Lethal clinical outcome and chemotherapy and immunotherapy resistance in patients with urothelial carcinoma with MDM2 amplification or overexpression by Weijuan Zhang, Jiejie Xu, Hailong Liu, Yu Zhu, Zewei Wang, Han Zeng, Zhaopei Liu, Yuan Chang, Le Xu, Kaifeng Jin, Jingtong Xu, Xiaohe Su, Yawei Ding, Lingkai Zhang, Jiaxing Sun, Yuzhen Wu

“…Additionally, 2264 UC samples from five independent external cohorts, with genomic, transcriptomic, and clinical data, were used for validation.Results MDM2 amplification (MDM2Amp) or protein overexpression (MDM2OE) was associated with inferior overall survival (ZSHS cohort, Log-rank p<0.001; FUSCC cohort, Log-rank p=0.030) and reduced response to platinum-based chemotherapy (ZSHS cohort, Log-rank p<0.001) as well as anti-PD-1/PD-L1 immunotherapy (FUSCC cohort, Log-rank p=0.016) in patients with UC, irrespective of TP53/p53 status. …”
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Risk Values of Weight and Body Mass Index for Chest Wall Thickness in Patients Requiring Needle Thoracostomy Decompression by Chia-Hung Hsu, Tzu-Yin Lin, Ju-Chi Ou, Jiann Ruey Ong, Hon-Ping Ma

“…For men, CWT at 5th ICS was predicted over 5 cm at BMI over 25.5 kg/m2 or weight over 157.4 kg. …”
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Which PSMA PET/CT interpretation criteria most effectively diagnose prostate cancer? a retrospective cohort study by Le Ma, Yaxin Hao, Luoping Zhai, Wanchun Zhang, Xiaoming Cao, Kaiyuan Jia

“…Method This retrospective analysis spans a five-year period, focusing on patients with clinically suspected or newly diagnosed, treatment-naïve PCa who underwent 18F-PSMA PET/CT. …”
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Evaluation on the Control Effects of Different Biogenic Pesticides Mixed with Metarhizium anisopliae CQMa421 on Empoasca onukii Matsuda by Jingjing LI, Kui KANG, Wenxuan QI, Jinghui SUN, Zhangli FENG, Daowei ZHANG

“…【Conclusion】The effects of single use of bio-pesticides against E. onukii ranked as: spinetoram > M. anisopliae CQMa421 > azadirachtin > veratrine; the effects of the combined use of bio-pesticides with M. anisopliae CQMa421 against E. onukii ranked as: spinetoram > veratrine > azadirachtin. …”
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Neurological history both twinned and queried by generative artificial intelligence by Jung-Hyun Lee, Jung-Hyun Lee, Jung-Hyun Lee, Eunhee Choi, Sergio L. Angulo, Sergio L. Angulo, Robert A. McDougal, Robert A. McDougal, Robert A. McDougal, Robert A. McDougal, William W. Lytton, William W. Lytton, William W. Lytton

“…Given the random variability of GPT-4 output, each case was presented five separate times to check consistency and reliability.ResultsThe study achieved an overall HPI content retrieval accuracy of 81%, with accuracies of 84% for headache, 82% for stroke, and 77% for neurodegenerative diseases. …”
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Real-world effectiveness of azvudine versus nirmatrelvir-ritonavir in hospitalized patients with COVID-19 and pre-existing diabetes by Guanyue Su, Silin Li, Donghua Zhang, Yongjian Zhou, Ling Wang, Yiqiang Yuan, Guowu Qian, Guotao Li, Na Han, Ming Cheng, Guangming Li, Shixi Zhang, Hong Luo, Mengzhao Yang, Yanyang Zhang, Zhan Song, Jiyuan Xing, Zujiang Yu, Zhigang Ren

“…No significant difference was found in composite disease progression between the two groups. Five sensitivity analyses verified the robustness of the results. …”
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NH3 release during the snow evaporation process in typical cities in Northeast China by Xiaoteng Liu, Hongsheng Jia, Yunze Zhao, Yachao Zhang, Haodong Hou, Yingying Xu

“…The average release flux (F) was 1624.58 ± 2064.5 μg/m2, and the average release rate (V) was 361.33 ± 465.31 ng/(m2·s). …”
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Critical Success Factor Proyek TI: Studi Kasus Mobile Government by Ikhsan Triadi Syaputra, Teguh Raharjo, Bob Hardian, Tiarma Simanungkalit

“…This study used eight CSF with five success criteria. The CSF are then sorted to find its priority using the Analytic Hierarchy Process (AHP). …”
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Real-World Experience with CDK4/6 Inhibitors in the First-Line Palliative Setting for HR+/HER2− Advanced Breast Cancer by Ram Patel, John Mathews, Caroline Hamm, Swati Kulkarni, Rasna Gupta, Tarquin Opperman, John Dean Chiong, Abdullah Nasser

“…Results: Seventy-five patients were included in the final analysis. …”
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Construct validity and responsiveness of clinical upper limb measures and sensor-based arm use within the first year after stroke: a longitudinal cohort study by Johannes Pohl, Geert Verheyden, Jeremia Philipp Oskar Held, Andreas Ruediger Luft, Chris Easthope Awai, Janne Marieke Veerbeek

“…Additionally, individuals wore five movement sensors (trunk, wrists, and ankles) for three days. …”
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Characterization of adult T-cell leukemia/lymphoma patients with specific skin lesions in a tertiary dermatological service in Brazil by Mariana Valente, José Antonio Sanches, Youko Nukui, Jade Cury-Martins, Bruno Castro Souza, Juliana Pereira, Denis Miyashiro

“…Survival curves using the Kaplan–Meier method were analyzed with log-rank test, univariate and multivariate analyses were performed with the Cox proportional hazards model.ResultsForty-four patients were studied, 24 females (54.5%), and 20 males (45.5%). …”
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Single-Cell Transcriptome Analysis Reveals Different Immune Signatures in HPV- and HPV + Driven Human Head and Neck Squamous Cell Carcinoma by Simin Li, Yang Wang, Rui Sun, Debora Franceschi, Hongying Pan, Chenxuan Wei, Anthony Chukwunonso Ogbuehi, Bernd Lethaus, Vuk Savkovic, Sebastian Gaus, Rüdiger Zimmerer, Dirk Ziebolz, Gerhard Schmalz, Xiao Jiang

“…A hidden Markov model (HMM) was used to predict gene expression states (on or off) throughout pseudotime. Five-year overall survival outcomes were compared in both HPV+ and HPV- subsets. …”
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Un ensemble funéraire de l’Antiquité tardive à dépôt atypique d’âne à Woippy (Moselle) by Gaël Brkojewitsch, Olivier Putelat

“…The remains were accompanied by five objects that rank this grave above average for the group in terms of burial wealth, without outperforming the whole. …”
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Anti-Methanogenic Potential of Seaweeds and Impact on Feed Fermentation and Rumen Microbiome In Vitro by Pradeep Kumar Malik, Atul Purshottam Kolte, Shraddha Trivedi, Govindan Tamilmani, Archit Mohapatra, Shalini Vaswani, Johnson Belevendran, Artabandhu Sahoo, Achamveetil Gopalakrishnan, Raghavendra Bhatta

“…A series of in vitro studies were conducted to explore the anti-methanogenic potential of five seaweeds collected from the Indian sea and to optimize the level(s) of incorporation of the most promising seaweed(s) into a straw and concentrate diet to achieve a significant reduction in methane (CH₄) production without disturbing rumen fermentation characteristics. …”
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Workload-capacity imbalances and their impact on self-management complexity in patients with multimorbidity: a multicenter cross-sectional study by Binyu Zhao, Yujia Fu, Jingjie Wu, Erxu Xue, Chuyang Lai, Dandan Chen, Qiwei Wu, Jianing Yu, Qiaoyu Wu, Zhihong Ye, Jing Shao

“…Environmental capacity ranked second for ‘high workload-high capacity’ (R² = 3.26) and ‘low workload-low capacity’ (R² = 5.32) profiles. …”
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Assessment of grain starch content and responses to CMS-S and CMS-C in high-starch maize hybrids by M. R. Firsova, B. R. Shomakhov, R. S. Kushkhova, Z. T. Khashirova, R. A. Kudaev, A. Kh. Gyaurgiev, S. P. Appaev, A. M. Kagermazov, A. V. Khachidogov, A. I. Buzurtanov, K. Sh. Badurgova, M. A. Bazgiev, V. G. Goldshtein, V. I. Khoreva, E. B. Khatefov

“…Assessing agronomic and breeding prospects of the best 68 hybrids between high-starch maize lines and sterile testers proved their potential for producing native starch to at least 70–72% DMB. Five hybrids were identified as promising for yielding native starch (69.02–70.4% DMB), as well as protein (10.3–13.5% DMB) and oil (3.77–5.03% DMB) by-products during deep grain processing.…”
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Comparison of Therapeutic Effects of Different Rehabilitation Methods on Patients Undergoing Total Knee Arthroplasty: A Network Meta‐Analysis of Randomized Controlled Trials by Zhaokai Jin, Yi Tang, Hua Huang, Lei Chen, Zhongyi Zhang, Tianyou Ma, Zhengming Wang, Hai Su, Haojing Zhou, Shuaijie Lv, Peijian Tong

“…Methods A comprehensive search of five databases and two clinical trial registration platforms was conducted from inception through March 31, 2024, and conducted to identify eligible randomized controlled trials (RCTs). …”
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Research Status and Direction of Chronic Obstructive Pulmonary Disease Complicated with Coronary Heart Disease: A Bibliometric Analysis from 2005 to 2024 by Bian H, Zhu S, Xing W, Qi L, Xue J, Peng X, Jin Z, Zhao H

“…The United States emerged as the leading country by publication count; Lin Cheng-li ranked first among authors, while China Medical University topped institutional contributions. …”
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Network Meta-Analysis of Factors Influencing the Carbon Sink Capacity of Urban Park Green Spaces by Yutong JI, Tianyi LIN, Lian LIU, Xiong LI

“…The Meta-analysis incorporates network evidence plots, league tables, and SUCRA (surface under the cumulative ranking curves) to evaluate the ranking and relative importance of different factors. …”
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A Comparative study of Daiva's Sin and its Evolution in the Stories of Ancient Iran and Ta'ziehs of Daiva's Tying Thumb Based on Six Poetic Verses by Mahdi mohamadi, Adel Meghdadian, Abolfazl Tajik

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