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Clonal hematopoiesis of indeterminate potential and type 2 diabetes mellitus among patients with STEMI: from a prospective cohort study combing bidirectional Mendelian randomizatio...
Published 2025-01-01“…Mendelian randomization studies suggest that the development of T2DM may increase the propensity for CHIP, as indicated by findings from the UK Biobank and FinnGen consortium. T2DM, type 2 diabetes mellitus; CHIP, clonal haematopoiesis of indeterminate potential.…”
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82
Branched-chain amino acids levels associated with risk of erectile dysfunction: A Mendelian randomization analysis
Published 2025-02-01“…The genetic data for ED were acquired from the FinnGen study (n = 95,178). The primary method used to assess causal associations was the inverse variance-weighted (IVW) method, supplemented by MR-Egger, weighted median, and simple median analyses. …”
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83
Causal relationship of familial hypercholesterolemia with risk of intestinal vascular disorders: A mendelian randomization study
Published 2025-03-01“…Methods: A Mendelian randomization (MR) analysis was performed by extracting summary-level datasets for FH or FH concurrently with ischemic heart disease (IHD) and intestinal vascular diseases from the FinnGen study including 329,115, 316,290 and 350,505 individuals. …”
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84
Causal Associations Between Sarcopenia and Gestational Diabetes Mellitus
Published 2025-02-01“…In this study, we used a bi-directional Mendelian randomization (MR) approach to explore this intricate relationship.Methods: This study utilized data from FinnGen datasets and genome-wide association studies. …”
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85
«Så sitter du der og plutselig leser for alle» – en nærstudie av barnehageansatte som litteraturformidlere
Published 2025-02-01“… Nyere forskning om barnehageansatte viser hvilke lesepraksiser som finnes i skandinaviske barnehager (Alatalo & Westlund, 2021; Damber, 2015; Dybvik et al., 2022; Tjäru, 2023). …”
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86
Safety and Phosphate‐Binding Capacity of Oxylanthanum Carbonate in Healthy Volunteers
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87
A Bidirectional Mendelian Randomization Study Investigating the Causal Relationship Between Ankylosing Spondylitis and Chronic Obstructive Pulmonary Disease
Published 2025-02-01“…Sensitivity analyses were also performed to evaluate the impact of heterogeneity and pleiotropy on the MR results.Results: The study included two datasets related to AS (ebi-a-GCST005529 and ukb-a-88) and two datasets related to COPD (ebi-a-GCST90018807 and finn-b-J10_COPD). In our forward MR, the analysis of ebi-a-GCST005529 dataset against ebi-a-GCST90018807 dataset showed that AS was associated with an increased risk of COPD (OR = 1.1326, 95% CI = 1.0181– 1.2600, P = 0.0221). …”
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88
Separating the Effects of Early-Life and Adult Body Size on Chronic Kidney Disease Risk: A Mendelian Randomization Study
Published 2025-01-01“…Biobank, and genetic associations with CKD were obtained from the CKDGen and FinnGen consortia. Results : A larger genetically predicted early-life body size was associated with an increased risk of CKD (odds ratio [OR], 1.27; 95% confidence interval [CI], 1.14 to 1.41; P=1.70E-05) and increased blood urea nitrogen (BUN) levels (β=0.010; 95% CI, 0.005 to 0.021; P=0.001). …”
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Effect of the gut microbiome in glaucoma risk from the causal perspective
Published 2024-05-01“…Genome-wide association study summary statistics of 196 GM taxa (n=18 340) and glaucoma (18 902 cases and 358 375 controls) were obtained from MiBioGen and FinnGen Consortium. Inverse variance weighted, MR-Egger, weighted median, weighted mode, Mendelian Randomisation Pleiotropy Residual Sum and Outlier, MR-Egger intercept and Cochran’s Q statistical analyses were used to supplement MR results and sensitivity analysis. …”
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90
Proteome‐Wide Mendelian Randomization Identifies Therapeutic Targets for Abdominal Aortic Aneurysm
Published 2025-02-01“…Genetic associations with AAA were sourced from the AAAgen consortium, a large‐scale genome‐wide association study meta‐analysis involving 37 214 cases and 1 086 107 controls, and the FinnGen study, which included 3869 cases and 381 977 controls. …”
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91
Multidimensional Plasma Lipids Affect Preeclampsia/Eclampsia: A Mendelian Randomization Study
Published 2025-01-01“…Summary statistics from plasma lipidomics of 7174 Finnish individuals and summary data on preeclampsia/eclampsia from the FinnGen consortium involving 219 817 European participants were employed. …”
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92
Advanced heart failure: guideline‐directed medical therapy, diuretics, inotropes, and palliative care
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93
Causal Effects of Air Pollution, Noise, and Shift Work on Unstable Angina and Myocardial Infarction: A Mendelian Randomization Study
Published 2024-12-01“…Summary statistics were derived from large genome-wide association studies (GWASs) from the UK Biobank and the FinnGen consortium (Helsinki, Finland), with replication using an independent GWAS data source for myocardial infarction. …”
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94
Immune Cells and Intracerebral Hemorrhage: A Causal Investigation Through Mendelian Randomization
Published 2025-01-01“…Summary statistics data for ICH were acquired from FinnGen, comprising 4056 ICH cases and 371,717 controls. …”
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Genetic insight into dissecting the immunophenotypes and inflammatory profiles in the pathogenesis of Sjogren syndrome
Published 2025-01-01“…Methods Our study leveraged the genetic variants of multi-omics statistics extracted from genome-wide association study (GWAS), the University of Bristol and the FinnGen study. We performed a bidirectional Mendelian randomization and mediation study based on randomly allocated instrumental variables to infer causality, followed by external validation with UK Biobank data and Bayesian colocalization. …”
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Predictors of sickness absence among employees with common mental disorders in Sweden– a longitudinal study
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98
Bokvalg i norske barnehager - hva som leses sammen med barn og hvorfor
Published 2025-02-01“…Det blir dermed tydelig at det finnes et uutnyttet potensial i barnehagen for å løfte fram nye barnebøker, både enkelttitler og serier. …”
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Exploring the genetic correlation and causal relationships between breast cancer and meningioma using bidirectional Mendelian randomization
Published 2025-02-01“…Meningioma GWAS data were obtained from the FinnGen consortium and were further divided into intracranial and spinal meningioma groups for analysis. …”
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Causal Association Between Obstructive Sleep Apnea and Migraine: A Bidirectional Mendelian Randomization Study
Published 2025-01-01“…The public genome-wide association study (GWAS) data for OSA, migraine, and subtypes were obtained from the IUE open GWAS project and the FinnGen consortium. To investigate the causal links between OSA and migraine, inverse variance weighted (IVW) analysis was used in conjunction with four additional statistical approaches. …”
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