The role of inflammasomes in hepatocellular carcinoma: Mechanisms and therapeutic insights by Valentina Arrè, Roberto Negro, Gianluigi Giannelli

“…Hepatocellular carcinoma is among the most frequent forms of primary liver cancer and develops within a context of chronic inflammation, frequently associated with a multitude of risk factors, including viral infections, metabolic dysfunction-associated fatty liver disease, metabolic dysfunction-associated steatohepatitis and liver fibrosis. The tumor microenvironment is crucial for the progression of HCC, as immune cells, tumor-associated fibroblasts and hepatic stellate cells interact to promote chronic inflammation and tumor spread. …”
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Unawareness of a Prolonged Retained Capsule Endoscopy: The Importance of Careful Follow-Up and Cooperation between Medical Institutions by Susumu Saigusa, Masaki Ohi, Hiroki Imaoka, Tadanobu Shimura, Ryo Uratani, Yasuhiro Inoue, Masato Kusunoki

“…Each ulcer had different histopathological findings such as the degree of fibrosis and monocyte infiltration. These differences led us to consider that the proximal ulcer may have been secondarily induced by capsule retention. …”
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Analysis of MicroRNA -155-5p Expression in Patients with Primary Myelofibrosis. by Sarah I. Khaleel, Jaffar N. AlAlsaidissa

“… Background: Primary myelofibrosis is a chronic myeloproliferative neoplasm characterized by abnormal megakaryocyte proliferation and fibrosis that destroys healthy bone marrow. This results in extramedullary hematopoiesis, variable blood cell deficiencies, hepatosplenomegaly, general symptoms, progression to leukemia, and a reduced lifespan. …”
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Fetoplacental Discrepancy with Normal Karyotype in Amniotic Fluid and Two Different Cell Lines in Placenta by Veronica Ortega, Christina Mendiola, Eric Williamson, Kenneth Higby, Gopalrao V. N. Velagaleti

“…Mother was a carrier for the Cystic Fibrosis (delta F508), Factor V Leiden mutations, HbD-Los Angeles and HbQ-India variants. …”
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Silica-exposed patients with silicosis show shorter telomeres than do unexposed individuals: a pilot study in a population in southeastern Brazil by Marcos César Santos de Castro, Lucas de Carvalho Costa, Kaio Cezar Rodrigues Salum, Hermano Albuquerque de Castro, Patrícia Canto Ribeiro, Walter Costa, Angela Santos Ferreira Nani, Fabiana Barzotto Kohlrausch

“…ABSTRACT Objective: Silicosis is a pneumoconiosis characterized by fibrosis of the lung parenchyma caused by the inhalation of silica particles. …”
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Lipoid Pneumonia in a Gas Station Attendant by Gladis Isabel Yampara Guarachi, Valeria Barbosa Moreira, Angela Santos Ferreira, Selma M. De A. Sias, Cristovão C. Rodrigues, Graça Helena M. do C. Teixeira

“…It presents acutely or chronically and may result in pulmonary fibrosis. We describe here a case of lipoid pneumonia in a gas station attendant who siphoned gasoline to fill motorcycles; he was hospitalized due to presenting with a respiratory infection that was hard to resolve. …”
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Molecular Mechanisms of Immunomodulation Properties of Mesenchymal Stromal Cells: A New Insight into the Role of ICAM-1 by Yury Rubtsov, Кirill Goryunov, Аndrey Romanov, Yulia Suzdaltseva, George Sharonov, Vsevolod Tkachuk

“…Mesenchymal stromal cells (MSC) control excessive inflammation and create a microenvironment for tissue repair protecting from chronic inflammation and tissue fibrosis. We examined the molecular mechanisms of MSC immunomodulatory function in mixed cultures of human adipose-derived MSC with lymphocytes. …”
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Exploratory study on the efficacy of topical pan-JAK inhibitor in ocular and skin GVHD in a sclerodermatous GVHD mouse model by Shinri Sato, Yoko Ogawa, Kazuki Asai, Eisuke Shimizu, Shota Shimizu, Hiroko Taniguchi, Takahiro Okazaki, Shigeto Shimmura, Kazuno Negishi, Masatoshi Hirayama

“…Pathological and immunohistochemical analyses revealed a substantial reduction in inflammation and pathological fibrosis of the skin and eyelids in delgocitinib-treated GVHD mice. …”
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Essential oils modulate virulence phenotypes in a multidrug-resistant pyomelanogenic Pseudomonas aeruginosa clinical isolate by Jayalekshmi Haripriyan, Christy Rose Binu, Nitasha D Menon, Muralidharan Vanuopadath, Malavika B. Hari, N Namitha, Kesiya Binoy, Anil Kumar, Bipin G. Nair, Victor Nizet, Geetha B. Kumar

“…Abstract Pyomelanogenic P. aeruginosa, frequently isolated from patients with urinary tract infections and cystic fibrosis, possesses the ability to withstand oxidative stress, contributing to virulence and resulting in persistent infections. …”
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Successful Treatment of Plasma Cell-Rich Acute Rejection Using Bortezomib: A Case Report by Sara Hashemi, Reut Hod-Dvorai, Rebecca Tong, Liye Suo

“…However, a repeated biopsy after 2 months showed persistent plasma cells infiltrate with increased interstitial fibrosis with tubular atrophy. Then, the patient was given one cycle of bortezomib with a total of four subcutaneous injections and continued immunosuppressants of tacrolimus, mycophenolate mofetil, and prednisone. …”
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Vimentin-Rab7a Pathway Mediates the Migration of MSCs and Lead to Therapeutic Effects on ARDS by Kai Wang, Boxiang Du, Yan Zhang, Congyou Wu, Xiuli Wang, Xu Zhang, Liwei Wang

“…H&E staining and Masson staining of mouse lung tissue allowed us to assess the degree of damage and fibrosis of mouse lung tissue. By measuring serum TNF-α, TGF-β, and INF-γ, we were able to monitor the release of inflammatory factors. …”
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Clinical manifestations in Egyptian Pompe disease patients: Molecular variability and enzyme replacement therapy (ERT) outcomes by Mohamed Abdelghafar Hussein, Heba ElTaher, Ranim Mahmoud, Donia Sobh, Mohammad Al-Haggar

“…CMR imaging revealed abnormalities in all cases that underwent the procedure, including myocardial and vascular changes, with feature tracking indicating issues across all parameters and LGE suggesting fibrosis. The patient with a positive immune response had the most severe cardiac abnormalities, despite improvements in muscle weakness and motor skills from ERT. …”
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Changes in Angiotensin Receptor Distribution and in Aortic Morphology Are Associated with Blood Pressure Control in Aged Metabolic Syndrome Rats by Verónica Guarner-Lans, Elizabeth Soria-Castro, Rocío Torrico-Lavayen, Araceli Patrón-Soberano, Karla G. Carvajal-Aguilera, Vicente Castrejón-Tellez, María Esther Rubio-Ruiz

“…Electron microscopy images showed premature aging in MS since the increased fibrosis, enlarged endothelium, and invasion of this layer by muscle cells that was present in control 18-month-old aortas were also found in 6-month-old aortas from MS rats. …”
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Liver lobes and cirrhosis: Diagnostic insights from lobar ratios by Kriti Pandey, Debabrata Dash, Raj Kumar Koiri

“…Liver cirrhosis is the formation of abnormal nodular structure and fibrosis. Globally it accounts for 4 ​% of all deaths. …”
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Lipid-lowering drug targets and lung related diseases: a Mendelian randomization study by Haifeng Yu, Xiaofei Zhang, Bian Wen, Shuo Hu, Bin Ni

“…RESULTS Our study did not find any significant association between genetically proxied APOB, CETP, HMGCR, NPCIL, PCSK9, and LDLR inhibition (equivalent to a one standard deviation reduction in LDL-C) with the risk of Small Cell Lung Cancer, Non-Small Cell Lung Cancer, idiopathic pulmonary fibrosis, and Pneumonia (P > 0.05). However, long-term inhibition of NPC1L that mimics the use of statin drugs may have contradictory effects on pulmonary edema (OR = 0.508, 95%CI = 0.328–0.786,P = 0.002) and chronic obstructive pulmonary disease (OR = 1.524, 95%CI = 1.099–2.115, P = 0.012). …”
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Dynamic Changes in Lung Function and Imaging in Patients with COVID-19 by Lingyan Ye, Bingyu Hu, Shuangxiang Lin, Meifang Chen, Yicheng Fang, Susu He

“…Three months after being clinically cured, patients with COVID-19 had good chest imaging absorption and no residual fibrosis. Some patients had mild to moderate pulmonary dysfunction, mainly restricted ventilation dysfunction, small airway dysfunction, and diffuse dysfunction.…”
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Managing Post COVID-19 Patient with Breathlessness by Yen Shen Wong, Muhammad Amin Ibrahim, Mohd Arif Mohd Zim, Mohd Fauzi Abdul Rani

“…Multidisciplinary team discussion concluded it as interstitial pneumonia with COVID-19 OP and fibrosis progression. Prednisolone was stopped and he responded well with antibiotics. …”
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Roles of retinoic acid-related orphan receptor α in high glucose-induced cardiac fibroblasts proliferation by Wenqing San, Qianyou Zhou, Danning Shen, Danyi Cao, Yun Chen, Guoliang Meng

“…Diabetic cardiomyopathy, characterized by myocardial fibrosis, is a common complication of diabetes. Retinoic acid-related orphan receptor α (RORα) participates in various pathological and physiological cardiovascular processes. …”
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Cost-effectiveness analysis of deep brain stimulation for the treatment of alcohol use disorder and alcoholic liver disease by Oluwatofunmi A. Abiola, Collin M. Lehmann, Khaled Moussawi, Hawre Jalal

“…However, for advanced ALD patients, defined as fibrosis stage 3 or beyond DBS becomes cost-effective. …”
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Emerging PPARγ-Independent Role of PPARγ Ligands in Lung Diseases by Ajit A. Kulkarni, Collynn F. Woeller, Thomas H. Thatcher, Sesquile Ramon, Richard P. Phipps, Patricia J. Sime

“…PPARγ ligands show great promise in moderating lung inflammation, as antiproliferative agents in combination to enhance standard chemotherapy in lung cancer and as treatments for pulmonary fibrosis, a progressive fatal disease with no effective therapy. …”
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