Epigenetically Mediated Pathogenic Effects of Phenanthrene on Regulatory T Cells by Jing Liu, Luhua Zhang, Lisa C. Winterroth, Marco Garcia, Shannon Weiman, Jillian W. Wong, John B. Sunwoo, Kari C. Nadeau

“…Methylation of CpG sites within the FOXP3 locus reduced FOXP3 expression, leading to impaired Treg function and conversion of Treg into a CD4+CD25lo Th2 phenotype in Phe-treated cells. …”
Get full text

A novel approach to digital characterisation of Tertiary Lymphoid Structures in colorectal cancer by Luis Munoz-Erazo, Luis Munoz-Erazo, Saem Mul Park, Saem Mul Park, Shelly Lin, Shelly Lin, Chun-Jen J. Chen, Chun-Jen J. Chen, Lisa Y. Y. Zhou, Lisa Y. Y. Zhou, Janet L. Rhodes, Janet L. Rhodes, Taesung Jeon, Sonya Fenton, John L. McCall, Roslyn A. Kemp, Roslyn A. Kemp, P. Rod Dunbar, P. Rod Dunbar

“…Multiplexed staining for CD20, CD3, CD8, Foxp3 and Ki-67 enabled us to identify B-cells, CD8+ T-cells, Foxp3– CD4 T-cells, and Foxp3+ CD4 Tcells in all sections, and quantify both the presence of these cell subsets in lymphocytic clusters and their degree of proliferation within those clusters.ResultsIn total we identified 524 lymphocytic clusters with morphology consistent with TLS. …”
Get full text

Altered AKT1 and MAPK1 Gene Expression on Peripheral Blood Mononuclear Cells and Correlation with T-Helper-Transcription Factors in Systemic Lupus Erythematosus Patients by Sonia Garcia-Rodriguez, Jose-Luis Callejas-Rubio, Norberto Ortego-Centeno, Esther Zumaquero, Raquel Ríos-Fernandez, Salvador Arias-Santiago, Pilar Navarro, Jaime Sancho, Mercedes Zubiaur

“…IL-10 expression was increased and correlated with plasma Tumor Necrosis Factor (TNF)-α and Th0-(IL-2), Th1-(IL-12A, T-bet), GATA3, Treg-(Forkhead/winged-helix transcription factor- (FOXP)-3), and IL-6 expressions. FOXP3 expression, FOXP3/RORC, and FOXP3/GATA3 expression ratios were increased. …”
Get full text

T-Cell Subpopulations and Differentiation Bias in Diabetic and Non-Diabetic Patients with Chronic Kidney Disease by Ana Cecilia Granda Alacote, Gabriela Goyoneche Linares, María Gracia Castañeda Torrico, Daysi Zulema Diaz-Obregón, Michael Bryant Castro Núñez, Alexis Germán Murillo Carrasco, Cesar Liendo Liendo, Katherine Susan Rufasto Goche, Víctor Arrunátegui Correa, Joel de León Delgado

“…In terms of transcription factor expression, a significant correlation was observed between T-bet and <i>FOXP3</i> in diabetic patients, and between RORyT and FOXP3 in non-diabetic patients. …”
Get full text

Natural regulatory T cells increase significantly in pediatric patients with parasitic infections: Flow cytometry study by Nadeem Kizilbash, Nida Suhail, A. Khuzaim Alzahrani, W. Jamith Basha, Mohamed Soliman

“…Background: The most accepted definition of regulatory T cells (Tregs) relies on the expression of several biomarkers, including CD4, CD25, and transcription factor, Foxp3. The Tregs maintain tolerance to self-antigens and prevent autoimmune diseases. …”
Get full text

The Balance of Th1/Th2 and LAP+Tregs/Th17 Cells Is Crucial for Graft Survival in Allogeneic Corneal Transplantation by Shang Li, Jing Yu, Chungang Guo, Ying Jie, Zhiqiang Pan

“…Results. The frequencies of Foxp3+Tregs, GARP+Tregs, and LAP+Tregs in the survival group were significantly higher than those in the rejection group. …”
Get full text

IVS1 −397T>C Estrogen Receptor α Polymorphism Is Associated with Low-Grade Systemic Inflammatory Response in Type 1 Diabetic Girls by Monika Ryba-Stanisławowska, Karolina Rybarczyk-Kapturska, Agnieszka Brandt, Małgorzata Myśliwiec, Jolanta Myśliwska

“…Serum concentrations of 17β-estradiol, as well as IL-6, TNF-α, VEGF, and IL-10, were measured. CD4+Foxp3+ TH17 cells were isolated and analyzed by flow cytometry. …”
Get full text

Effects of Quorum Sensing Systems on Regulatory T Cells in Catheter-Related Pseudomonas aeruginosa Biofilm Infection Rat Models by Lei Feng, Qingqing Xiang, Qing Ai, Zhengli Wang, Yunhui Zhang, Qi Lu

“…In PAO1 group, the bacterial clearance rates were lower, total cell counts were higher, pathological changes were severer, and the levels of Foxp3, TGF-β1, and IL-10 were significantly higher compared with QS-mutant groups (p<0.05). …”
Get full text

Effect of neoadjuvant chemotherapy on the immune microenvironment in gastric cancer as determined by multiplex immunofluorescence and T cell receptor repertoire analysis by Jian Zhang, Xiaomei Li, Ying Hu, Bin Dong, Yongning Jia, Ziyu Li, Xiaojing Cheng, Jinyao Shi, Jiafu Ji, Zhongwu Li, Hong Du, Ting Guo, Shuqin Jia, Xiaofang Xing, Yunsheng Dou

“…Pre-NAC FOXP3+ T reg cells level was much richer in the response group and decreased more significantly in the stromal compartment. …”
Get full text

Vitamin D Deficiency Contributes to the Reduction and Impaired Function of Naïve CD45RA+ Regulatory T Cell in Chronic Heart Failure by Yan-hui Ma, Yun-lan Zhou, Chao-yan Yue, Guang-hui Zhang, Lin Deng, Guo-hua Xie, Wei-ping Xu, Li-song Shen

“…Naïve Treg cell (CD4+CD45RA+Foxp3loT) subset, rather than whole Treg cells, contributes to the reduction of Treg in CHF. 1,25(OH)2D treatment maintained partial expression of CD45RA on CD4+T cell after αCD3/CD28 monoclonal antibodies activation and ameliorated the impaired CD4+CD45RA+T cell function from CHF patients through upregulating Foxp3 expression and IL-10 secretion in vitro. …”
Get full text

Atorvastatin Improves Inflammatory Response in Atherosclerosis by Upregulating the Expression of GARP by Xiaoqi Zhao, Yuzhou Liu, Yucheng Zhong, Bo Liu, Kunwu Yu, Huairui Shi, Ruirui Zhu, Kai Meng, Wei Zhang, Bangwei Wu, Qiutang Zeng

“…In this paper, we present that atorvastatin could upregulate the expression of GARP and TGF-β in CD4+ T cells and increase the numbers of CD4+LAP+ and CD4+Foxp3+ regulatory T cells in ApoE−/− mice. Also, we indicate that atorvastatin promotes the aggregation of GARP+ and Foxp3+ cells and secretory of the TGF-β1 in atherosclerotic plaques. …”
Get full text

Enhanced Suppressive Activity of Regulatory T Cells in the Microenvironment of Malignant Pleural Effusions by Joanna Budna, Mariusz Kaczmarek, Agata Kolecka-Bednarczyk, Łukasz Spychalski, Piotr Zawierucha, Joanna Goździk-Spychalska, Michał Nowicki, Halina Batura-Gabryel, Jan Sikora

“…Thus, we investigated the prevalence of Tregs and the relationship between them and TGF-β and IL-10 concentrations and measured expression of FOXP3, CTLA-4, CD28, and GITR genes, as well as protein expression of selected genes in benign effusions and MPEs. …”
Get full text

A Novel Liposome Formulation Carrying Both an Insulin Peptide and a Ligand for Invariant Natural Killer T Cells Induces Accumulation of Regulatory T Cells to Islets in Nonobese Dia... by Hidetoshi Akimoto, Emi Fukuda-Kawaguchi, Omar Duramad, Yasuyuki Ishii, Kazunari Tanabe

“…Immunopathological analysis showed that Foxp3+ Tregs accumulated in the islets in RGI-3100-iB-treated mice. …”
Get full text

Regulatory T Cells Accumulate in the Lung Allergic Inflammation and Efficiently Suppress T-Cell Proliferation but Not Th2 Cytokine Production by Lucas Faustino, Daniel Mucida, Alexandre Castro Keller, Jocelyne Demengeot, Karina Bortoluci, Luiz Roberto Sardinha, Maisa Carla Takenaka, Alexandre Salgado Basso, Ana Maria Caetano Faria, Momtchilo Russo

“…Foxp3+CD25+CD4+ regulatory T cells are vital for peripheral tolerance and control of tissue inflammation. …”
Get full text

Luteolin Regulates the Differentiation of Regulatory T Cells and Activates IL-10-Dependent Macrophage Polarization against Acute Lung Injury by Ke Xie, Yu-sen Chai, Shi-hui Lin, Fang Xu, Chuan-jiang Wang

“…At this time, luteolin upregulated the level of IL-10 in serum and BALF and the frequency of CD4+CD25+FOXP3+ Tregs in PBMCs and splenic mononuclear cells of CLP mice. …”
Get full text

The Treg/Th17 Imbalance in Patients with Obstructive Sleep Apnoea Syndrome by Jin Ye, Hui Liu, Gehua Zhang, Peng Li, Zhiyuan Wang, Shaotong Huang, Qintai Yang, Yuan Li

“…Our purpose is to assess the pattern of Th17 cells and CD4+CD25+Foxp3+ regulatory T (Treg) cells in peripheral blood of patients with OSAS. …”
Get full text

A Case of Recalcitrant Plantar Warts Associated with Statin Use by Aaron G. Wernham, Shireen S. Velangi

“…This case correlates with emerging literature demonstrating a link between statin medication and proliferation of HPV through increased levels of FOXP3+ regulatory T cells.…”
Get full text

Schistosoma japonicum Infection in Treg-Specific USP21 Knockout Mice by Youxiang Zhang, De-Hui Xiong, Yangyang Li, Guina Xu, Baoxin Zhang, Yang Liu, Shan Zhang, Qing Huang, Simin Chen, Fansheng Zeng, Jingyi Guo, Bin Li, Zhiqiang Qin, Zuping Zhang

“…Using a murine model infected with Schistosoma japonicum, we observed that there were more cercariae developed into adults and more eggs deposited in the livers of the USP21fl/flFOXP3Cre (KO) mice. However, immunohistochemistry showed that the degree of egg granuloma formation and liver fibrosis was reduced. …”
Get full text

Protein Phosphatase 2A: Role in T Cells and Diseases by Suyasha Roy, Lalit Batra

“…Genetic deletion of PP2A in Tregs disrupts Foxp3 expression due to hyperactivation of mTORC1 signaling which impairs the development and immunosuppressive functions of Tregs. …”
Get full text

Regulatory T Cells in Allogeneic Stem Cell Transplantation by Maria Michael, Avichai Shimoni, Arnon Nagler

“…Naturally arising CD4+CD25+Foxp3+ regulatory T cells (Treg) have emerged as a key component in this regard. …”
Get full text