Isoproterenol mechanisms in inducing myocardial fibrosis and its application as an experimental model for the evaluation of therapeutic potential of phytochemicals and pharmaceutic... by Lujain Bader Eddin, Mohamed Fizur Nagoor Meeran, Niraj Kumar Jha, Samer N. Goyal, Shreesh Ojha

“…Cardiac fibrosis is characterized by the accumulation of extracellular matrix proteins, mainly collagen in the cardiac interstitium. …”
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PAI-1: An Integrator of Cell Signaling and Migration by Ralf-Peter Czekay, Cynthia E. Wilkins-Port, Stephen P. Higgins, Jennifer Freytag, Jessica M. Overstreet, R. Matthew Klein, Craig E. Higgins, Rohan Samarakoon, Paul J. Higgins

“…Cellular migration, over simple surfaces or through complex stromal barriers, requires coordination between detachment/re-adhesion cycles, involving structural components of the extracellular matrix and their surface-binding elements (integrins), and the precise regulation of the pericellular proteolytic microenvironment. …”
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Extracellular MMP-9-Based Assessment of Ocular Surface Inflammation in Patients with Primary Open-Angle Glaucoma by Anna Zaleska-Żmijewska, Ewa Strzemecka, Zbigniew M. Wawrzyniak, Jacek P. Szaflik

“…Objective assessment of dry eye disease (DED) severity and ocular inflammation using the InflammaDry® test for extracellular matrix metalloproteinase-9 (MMP-9) and the impact of antiglaucoma eye drops in people with primary open-angle glaucoma (POAG). …”
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Post-Translational Modifications of Proteins Orchestrate All Hallmarks of Cancer by Pathea Shawnae Bruno, Aneeta Arshad, Maria-Raluca Gogu, Natalie Waterman, Rylie Flack, Kimberly Dunn, Costel C. Darie, Anca-Narcisa Neagu

“…In this review, we summarized and analyzed a wide spectrum of PTMs of proteins involved in all regulatory mechanisms that drive tumorigenesis, genetic instability, epigenetic reprogramming, all events of the metastatic cascade, cytoskeleton and extracellular matrix (ECM) remodeling, angiogenesis, immune response, tumor-associated microbiome, and metabolism rewiring as the most important hallmarks of cancer. …”
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Molecular mechanisms and therapeutic strategies of Naegleria fowleri Carter (1970): a review of the fatal brain-eating amoeba by N. Datta

“…These mechanisms include the expression of various surface molecules that mediate adhesion, motility, and phagocytosis of host cells, as well as the secretion of proteases and other factors that degrade host extracellular matrix and modulate host immune response. However, there are still many unanswered questions regarding the complex interactions between the amoeba and its host, which limit the development of effective diagnostic and therapeutic strategies. …”
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Smac127 Has Proapoptotic and Anti-Inflammatory Effects on Rheumatoid Arthritis Fibroblast-Like Synoviocytes by D. Lattuada, R. Gualtierotti, K. Crotta, P. Seneci, F. Ingegnoli, C. Corradini, R. Viganò, O. Marelli, C. Casnici

“…Fibroblast-like synoviocytes (FLSs) are apoptosis-resistant and contribute to the pathogenesis of RA by producing cytokines and proteolytic enzymes, which degrade the extracellular matrix. We evaluated the proapoptotic and anti-inflammatory activity of the small molecule Smac127 on RA-FLSs cultured in synovial fluid (SF), in order to reproduce the physiopathological environmental characteristic of RA joints. …”
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Effects of adipose allograft matrix on viability of humeral head cartilage and rotator cuff tendon by Andrea Karen Persons, Michael R. Baria, Ryan Rauck, Tyler Barker, Zarah Belacic, Sunjit Neginhal, Sushmitha Durgam

“…After 48 h, the tissues and cells were measured for cell viability, cell proliferation, extracellular matrix (ECM) and metalloproteinase (MMP) gene expression and for MMP, inflammatory cytokine, and growth factor concentrations. …”
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TGFβ-specific T cells induced by a TGFβ-derived immune modulatory vaccine both directly and indirectly modulate the phenotype of tumor-associated macrophages and fibroblasts by Mads Hald Andersen, Inés Lecoq, Evelina Martinenaite, Maria Perez-Penco, Lucia Lara de la Torre

“…In addition, myofibroblast-like CAFs create a stiff extracellular matrix that restricts T cell infiltration, impeding the effectiveness of immune therapies in desmoplastic tumors, such as pancreatic ductal adenocarcinoma. …”
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Effects of Compressive and Tensile Strain on Macrophages during Simulated Orthodontic Tooth Movement by Agnes Schröder, Paul Käppler, Ute Nazet, Jonathan Jantsch, Peter Proff, Fabian Cieplik, James Deschner, Christian Kirschneck

“…We determined cell number, cytotoxicity, and gene/protein expression of Vegf-a/VEGF-A (macrophage-mediated angiogenesis), Mmp-8/9 (extracellular matrix reorganization), and Cox-2/PG-E2, Il-6/IL-6, and Tnf-α/TNF-α (proinflammatory mediators) by RT-qPCR and ELISA. …”
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A versatile platform based on matrix metalloproteinase-sensitive peptides for novel diagnostic and therapeutic strategies in arthritis by Mingyang Li, Tao Deng, Quan Chen, Shenghu Jiang, Hang Li, Jiayi Li, Shenglan You, Hui-qi Xie, Bin Shen

“…Matrix metalloproteinases (MMPs), coupled with other proteinases and glycanases, can degrade proteoglycans, collagens, and other extracellular matrix (ECM) components in inflammatory and non-inflammatory arthritis, making them important pathogenic molecules and ideal disease indicators and pharmaceutical intervention triggers. …”
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A structural genomics approach to investigate Dystrophin mutations and their impact on the molecular pathways of Duchenne muscular dystrophy by Abdelbaset Mohamed Elasbali, Farah Anjum, Osama A. AlKhamees, Waleed Abu Al-Soud, Mohd Adnan, Anas Shamsi, Md. Imtaiyaz Hassan

“…BackgroundDystrophin is a key protein encoded by the DMD gene, serves as a scaffold linking the cytoskeleton to the extracellular matrix that plays a critical role in muscle contraction, relaxation, and structural integrity. …”
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Development and in vitro evaluation of biomimetic injectable hydrogels from decellularized human nerves for central nervous system regeneration by Gopal Agarwal, Kennedy Moes, Christine E. Schmidt

“…Using a modified Hudson method, human sciatic nerves were decellularized, effectively removing immunogenic cellular debris while retaining the extracellular matrix. Two delipidation solvents, dichloromethane: ethanol (2:1 v/v) and n-hexane: isopropanol (3:1 v/v), were evaluated, with the former achieving optimal lipid removal and better digestion. …”
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Comprehensive Analysis of Differentially Expressed miRNAs and mRNAs Reveals That miR-181a-5p Plays a Key Role in Diabetic Dermal Fibroblasts by Peng Liu, Yi Zhu, Qin Li, Biao Cheng

“…Enrichment analyses showed that these genes are closely related to wound healing, for example, extracellular matrix (ECM) organization, angiogenesis, cell proliferation, and migration. …”
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Identification of Hepatocellular Carcinoma Subtypes Based on Global Gene Expression Profiling to Predict the Prognosis and Potential Therapeutic Drugs by Cunzhen Zhang, Jiyao Wang, Lin Jia, Qiang Wen, Na Gao, Hailing Qiao

“…Subtype S1 was characterized by the upregulation of pathways related to collagen and the extracellular matrix, as well as downregulation associated with the xenobiotic metabolic process and fatty acid degradation. …”
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Network pharmacology and molecular analysis of mechanisms underlying the therapeutic effects of Rhubarb in treating atherosclerosis and abdominal aortic aneurysm by Huilin Xu, Jun Huang, Youjie Zeng, Xia Wang, Huilin Lian, Siyi Zhang, Ren Guo

“…The analysis indicated that Rhubarb may be effective in treating AS/AAA through processes such as lipids, atherosclerosis, extracellular matrix catabolism, collagenolytic metabolic processes, and the extracellular environment. …”
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Integrative analysis of anoikis-related prognostic signature to evaluate the immune landscape and predict therapeutic response in stomach adenocarcinoma by Ziyi Zhou, Lanlan Yang, Yuan Fang, Rongzhong Xu, Xi Wang, Yuli Wang, Zhihong Fang

“…Anoikis, a process of programmed cell death that occurs when cells detach from the extracellular matrix, is closely associated with tumor invasion and metastasis. …”
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Promoting ER stress in a plasmacytoid dendritic cell line drives fibroblast activation by Beatriz H. Ferreira, Inês S. Silva, Andreia Mendes, Fátima Leite-Pinheiro, Adrienne W. Paton, James C. Paton, Iola F. Duarte, Philippe Pierre, Catarina R. Almeida

“…ER stress was then induced by the bacterial toxin SubAB. Extracellular matrix (ECM) production was assessed using immunoblotting, qPCR and confocal microscopy. …”
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Evolution of the umbilical cord blood proteome across gestational development by Leena B. Mithal, Nicola Lancki, Ted Ling-Hu, Young Ah Goo, Sebastian Otero, Nathaniel J. Rhodes, Byoung-Kyu Cho, William A. Grobman, Judd F. Hultquist, Denise Scholtens, Karen K. Mestan, Patrick C. Seed

“…Proteins that function in structural development and growth (e.g., extracellular matrix organization, lipid particle remodeling, and blood vessel development) are more abundant earlier in gestation. …”
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Amorphous calcium phosphate-coated surfaces as a model for bone microenvironment in prostate cancer by Rebeca San Martin, Prijoyit Das, Tianchun Xue, Morgan Rose Brown, Renata Dos Reis Marques, Michael Essington, Adrian Gonzalez, Rachel Patton McCord

“…Modeling a complex microenvironment in-vitro such as the bone niche, requires interrogation of cell-cell interactions, specific extracellular matrix proteins, and a high calcium environment. …”
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Actin Alpha 2 (ACTA2) Downregulation Inhibits Neural Stem Cell Migration through Rho GTPase Activation by Ji Zhang, Xuheng Jiang, Chao Zhang, Jun Zhong, Xuanyu Fang, Huanhuan Li, Fangke Xie, Xiaofei Huang, Xiaojun Zhang, Quan Hu, Hongfei Ge, Anyong Yu

“…Although neural stem cells (NSCs) could migrate towards lesions after central nervous system (CNS) injury, the migration ability always is restricted due to the disturbed composition and density of the adhesion ligands and extracellular matrix (ECM) gradient after CNS injury. To date, various methods have been developed to enhance NSC migration and a number of factors, which are affecting NSC migration potential, have been identified. …”
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