Clostridium butyricum attenuates LPS-induced myocardial injury in septic mice by modulating CD4 + CD25 + FOXP3 + Treg by Jinglin Zhao, Liuli Wu, Rupan Zhang, Mei Yuan, Junchao Huang, Xiongfei Jia, Xiaoqin Mao

“…The bacterium's ability to prevent intestinal mucosal damage and alleviate the immunosuppressive state during the later stages of sepsis by regulating CD4 + CD25 + FOXP3 + Treg cells is particularly noteworthy. This suggests a therapeutic role for C. butyricum in sepsis management by protecting against myocardial injury and improving immune regulation.…”
Get full text

哮喘患儿外周血RORC和FOXP3mRNA表达水平的变化及其意义

Subjects: Get full text

CD4+ CD25high T细胞和FOXP3在不明原因复发性自然流产中的作用

“…【目的】 检测不明原因复发性自然流产(URSA)患者外周血及蜕膜的CD4+ CD25high T细胞和FOXP3的表达,探讨CD4+ CD25high T细胞和FOXP3在母胎免疫耐受中的作用65377;【方法】 选择从2005年9月至2006年6月就诊的154例URSA患者根据就诊时的妊娠状态分成未孕组129例,早期流产组25例;正常早孕要求人工终止妊娠的妇女组50例及正常未孕女性组42例为对照组65377;收集所有研究对象的外周血及由于计划外妊娠要求行人工流产者和已确认胚胎停育的URSA患者行清宫术后的新鲜蜕膜组织,采用流式细胞仪分析外周血及蜕膜组织CD4+ CD25+ 调节性T细胞及其亚群的比例及FOXP3表达65377; 【结果】 ①外周血及蜕膜中CD4+ CD25high T细胞的比例:正常早孕妇女外周血CD4+ CD25high T细胞高于正常未孕妇女及URSA流产组, 差异有统计学意义(P < 0.01),URSA未孕患者外周血CD4+ CD25high T细胞也显著低于正常未孕女性及URSA流产患者(P < 0.01);URSA流产患者蜕膜CD4+ CD25high T细胞低于正常早孕妇女蜕膜(0.62 ± 0.27 vs. 1.41 ± 0.31, P < 0.01)65377;②外周血及蜕膜中FOXP3表达比例:正常早孕妇女外周血CD4+ CD25high T细胞中FOXP3的表达比例为(95.6 ± 3.6),高于正常未孕妇(92.1 ± 3.4)及URSA流产患者,差异有统计学意义(P < 0.01;P < 0.05);URSA未孕组患者外周血中FOXP3的表达与正常未孕妇女及URSA流产组之间相比无统计学差异(P > 0.05);URSA流产患者蜕膜CD4+ CD25high T细胞中FOXP3的表达比例低于正常早孕妇女蜕膜,差异有统计学意义(94.3 ± 3.1 vs. 97.1 ± 2.2, P < 0.01)65377;【结论】 CD4+CD25high T细胞在维持正常妊娠中发挥重要作用,URSA的发生与CD4+CD25high T细胞的减少有关,URSA患者CD4+ CD25high T细胞比例下降与FOXP3表达的降低有关65377;…”
Get full text

Efficient Therapeutic Function and Mechanisms of Human Polyclonal CD8+CD103+Foxp3+ Regulatory T Cells on Collagen-Induced Arthritis in Mice by Juan Sun, Yiming Yang, Xiaona Huo, Beibei Zhu, Zhenhua Li, Xueyu Jiang, Rufeng Xie, Li Gao, Ying Sun, Huahua Fan, Yongming Zhu, Jie Yang

“…Human CD8+Tregs induced by TGF-β1/RAPA showed high expression of Foxp3 and CD103, exhibited vigorous suppression ability, and were stable in inflammatory microenvironments. …”
Get full text

TIM‐4 increases the proportion of CD4+CD25+FOXP3+ regulatory T cells in the pancreatic ductal adenocarcinoma microenvironment by inhibiting IL‐6 secretion by Ziyao Wang, Zerong Xie, Yu Mou, Ruiman Geng, Chen Chen, Nengwen Ke

Get full text

Successful Regulatory T Cell-Based Therapy Relies on Inhibition of T Cell Effector Function and Enrichment of FOXP3+ Cells in a Humanized Mouse Model of Skin Inflammation by S. Landman, V. L. de Oliveira, M. Peppelman, E. Fasse, E. van Rijssen, S. C. Bauland, P. van Erp, I. Joosten, H. J. P. M. Koenen

“…As a novel finding, we demonstrate that human Treg injection led to a reduction of IL-17-secreting cells while promoting a relative increase in immunosuppressive FOXP3+ Treg in the human skin, indicating active immune regulation in controlling the local proinflammatory response. …”
Get full text

Correlation of Interleukin-17-Producing Effector Memory T Cells and CD4+CD25+Foxp3 Regulatory T Cells with the Phosphate Levels in Chronic Hemodialysis Patients by Cheng-Lin Lang, Min-Hui Wang, Kuan-Yu Hung, Sung-Hao Hsu, Chih-Kang Chiang, Kuo-Cheng Lu

“…Interleukin-17-producing CD4+ effector memory T (Th17) cells and CD4+CD25+Foxp3 regulatory T (Treg) cells both play critical roles in immune activation and inflammation. …”
Get full text

Illicium verum Extract and Trans-Anethole Attenuate Ovalbumin-Induced Airway Inflammation via Enhancement of Foxp3+ Regulatory T Cells and Inhibition of Th2 Cytokines in Mice by Yoon-Young Sung, Seung-Hyung Kim, Dong-Seon Kim, Ji-eun Lee, Ho Kyoung Kim

“…IVE and AET increased Foxp3 expression in lungs (p<0.05). IVE and AET reduced IL-4 and increased IFN-γ production in the supernatant of splenocyte cultures (p<0.05). …”
Get full text

ESAT-6 protein suppresses allograft rejection by inducing CD4+Foxp3+ regulatory T cells through IκBα/cRel pathway by Xiaofei Huang, Xiaofei Huang, Yuqun Zeng, Jingru Lin, Huazhen Liu, Huazhen Liu, Chun-Ling Liang, Chun-Ling Liang, Yuchao Chen, Yuchao Chen, Feifei Qiu, Feifei Qiu, Jonathan S. Bromberg, Zhenhua Dai, Zhenhua Dai

“…Flow cytometric analyses were conducted to quantify CD4+Foxp3+ Tregs, while immunohistochemistry was carried out to observe allograft immunopathology. …”
Get full text

使用FLAG标签肽及慢病毒载体共同筛选小鼠foxp3基因RNA干扰的有效靶点 by 史艳侠, 韩文杰, 彭柔君, 张景航, 黄慧强, 姜文奇

Subjects: “…foxp3…”
Get full text

DNA Methyltransferase Inhibition Promotes Th1 Polarization in Human CD4+CD25high FOXP3+ Regulatory T Cells but Does Not Affect Their Suppressive Capacity by Sija Landman, Marjan Cruijsen, Paulo C. M. Urbano, Gerwin Huls, Piet E. J. van Erp, Esther van Rijssen, Irma Joosten, Hans J. P. M. Koenen

“…Regulatory T cells (Treg) can show plasticity whereby FOXP3 expression, the master transcription factor for Treg suppressor function, is lost and proinflammatory cytokines are produced. …”
Get full text

Anti-IL-22 Antibody Attenuates Acute Graft-versus-Host Disease via Increasing Foxp3+ T Cell through Modulation of CD11b+ Cell Function by Jianbo Wu, Jian Gu, Shun Zhou, Hao Lu, Yunjie Lu, Ling Lu, Xuehao Wang

Get full text

Disturbances of Modulating Molecules (FOXP3, CTLA-4/CD28/B7, and CD40/CD40L) mRNA Expressions in the Orbital Tissue from Patients with Severe Graves’ Ophthalmopathy by Przemyslaw Pawlowski, Natalia Wawrusiewicz-Kurylonek, Anja Eckstein, Joanna Reszec, Wlodzimierz Luczynski, Kristian Johnson, Adam Kretowski, Alina Bakunowicz-Lazarczyk, Maria Gorska, Jacek Szamatowicz, Lech Chyczewski, Janusz Mysliwiec

“…To evaluate the relationship between the expression of orbital tissue mRNA for FOXP3, CTLA-4/CD28/CD80/CD86, and CD40/CD40 and the severity of Graves’ orbitopathy (GO). …”
Get full text

The clinical significance of T cell infiltration and immune checkpoint expression in central nervous system germ cell tumors by Jiajun Zhou, Jiajun Zhou, Wenhao An, Lei Guan, Lei Guan, Jinyu Shi, Qiaozhen Qin, Shuai Zhong, Zheng Huang, Rui Liu, Chenxing Wu, Zhong Ma, Xueling Qi, Xiaoxia Jiang, Yan Wang, Shouwei Li

Subjects: Get full text

Nursing of a pediatric patient with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (1例罕见IPEX综合征患儿的护理) by ZHU Huiyun (朱慧云), WANG Suling (王苏玲)

Subjects: “…foxp3 gene…”
Get full text

Paradoxical control of multifocal mammary oncogenesis by radiation therapy by Lorenzo Galluzzi, Aitziber Buqué

Subjects: “…CD4+CD25+FOXP3+ TREG cells…”
Get full text

Analysis of Sodium Chloride Intake and Treg/Th17 Lymphocytes in Healthy Individuals and Patients with Rheumatoid Arthritis or Systemic Lupus Erythematosus by Marlen Vitales-Noyola, Esther Layseca-Espinosa, Lourdes Baranda, Carlos Abud-Mendoza, Perla Niño-Moreno, Adriana Monsiváis-Urenda, Yvonne Rosenstein, Roberto González-Amaro

“…Levels and suppressive function of CD4+CD25+Foxp3+ and CD4+CD69+Foxp3− Treg cells were determined by flow cytometry in blood samples. …”
Get full text

不同原发病的肝移植患者围术期调节性Ｔ细胞的变化

“…各组患者分别于术前、术后１、３、７、１４ ｄ分别检测外周血Ｔ淋巴细胞百分比（Ｔ％），ＣＤ４＋ＣＤ２５＋Ｆｏｘｐ３＋Ｔｒｅｇ百分比（Ｔｒｅｇ％）和Ｆｏｘｐ３ ｍＲＮＡ表达。观察其于不同组间的表达水平和术后的变化趋势。…”
Get full text

Prognostic value of immune biomarkers in melanoma loco-regional metastases. by Emilia Hugdahl, Sura Aziz, Tor A Klingen, Lars A Akslen

“…Low FOXP3 TIL count was significantly associated with low CD8, CD3 and PD-L1 TIL counts. …”
Get full text

Repeated Long-Term DT Application in the DEREG Mouse Induces a Neutralizing Anti-DT Antibody Response by Junhua Wang, Myriam Siffert, Markus Spiliotis, Bruno Gottstein

“…Regulatory T (Tregs) cells play an important role in mediating tolerance to self-antigens but can also mediate detrimental tolerance to tumours and pathogens in a Foxp3-dependent manner. Genetic tools exploiting the foxp3 locus including bacterial artificial chromosome- (BAC-) transgenic DEpletion of REGulatory T cells (DEREG) mice have provided essential information on Treg biology and the potential therapeutic modulation of tolerance. …”
Get full text