Spatial deconvolution from bulk DNA methylation profiles determines intratumoral epigenetic heterogeneity by Binbin Liu, Yumo Xie, Yu Zhang, Guannan Tang, Jinxin Lin, Ze Yuan, Xiaoxia Liu, Xiaolin Wang, Meijin Huang, Yanxin Luo, Huichuan Yu

“…A PCR-based assay for quantitative analysis of DNA methylation (QASM) was developed to specifically determine the methylation status of each CpG in MeHEG assay at single-base resolution to realize fast evaluation of epigenetic heterogeneity. Results In the discovery set with 79 patients, the differentially methylated CpGs among the three tumor regions were found. …”
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Increasing brain half-life of antibodies by additional binding to myelin oligodendrocyte glycoprotein, a CNS specific protein by Marie-Lynn Cuypers, Tom Jaspers, Jarne Clerckx, Simon Leekens, Christopher Cawthorne, Guy Bormans, Frederik Cleeren, Nick Geukens, Bart De Strooper, Maarten Dewilde

“…While higher brain exposure is achieved with RMT, the timeframe is short due to rather fast brain clearance. Therefore, we aim to increase the brain half-life of antibodies by binding to myelin oligodendrocyte glycoprotein (MOG), a CNS specific protein. …”
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Applications of MR Finger printing derived T1 and T2 values in Adult brain: A Systematic review [version 1; peer review: 2 approved] by Rajagopal Kadavigere, Obhuli Chandran M, Kaushik Nayak, Abhijith S, Saikiran Pendem, Varsha Raghu, Shailesh Nayak S, Riyan Mohamed Sajer, Tancia Pires, Priyanka -

“…Magnetic resonance finger printing (MRF) addresses these limitations by enabling fast, simultaneous mapping of multiple tissue properties like T1, T2. …”
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Regular versus as-needed treatments for mild asthma in children, adolescents, and adults: a systematic review and network meta-analysis by Prapaporn Pornsuriyasak, Sunatee Sa-nguansai, Kunlawat Thadanipon, Pawin Numthavaj, Gareth J. McKay, John Attia, Ammarin Thakkinstian

“…RCTs in children or adolescents/adults with mild asthma were eligible if they compared any of the following treatments: ICS alone or in combination with fast-acting bronchodilators (FABA, i.e., formoterol or SABA) or long-acting β2-agonists (LABA), LTRA, tiotropium, and SABA alone, for the following outcomes: exacerbations, asthma symptoms, forced expiratory volume in 1 s (FEV1), asthma-specific quality-of-life (QoL), or severe adverse events (SAEs). …”
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Аssessment of the prospects for growing forest crops of European larch in the Eastern Forest-Steppe of Ukraine by Svitlana Raspopina, Maksim Didenko

“…Larix decidua Mill. is of interest in meeting the needs of industry in obtaining fast timber not only in European countries, but it also has significant prospects for cultivation in different natural zones of Ukraine. …”
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A Randomized, Placebo-Controlled, Single-Center, Crossover Study to Evaluate the Effects of Pre-Meal Whey Protein Microgel on Post-Prandial Glucometabolic and Amino Acid Response i... by Ian J Neeland, Luiz H de Gregório, Roberto Zagury, Bo Ahrén, Joel Neutel, Christian Darimont, John Corthesy, Yohan Grzywinski, Emilie Perrin, Maximilian von Eynatten, Odd Erik Johansen

“…In a randomized-crossover design, participants performed two 240 min lunch meal (622 kcal) tests 7 ± 4 days apart. After an overnight fast and a standardized breakfast, 10 g (125 mL) WPM (40 kcal) or placebo (125 mL water, 0 kcal) was consumed 15 min ahead of the mixed-nutrient meal. …”
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Critical technologies and geology-engineering integration practices for deep CBM production in the Yanchuannan CBM field by Zhenlong CHEN, Yunhai WANG, Xiao LIU, Bin CUI, Song YANG, Xin LI, Qilong FANG

“…[Results and Conclusions] The following achievements were obtained: (1) The geological understanding of four critical indicators for the selection of optimal geological-engineering “sweet spots” and efficient CBM production. (2) The concept of fracturing through effective propping and key supporting technologies for reservoir stimulation. (3) The optimal and fast production technologies characterized by four stages, three pressures, and three aspects of control. …”
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The antiarthritic effect of CBR‐470‐1 in hypoxic environment is to increase the level of NOD‐like receptor family pyrin domain containing 3 ubiquitination by decreasing phosphoglyc... by Ao Duan, Zemeng Ma, Xiaolong Shao, Zhencheng Xiong, Chaoyi Zhang, Wenzheng Liu, Guanglin Wang, Shouye Hu, Wei Lin

“…Methods The effects of CBR‐470‐1 were assessed in a mouse model of OA induced by destabilization of the medial meniscus (DMM) by micro‐computed tomography imaging, Safranin‐O and Fast Green staining, immunofluorescence staining and enzyme‐linked immunosorbent assay. …”
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Effect of Bee Resin on Blood Profiles of Infected Carassius auratus by Aeromonas hydrophila by Sri Nuryati, Y. Kuswardani, Y. Hadiroseyani

“… Bee resin is an organic matter that can be used as immunostimulant to induce cells and tissues regeneration for fast injury recovery. In order to determine the effect of bee resin on blood profile of goldfish, Carassius auratus that had been infected by Aeromonas hydrophila, the numbers of hemoglobin, hetmaocrite, erythrocyte and leukocyte, and leukocyte differentiation were observed.   …”
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Influence of interlayer dwell time on microstructure and mechanical properties additively manufactured 316L stainless steel by laser directed energy deposition by Zhaoqiang Chen, Ziyu Zhang, Yuying Yang, Guangchun Xiao, Mingdong Yi, Tingting Zhou, Chonghai Xu

“…Laser directed energy deposition (LDED) is widely utilized due to its high precision, fast processing speed, small heat affected zone, strong machinability, environmental protection, energy saving, and high reliability. 316L stainless steel is one of the most extensively studied materials employed in the LDED process. …”
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Exploring the Diversity of Some Microorganisms from Lake Al-Asfar, KSA: The Good, the Bad, and the Pathogenic by Fatimah Al Tammar, Nermin El Semary, Munirah F. Aldayel, Duaa Althumairy, Gowhara Alfayad

“…<b>Conclusions:</b> Vitek technology is an emerging less time- and effort-consuming fast technology for identifying bacteria. Bacteria identified have significant ecological bioremediating roles, together with their algal partners, but some pose pathogenic risks. …”
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Carboxylated Graphene: An Innovative Approach to Enhanced IgA-SARS-CoV-2 Electrochemical Biosensing by Luciana de Souza Freire, Ariamna María Dip Gandarilla, Yonny Romaguera Barcelay, Camila Macena Ruzo, Barbara Batista Salgado, Ana P. M. Tavares, Francisco Xavier Nobre, Julio Nino de Souza Neto, Spartaco Astolfi-Filho, Ștefan Țălu, Pritesh Lalwani, Niranjan Patra, Walter Ricardo Brito

“…This device shows considerable potential because of its fast response time, miniaturized design facilitated by SPCEs, reduced sample volume requirements, high sensitivity and specificity, low detection limits, and signal enhancement achieved through nanomaterial integration.…”
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Evaluasi Tata Kelola Sumber Daya Teknologi Informasi Menggunakan Kerangka Kerja COBIT 5 Subdomain EDM04, APO07 dan DSS03 pada Perusahaan Jasa Pelabuhan PT. XYZ by Audi Kresna Fathurino, Yusi Tyroni Mursityo, Aditya Rachmadi

“…Aiding its operational activities, the Information Technology Department of PT XYZ faces several disturbances, including frequent reports of complaints related to IT services problems which require the teams to always be fast and responsive in fixing and anticipating problems. …”
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The Effect of Postoperative Tranexamic Acid and Dexamethasone on Quality of Recovery After Arthroscopic Rotator Cuff Repair: a Double-Blinded, Randomized Controlled Trial by Jiang X, Xu C, Yuan C, Gao W, Liu W, Wang Y, Wang H, Yu W, He Y

“…Our goal is to relieve the acute postoperative pain and promote fast recovery and rapid discharge for ARCR patients.Patients and Methods: Ninety-six patients who underwent ARCR from December 2023 to March 2024 were enrolled in this double-blinded, randomized control trial (Registration number, ChiCTR2300078507). …”
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[^99mTc]Technetium and Rhenium Dithiocarbazate Complexes: Chemical Synthesis and Biological Assessment by André Gustavo de Araujo Fernandes, Alyne Eloise Lafratta, Carolina Portela Luz, Debora Levy, Daniele de Paula Faria, Carlos Alberto Buchpiguel, Ulrich Abram, Victor Marcelo Deflon, Fabio Luiz Navarro Marques

“…Ex vivo biodistribution demonstrated that the compound has a fast and persistent (until 2 h) uptake by the spleen (55.46%), and tumor B16F10 and TM1M uptake is lower than 1%. …”
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Analisis Klasifikasi Sentimen Ulasan pada E-Commerce Shopee Berbasis Word Cloud dengan Metode Naive Bayes dan K-Nearest Neighbor by Josua Josen Alexander Limbong, Irwan Sembiring, kristoko dwi hartomo

“…Then based on the word cloud results obtained word information with positive sentiments that are most often shared by customers related to words: free, good, like, cheap, easy, and fast. Meanwhile, the negative sentiment information obtained includes the words: disappointed, ugly, expensive, lying, complicated, and fix.   …”
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Analysis of the Spatial Pattern of Military River Defense on the Ming Great Wall: A Case Study of the Shanxi Section of the Yellow River by Tianlian WANG, Zhe LI

“…During this process, the Yellow River experiences changes in elevation from high to low and water velocity from fast to slow, forming a geographical spatial change pattern from a curved river valley to an accumulation of shoals. 3) In the development of node facilities, city defense facilities and border wall nodes are tailored to cater to the requirements of river defense. …”
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Regulation and Mechanism of miR-518d through the PPARα-Mediated NF-κB Pathway in the Development of Gestational Diabetes Mellitus by Hui Qiu, Xuemin Liu, Shenshen Yao, Jiaren Zhou, Xue Zhang, Juan Du

“…The contents of total cholesterol (CH), triglyceride (TG), fast glucose, and insulin (INS) were examined using ELISA, followed by the evaluation of insulin resistance (IR). …”
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Introducing ‘trident’: a graphical interface for discriminating groups using dental microwear texture analysis by Thiery, Ghislain, Francisco, Arthur, Louail, Margot, Berlioz, Emilie, Blondel, Cécile, Brunetière, Noël, Ramdarshan, Anusha, Walker, Axelle EC, Merceron, Gildas

“…The trident package comes with independent functions and a user interface, trident, enabling easy and fast proficiency. It can import .SUR files, then remove aberrant peaks and possibly polynomial surfaces. …”
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Key Performance Indicators in Freestyle Swimming: Comparing Start, Turn, and Swimming Velocity in Top-Elite Female Junior and Adult Swimmers by Chantal Widmer, Julia Hernandez, Michael Romann, Wolfgang Taube, Dennis-Peter Born

“…., & Stöggl, T. (2022). Start fast, swim faster, turn fastest: Section analyses and normative data for individual medley. …”
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