Oxidative stress in viral hepatitis by Huseyin Erdal, Hacer Ozlem Kalayci

“…This damage manifests as lipid peroxidation, DNA damage, and protein oxidation, which in turn promote hepatic inflammation, fibrosis, and hepatocellular carcinoma. Furthermore, OS has been implicated in the resistance to antiviral therapy observed in some patients. …”
Get full text

Iron depletion in “metabolic fatty liver syndromes”: a strong biological rationale with disappointing liver outcomes by Amedeo Lonardo

“…Iron plays a key role in many of the key pathogenic steps concurring in the development and progression of MFLS, notably including genetics, intestinal dysbiosis, adipositis, insulin resistance, metaflammation, oxidative stress and ferroptosis, endoplasmic reticulum stress, and hepatic fibrosis. This notion raises the logical expectation that iron depletion, which can easily be implemented with venesection, might improve several aspects of MFLS. …”
Get full text

Controlled Attenuation Parameter for Quantification of Steatosis: Which Cut-Offs to Use? by Roxana Sirli, Ioan Sporea

“…., plays an important role in fibrosis progression, regardless of CLD etiology; thus, detection and quantification of HS are imperative. …”
Get full text

Long-term post-COVID-19 sequelae. A review study by Cinthia Rosales Márquez, Ericson Félix Castillo Saavedra

“…The results indicated sequelae in the respiratory system such as dyspnea, fatigue, lesions compatible with pulmonary fibrosis; while, in the cardiovascular system, sequelae such as tachycardia, palpitations, arterial hypertension, myocarditis and pericardial effusion were reported. …”
Get full text

Pulmonary Silicosis Presents with Pleural Effusion by Mohsin Salih, Tarake Aljarod, Mohamed Ayan, Melnick Jeffrey, Bobby H. Shah

“…These include pulmonary silicotic nodules, interstitial infiltrate, fibrosis, and pleural thickening. Pleural effusion is an extremely rare presentation of silicosis. …”
Get full text

Liver Transplantation and Hepatitis C by Nobuhisa Akamatsu, Yasuhiko Sugawara

“…Unfortunately, however, HCV is not eliminated by transplantation and graft reinfection is universal, resulting in fibrosis, cirrhosis, and finally graft decompensation. …”
Get full text

Diabetic Mastopathy: An Uncommon Complication of Diabetes Mellitus by R. X. Kirby, D. I. Mitchell, N. P. Williams, D. A. Cornwall, S. O. Cawich

“…Histopathologic evaluation revealed classic features of DMP: parenchymal fibrosis; keloid-like hyalinization of interlobular stroma; adipose tissue entrapment; lobular compression; dense chronic inflammatory cell infiltration; and lymphoid follicle formation. …”
Get full text

Immunometabolism of Tregs: mechanisms, adaptability, and therapeutic implications in diseases by Yuming Lu, Yifan Wang, Tiantian Ruan, Yihan Wang, Linling Ju, Mengya Zhou, Luyin Liu, Dengfu Yao, Min Yao

“…The complex mechanisms of Tregs in metabolic diseases are intriguing, particularly in conditions like MASLD, where Tregs are significantly upregulated and contribute to fibrosis, while in diabetes, systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA), they show downregulation and reduced anti-inflammatory capacity. …”
Get full text

When the Benign Pneumatosis Intestinalis Becomes No Longer Benign: A Rare Case of Bowel Perforation in a Patient with Systemic Sclerosis by Jian Guan, Alvina Munaf, Alric V. Simmonds, Irteza Inayat

“…Systemic sclerosis is a multisystem disease featured with autoimmunity and organ fibrosis. Although gastrointestinal (GI) tract involvement is common in patients with systemic sclerosis, colonic perforation is extremely rare. …”
Get full text

An unexpected and tumultuous diagnosis of a left atrial mass by Catarina Amaral Marques, Carlos Xavier Resende, João Rebelo, Paulo Pinho, Mariana Vasconcelos, Rui André Rodrigues

“…Unexpectedly, the histopathological study revealed the absence of malignancy, identifiable inflammatory and cardiac muscle tissue, and fibrosis. This pattern was compatible with inflammatory myofibroblastic tumor diagnosis, a rare entity with uncertain behavior but a known risk of recurrence and/or potentially fatal complications. …”
Get full text

Complex application of mathematical methods in diagnostics of diffuse liver diseases by I. Yu. Pirogova, S. A. Pyshkin, A. A. Bolotov

“…The standard of diffuse liver disease (DLD) diagnostics, allowing to determine etiology, stage of liver fibrosis (LF), histological activity index (HAI) is the liver biopsy (LB). …”
Get full text

Precision cut lung slices: an integrated ex vivo model for studying lung physiology, pharmacology, disease pathogenesis and drug discovery by Cynthia Koziol-White, Eric Gebski, Gaoyaun Cao, Reynold A. Panettieri

“…Abstract Precision Cut Lung Slices (PCLS) have emerged as a sophisticated and physiologically relevant ex vivo model for studying the intricacies of lung diseases, including fibrosis, injury, repair, and host defense mechanisms. …”
Get full text

Solitary Pulmonary Nodule: A Diagnostic Dilemma by Pardeep Masuta, Ioana Amzuta

“…The pathology of the lung showed necrotizing granulomas with giant cells and fibrosis, but lacked active vasculitis or palisading histiocytes, further obscuring the diagnosis. …”
Get full text

An Unusual Case of Gastrointestinal Bleeding from Isolated Gallbladder Varices in a Patient with Pancreatic Cancer Complicated by Portal Biliopathy by Mahir Gachabayov, Kubach Kubachev, Elbrus Abdullaev, Nonna Zarkua, Abakar Abdullaev, Artur Fokin

“…Portal biliopathy is the complex of abnormalities of extrahepatic and intrahepatic bile ducts, cystic duct, and gallbladder, arising as a result of extrahepatic portal vein obstruction and noncirrhotic portal fibrosis, which can be caused by coagulopathies, tumors, inflammation, postoperative complications, dehydration, and neonatal umbilical vein catheterization. …”
Get full text

Extensive Mycobacterium abscessus Pneumonia in an Immunocompetent Infant with No Underlying Lung Pathology by Morouge M. Alramadhan, James R. Murphy, Michael L. Chang

“…Pulmonary infection due to Mycobacterium abscessus occurs in patients with cystic fibrosis, but rarely in immunocompetent children without underlying lung pathology. …”
Get full text

Valvular Cardiomyopathy: The Value of Cardiovascular Magnetic Resonance Imaging by Vasiliki Tsampasian, Sandeep S. Hothi, Thuwarahan Ravindrarajah, Andrew J. Swift, Pankaj Garg, Vassilios S. Vassiliou

“…T1 mapping and late gadolinium enhancement (LGE) imaging provide deep myocardial tissue characterisation that is changing the approach towards risk stratification of patients as an increasing body of evidence suggests that the presence of fibrosis is related to adverse events and prognosis. …”
Get full text

Mitochondrial Dysfunction as a Therapeutic Target in Diabetic Cardiomyopathy: Progress and Prospects by Feng Zhang, Zhuqing Li, Yanxin Wang, Chao Li, Chengzhi Lu

“…DCM causes microvascular disease, myocardial metabolic disorder, and myocardial fibrosis, thereby leading to left ventricular remodeling, diastolic and/or systolic dysfunction, and eventually progressing to congestive heart failure. …”
Get full text

A Curious Case of Iron-Deficiency Anemia by Seth Shaffer, Mayur Brahmania, Hemant Shah

“…His past history was significant for cirrhosis based on a previous variceal bleed but a workup for chronic liver disease was negative and a liver biopsy did not show steatosis, fibrosis, or cirrhosis. A gastroscopy in this admission showed large esophageal varices without high-risk stigmata and no overt bleeding was seen. …”
Get full text

Cardiac regeneration: 20 years of development and update in zebrafish and mouse by Lekun Gui, Lijun Jin, Huangjun Liu

“…Zebrafish are extremely sensitive to cardiac injury and, within a short period, stimulate the proliferation of cardiomyocytes in numbers that fully regenerate to pre-injury levels; meanwhile, the initial scarring is gradually absorbed until there is little or no visible sign of fibrosis in the regenerating myocardium. The newborn mouse heart has the same remarkable regenerative potential before birth as one week after cardiac injury. …”
Get full text

A case report of idiopathic hypertrophic pachymeningitis by G. Makarevičius, J. Grigaitė, M. Jokubaitis, A. Klimašauskienė

“… Idiopathic hypertrophic pachymeningitis (IHP) is a condition characterised by diffuse or local thickening and fibrosis of dura matter caused by inflammation of unknown origin. …”
Get full text