Effectively alleviate rheumatoid arthritis via maintaining redox balance, inducing macrophage repolarization and restoring homeostasis of fibroblast-like synoviocytes by metformin-... by Rui Zhang, Xingyu Lin, Rongjie Lin, Zhenbin Chen, Chenfang Miao, Yao Wang, Xiaoqin Deng, Jianlong Lin, Shishui Lin, Shaohuang Weng, Min Chen

“…Abstract Overproduction of reactive oxygen species (ROS), elevated synovial inflammation, synovial hyperplasia and fibrosis are the main characteristic of microenvironment in rheumatoid arthritis (RA). …”
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The Frequency of Epidermal Growth Factor Receptor Mutation of Nonsmall Cell Lung Cancer according to the Underlying Pulmonary Diseases by Kazuhiro Usui, Tomonori Ushijima, Yoshiaki Tanaka, Chiharu Tanai, Hiromichi Noda, Norifumi Abe, Hajime Horiuchi, Teruo Ishihara

“…EGFR mutations were identified in 43 (35.2%) of 122 patients with normal lungs, 8 (13.6%) of 59 with emphysema, and 1 (5.9%) of 17 with pulmonary fibrosis. Of the 52 patients with EGFR mutation, 43 patients received gefitinib. …”
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Penggunaan Tetes Telinga Serum Autologous dengan Amnion untuk Penutupan Perforasi Membran Timpani by Hidayatul Fitria, Yan Edward

“…Membran amnion mempercepat pembentukan epitel normal dengan menekan pembentukan jaringan fibrosis. Sel epitel amnion memproduksi faktor pertumbuhan seperti fibroblast growth factor dan transforming growth factor beta. …”
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Prediction and Treatment of Difficult Cases in Colorectal Endoscopic Submucosal Dissection by Yutaka Inada, Naohisa Yoshida, Munehiro Kugai, Kazuhiro Kamada, Kazuhiro Katada, Kazuhiko Uchiyama, Osamu Handa, Tomohisa Takagi, Hideyuki Konishi, Nobuaki Yagi, Yuji Naito, Naoki Wakabayashi, Akio Yanagisawa, Yoshito Itoh

“…Severe fibrosis was detected in protruding tumors >40 mm in diameter. …”
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Safety and efficacy of telaprevir in treatment of a chronic hepatitis C in patients of the Russian population included in early access program study by D. T. Abrurakhmanov, V. G. Morozov, I. G. Nikitin, P. O. Bogomolov, N. I. Geyvandova, Ye. N. Bessonova, I. G. Bakulin, V. A. Isakov, K. V. Zhdanov, M. V. Mayevskaya, Ye. A. Nurmukhametova, E. Z. Burnevich, Ye. V. Chesnokov, V. D. Pasechnikov, A. Hill, I. Lonjon-Domanec, S. N. Kizhlo

“…HEP3002 is the international early access program of efficacy and safety estimation of telaprevir in combination to peginterferon alpha and ribavirin for patients with severe fibrosis or liver cirrhosis caused by hepatitis C virus (HCV) genotype 1. …”
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Energy Expenditure in Infants in Health and Disease by Ross Shepherd

“…In cystic fibrosis, both TEE and REE are 25% higher than values in healthy infants. …”
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PET-CT Imaging in Hypertrophic Cardiomyopathy: A Narrative Review on Risk Stratification and Prognosis by Patrícia Marques-Alves, Lino Gonçalves, Maria João Ferreira

“…These abnormalities are linked to several factors influencing disease progression, including arrhythmia development, ventricular dilation, and myocardial fibrosis. Fibroblast activation can also be evaluated using PET imaging, providing further insights into early-stage myocardial fibrosis. …”
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Nonfamilial, MPL S505N-Mutated Essential Thrombocythaemia by Ruth Morrell, Stephen E. Langabeer, Liam Smyth, Meegahage Perera, Gerard Crotty

“…Another exon 10 mutation, MPL S505N, has been shown to be a founder mutation in several pedigrees with familial thrombocythaemia where it is associated with a high thrombotic risk, splenomegaly and progression to bone marrow fibrosis. Rare cases of sporadic, nonfamilial, MPL S505N MPN have been documented, but the presenting laboratory and clinical features have not been described in detail. …”
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A Young Male with Severe Myocarditis and Skeletal Muscle Myositis by Abdalla Ibrahim, Eoghan Meagher, Alexander Fraser, Thomas J. Kiernan

“…Cardiac magnetic resonance imaging (MRI) confirmed active myocarditis with extensive myocardial fibrosis and normal left ventricular ejection fraction (LVEF). …”
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Preoperative assessment of liver regeneration using T1 mapping and the functional liver imaging score derived from Gd-EOB-DTPA-enhanced magnetic resonance for patient with hepatoce... by Qian Li, Tong Zhang, Shan Yao, Feifei Gao, Lisha Nie, Hehan Tang, Bin Song, Bin Song, Yi Wei

“…T1pre showed significant correction with steatosis grade (r = 0.415, P =0.001). Fibrosis stage and steatosis grade were associated with RI (r = -0.436, P<0.001; r = -0.338, P =0.008). …”
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Anti-Scar Effects of Micropatterned Hydrogel after Glaucoma Drainage Device Implantation by Yiling Han, Qiangwang Geng, Aimeng Dong, Menglu Jiang, Jingyi Ma, Wulian Song, Pan Fan, Yuanyuan Li, Jiawen Gao, Fenghua Zhang, Jinsong Leng, Huiping Yuan

“…Excessive fibrosis is the primary factor for the failure of glaucoma drainage device (GDD) implantation. …”
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Scrotal Swelling and Testicular Atrophy due to Schistosomiasis in a 9-Year-Old Boy: A Case Report by Peter F. Rambau, Alphonce Chandika, Philipo L. Chalya, Kahima Jackson

“…Complications can lead to portal hypertension due portal fibrosis in liver, and fibrosis in lung can lead to pulmonary hypertension; this commonly seen with S. mansoni. …”
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Penile Corporeal Reconstruction during Difficult Placement of a Penile Prosthesis by Viet Q. Tran, Timothy F. Lesser, Dennis H. Kim, Sherif R. Aboseif

“…For some patients with impotence and concomitant severe tunical/corporeal tissue fibrosis, insertion of a penile prosthesis is the only option to restore erectile function. …”
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NFAT5 Contributes to Osmolality-Induced MCP-1 Expression in Mesothelial Cells by Christoph Küper, Franz-X. Beck, Wolfgang Neuhofer

“…NFAT5 in turn upregulates MCP-1, likely in combination with NF-κB, and thus may participate in the development of peritoneal fibrosis during CAPD.…”
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Influence of Angiotensin II Subtype 2 Receptor (AT2R) Antagonist, PD123319, on Cardiovascular Remodelling of Aged Spontaneously Hypertensive Rats during Chronic Angiotensin II Subt... by Emma S. Jones, M. Jane Black, Robert E. Widdop

“…The severe degree of cardiac perivascular fibrosis in senescent animals was regressed by AT1R blockade and this effect was reversed by simultaneous AT2R inhibition, demonstrating an antifibrotic role of AT2R stimulation in the aging hypertensive heart.…”
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Fabrication of Customized Sectional Impression Trays in Management of Patients with Limited Mouth Opening: A Simple and Unique Approach by Vamsi Krishna CH, K. Mahendranadh Reddy, Nidhi Gupta, Y. Mahadev Shastry, N. Chandra Sekhar, Venkat Aditya, G. V. K. Mohan Reddy

“…The present case reports describe the fabrication of sectional custom trays designed for dentulous patients with chronic tobacco-induced submucous fibrosis.…”
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Management of the Kidney Transplant Patient with Chronic Hepatitis C Infection by Ignatius Y. S. Tang, Natasha Walzer, Nidhi Aggarwal, Ivo Tzvetanov, Scott Cotler, Enrico Benedetti

“…Renal transplant candidates with serologic evidence of HCV infection should undergo a liver biopsy to assess for fibrosis and cirrhosis. Patients with Metavir fibrosis score ≤3 and compensated cirrhosis should be evaluated for interferon-based therapy. …”
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Associations between Extracellular Matrix Protein 1 Gene Polymorphism and Progression of Liver Disease by Xiuting He, Ting Liu, Rui Zhang, Xu Li

“…ECM1 gene polymorphism in rs3834087 and rs3754217 loci is associated with a reduced risk of chronic HBV infection but not with liver fibrosis development and the occurrence of HCC.…”
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Follistatin like-1 aggravates silica-induced mouse lung injury by Yinshan Fang, Si Zhang, Xiaohe Li, Fangxin Jiang, Qiao Ye, Wen Ning

“…Meanwhile, Fstl1 promoted fibrosis via positive regulation of TGF-β1 signaling. …”
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Immunoglobulin G4 Sclerosing Cholangitis: An Unusual Cause of Obstructive Jaundice—Case Report and Literature Review by Pragya Shrestha, Brian Le, Brent Wagner, William Pompella, Paras Karmacharya

“…The presence of extra-biliary clinical manifestations of IgG4-RD, such as parotid and lacrimal swelling, lymphadenopathy, autoimmune pancreatitis, and retroperitoneal fibrosis, if present could provide important clues to diagnosis. …”
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