Azole-Induced Myositis after Combined Lung-Liver Transplantation by Sofie Happaerts, Michiel Wieërs, Ward Vander Mijnsbrugge, Laurent Godinas, Dirk Van Raemdonck, Laurens J. Ceulemans, Robin Vos, Geert M. Verleden

“…Our patient was a 38-year-old man who received a single sequential lung transplantation and liver transplantation because of end-stage cystic fibrosis. He presented to our emergency room with acute pain in both forearms at 3 weeks after voriconazole was initiated for invasive pulmonary aspergillosis infection. …”
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Ankylosing Spondyloarthritis Resulting Severe Aortic Insufficiency and Aortitis: Exacerbation of Ankylosing Spondyloarthritis and Stenosis of the Main Left Coronary Artery after Me... by Agnė Balčiūnaitė, Algimantas Budrikis, Eglė Rumbinaitė, Jurgita Sabaliauskienė, Vaiva Patamsytė, Vaiva Lesauskaitė

“…Cardiac involvement in AS manifests in 2 to 10% of patients as aortic insufficiency, aortitis, mitral valve fibrosis, or disturbance in the conduction of the heart. …”
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Ginkgolide B Blocks Vascular Remodeling after Vascular Injury via Regulating Tgfβ1/Smad Signaling Pathway by Quan Wang, Shuai Ni, Li Ling, Siqi Wang, Hanbin Xie, Zhanhong Ren

“…Moreover, the beneficial effect of GB is abolished after incubated with pirfenidone (PFD, a drug for idiopathic pulmonary fibrosis, IPF), which can inhibit Tgfβ1. In Tgfβ1-/- mice, treatment with pirfenidone capsules and Yinxingneizhi Zhusheye (including Ginkgolide B) fails to improve vascular remodeling and restenosis. …”
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RAGE is a Potential Cause of Onset and Progression of Nonalcoholic Fatty Liver Disease by Kamyar Asadipooya, Kamran B. Lankarani, Rishi Raj, Mohammadreza Kalantarhormozi

“…AGE-RAGE interaction contributes to fat accumulation in the liver leading to inflammation, fibrosis, insulin resistance, and other complications of the fatty liver disease. …”
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Crackle Pitch Rises Progressively during Inspiration in Pneumonia, CHF, and IPF Patients by Andrey Vyshedskiy, Raymond Murphy

“…These patients included 34 with pneumonia, 38 with heart failure, and 28 with interstitial fibrosis. Results. Crackle pitch progressively increased during inspirations in 79% of all patients. …”
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Cardiac Resynchronization Therapy Outcomes in Type 2 Diabetic Patients: Role of MicroRNA Changes by Celestino Sardu, Michelangela Barbieri, Maria Rosaria Rizzo, Pasquale Paolisso, Giuseppe Paolisso, Raffaele Marfella

“…CRT effects are related to alterations in genes and microRNAs (miRs) expression, which regulate cardiac processes involved in cardiac apoptosis, cardiac fibrosis, cardiac hypertrophy and angiogenesis, and membrane channel ionic currents. …”
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The systemic evolutionary theory of the origin of cancer (SETOC): an update by Antonio Mazzocca, Giovanni Ferraro, Giovanni Misciagna

“…The SETOC proposes that malignant transformation occurs when cells undergo a continuous adaptation process in response to long-term injuries, leading to tissue remodeling, chronic inflammation, fibrosis, and ultimately cancer. This process involves a maladaptive response, wherein the 'endosymbiotic contract’ between the nuclear-cytoplasmic system (derived from the primordial archaeal cell) and the mitochondrial system (derived from the primordial α-proteobacterium) gradually breaks down. …”
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Nuclear receptors in regulation of bile acids transport and metabolism by A. F. Sheptulina, Ye. N. Shirokova, V. T. Ivashkin

“…Accumulation of BA and other bile components in hepatocytes during cholestatic liver diseases is accompanied by liver cells damage and ready to fibrosis and cirrhosis. This article is devoted to the above-mentioned issues.Key points. …”
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Proinflammatory Cytokines and Potassium Channels in the Kidney by Kazuyoshi Nakamura, Hikaru Hayashi, Manabu Kubokawa

“…Transforming growth factor-β1 activated KCa3.1 K+ channel in immortalized human proximal tubule cells, which would be involved in the pathogenesis of renal fibrosis. This review discusses the effects of proinflammatory cytokines on renal K+ channels and the causal relationship between the cytokine-induced changes in K+ channel activity and renal dysfunction.…”
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PPARγ Signaling Mediates the Evolution, Development, Homeostasis, and Repair of the Lung by Virender K. Rehan, John S. Torday

“…A wide variety of molecular insults disrupt such highly evolved physiologic cell-cell interactions, ranging from overdistention to oxidants, infection, and nicotine, all of which predictably cause loss of mesenchymal peroxisome-proliferator-activated receptor gamma (PPARγ) expression and the transdifferentiation of lipofibroblasts to myofibroblasts, the signature cell type for lung fibrosis. By exploiting such deep cell-molecular functional homologies as targets for leveraging lung homeostasis, we have discovered that we can effectively prevent and/or reverse the deleterious effects of these pathogenic agents, demonstrating the utility of evolutionary biology for the prevention and treatment of chronic lung disease. …”
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Treatment of Cytomegalovirus Infection with Cidofovir and CMV Immune Globulin in a Lung Transplant Recipient by Heinrike Wilkens, Martina Sester

“…A CMV-seronegative 42-year-old man with cystic fibrosis received a lung from a CMV-seropositive donor. …”
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Assessment of Some Heavy Metals and Trace Elements in a Sample of Patients with Viral Hepatitis in Baghdad by Najlaa Fattah-Allah Rasheed, Hind Salman Jassim, Ahmad Saadi Hassan

“…Impairment of liver functions disrupts trace element metabolism, causing oxidative stress, which subsequently leads to liver inflammation and fibrosis. This study aims to evaluate zinc (Zn), copper (Cu), iron (Fe), cadmium (Cd), and lead (Pb) levels in chronic viral hepatitis (HBV or HCV) patients in Baghdad. …”
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Heart-on-a-chip: a revolutionary organ-on-chip platform for cardiovascular disease modeling by Beiqin Liu, Shuyue Wang, Hong Ma, Yulin Deng, Jichen Du, Yimeng Zhao, Yu Chen

“…Then we introduce the current proceedings of in vitro models for studying cardiovascular diseases (CVD) based on the HoC platform, including ischemia and myocardial infarction, cardiac fibrosis, cardiac scar, myocardial hypertrophy and other CVD models. …”
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Differential regulation of metalloproteinase production, proliferation and chemotaxis of human lung fibroblasts by PDGF, Interleukin-1β and TNF-α by Masahiro Sasaki, Masayuki Kashima, Takefumi Ito, Akiko Watanabe, Noriko Izumiyama, Masaaki Sano, Manabu Kagaya, Takanobu Shioya, Mamoru Miura

“…Less is known about the interaction of these substances on lung fibroblast function in pulmonary fibrosis.…”
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Montelukast: More than a Cysteinyl Leukotriene Receptor Antagonist? by Gregory R. Tintinger, Charles Feldman, Annette J. Theron, Ronald Anderson

“…If so, montelukast is potentially useful in the chemotherapy of intermittent asthma, chronic obstructive pulmonary disease, cystic fibrosis, and viral bronchiolitis, which, to a large extent, involve airway epithelial cell/neutrophil interactions. …”
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Urinary System Manifestation of IgG4-Related Disease: Clinical, Laboratory, Radiological, and Pathological Spectra of a Chinese Single-Centre Study by Fei Teng, Hui Lu, Ke Zheng, Gang Chen, Yubing Wen, Zheng Liu, Linyi Peng, Li Huo, Xiaofeng Zeng, Wen Zhang, Xuemei Li

“…Infiltration of plasma lymphocytes and storiform fibrosis were histopathological features of IgG4-RUD. …”
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Helicobacter mastomyrinus infection induces autoimmune hepatitis in mice by Liqi Zhu, Yuanyuan Liang, Linghan Yang, Qihui Yang, Jun Yin, Tao Wang, Xiangming Xu, Quan Zhang

“…Additionally, the liver tissue was examined for pathological analysis, fibrosis, bacterial content, and the distribution of immune cells. …”
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Research progress of hypoxia-inducible factor-1α and zinc in the mechanism of diabetic kidney disease by Wei Qin, Ping Nie, Xuejun Hui, Fei Chen, Xingbao Hu, Wenjiao Shi, Manyu Luo, Bing Li

“…This article provides a detailed review of the multiple roles of hypoxia-inducible factor-1α in the pathogenesis of diabetic kidney disease, including: regulating angiogenesis, increasing the expression of erythropoietin, modulating oxidative stress through the PI3K/AKT and HIF-1α/HO-1 pathways, promoting inflammatory cell infiltration and the release of inflammatory factors to induce inflammatory responses, facilitating epithelial-mesenchymal transition, pathological angiogenesis, and promoting the release of fibrotic factors, ultimately leading to renal fibrosis. Furthermore, HIF-1α also participates in the occurrence and development of diabetic kidney disease through mechanisms such as regulating apoptosis, inducing mitochondrial autophagy, and vascular calcification. …”
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Concurrent Liver Hodgkin Lymphoma and Nodular Regenerative Hyperplasia on an Explanted Liver with Clinical Diagnosis of Alcoholic Cirrhosis at University Hospital Fundación Santa F... by R. López, L. Barrera, A. Vera, R. Andrade

“…Hematoxylin and eosin stain (H&E) showed abnormal liver architecture with hepatocytes nodules highlighted by reticulin stain with absent fibrosis on the trichrome stain. The portal spaces had diffuse infiltration by Reed-Sternberg cells positive for CD15, CD30, and latent membrane protein (LMP) on immunohistochemical studies. …”
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Effectiveness of Palivizumab in Preventing RSV Hospitalization in High Risk Children: A Real-World Perspective by Nusrat Homaira, William Rawlinson, Thomas L. Snelling, Adam Jaffe

“…Data are limited to allow commenting on the protective effect of palivizumab among other high risk children, including those with Down syndrome, cystic fibrosis, and haematological malignancy, indicating further research is warranted in these groups.…”
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