Patients Do Not Associate with Clinical Outcome by Fabio Morandi, Michela Croce, Giuliana Cangemi, Sebastiano Barco, Valentina Rigo, Barbara Carlini, Loredana Amoroso, Vito Pistoia, Silvano Ferrini, Maria Valeria Corrias

“…The expression of the immunosuppressive molecules IL-10 and arginase 1 (ARG-1), and of FOXP3 and CD163, as markers of regulatory T cells (Treg) and macrophages, respectively, was evaluated in bone marrow (BM) and peripheral blood (PB) samples collected at diagnosis from patients with metastatic neuroblastoma (NB). …”
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Phenotypical and Functional Analysis of Intraepithelial Lymphocytes from Small Intestine of Mice in Oral Tolerance by Maristela Ruberti, Luis Gustavo Romani Fernandes, Patricia Ucelli Simioni, Dirce Lima Gabriel, Áureo Tatsumi Yamada, Wirla Maria da Silva Cunha Tamashiro

“…Administration of OVA via oral + ip increased the frequency of CD103+ cells in CD4+ T-cell subset in IELs of both BALB/c and TGN mice and elevated its expression in CD8β+ T-cell subset in IELs of TGN. The frequency of Foxp3+ cells increased in all subsets in IELs of BALB/c treated with OVA; in IELs of TGN, it increased only in CD25+ subset. …”
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The Protective Effects of 18β-Glycyrrhetinic Acid on Imiquimod-Induced Psoriasis in Mice via Suppression of mTOR/STAT3 Signaling by Haiming Chen, Huazhen Liu, Bin Tang, Yuchao Chen, Ling Han, Jingjie Yu, Yuhong Yan, Chuanjian Lu

“…GA also suppressed the mRNA levels of IL-6, TNF-α, IL-17, IL-23, and IL-1β in the skin and increased the proportion of CD4+ Foxp3+ regulatory T cells (Tregs) in both lymph nodes and spleens. …”
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Changes of Cell Adhesion Molecules and T Cell Subset Populations in Acute Myeloid Leukemia Patients Undergoing Intravenous Administration of Cytarabine Supplemented with Idarubicin by Jinhua Piao, Didi Wang, Siying Pei, Tangdong Ge, Jing Li, Pengxia Zhang

“…Phenotypic characteristics of T cell subsets including CD4+, CD8+, CD4+IL-10 Tregs, and CD4+CD25+CD127−Foxp3+ Tregs were analyzed by flow cytometry. Results. …”
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Interleukin-2/Anti-Interleukin-2 Immune Complex Expands Regulatory T Cells and Reduces Angiotensin II-Induced Aortic Stiffening by Beenish Majeed, Supannikar Tawinwung, Lance S. Eberson, Timothy W. Secomb, Nicolas Larmonier, Douglas F. Larson

“…To study the role of immune inhibitory cells, CD4+CD25+Foxp3+ regulatory T cells (Tregs), on vascular stiffness, we stimulated the proliferation of Treg lymphocytes in vivo using a novel cytokine immune complex of Interleukin-2 (IL-2) and anti-IL-2 monoclonal antibody clone JES6-1 (mAbCD25). …”
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Follicular Helper CD4+ T Cells, Follicular Regulatory CD4+ T Cells, and Inducible Costimulator and Their Roles in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis by Xue Zhang, Ruli Ge, Hongliang Chen, Maxwell Ahiafor, Bin Liu, Jinbo Chen, Xueli Fan

“…TFR cells not only express markers of TFH cells but also express markers of regulatory T (Treg) cells containing FOXP3, glucocorticoid-induced tumor necrosis factor receptor (GITR), cytotoxic T lymphocyte antigen 4 (CTLA-4), and IL-10, hence owing to the dual characteristic of TFH cells and Treg cells. …”
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Evaluation of the PEΔIII-LC3-KDEL3 Chimeric Protein of Entamoeba histolytica-Lectin as a Vaccine Candidate against Amebic Liver Abscess by Sandra L. Martínez-Hernández, Viridiana M. Becerra-González, Martín H. Muñoz-Ortega, Víctor M. Loera-Muro, Manuel E. Ávila-Blanco, Marina N. Medina-Rosales, Javier Ventura-Juárez

“…PEΔIII-LC3-KDEL3 reduced the expression of TNF-α, IL-1β, and NF-κB in all immunized groups at 4- and 7-day postinfection. The levels of IL-10, FOXP3, and IFN-γ were elevated at 7 days. The immunohistochemistry assay confirmed this result, revealing an elevated quantity of +IFN-γ cells in the liver tissue. …”
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PD-1/PD-L1及Treg细胞在JAK2V617F阳性骨髓增殖性肿瘤中的表达及意义 by 成志勇, 张丽军, 付建珠, 刘芳, 颜晓燕, 孙立娜, 孙雪珊, 王素云

“…【目的】探讨程序性死亡受体-1（PD-1）、程序性死亡配体-1（PD-L1）及CD4+CD25+Foxp3+调节性T细胞（Treg）、CD4+/CD8+比值在JAK2V617F突变阳性骨髓增殖性肿瘤（MPN）患者骨髓中的表达及临床意义。…”
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The XIAP inhibitor AZD5582 improves the treatment effect of microwave ablation on hepatocellular carcinoma by Wenhui Wang, Fuyuan Wu, Zhe Wu, Mengfan Zhang, Qiang Lu

“…Concurrently, in C57 BL/6 mice with AZD5582 application, the level of local CD8+ T-cell infiltration in the tumor was increased, while the level of Foxp3+ regulatory T-cell infiltration was significantly reduced. …”
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Akkermansia muciniphila Enhances the Antitumor Effect of Cisplatin in Lewis Lung Cancer Mice by Zhuo Chen, Xiang Qian, Shasha Chen, Xiaoxuan Fu, Guanjun Ma, Aiqin Zhang

“…Compared with the CDDP group, CDDP combining with Akk slowed down the growth of tumor volume, downregulated the levels of ki-67, p53, and factor-associated suicide (Fas) ligand proteins and upregulated Fas proteins, increased the levels of interferon-γ, interleukin-6, and tumor necrosis factor-α, and suppressed the expression of CD4+CD25+Foxp3+ Treg in mouse peripheral blood and spleen. …”
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The MicroRNA-106a/20b Strongly Enhances the Antitumour Immune Responses of Dendritic Cells Pulsed with Glioma Stem Cells by Targeting STAT3 by Hui Zhou, Chengmei Sun, Cong Li, Shiting Hua, Feng Li, Ruichun Li, Dongpeng Cai, Yuxi Zou, Yingqian Cai, Xiaodan Jiang

“…Moreover, the reduction in STAT3 levels in GSC-DCs enhanced the generation of CD8+ T cells and reduced the generation of Foxp3+ regulatory T cells. Meanwhile, the secretion of the T cell cytokine IFN-γ was significantly increased. …”
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Effects of anti-CD4 antibody treatment on calcium ions influx in peanut-sensitized C3H/HeJ mice by Junjuan Wang, Cui Zhou, Shiwen Han, Zainabu Majid, Na Sun, Huilian Che

“…Stimulation with PPE increased the specific immunoglobulin (IgE), cytokine, histamine, and mMcp-1 levels, upregulated decorin (Dcn) expression, induced Ca2+ inflow in the spleen, and augmented the expression of the transcription factors GATA-3 and Foxp3, which resulted in Th2 and Treg cell activation. …”
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Activin levels correlate with lymphocytic infiltration in epithelial ovarian cancer by Elizabeth T. Evans, Emily F. Page, Alex Seok Choi, Zainab Shonibare, Andrea G. Kahn, Rebecca C. Arend, Karthikeyan Mythreye

“…Immunohistochemistry analysis revealed a positive correlation of CD8 and FOXP3 staining with activin A at the protein level in both primary and metastatic epithelial ovarian cancer samples. …”
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