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Causal Effects of Air Pollution, Noise, and Shift Work on Unstable Angina and Myocardial Infarction: A Mendelian Randomization Study
Published 2024-12-01“…Summary statistics were derived from large genome-wide association studies (GWASs) from the UK Biobank and the FinnGen consortium (Helsinki, Finland), with replication using an independent GWAS data source for myocardial infarction. …”
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143
Immune Cells and Intracerebral Hemorrhage: A Causal Investigation Through Mendelian Randomization
Published 2025-01-01“…Summary statistics data for ICH were acquired from FinnGen, comprising 4056 ICH cases and 371,717 controls. …”
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144
Association of genetically proxied cancer-targeted drugs with cardiovascular diseases through Mendelian randomization analysis
Published 2025-01-01“…Genome-wide association study (GWAS) summary statistics for 19 cardiovascular diseases were derived from the FinnGen database. Primary analysis was carried out using the summary-data-based MR (SMR) method, with sensitivity analysis for validation. …”
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145
Exploring the genetic correlation and causal relationships between breast cancer and meningioma using bidirectional Mendelian randomization
Published 2025-02-01“…Meningioma GWAS data were obtained from the FinnGen consortium and were further divided into intracranial and spinal meningioma groups for analysis. …”
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146
Advanced heart failure: guideline‐directed medical therapy, diuretics, inotropes, and palliative care
Published 2022-06-01Get full text
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147
Genetic insight into dissecting the immunophenotypes and inflammatory profiles in the pathogenesis of Sjogren syndrome
Published 2025-01-01“…Methods Our study leveraged the genetic variants of multi-omics statistics extracted from genome-wide association study (GWAS), the University of Bristol and the FinnGen study. We performed a bidirectional Mendelian randomization and mediation study based on randomly allocated instrumental variables to infer causality, followed by external validation with UK Biobank data and Bayesian colocalization. …”
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Predictors of sickness absence among employees with common mental disorders in Sweden– a longitudinal study
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150
Bokvalg i norske barnehager - hva som leses sammen med barn og hvorfor
Published 2025-02-01“…Det blir dermed tydelig at det finnes et uutnyttet potensial i barnehagen for å løfte fram nye barnebøker, både enkelttitler og serier. …”
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151
Association of antihypertensive drug target genes with alzheimer’s disease: a mendelian randomization study
Published 2025-01-01“…We performed two-sample Mendelian randomization (MR) to estimate the potential effect of different antihypertensive drug classes on AD using summary statistics from a meta-analysis (111,326 cases and 677,663 controls) and further replicated in FinnGen cohorts (9301 cases and 367,976 controls). …”
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152
Effect of trace elements and nutrients on 21 autoimmune diseases: a Mendelian randomization study
Published 2025-01-01“…Outcome GWAS data were derived from the FinnGen database. MR was employed to explore the causal relationships between 9 trace elements and 6 vitamins and autoimmune diseases. …”
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153
Exploring the role of inflammatory biomarkers in trigeminal neuralgia
Published 2025-02-01“…Methods: A two-sample MR approach was employed using genome-wide association study (GWAS) data from 8293 Finnish individuals for inflammatory cytokines and data from the FinnGen database for TN. Instrumental variables (IVs) were selected based on genome-wide significance and clumping thresholds to avoid linkage disequilibrium. …”
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154
Causal Association Between Obstructive Sleep Apnea and Migraine: A Bidirectional Mendelian Randomization Study
Published 2025-01-01“…The public genome-wide association study (GWAS) data for OSA, migraine, and subtypes were obtained from the IUE open GWAS project and the FinnGen consortium. To investigate the causal links between OSA and migraine, inverse variance weighted (IVW) analysis was used in conjunction with four additional statistical approaches. …”
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Human ACE2 transgenic pigs are susceptible to SARS-CoV-2 and develop COVID-19-like disease
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Healthcare resource use of patients with transthyretin amyloid cardiomyopathy
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Mendelian Randomization Reveals Potential Causal Relationships Between DNA Damage Repair-Related Genes and Inflammatory Bowel Disease
Published 2025-01-01“…The GWAS summarized data for IBD and its two subtypes, Crohn’s disease (CD) and ulcerative colitis (UC), were acquired from the FinnGen study. We elected from genetic variants located within or near 2000 DDR-related genes in cis, which are closely associated with DDR-related gene changes. …”
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