A Gentleman with Anemia and Cholestasis by Siu-Tong Law, Wai-Ki Lee, Michael Kin-Kong Li, Ka-Ho Lok

“…Primary sclerosing cholangitis is a rare cause of cholestasis caused by progressive inflammation and fibrosis of both intrahepatic and extrahepatic bile ducts leading to multifocal ductal strictures. …”
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CALLY index, but not HALP score, is associated with mortality in cirrhosis patients by Yıldız Günay, Bedel Cihan, Zortuk Ökkeş, Selvi Fatih, Karanci Yusuf

“…Cirrhosis is a chronic liver disease that is characterized by inflammation and fibrosis, as well as liver dysfunction. The CALLY index and HALP score have recently provided crucial data in the diagnosis, follow-up, and prognosis of numerous diseases, particularly those of a malignant nature and those affecting the gastrointestinal system. …”
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Granulomatosis with Polyangiitis with Myocarditis and Ventricular Tachycardia by Ramy Magdy Hanna, Eduardo Lopez, James Wilson

“…Pulmonary manifestations include hemorrhage, lung cavitary lesions, and pulmonary fibrosis. Within the kidney, GPA is known to cause rapidly progressive pauci-immune crescentic glomerulonephritis. …”
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Knockdown ATG5 gene by rAAV9 alleviates doxorubicin-induced cardiac toxicity by inhibiting GATA4 autophagic degradation by Ai-Li Xu, Zheng Shen, Shi-Hao Wang, Hai-Yun Luan, Yong Xu, Ze-Chun Kang, Zi-Qi Liao, Jie Liu, Xiao-Lei Duan, Wei-Hua Bian, Hui Sun, Xin Xie

“…DOX–treated mice exhibited decreased heart function and cardiomyocyte size and increased cardiac fibrosis, oxidative stress, and apoptosis. These effects of DOX were partially alleviated by rAAV9 expressing shRNA-ATG5 and deteriorated by rAAV9-ATG5. …”
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Evaluation of Inflammatory Cytokine Secretion by Human Alveolar Macrophages by J. E. Losa García, F. M. Rodríguez, M. R. Martín de Cabo, M. J. García Salgado, J. P. Losada, L. G. Villarón, A. J. López, J. L. P. Arellano

“…Human AMs were collected by bronchoalveolar lavage (BAL) from four healthy controls and 13 patients with diffuse interstitial lung disease (five cases of sarcoidosis, three of hypersensitivity pneumonitis and five of idiopathic pulmonary fibrosis). AMs were cultured in the presence or absence of different concentrations of lipopolysaccharide (LPS), phorbolmyristate and gammainterferon. …”
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Anti-Interleukin-22-Neutralizing Antibody Attenuates Angiotensin II-Induced Cardiac Hypertrophy in Mice by Jing Ye, Ling Liu, Qingwei Ji, Ying Huang, Ying Shi, Lei Shi, Jianfang Liu, Menglong Wang, Yao Xu, Huimin Jiang, Zhen Wang, Yingzhong Lin, Jun Wan

“…Anti-IL-22 nAb significantly alleviated the severity of hypertrophy, prevented systolic and diastolic abnormalities, reduced cardiac fibrosis, STAT3 and ERK phosphorylation, and downregulated the mRNA expression of IL-17, IL-6, IL-1β, IFN-γ, and TNF-α. …”
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Epidermal stem cell derived exosomes-induced dedifferentiation of myofibroblasts inhibits scarring via the miR-203a-3p/PIK3CA axis by Shixin Zhao, Haoran Kong, Dahu Qi, Yushuang Qiao, Yu Li, Zhiming Cao, Hanwen Wang, Xuefeng He, Hengdeng Liu, Hao Yang, Suyue Gao, Tao Liu, Julin Xie

“…Our results indicate that PIK3CA is overexpressed in HS tissues and positively correlates with fibrosis. EpiSC-EVs were absorbed by scar-derived fibroblasts, promoting dedifferentiation from myofibroblasts to quiescent fibroblasts. …”
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Urinary exosomal miRNA-451a can be used as a potential noninvasive biomarker for diagnosis, reflecting tubulointerstitial damage and therapeutic response in IgA nephropathy by Qiong Zhang, Yan Zhao, Yankun Luo, Songjia Guo, Haizhu Hou, Xiaoli Han, Yun Zhou

“…Additionally, the uE miR-451a level could distinguish patients with IgAN with mild tubular atrophy/interstitial fibrosis from those with severe tubular atrophy/interstitial fibrosis. …”
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Screening high-risk Veterans for cirrhosis: taking a stepwise population health approach by Jonathan Dounel, Carolyn Lamorte, Heather Patton, Ponni Perumalswami, Heather McCurdy, Nicole J. Kim, Lauren A. Beste, Dawn Scott, Jessimarie Casey, Patrick Spoutz, Linda Chia, Yiwen Yao, Elliott Lowy, Sandra Gibson, Timothy R. Morgan, Shari S. Rogal

“…The VHA Corporate Data Warehouse was queried to identify Veterans with possible undiagnosed cirrhosis using Fibrosis-4 (FIB-4) ≥ 3.25 and at least one risk factor for liver disease (e.g., obesity), and generate an age-stratified sample. …”
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Role of IPF genetic risk loci in post-COVID-19 lung abnormalities: a cohort study by James Johnston, Christopher Carlsten, Christopher J Ryerson, Alyson W Wong, Cameron J Hague, Julia Yang, Janice Leung, Daniel-Costin Marinescu, Aditi Shah, Darra Murphy

“…This hypothesis-generating result suggests a possible protective effect of MUC5B in postinfectious lung abnormalities as compared with fibrosis in IPF, highlighting a plausible trade-off between its role in immune defence and epithelial cell function.…”
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Value of original and modified pathological scoring systems for prognostic prediction in paraffin-embedded donor kidney core biopsy by Jinghong Tan, Huanxi Zhang, Longshan Liu, Jun Li, Qian Fu, Yan Li, Chenglin Wu, Ronghai Deng, Jiali Wang, Bowen Xu, Wenfang Chen, Shicong Yang, Changxi Wang

“…Score of glomerulosclerosis (GS), interstitial fibrosis (IF), tubular atrophy (TA), and arteriolar hyalinosis (AH) had good eGFR predictive capacities. …”
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Shen Shuai II recipe improves renal hypoxia to attenuate renal injury in 5/6 renal ablation/infarction rats and effect evaluation using blood oxygenation level-dependent functional... by Yizeng Xu, Fang Lu, Meng Wang, Lingchen Wang, Chaoyang Ye, Shuohui Yang, Chen Wang

“…With the improvement of renal hypoxia, renal function and fibrosis were improved in 5/6 (A/I) rats, accompanied by reduced proteinuria. …”
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The Correlation between FSTL1 Expression and Airway Remodeling in Asthmatics by Yahui Liu, Tian Liu, Jinxiang Wu, Tao Li, Xingai Jiao, Haiqing Zhang, Jiping Zhao, Junfei Wang, Lin Liu, Liuzhao Cao, Shuo Li, Jiawei Xu, Jianfeng Xu, Xiaohui Ma, Lei Yang, Liang Dong

“…Plasma FSTL1 levels were associated with fibrosis levels around the airways (rs=0.529, p=0.043) and α-smooth muscle actin (α-SMA) (rs=0.554, p=0.032). …”
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Advance of Mesenchymal Stem Cells in Chronic End-Stage Liver Disease Control by Yun Gao, Xiushan Yin, Xiaomeng Ren

“…The chronic liver diseases will slowly develop into liver fibrosis, cirrhosis, and even liver cancer if no proper control is performed with high efficiency. …”
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Glutamine Supplementation in Sick Children: Is It Beneficial? by Elise Mok, Régis Hankard

“…This includes premature infants, infants with gastrointestinal disease, children with Crohn's disease, short bowel syndrome, malnutrition/diarrhea, cancer, severe burns/trauma, Duchenne muscular dystrophy, sickle cell anemia, cystic fibrosis, and type 1 diabetes. Moreover, methodological issues have been noted in some studies. …”
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Autophagy in Inflammatory Diseases by Alexander J. S. Choi, Stefan W. Ryter

“…Furthermore, autophagy-dependent mechanisms have been proposed in the pathogenesis of several pulmonary diseases that involve inflammation, including cystic fibrosis and pulmonary hypertension. Strategies aimed at modulating autophagy may lead to therapeutic interventions for diseases associated with inflammation.…”
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Sarcoidosis with Major Airway, Vascular and Nerve Compromise by Hiroshi Sekiguchi, Jun Suzuki, James P Utz

“…Its presentation mimicked idiopathic mediastinal fibrosis.…”
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CLINICAL PATTERNS OF MALABSORPTION SYNDROMES IN CHILDREN by Ginel Baciu, Carmen Baciu, Cristina Maria Mihai, Tatiana Chisnoiu, Ramona Mihaela Stoicescu, Adriana Luminita Balasa, Adriana Mocanu, Lorenza Forna, Alexandru Paul Baciu

“…Celiac disease (51%), cystic fibrosis (32%), and Cow’s milk protein allergy (17%) were the leading causes. …”
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The Biology and Function of Tissue Inhibitor of Metalloproteinase 2 in the Lungs by Louis Costanzo, Brian Soto, Richard Meier, Patrick Geraghty

“…Classically, elevated levels of TIMPs are suggested to result in ECM accumulation leading to fibrosis, whereas loss of TIMP responses leads to enhanced matrix proteolysis. …”
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Amiodarone Pulmonary, Neuromuscular and Ophthalmologic Toxicity by Karen EA Burns, Eugenia Piliotis, Bertha M Garcia, Kathleen A Ferguson

“…Numerous adverse effects have been documented including skin discolouration, photosensitivity, hepatitis, thyroid dysfunction, corneal deposits, pulmonary fibrosis, bone marrow suppression and drug interactions. …”
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