Conditioned Medium from Human Amnion-Derived Mesenchymal Stem Cells Regulates Activation of Primary Hepatic Stellate Cells by Qingjie Fu, Shunsuke Ohnishi, Naoya Sakamoto

“…Human amnion-derived mesenchymal stem cell (hAMSC) transplantation has been reported to ameliorate liver fibrosis in animal models. However, the mechanism for the prevention of liver fibrosis is poorly understood. …”
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High Lyso-Gb3 Plasma Levels Associated with Decreased miR-29 and miR-200 Urinary Excretion in Young Non-Albuminuric Male Patient with Classic Fabry Disease by Sebastián Jaurretche, Germán R. Perez, Graciela Venera

“…In renal cells, exposure to Lyso-Gb3 is correlated with increased expression of Transforming Growth Factor-βeta (TGF-β). miR-21, miR-192, and miR-433 that promote fibrosis are activated by TGF-β, and miR-29 and miR-200 that suppress fibrosis are inhibited by TGF-β. …”
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ERK1/2 Inhibition Alleviates Diabetic Cardiomyopathy by Suppressing Fatty Acid Metabolism by Erin McLean, Caroline De Roo, Annabel Maag, Megan Coble, Jefferson Cano, Ruijie Liu

“…Inhibition of ERK1/2 by U0126 in both streptozotocin-induced diabetic mice and db/db mice resulted in a significant reduction in the expression of genes associated with hypertrophy and fibrosis. In contrast, elevated phosphorylation of ERK1/2 in Dusp6/8 knockout (DKO) mice resulted in fibrosis. …”
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HGF-Modified Dental Pulp Stem Cells Mitigate the Inflammatory and Fibrotic Responses in Paraquat-Induced Acute Respiratory Distress Syndrome by Panpan Geng, Yuning Zhang, Huan Zhang, Xiwen Dong, Yuefeng Yang, XiaoNa Zhu, Chu-Tse Wu, Hua Wang

“…Paraquat (PQ) poisoning can cause acute lung injury and progress to pulmonary fibrosis and eventually death without effective therapy. …”
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Combination of autoimmune hepatitis to non-alcoholic steatohepatitis (Clinical case) by A. A. Driga, M. V. Mayevskaya, V. T. Ivashkin

“…Liver biopsy was repeated: HAI was 10 points (3+1+3+3), hydropic, small and large droplet fatty dystrophy, moderate fibrosis. Clinical diagnosis was following: AIH of 1-st type with high degree of activity, NASH with severe fibrosis, second type DM in compensated phase, morbid obesity, dyslipidemia, systemic hypertension («metabolic syndrome»). …”
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The Effect of Vascular Endothelial Growth Factor on Bone Marrow Mesenchymal Stem Cell Engraftment in Rat Fibrotic Liver upon Transplantation by Ke Yuan, Chunyou Lai, Lingling Wei, Tianhang Feng, Qinyan Yang, Tianying Zhang, Tao Lan, Yutong Yao, Guangming Xiang, Xiaolun Huang

“…Using a Sprague-Dawley rat liver fibrosis model, we transplanted into fibrosis liver allograft bone marrow mesenchymal stem cells (BMSCs) which were labelled with chlormethylbenzamido-1,1-dioctadecyl-3,3,3′3′-tetramethylin-docarbocyamine (CM-DiI) or injected VEGF adenovirus solution through the tail vein or conducted the above two operations simultaneously. …”
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The Predictive Value of Time-Varying Noninvasive Scores on Long-Term Prognosis of NAFLD in South Korea by Sung Won Chung, Min Kyung Park, Xiao Zhang, Tongtong Wang, Thomas Jemielita, Gail Fernandes, Samuel S. Engel, Heejoon Jang, Yun Bin Lee, Eun Ju Cho, Jeong-Hoon Lee, Su Jong Yu, Jung-Hwan Yoon, Yoon Jun Kim

“…This study aimed to examine whether repeated measurements on noninvasive fibrosis scores during follow-up improve long-term nonalcoholic fatty liver disease (NAFLD) outcome prediction. …”
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Adverse outcome pathway-based assessment of pulmonary toxicity from the in vivo mixture of biocides dinotefuran and cetylpyridinium chloride by Yoon Cho, Mi-Kyung Song, Dong Im Kim, Min-Seok Kim, Kyuhong Lee

“…We previously identified cetylpyridinium chloride and dinotefuran as a potential binary biocidal combination associated with pulmonary fibrosis, based on two intersecting adverse outcome pathways (AOPs) using the molecular initiating events (MIE) modeling method and in vitro testing. …”
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Nonalcoholic Fatty Liver Disease in Patients Investigated for Elevated Liver Enzymes by Krikor Kichian, Ross Mclean, Leah M Gramlich, Robert J Bailey, Vincent G Bain

“…NAFLD with biopsies showing significant fibrosis and ballooning cell degeneration was associated with obesity, diabetes and older age. …”
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Metformin Regulating miR-34a Pathway to Inhibit Egr1 in Rat Mesangial Cells Cultured with High Glucose by Can Wu, Ningning Qin, Huiwen Ren, Min Yang, Shuang Liu, Qiuyue Wang

“…To clarify the function of Egr1 on the inflammation and fibrosis in high glucose-cultured MCs, as well as to explore the effects of metformin on miR-34a pathway and Egr1 expression. …”
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Two faces of the same coin non alcoholic fatty liver disease; with and without diabetes: Comparative clinico pathological analysis: A cross sectional observational study by Syed Mushfiq, Ghulam Nabi Yatoo, Bilal Ahmad Mir, Zubaida Rasool

“…The histological grade of steatosis and fibrosis as depicted by the mean NAS score (5.7 ± 1.2 vs 4.63 ± 0.8) was higher in diabetic NAFLD vs non-diabetic NAFLD; however, only the fibrosis stage was statistically significant between the groups (P < 0.001). …”
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Cell autonomous TLR4 signaling modulates TGF-β induced activation of human cardiac fibroblasts by Gayathri Vijayakumar, Anisha Latha, Aiswaria P. Anil, Yogini Surve, Aiswarya R, Bipin G. Nair, Indulekha CL. Pillai

“…Fibrosis is one of the major outcomes following injury in the heart. …”
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Chronic C-Type Natriuretic Peptide Infusion Attenuates Angiotensin II-Induced Myocardial Superoxide Production and Cardiac Remodeling by Yasuhiro Izumiya, Satoshi Araki, Hiroki Usuku, Taku Rokutanda, Shinsuke Hanatani, Hisao Ogawa

“…CNP reduced Ang II-induced increases in cardiomyocyte size and interstitial fibrosis and suppressed hypertrophic- and fibrosis-related gene expression. …”
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The Predictive Role of Parathyroid Hormone for Nonalcoholic Fatty Liver Disease following Bariatric Surgery by Tannaz Jamialahmadi, Mohsen Nematy, Mohammed Abdalla, Ali Jangjoo, Ladan Goshayeshi, Matthew Kroh, Seyed Adel Moallem, Mitra Abbasifard, Thozhukat Sathyapalan, Amirhossein Sahebkar

“…Morbid obesity is frequently complicated by chronic liver diseases, including nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), and fibrosis. Parathyroid hormone (PTH) is found to be elevated in morbid obesity due to the defective hepatic metabolism of vitamin D. …”
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Macrophage Heterogeneity in Respiratory Diseases by Carian E. Boorsma, Christina Draijer, Barbro N. Melgert

“…Phenotypical changes of macrophages within the lung are found in many respiratory diseases including asthma, chronic obstructive pulmonary disease (COPD), and pulmonary fibrosis. This paper will give an overview of what macrophage phenotypes have been described, what their known functions are, what is known about their presence in the different obstructive and restrictive respiratory diseases (asthma, COPD, pulmonary fibrosis), and how they are thought to contribute to the etiology and resolution of these diseases.…”
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Glucose Metabolism Changes in Patients with Chronic Hepatitis C Treated with Direct Acting Antivirals by Sylvia Drazilova, Martin Janicko, Lubomir Skladany, Pavol Kristian, Marian Oltman, Maria Szantova, Dusan Krkoska, Eva Mazuchova, Lubica Piesecka, Veronika Vahalova, Marek Rac, Ivan Schreter, Ladislav Virag, Tomas Koller, Adriana Liptakova, Miriam Ondrasova, Peter Jarcuska

“…We included 370 patients; 45.9% had F4 fibrosis. At baseline, the prevalence of T2DM increased with the degree of fibrosis (F0-F2 14.4%, F3 21.3%, and F4 31.8%, p=0.004). …”
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The theses for PhD degree by article Editorial

“…Ch.S. Pavlov – Liver fibrosis at chronic viral hepatitis B and C.…”
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Roles of Lymphocyte Kv1.3-Channels in the Pathogenesis of Renal Diseases and Novel Therapeutic Implications of Targeting the Channels by Itsuro Kazama

“…In renal diseases, in which “chronic inflammation” or “the overstimulation of cellular immunity” is responsible for the pathogenesis, the overexpression of Kv1.3-channels in lymphocytes promotes their cellular proliferation and thus contributes to the progression of tubulointerstitial fibrosis. We recently demonstrated that benidipine, a potent dihydropyridine calcium channel blocker, which also strongly and persistently inhibits the lymphocyte Kv1.3-channel currents, suppressed the proliferation of kidney lymphocytes and actually ameliorated the progression of renal fibrosis. …”
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Genetic Factors in Animal Models of Intestinal Inflammation by R Balfour Sartor

“…Inbred Lewis rats challenged by purified bacterial cell wall polymers, indomethacin or small bowel bacterial overgrowth develop chronic granulomatous intestinal inflammation with fibrosis and extraintestinal manifestations, whereas Fischer (major histocompatibility complex identical to Lewis) and Buffalo rats identically stimulated demonstrate only self-limited enterocolitis with no chronic inflammation, fibrosis, granulomas or extraintestinal inflammation. …”
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Differential diagnosis of hypertrophic pachymeningitis: literature review by G. Makarevičius, J. Grigaitė, M. Jokubaitis, A. Klimašauskienė

“… Hypertrophic pachymeningitis (HP) is a focal or diffuse thickening of cranial and/or spinal dura mater caused by chronic inflammatory process, which induces fibrosis and thickening of the pachymeninges. Fibrotic, thickened dura causes compression of adjacent structures that results in HP symptoms. …”
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