Therapeutic effects of composite probiotics derived from fermented camel milk on metabolic dysregulation and intestinal barrier integrity in type 2 diabetes rats by Tabusi Manaer, Tabusi Manaer, Tabusi Manaer, Tabusi Manaer, Jialehasibieke Sailike, Xin Sun, Baheban Yeerjiang, Baheban Yeerjiang, Baheban Yeerjiang, Baheban Yeerjiang, Xinhua Nabi, Xinhua Nabi, Xinhua Nabi, Xinhua Nabi

“…Measurements over 6 weeks included body weight (BW), fasting blood glucose (FBG), oral glucose tolerance test (OGTT), glycated hemoglobin (HbA1c), C-peptide (CP), lipid profiles, inflammatory markers, fecal short-chain fatty acids (SCFAs), and tight junction protein expression in colonic tissues.ResultsHigh-dose CPCM significantly increased BW by 22.2% (p < 0.05) and reduced FBG by 6.5 mmol/L (p < 0.001). …”
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Longitudinal association between DNA methylation and type 2 diabetes: findings from the KORA F4/FF4 study by Liye Lai, Dave Laurence Juntilla, Monica Del, Monica Del C Gomez-Alonso, Harald Grallert, Barbara Thorand, Aiman Farzeen, Wolfgang Rathmann, Juliane Winkelmann, Holger Prokisch, Christian Gieger, Christian Herder, Annette Peters, Melanie Waldenberger

“…Linear mixed-effects models were employed to identify significant associations between methylation sites and diabetes status, as well as with fasting plasma glucose (FPG), hemoglobin A1c (HbA1c), homoeostasis model assessment of beta cell function (HOMA-B), and homoeostasis model assessment of insulin resistance (HOMA-IR). …”
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Identifying pre-diabetes ‘hotspots’ in Northern California using geospatial analysis: opportunities to target diabetes prevention strategies and improve health equity by Tannaz Moin, Luis A Rodriguez, Obidiugwu Kenrik Duru, Julie Schmittdiel, Tainayah W Thomas, Maher Yassin, Yelba Castellon-Lopez

“…We used health system and census data to identify pre-diabetes hotspots using a systematic five-step geoprocessing approach that made use of incremental spatial autocorrelation and Getis-Ord Gi*.Setting This study was set in Kaiser Permanente Northern California (KPNC), an integrated health delivery system with over four million members.Participants KPNC adults ages 35–70 who underwent a haemoglobin A1c (HbA1c) or fasting plasma glucose (FPG) screening test in 2019 were mapped to census tracts in Northern California. …”
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Effect of extended care APPs based on the transtheoretical model of behavior change on self-management abilities in young and middle-aged patients with newly diagnosed diabetes mel... by YANG Yongfang (杨永芳), YAN Wei (严娓)

“…The Diabetes Self-Care Scale(DSCS) score and indexes of glucose metabolism were compared between two groups before and 6 months after intervention. Results Levels of fasting blood Glucose(FBG), 2-hour postprandial blood glucose(2hPG)and hemoglobin A1c (HbA1c) decreased in both groups after intervention, and better outcomes of FBG, 2hPG and HbA1c were observed in the study group compared with those in the control group (P＜0. 05). …”
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Observation on the curative effect of umbilicus application therapy combined with Cucurbit moxibustion in the treatment of spleen deficiency syndrome of type 2 diabetes mellitus (敷... by GAO Junluan (高俊娈), XUE li (薛丽), ZHANG Gengliang (张庚良), HAO Min (郝民), MAO Hui (毛慧), SHEN Yanru (沈彦如)

“…Results There were statistically significant differences in spleen deficiency symptom score, fasting blood glucose (FBG) and 2-hour postprandial blood glucose (2hPBG) before and after treatment (P<0. 05). …”
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A prospective cohort study on the impact of healthy lifestyles on all-cause and cardiovascular disease mortality among adult residents in Guizhou province by Jie ZHOU, Ling LI, Ji ZHANG, Lisha YU, Yujin REN, Wei JI, Yingjiao MU, Tao LIU

“…After adjusting for confounding factors such as sex, age, ethnicity, education level, marital status, residence, systolic blood pressure, diastolic blood pressure, fasting blood glucose (FBG), 2-hour postprandial blood glucose (PBG), total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C), the multivariable Cox proportional hazards regression analysis showed that the risks of all-cause mortality among adult residents in Guizhou province with 4, 5, 6, and ≥ 7 healthy lifestyle factors were 0.732 times (HR = 0.732, 95%CI: 0.542 – 0.990), 0.667 times (HR = 0.667, 95%CI: 0.499 – 0.893), 0.664 times (HR = 0.664, 95%CI: 0.490 – 0.900), and 0.566 times (HR = 0.566, 95%CI: 0.391 – 0.820) that of those with ≤ 3 healthy lifestyle factors, respectively. …”
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The efficacy and safety of Ginkgo biloba L. leaves extract combined with ACEI/ARB on diabetic kidney disease: a systematic review and meta-analysis of 41 randomized controlled tria... by Zehua Zhang, Shiyun Tang, Shiyu Liu, Yulin Leng, Xiaoxu Fu, Hongyan Xie, Hong Gao, Hong Gao, Chunguang Xie, Chunguang Xie

“…Compared with angiotensin-converting enzyme inhibitor (ACEI)/angiotensin II receptor blocker (ARB) alone, the combination with GBE was more beneficial in improving urinary albumin excretion rate (UAER) [mean difference (MD) = -22.99 μg/min, 95% confidence interval (CI): −27.66 to −18.31, p &lt; 0.01], serum creatinine (SCr) [MD = −8.30 μmol/L, 95% CI: −11.55 to −5.05, p &lt; 0.01], blood urea nitrogen (BUN) [MD = −0.77 mmol/L, 95% CI: −1.04 to −0.49, p &lt; 0.01], 24-hour urinary total protein (24hUTP) [MD = −0.28 g/d, 95% CI: −0.35 to −0.22, p &lt; 0.01], cystatin C (Cys-C) [MD = −0.30 mg/L, 95% CI: −0.43 to −0.17, p &lt; 0.01], total cholesterol (TC) [MD = −0.69 mmol/L, 95% CI: −1.01 to −0.38, p &lt; 0.01], triglyceride (TG) [MD = −0.40 mmol/L, 95% CI: −0.56 to −0.23, p &lt; 0.01], low-density lipoprotein cholesterol (LDL-C) [MD = −0.97 mmol/L, 95% CI: −1.28 to −0.65, p &lt; 0.01], fasting blood glucose (FBG) [MD = −0.30 mmol/L, 95% CI: −0.54 to −0.05, p = 0.02], hematocrit [MD = −4.58%, 95% CI: −5.25 to −3.90, p &lt; 0.01] and fibrinogen [MD = −0.80 g/L, 95% CI: −1.12 to −0.47, p &lt; 0.01]. …”
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Serum NFL and neuropsychological performance over ∼8 years in women with and without HIV: a longitudinal repeated measures studyResearch in context by Deborah R. Gustafson, Xuantao Li, Alison E. Baird, Henrik Zetterberg, Kaj Blennow, Jinbing Zhang, Amanda Blair Spence, Pauline Maki, Anjali Sharma, Kathleen Weber, Recai Yucel

“…Baseline and repeated ∼8-year fasting sNFL levels were measured using Simoa. Sociodemographically-adjusted NP T-scores (attention, working memory, executive function, processing speed, learning, verbal fluency and global) were calculated. …”
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The Effect of Corona Dormancy on the Physiological Stress and Main Nutritional Components in the Transport of Trachinotus ovatus During Survival by Siwei LIU, Jiamei ZHONG, Xiuping FAN, Xiaoming QIN, Jian SHEN, Wenqi XU

“…The content of liver glycogen (Gly) show a downward trend during the preservation process, while the content of lactic acid (LD) in liver and muscle increase significantly (P < 0.05), indicating that anaerobic metabolism occurs during the preservation process of fasting, which consume glycogen and produced lactic acid. …”
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Safety and effects of anti-obesity medications on weight loss, cardiometabolic, and psychological outcomes in people living with overweight or obesity: a systematic review and meta... by Leiling Liu, Zhiqi Li, Wenrui Ye, Pu Peng, Yurong Wang, Luqing Wan, Jiangnan Li, Mei Zhang, Yihua Wang, Runqi Liu, Danyan Xu, Jingjing Zhang

“…Tirzepatide had the strongest antihypertensive effect on both systolic (WMD −5.74, −9.00 to −2.48; P = 0.0006; I2 = 99.8%; moderate certainty) and diastolic blood pressure (WMD −2.91, −4.97 to −0.85; P = 0.0056; I2 = 99.8%; moderate certainty) and best reduced triglycerides (WMD −0.77, −0.85 to −0.69; P < 0.0001; I2 = 3.2%; high certainty), fasting glucose (WMD −3.06, −5.53 to −0.59; P = 0.015; I2 = 100.0%; moderate certainty), insulin (WMD −4.91, −8.15 to −1.68; P = 0.0029; I2 = 97.0%; moderate certainty), and glycated haemoglobin levels (WMD −1.27, −1.82 to −0.73; P < 0.0001; I2 = 100.0%; moderate certainty). …”
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60-month follow-up of Long Limb vs. Standard Limb Roux-en-Y gastric bypass for type 2 diabetes and obesity: the LONG LIMB RCT by Saleem Ansari, Anna Kamocka, Tina Mazaheri, Ibiyemi Ilesanmi, Lara Jimenez-Pacheco, Kleopatra Alexiadou, Joanna Tan, Harvinder Chahal, Krishna Moorthy, Sanjay Purkayastha, Anne Margot Umpleby, Stephen Robert Bloom, Francesco Rubino, Alexander Dimitri Miras, Ahmed Rashid Ahmed, Tricia Tan

“…Secondary outcomes were insulin sensitivity and fasting/postprandial glucose and insulin concentrations. …”
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