DNA Methyltransferase Inhibition Promotes Th1 Polarization in Human CD4+CD25high FOXP3+ Regulatory T Cells but Does Not Affect Their Suppressive Capacity by Sija Landman, Marjan Cruijsen, Paulo C. M. Urbano, Gerwin Huls, Piet E. J. van Erp, Esther van Rijssen, Irma Joosten, Hans J. P. M. Koenen

“…Regulatory T cells (Treg) can show plasticity whereby FOXP3 expression, the master transcription factor for Treg suppressor function, is lost and proinflammatory cytokines are produced. …”
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Anti-IL-22 Antibody Attenuates Acute Graft-versus-Host Disease via Increasing Foxp3+ T Cell through Modulation of CD11b+ Cell Function by Jianbo Wu, Jian Gu, Shun Zhou, Hao Lu, Yunjie Lu, Ling Lu, Xuehao Wang

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The clinical significance of T cell infiltration and immune checkpoint expression in central nervous system germ cell tumors by Jiajun Zhou, Jiajun Zhou, Wenhao An, Lei Guan, Lei Guan, Jinyu Shi, Qiaozhen Qin, Shuai Zhong, Zheng Huang, Rui Liu, Chenxing Wu, Zhong Ma, Xueling Qi, Xiaoxia Jiang, Yan Wang, Shouwei Li

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Disturbances of Modulating Molecules (FOXP3, CTLA-4/CD28/B7, and CD40/CD40L) mRNA Expressions in the Orbital Tissue from Patients with Severe Graves’ Ophthalmopathy by Przemyslaw Pawlowski, Natalia Wawrusiewicz-Kurylonek, Anja Eckstein, Joanna Reszec, Wlodzimierz Luczynski, Kristian Johnson, Adam Kretowski, Alina Bakunowicz-Lazarczyk, Maria Gorska, Jacek Szamatowicz, Lech Chyczewski, Janusz Mysliwiec

“…To evaluate the relationship between the expression of orbital tissue mRNA for FOXP3, CTLA-4/CD28/CD80/CD86, and CD40/CD40 and the severity of Graves’ orbitopathy (GO). …”
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Paradoxical control of multifocal mammary oncogenesis by radiation therapy by Lorenzo Galluzzi, Aitziber Buqué

Subjects: “…CD4+CD25+FOXP3+ TREG cells…”
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Analysis of Sodium Chloride Intake and Treg/Th17 Lymphocytes in Healthy Individuals and Patients with Rheumatoid Arthritis or Systemic Lupus Erythematosus by Marlen Vitales-Noyola, Esther Layseca-Espinosa, Lourdes Baranda, Carlos Abud-Mendoza, Perla Niño-Moreno, Adriana Monsiváis-Urenda, Yvonne Rosenstein, Roberto González-Amaro

“…Levels and suppressive function of CD4+CD25+Foxp3+ and CD4+CD69+Foxp3− Treg cells were determined by flow cytometry in blood samples. …”
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Prognostic value of immune biomarkers in melanoma loco-regional metastases. by Emilia Hugdahl, Sura Aziz, Tor A Klingen, Lars A Akslen

“…Low FOXP3 TIL count was significantly associated with low CD8, CD3 and PD-L1 TIL counts. …”
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Repeated Long-Term DT Application in the DEREG Mouse Induces a Neutralizing Anti-DT Antibody Response by Junhua Wang, Myriam Siffert, Markus Spiliotis, Bruno Gottstein

“…Regulatory T (Tregs) cells play an important role in mediating tolerance to self-antigens but can also mediate detrimental tolerance to tumours and pathogens in a Foxp3-dependent manner. Genetic tools exploiting the foxp3 locus including bacterial artificial chromosome- (BAC-) transgenic DEpletion of REGulatory T cells (DEREG) mice have provided essential information on Treg biology and the potential therapeutic modulation of tolerance. …”
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Upregulated Expression of Indoleamine 2, 3-Dioxygenase in Primary Breast Cancer Correlates with Increase of Infiltrated Regulatory T Cells In Situ and Lymph Node Metastasis by Jinpu Yu, Jingyan Sun, Shizhen Emily Wang, Hui Li, Shui Cao, Yizi Cong, Juntian Liu, Xiubao Ren

“…In this study, the expression of IDO in primary breast cancer was examined and the correlation between the expression levels of IDO and the densities of Foxp3+ Tregs in situ was studied. The IDO stably-expressing CHO cells(IDO/CHO) were generated to evaluate the induction of Foxp3+ Tregs after coculturing with CD3+ T cells in vitro. …”
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Immunosuppressive Phenotype of Esophagus Tumors Stroma by Olga V. Kovaleva, Madina A. Rashidova, Daria V. Samoilova, Polina A. Podlesnaya, Valeria V. Mochalnikova, Alexei Gratchev

“…Large amounts of CD163+ macrophages and FOXP3+ Т cells appear to be markers of good prognosis of ESCC. …”
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Regulatory T Cells Resist Cyclosporine-Induced Cell Death via CD44-Mediated Signaling Pathways by Shannon M. Ruppert, Ben A. Falk, S. Alice Long, Paul L. Bollyky

“…Cyclosporine A (CSA) is an immunosuppressive agent that specifically targets T cells and also increases the percentage of pro-tolerogenic CD4+Foxp3+ regulatory T cells (Treg) through unknown mechanisms. …”
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Aspergillus fumigatus Influences Gasdermin-D-Dependent Pyroptosis of the Lung via Regulating Toll-Like Receptor 2-Mediated Regulatory T Cell Differentiation by Wei Yan, Yi-si Zhao, Ke Xie, Yu Xing, Fang Xu

“…ELISA kits we used to detect the expression levels of IL-1β, IL-6, IL-2R, and IL-10 in the serum and flow cytometry to detect the percentage of CD4+CD25+Foxp3+ Tregs in the patients’ peripheral blood mononuclear cells (PBMCs). …”
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Changes of Regulatory T Cells and of Proinflammatory and Immunosuppressive Cytokines in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis by Yong-chao Qiao, Jian Shen, Lan He, Xue-zhi Hong, Fang Tian, Yan-hong Pan, Ling Liang, Xiao-xi Zhang, Hai-lu Zhao

“…Presence of diabetic complications further lowers the peripheral CD4+CD25+Foxp3+Treg number.…”
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The Role of CD40 in Allergic Rhinitis and Airway Remodelling by Ke-Jia Cheng, Min-Li Zhou, Yong-Cai Liu, Chen Wang, Ying-Ying Xu

“…We detected OVA-sIgE, IL-4, IL-5, IL-13, IL-10, IFN-γ, and TGF-β levels in serum and supernatant by ELISA, CD40+ splenic DCs, and Foxp3+ Tregs by flow cytometry and CD40 mRNA by RT2-PCR. …”
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Trichostatin A Promotes the Generation and Suppressive Functions of Regulatory T Cells by Cristian Doñas, Macarena Fritz, Valeria Manríquez, Gabriela Tejón, María Rosa Bono, Alejandra Loyola, Mario Rosemblatt

“…The forkhead box P3 transcription factor (Foxp3) is a crucial molecule regulating the generation and function of Tregs. …”
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Notch1 Signaling Regulates the Th17/Treg Immune Imbalance in Patients with Psoriasis Vulgaris by Lei Ma, HaiBo Xue, Tianqin Gao, MeiLan Gao, YuJie Zhang

“…Notch1, Hes-1, RORγt, Foxp3, IL-17, and IL-10 mRNA expression, as well as Th17 and Treg cell percentages in peripheral CD4+ T cells, were detected by real-time quantitative RT-PCR and flow cytometry, and serum concentrations of IL-17 and IL-10 were detected by ELISA in 36 PV patients and 32 healthy controls. …”
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Comparative Study of Regulatory T Cell Function of Human CD25+CD4+ T Cells from Thymocytes, Cord Blood, and Adult Peripheral Blood by Wakae Fujimaki, Nozomu Takahashi, Kei Ohnuma, Masayoshi Nagatsu, Hiromi Kurosawa, Satoko Yoshida, Nam H. Dang, Takehiko Uchiyama, Chikao Morimoto

“…CB CD25+CD4+ T cells displayed low-FOXP3 protein expression level and had no suppressive activity. …”
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CD3+CD8+CD28− T Lymphocytes in Patients with Lupus Nephritis by Marcelina Żabińska, Magdalena Krajewska, Katarzyna Kościelska-Kasprzak, Marian Klinger

“…We determined absolute count of CD3+CD8+CD28- and CD3+CD8+CD28-Foxp3+ subpopulations by flow cytometry. We observed a statistically significant increase in absolute count and percentage of CD3+CD8+CD28- in SLE patients compared to HC (p<0.001). …”
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The Role and Function of Regulatory T Cells in Toxoplasma gondii-Induced Adverse Pregnancy Outcomes by Xuyang Gao, Yue Zhong, Yifan Liu, Runmin Ding, Jinling Chen

“…In this review, we summarize the effects of T. gondii infection on host Tregs and its critical transcriptional factor, Foxp3.…”
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Effect of RAS mutations and related immune characteristics on the prognosis of patients with MSI-H/dMMR colorectal cancer by Yupeng Jiang, Yuyao Liu, Hong Huang, Tiantian Zhao, Zengyi Zhao, Yawen Gao

“…Conclusion RAS mutations in patients with MSI-H/dMMR CRC may reduce the infiltration of CD11c+ dendritic cells, CD4+ T cells, and CD8+ T cells, and increase the infiltration of Foxp3+ Treg cells to affect the tumor microenvironment of patients. …”
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