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Skullcapflavone II suppresses TGF-β-induced corneal epithelial mesenchymal transition in vitro
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Protocol for the purification of the plastid-encoded RNA polymerase from transplastomic tobacco plants
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Tunable control of Cas12 activity promotes universal and fast one-pot nucleic acid detection
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Is the Adventitial Vasa Vasorum in Vulnerable Carotid Plaques Increased or Decreased?
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Steering acidic oxygen reduction selectivity of single-atom catalysts through the second sphere effect
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High-throughput fluorescence lifetime imaging flow cytometry
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Publisher Correction: High-throughput fluorescence lifetime imaging flow cytometry
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The giant genome of lily provides insights into the hybridization of cultivated lilies
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In vitro Antibacterial Effect of Reduning Combined with Polymyxin on Carbapenem Resistant Klebsiella pneumoniae
Published 2025-01-01“…Zui-Fei Shangguan,1 Hong-Lei Chen,2 Yi-Fan Li,3 Na Shi,4 Qi-Fen Mao2 1Department of Clinical Laboratory, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, 310006, People’s Republic of China; 2Department of Clinical Laboratory, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, 310012, People’s Republic of China; 3College of Laboratory Medicine and College of Bioengineering, Hangzhou Medical University, Hangzhou, Zhejiang, 311399, People’s Republic of China; 4Medical Laboratory, Second Sanatorium of Air Force Healthcare Center for Special Services, Hangzhou, Zhejiang, 310007, People’s Republic of ChinaCorrespondence: Qi-Fen Mao, Department of Clinical Laboratory, Tongde Hospital of Zhejiang Province, 234#, Gucui Road, Hangzhou, Zhejiang, 310012, People’s Republic of China, Email maoqifen@alu.zcmu.edu.cnObjective: This study aimed to investigate the status of carbapenem-resistant strains of Klebsiella pneumoniae isolated from the Department of Microbiology, Zhejiang Tongde Hospital between September 2023 and February 2024, and to examine the in vitro antibacterial effect of Reduning combined with polymyxin on carbapenem-resistant Klebsiella pneumoniae (CRKP), which may provide evidence on the application of Reduning in the clinical anti-infective therapy.Methods: A total of 50 different isolates of CRKP were collected, and the minimum inhibitory concentrations (MIC) of polymyxin, Reduning and polymyxin plus Reduning were measured with microbroth dilution method. …”
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Acid-Unlocked Two-Layer Ca-Loaded Nanoplatform to Interfere With Mitochondria for Synergistic Tumor Therapy
Published 2025-02-01“…Yilu Zheng,1 Gareth R Williams,2 Ran Hu,1 Sen Tong,3 Jianxiang Xu,1 Tong Wang,1 Yanyan Zhang,1 Junzi Wu,3 Fan Li,4 Yingyu Cai,4 Li-Min Zhu1 1College of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai, 201620, People’s Republic of China; 2UCL School of Pharmacy, University College London, London, WC1N 1AX, UK; 3The Key Laboratory of Microcosmic Syndrome Differentiation, Education Department of Yunnan, Yunnan University of Chinese Medicine, Kunming, 650500, People’s Republic of China; 4Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, People’s Republic of ChinaCorrespondence: Yingyu Cai, Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, People’s Republic of China, Email yingyu.cai@shgh.cn Li-Min Zhu, College of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai, 201620, People’s Republic of China, Email lzhu@dhu.edu.cnBackground: The development of selective formulations able to target and kill tumor cells without the application of external energy has shown great promise for anti-tumor therapy.Methods: Here, we report a “nanobomb” that explosively increases Ca content within cells. …”
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