Clinical and Diagnostic Considerations for Atypical, Adult Onset Presentation of Chronic Recurrent Multifocal Osteomyelitis (CRMO) by Stacey Mahady, Amit Ladani

“…Bone biopsy histologic results of marrow fibrosis and plasma cell infiltrate indicative of chronic inflammation lead to the diagnosis of CRMO. …”
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Chagas Disease Cardiomyopathy: Immunopathology and Genetics by Edecio Cunha-Neto, Christophe Chevillard

“…CCC heart lesions present a Th1 T-cell-rich myocarditis, with cardiomyocyte hypertrophy and prominent fibrosis. Data suggest that the myocarditis plays a major pathogenetic role in disease progression. …”
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Bilateral Renal Colic as an Initial Presentation of Erdheim-Chester Disease by Julien Sarkis, Fady Haddad, Sarah Nasr, Elie Hanna, Ahmad Mroueh, Elie Nemr

“…Abdominopelvic CT scan revealed renal infiltration with signs of retroperitoneal fibrosis and hydronephrosis. Kidney CT-guided biopsy and 18-fluorodeoxyglucose (FDG) positron emission tomography whole body scan as well as the history of hypopituitarism and vasculitis confirmed the diagnosis of Erdheim-Chester disease. …”
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Moving from an “anti-aging” paradigm toward the concept of “disease-free aging”: the role of senolytics in modern medicine by Ivan Aprahamian, Andréia Pain, Virgílio Garcia Moreira

“…Senolytic therapy requires strong evidence in human trials, and dasatinib and quercetin have shown good results in phase II trials with idiopathic pulmonary fibrosis and diabetic renal disease. However, these trials are small and merely represent a proof-of-concept for these drugs. …”
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Walking along the Fibroblast Growth Factor 10 Route: A Key Pathway to Understand the Control and Regulation of Epithelial and Mesenchymal Cell-Lineage Formation during Lung Develop... by Elie El Agha, Saverio Bellusci

“…However, it is also an organ that is linked to a vast array of clinical problems in humans such as bronchopulmonary dysplasia in premature babies and emphysema, chronic obstructive pulmonary disease, fibrosis, and cancer in adults. Epithelial stem/progenitor cells reside in niches where they interact with specific extracellular matrices as well as with mesenchymal cells; the latter are still poorly characterized. …”
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Gut-Lung Microbiota in Chronic Pulmonary Diseases: Evolution, Pathogenesis, and Therapeutics by Chang Yi Shi, Chen Huan Yu, Wen Ying Yu, Hua Zhong Ying

“…Patients with chronic respiratory diseases, including asthma, COPD, bronchiectasis, and idiopathic pulmonary fibrosis, often have alteration of the composition and function of intestinal and lung microbiota. …”
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Intrahepatic Cholestasis in Non-Alcoholic Fatty Liver Disease: Pathogenesis and Role of Ademetionine in Treatment by Ye. N. Shirokova

“…IHC in NAFLD is associated with increased risks of fibrosis and all-cause death. Ademetionine may restore transmethylation and improve rheologic properties of hepatocyte membranes in liver disease. …”
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Pulmonary Hypertension in Pulmonary Langerhans Cell Granulomatosis by Matthias Held, Philipp Schnabel, Arne Warth, Berthold Jany

“…A vasculopathy which ist not related to ventilatory disturbance and fibrosis has been identified. An arteriopathy and even a venulopathy have been described. …”
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A mutation in LXRα uncovers a role for cholesterol sensing in limiting metabolic dysfunction-associated steatohepatitis by Alexis T. Clark, Lillian Russo-Savage, Luke A. Ashton, Niki Haghshenas, Nicolas A. Amselle, Ira G. Schulman

“…When fed a high fat, high cholesterol diet LXRα mutant mice rapidly develop pathologies associated with Metabolic Dysfunction-Associated Steatohepatitis (MASH) including ballooning hepatocytes, liver inflammation, and fibrosis. Strikingly LXRα mutant mice have decreased liver triglycerides but increased liver cholesterol. …”
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Effect of Caloric Restriction on Hepatic Sinusoidal System and Stellate Cells in Mice by Jian Chen, Kara King, Jian X. Zhang

“…Our results showed that caloric restriction was effective in ameliorating the increase in stellate cells and the mild fibrosis in old mice. However, caloric restriction had no impact on stellate cell activity level as indicated by the unaffected α-smooth muscle actin expression.…”
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Juvenile Hemochromatosis due to a Homozygous Variant in the HJV Gene by María-Belén Moreno-Risco, Manuel Méndez, María-Isabel Moreno-Carralero, Ana-María López-Moreno, José-Manuel Vagace-Valero, María-José Morán-Jiménez

“…Hemochromatosis type 2 or juvenile hemochromatosis has an early onset of severe iron overload resulting in organ manifestation such as liver fibrosis, cirrhosis, cardiomyopathy, arthropathy, hypogonadism, diabetes, osteopathic medicine, and thyroid abnormality, before age of 30. …”
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Novel CT Features of an Abdominal Gossypiboma in a Female Dog by Mylene Auger, Shelly Olin, Federica Morandi

“…Surgical recovery was uneventful and a follow-up CT after 3 months was consistent with resolving granulomatous inflammation and fibrosis. Clinical Relevance. The presence of multiple peripherally enhancing tracts extending from the abdominal mass through the hypaxial musculature is a CT feature which has not yet been described in the veterinary literature. …”
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PPARγ as a Potential Target to Treat Airway Mucus Hypersecretion in Chronic Airway Inflammatory Diseases by Yongchun Shen, Lei Chen, Tao Wang, Fuqiang Wen

“…Airway mucus hypersecretion (AMH) is a key pathophysiological feature of chronic airway inflammatory diseases such as bronchial asthma, cystic fibrosis, and chronic obstructive pulmonary disease. …”
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Nicotinamide Adenine Dinucleotide Phosphate Oxidases and Metabolic Dysfunction-Associated Steatotic Liver Disease by Vittoria Cammisotto, Emanuele Valeriani, Pasquale Pignatelli, Francesco Violi

“…Growing evidence linked the activity of nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOX) to the increased liver production of reactive oxygen species up to liver damage and fibrosis. NOX acts both in hepatocytes and in non-parenchymal hepatic cells, contributing to hepatocyte lipotoxicity, impaired hepatic microcirculation, hepatic stellate, and mesenchymal stem cells activation and proliferation. …”
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Cancer-associated fibroblasts in carcinogenesis by Shufen Zhou, Zekun Zhao, Zhaojun Wang, Hanzheng Xu, Yijie Li, Ke Xu, Wei Li, Jiahua Yang

“…Carcinogenesis is a complex, multi-faceted, and multi-stage process, with numerous underlying causes, including inflammation and fibrosis. Cancer-associated fibroblasts (CAFs), however, occupy a pivotal and substantial role within the tumor microenvironment, facilitating carcinogenesis through diverse mechanisms such as creating inflammation, fostering a fibrotic tumor microenvironment, and immunosuppression. …”
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Gambaran Derajat Varises Esofagus Berdasarkan Beratnya Sirosis Hepatis by Yestria Elfatma, Arnelis Arnelis, Nice Rachmawati

“…Sirosis hepatis adalah suatu keadaan patologis yang menggambarkan stadium akhir fibrosis hepatik yang berlangsung progresif. Varises esofagus merupakan salah satu komplikasi tersering sirosis hepatis. …”
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Potential Nephroprotective Effect of Kaempferol: Biosynthesis, Mechanisms of Action, and Clinical Prospects by Maulana Yusuf Alkandahri, Asman Sadino, Barolym Tri Pamungkas, Zulpakor Oktoba, Maya Arfania, Nia Yuniarsih, Eko Sri Wahyuningsih, Yuliani Dewi, Sri Ayu Winarti, Sri Tantia Dinita

“…Several studies have shown that untreated injuries to this organ can cause glomerulosclerosis, tubulointerstitial fibrosis, and tubular cell apoptosis, leading to kidney failure. …”
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Diretrizes para desenvolvimento da competência em informação para pessoas com fibrose cística by Eliane Rodrigues Mota Orelo, Elizete Vieira Vitorino

“…A Coleta de dados se deu no acervo da Biblioteca Universitária da UFSC, no portal Scielo Brasil, no Portal Capes, nas bases de dados Ebsco e Web Of Science e, nas revistas nacionais de Biblioteconomia e Ciência da Informação, os termos de busca foram: “Information Literacy”, “Competência em Informação” “Cystic Fibrosis” e “Fibrose Cística”. Realizou-se entrevistas semiestruturadas via plataforma “google meet”, com pessoas com Fibrose Cística, acima de 18 anos de idade, residentes no estado de SC. …”
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Pretransplant Evaluation and Liver Transplantation Outcome in PBC Patients by Maja Mijic, Ivona Saric, Bozena Delija, Milos Lalovac, Nikola Sobocan, Eva Radetic, Dora Martincevic, Tajana Filipec Kanizaj

“…Primary biliary cholangitis (PBC) is an autoimmune chronic cholestatic liver disease characterized by progressive cholangiocyte and bile duct destruction leading to fibrosis and finally to liver cirrhosis. The presence of disease-specific serological antimitochondrial antibody (AMA) together with elevated alkaline phosphatase (ALP) as a biomarker of cholestasis is sufficient for diagnosis. …”
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Deciphering Oxidative Stress in Cardiovascular Disease Progression: A Blueprint for Mechanistic Understanding and Therapeutic Innovation by Zhaoshan Zhang, Jiawei Guo

“…This review focuses on the signaling pathways of oxidative stress during the development of CVDs, delving into the molecular regulatory networks underlying oxidative stress in various disease stages, particularly apoptosis, inflammation, fibrosis, and metabolic imbalance. By examining the dual roles of oxidative stress and the influences of sex differences on oxidative stress levels and cardiovascular disease susceptibility, this study offers a comprehensive understanding of the pathogenesis of cardiovascular diseases. …”
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