A maturity model for Clinical Trials Management Ecosystem by Shruti Sehgal, E. Chris Pua, Svetlana Rojevsky, Michael J. Becich, Joshua Fehrmann, Boyd M. Knosp, Adam Wilcox, Jeffery C. Talbert, Catherine K. Craven, Justin Starren

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Categorising implementation determinants and strategies within the US HIV implementation literature: a systematic review protocol by Justin D Smith, Brian Mustanski, Virginia McKay, James Lorenz Merle, Dennis Li, Brennan Keiser, Alithia Zamantakis, Artur Queiroz, Carlos G Gallo, Juan A Villamar, Juan Pablo Zapata, Nanette Benbow

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Intercellular TIMP-1-CD63 signaling directs the evolution of immune escape and metastasis in KRAS-mutated pancreatic cancer cells by Chu-An Wang, Ya-Chin Hou, Yi-Kai Hong, Yu-Jing Tai, Chieh Shen, Pei-Chi Hou, Jhao-Lin Fu, Cheng-Lin Wu, Siao Muk Cheng, Daw-Yang Hwang, Yung-Yeh Su, Yan-Shen Shan, Shaw-Jenq Tsai

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Reshaping lipid metabolism with long-term alternate day feeding in type 2 diabetes mice by Eleni Beli, Yuanqing Yan, Leni Moldovan, Todd A. Lydic, Preethi Krishman, Sarah A. Tersey, Yaqian Duan, Tatiana E. Salazar, James M. Dominguez, Dung V. Nguyen, Abigail Cox, Sergio Li Calzi, Craig Beam, Raghavendra G. Mirmira, Carmella Evans-Molina, Julia V. Busik, Maria B. Grant

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Development of a checklist for cognitive assessment requirements (CARE) based on a Delphi consensus study by Vahid Nejati, Reza Estaji, Vicent Balanzá-Martínez, David A Balota, Suzanne Barker-Collo, Morris Bell, Jacquelyn H Berry, Khatereh Borhani, Munro Cullum, Anthony Feinstein, Charles J Golden, Raul Gonzalez, Jordan Henry Grafman, Steven D Hollon, Petra Jansen, Nicole A Kochan, Ryan Van Patten, Olivier Piguet, Sarah A Raskin, Sean B. Rourke, Andrew Scholey, Yaakov Stern, Steven Paul Woods, Michael I. Posner

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Development and Validation of Risk Stratification for Heart Failure After Acute Coronary Syndrome Based on Dynamic S100A8/A9 Levels by Jie Ma, Ke Ma, Jing Chen, Xinying Yang, Fei Gao, Hai Gao, Hui Zhang, Xin‐Liang Ma, Jie Du, Ping Li, Yulin Li

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Elucidating epigenetic landscape of gastric premalignant lesions through genome‐wide mapping of 5‐hydroxymethylcytosines: A 12‐year median follow‐up study by Zhongguang Luo, Wenshuai Li, Wanwei Zheng, Yixiang Shi, Maolin Ye, Xiangyu Guo, Kaiyi Fu, Changsheng Yan, Bowen Wang, Bin Lv, Shaocong Mo, Hongyang Zhang, Jun Zhang, Chuan He, Feifei Luo, Wei Zhang, Jie Liu

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Pilot study of a comprehensive multidisciplinary inpatient-based approach to smoking cessation in patients with vascular disease by Tanner Kim, MD, Anand Brahmandam, MBBS, Dana Alameddine, MD, Rachel Forman, MD, Amin Hardik, MD, Lisa Fucito, PhD, Carlos Mena-Hurtado, MD, Raul Guzman, MD, Cassius Iyad Ochoa Chaar, MD, MS, MPH

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Implementation of the Lupus Low Disease Activity State in Pediatric Rheumatology Care: The Role of the Visual Analog Scale by Ekemini A. Ogbu, Anna Carmela P. Sagcal‐Gironella, B. Anne Eberhard, Jennifer M. Huggins, Marisa S. Klein‐Gitelman, Karen Onel, Chen Chen, Bin Huang, Hermine I. Brunner

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Stem Cells and Platelet-Rich Plasma Enhance the Healing Process of Tendinitis in Mice by Rosangela Alquieri Fedato, Júlio César Francisco, Gabriel Sliva, Lúcia de Noronha, Márcia Olandoski, Jose Rocha Faria Neto, Priscila Elias Ferreira, Rossana Baggio Simeoni, Eltyeb Abdelwahid, Katherine Athayde Teixeira de Carvalho, Luiz César Guarita-Souza

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Regeneration of Tracheal Tissue in Partial Defects Using Porcine Small Intestinal Submucosa by Nelson Bergonse Neto, Lianna Ferrari Jorge, Julio C. Francisco, Bruna Olandoski Erbano, Barbara Evelin Gonçalves Barboza, Larissa Luvison Gomes da Silva, Marcia Olandoski, Katherine Athayde Teixeira de Carvalho, Luiz Felipe Pinho Moreira, Jose Rocha Faria Neto, Eltyeb Abdelwahid, Luiz Cesar Guarita-Souza

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Kidney Function and Incident Stroke and Dementia Using an Updated Estimated Glomerular Filtration Rate Equation Without Race: The Multi-Ethnic Study of Atherosclerosis by Samuel R. Moen, Jeffrey R. Misialek, Timothy M. Hughes, Craig W. Johnson, Mark J. Sarnak, Sarah N. Forrester, W.T. Longstreth, Jr., Mercedes R. Carnethon, James S. Pankow, Sanaz Sedaghat

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Evaluating the World Health Organization’s Hearts Model for Hypertension and Diabetes Management: A Pilot Implementation Study in Guatemala by Irmgardt Alicia Wellmann, Luis Fernando Ayala, Taryn M. Valley, Vilma Irazola, Mark D. Huffman, Michele Heisler, Peter Rohloff, Rocío Donis, Eduardo Palacios, Manuel Ramírez-Zea, David Flood

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Heterogeneous clinical phenotypes of sporadic early-onset Alzheimer’s disease: a neuropsychological data-driven approach by Deepti Putcha, Yuta Katsumi, Alexandra Touroutoglou, Ani Eloyan, Alexander Taurone, Maryanne Thangarajah, Paul Aisen, Jeffrey L. Dage, Tatiana Foroud, Clifford R. Jack, Joel H. Kramer, Kelly N. H. Nudelman, Rema Raman, Prashanthi Vemuri, Alireza Atri, Gregory S. Day, Ranjan Duara, Neill R. Graff-Radford, Ian M. Grant, Lawrence S. Honig, Erik C. B. Johnson, David T. Jones, Joseph C. Masdeu, Mario F. Mendez, Erik Musiek, Chiadi U. Onyike, Meghan Riddle, Emily Rogalski, Stephen Salloway, Sharon Sha, R. Scott Turner, Thomas S. Wingo, David A. Wolk, Kyle Womack, Maria C. Carrillo, Gil D. Rabinovici, Bradford C. Dickerson, Liana G. Apostolova, Dustin B. Hammers, the LEADS Consortium

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SPIRIT-DEFINE explanation and elaboration: recommendations for enhancing quality and impact of early phase dose-finding clinical trials protocolsResearch in context by Moreno Ursino, Guillermo Villacampa, Jan Rekowski, Munyaradzi Dimairo, Olga Solovyeva, Deborah Ashby, Jordan Berlin, Oliver Boix, Melanie Calvert, An-Wen Chan, Courtney H. Coschi, Thomas R. Jeffry Evans, Elizabeth Garrett-Mayer, Robert M. Golub, Christina Guo, Kathryn S. Hayward, Sally Hopewell, John D. Isaacs, S. Percy Ivy, Thomas Jaki, Olga Kholmanskikh, Andrew Kightley, Shing Lee, Rong Liu, Adrian Mander, Lynley V. Marshall, James Matcham, Dhrusti Patel, Richard Peck, Khadija Rerhou Rantell, Dawn P. Richards, Mahtab Rouhifard, Lesley Seymour, Yoshiya Tanaka, Christopher J. Weir, Johann de Bono, Christina Yap

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CONSORT-DEFINE explanation and elaboration: recommendations for enhancing reporting quality and impact of early phase dose-finding clinical trialsResearch in context by Jan Rekowski, Christina Guo, Olga Solovyeva, Munyaradzi Dimairo, Mahtab Rouhifard, Dhrusti Patel, Emily Alger, Deborah Ashby, Jordan Berlin, Oliver Boix, Melanie Calvert, An-Wen Chan, Courtney H. Coschi, Johann de Bono, Thomas R. Jeffry Evans, Elizabeth Garrett–Mayer, Robert M. Golub, Kathryn S. Hayward, Sally Hopewell, John D. Isaacs, S. Percy Ivy, Thomas Jaki, Olga Kholmanskikh, Andrew Kightley, Shing Lee, Rong Liu, Israel Maia, Adrian Mander, Lynley V. Marshall, James Matcham, Richard Peck, Khadija Rerhou Rantell, Dawn P. Richards, Lesley Seymour, Yoshiya Tanaka, Moreno Ursino, Christopher J. Weir, Christina Yap

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Changes in laboratory value improvement and mortality rates over the course of the pandemic: an international retrospective cohort study of hospitalised patients infected with SARS... by Ramakanth Kavuluru, Xuan Wang, Paul Avillach, Florence Bourgeois, Kee Yuan Ngiam, Gabriel A Brat, Isaac Kohane, Tianxi Cai, Yuk-Lam Ho, Yuan Luo, Harrison G Zhang, Kelly Cho, Vincent Benoit, Antoine Neuraz, Chuan Hong, Sehi L'Yi, Griffin Weber, Bryce W Q Tan, Alba Gutiérrez-Sacristán, Clara-Lea Bonzel, Nathan P Palmer, Alberto Malovini, Valentina Tibollo, Meghan R Hutch, Molei Liu, Riccardo Bellazzi, Luca Chiovato, Fernando J Sanz Vidorreta, Trang T Le, William Yuan, Bertrand Moal, Michele Morris, David A Hanauer, Sarah Maidlow, Kavishwar Wagholikar, Shawn Murphy, Hossein Estiri, Adeline Makoudjou, Patric Tippmann, Jeffery Klann, Robert W Follett, Nils Gehlenborg, Gilbert S Omenn, Zongqi Xia, Arianna Dagliati, Shyam Visweswaran, Lav P Patel, Danielle L Mowery, Emily R Schriver, Malarkodi Jebathilagam Samayamuthu, Sara Lozano-Zahonero, Daniela Zöller, Amelia L M Tan, Byorn W L Tan, John H Holmes, Petra Schubert, Brett K. Beaulieu-Jones, Miguel Pedrera-Jiménez, Noelia García-Barrio, Pablo Serrano-Balazote, Andrew South

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