The Effect of Clopidogrel and Ticagrelor on Human Adipose Mesenchymal Stem Cell Osteogenic Differentiation Potential: In Vitro Comparative Study by Sally S. Mohamed, Hala F. Zaki, Shereen N. Raafat

“…In comparison to all study groups, the TICA group showed significant increase in the mineralized extracellular matrix, ALP enzyme activity, and bone markers expression as RUNX2 (P<0.0001), OC, and OPG (P<0.05). …”
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Anti-Inflammatory and Antioxidant Properties of a New Mixture of Vitamin C, Collagen Peptides, Resveratrol, and Astaxanthin in Tenocytes: Molecular Basis for Future Applications in... by Monica Marzagalli, Stefania Battaglia, Michela Raimondi, Fabrizio Fontana, Marco Cozzi, Francesca R. Ranieri, Roberto Sacchi, Valeria Curti, Patrizia Limonta

“…Tendinopathy is one of the most frequent musculoskeletal disorders characterized by sustained tissue inflammation and oxidative stress, accompanied by extracellular matrix remodeling. Patients suffering from this pathology frequently experience pain, swelling, stiffness, and muscle weakness. …”
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Integrated Bioinformatics and Experimental Approaches Identified the Role of NPPA in the Proliferation and the Malignant Behavior of Breast Cancer by Aijun Sun, Xiaonan Sheng, Jinhai Tang, Zhenfeng Yu, Jian Zhang

“…In this study, we aimed to demonstrate the value of extracellular matrix- (ECM-) related genes in breast cancer patients. …”
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Bleomycin-Treated Chimeric Thy1-Deficient Mice with Thy1-Deficient Myofibroblasts and Thy-Positive Lymphocytes Resolve Inflammation without Affecting the Fibrotic Response by Pazit Y. Cohen, Raphael Breuer, Philip Zisman, Shulamit B. Wallach-Dayan

“…Using gene chip analysis, we detected that myofibroblast Thy1 crosslinking mediates downregulation of genes promoting cell proliferation, survival, and differentiation, and reduces production of extracellular matrix (ECM) components, while concurrently mediating the upregulation of genes known to foster inflammation and immunological functions. …”
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E2F1 activates breast stromal fibroblasts and promotes their paracrine pro-carcinogenic effects by Layla A. Al-Kharashi, Falah H. Al-Mohanna, Abdelilah Aboussekhra, Abdelilah Abousekhra

“…Abstract Breast cancers (BC) are complex neo-organs composed of neoplastic as well as non-carcinogenic cells, in addition to a dynamic extracellular matrix. Active cancer-associated fibroblasts (CAFs) play major roles in the development and spread of breast cancers, through paracrine signaling, which are under the control of several transcription regulators. …”
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Continuous Drip Flow System to Develop Biofilm of E. faecalis under Anaerobic Conditions by Ana Maria Gonzalez, Erika Corpus, Amaury Pozos-Guillen, Daniel Silva-Herzog, Antonio Aragon-Piña, Nestor Cohenca

“…In the mature biofilm bacterial cells are totally encased in a polymeric extracellular matrix. Conclusions. The proposed in vitro system model provides an additional useful tool to study the biofilm concept in endodontic microbiology, allowing for a better understanding of persistent root canal infections.…”
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Sirolimus Enhances Cyclosporine A-Induced Cytotoxicity in Human Renal Glomerular Mesangial Cells by Séin O'Connell, Craig Slattery, Michael P. Ryan, Tara McMorrow

“…The CsA/SRL combination therapy significantly enhanced Smad signalling and altered the extracellular matrix regulator matrix metalloproteinase 9 (MMP-9). …”
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Metalloproteinases and their Inhibitors under the Course of Immunostimulation by CPG-ODN and Specific Antigen Inhalation in Equine Asthma by Ann Kristin Barton, Tarek Shety, John Klier, Sabine Geis, Ralf Einspanier, Heidrun Gehlen

“…Misbalance of elastinolytic activity seems to improve by CpG-ODN inhalation for at least 6 weeks posttherapy, which may reduce the remodeling of the extracellular matrix. Further studies should evaluate this effect in comparison to glucocorticoid inhalation therapy. …”
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Hyaluronan Synthesis, Catabolism, and Signaling in Neurodegenerative Diseases by Larry S. Sherman, Steven Matsumoto, Weiping Su, Taasin Srivastava, Stephen A. Back

“…The glycosaminoglycan hyaluronan (HA), a component of the extracellular matrix, has been implicated in regulating neural differentiation, survival, proliferation, migration, and cell signaling in the mammalian central nervous system (CNS). …”
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Bioprinting of bespoke islet-specific niches to promote maturation of stem cell-derived islets by Myungji Kim, Seungyeon Cho, Dong Gyu Hwang, In Kyong Shim, Song Cheol Kim, Jiwon Jang, Jinah Jang

“…Here, we bioengineer the in vivo-like pancreatic niches by optimizing the combination of pancreatic tissue-specific extracellular matrix and basement membrane proteins and utilizing bioprinting-based geometrical guidance to recreate the spatial pattern of islet peripheries. …”
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Therapies with Emerging Evidence of Efficacy: Avotermin for the Improvement of Scarring by Jim Bush, Karen So, Tracey Mason, Nick L. Occleston, Sharon O'Kane, Mark W. J. Ferguson

“…Extensive pre-clinical and human Phase I and II clinical trial programmes have confirmed the scar improving efficacy of avotermin which produces macroscopic and histological improvements in scar architecture, with improved restitution of the epidermis and an organisation of dermal extracellular matrix that more closely resembles normal skin. …”
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Conditioned Medium from Human Amnion-Derived Mesenchymal Stem Cells Regulates Activation of Primary Hepatic Stellate Cells by Qingjie Fu, Shunsuke Ohnishi, Naoya Sakamoto

“…We observed that in routine culture, hAMSC-CM in HSCs significantly inhibited the expression of alpha-smooth muscle actin (α-SMA), an activation marker of HSCs, and the production of collagen type 1 (COL1), a dominant component of the extracellular matrix (ECM) in the culture medium. In addition, hAMSC-CM upregulated the expression of ECM degradation-related genes, such as metalloproteinase- (Mmp-) 2, Mmp-9, Mmp-13, and tissue inhibitor of metalloproteinase- (Timp-) 1; however, it did not affect the expression of collagen type 1α1 (Col1a1). …”
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BMP9 induces postnatal zonal stratification of immature articular cartilage through reconfiguration of the existing collagen framework by Miles Anderson-Watters, Ilyas M. Khan

“…This reshaping of the extracellular matrix is similar across all species and is critical for the lifelong strength and durability of cartilage. …”
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Integrated Bioinformatics Identifies FREM1 as a Diagnostic Gene Signature for Heart Failure by Chenyang Jiang, Weidong Jiang

“…Three machine learning methods assisted in determining the potential characteristic signals Fras1-related extracellular matrix 1 (FREM1) and meiosis-specific nuclear structural 1 (MNS1). …”
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The Use of Porous Scaffold as a Tumor Model by Mei Zhang, Philip Boughton, Barbara Rose, C. Soon Lee, Angela M. Hong

“…Human cancer is a three-dimensional (3D) structure consisting of neighboring cells, extracellular matrix, and blood vessels. It is therefore critical to mimic the cancer cells and their surrounding environment during in vitro study. …”
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Impact of developmental state, p53 status, and interferon signaling on glioblastoma cell response to radiation and temozolomide treatment. by Artem Berezovsky, Oluwademilade Nuga, Indrani Datta, Kimberly Bergman, Thais Sabedot, Katherine Gurdziel, Susan Irtenkauf, Laura Hasselbach, Yuling Meng, Claudius Mueller, Emanuel F Petricoin, Stephen Brown, Neeraja Purandare, Sidhesh Aras, Tom Mikkelsen, Laila Poisson, Houtan Noushmehr, Douglas Ruden, Ana C deCarvalho

“…Differentiated CSC progenies retained the expression of key stemness genes and survival pathways, while activating the BMP-Smad signaling pathway and upregulating extracellular matrix components. This was associated with increased resistance to TMZ, though not to RT, across all models. …”
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Recent Advances in Three-Dimensional Stem Cell Culture Systems and Applications by Xiaowen Wu, Junxiang Su, Jizhen Wei, Nan Jiang, Xuejun Ge

“…Compared to two-dimensional culture, three-dimensional culture system is better to realistically simulate the local microenvironment of cells, promote the exchange of information among cells and the extracellular matrix (ECM), and retain the original biological characteristics of stem cells. …”
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Differential Expression of Matrix Metalloproteases in Human Fibroblasts with Different Origins by Diana Lindner, Christin Zietsch, P. Moritz Becher, Karsten Schulze, Heinz-Peter Schultheiss, Carsten Tschöpe, Dirk Westermann

“…Fibroblasts are widely distributed cells and are responsible for the deposition of extracellular matrix (ECM) components but also secrete ECM-degrading matrix metalloproteases. …”
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Sestrin2 Signaling Pathway Regulates Podocyte Biology and Protects against Diabetic Nephropathy by Moein Ala

“…By suppressing transforming growth factor beta (TGF-β)/Smad and Yes-associated protein (YAP)/transcription enhancer factor 1 (TEF1) signaling pathways in experimental models, Sestrin2 hindered epithelial-mesenchymal transition and extracellular matrix accumulation in diabetic kidneys. Moreover, modulation of the downstream molecules of Sestrin2, for instance, augmentation of AMPK or Nrf2 signaling and inhibition of mTORC1, has been protective in diabetic nephropathy. …”
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Imaging cell spheroid clusters: An MRI protocol for non-invasive standardized characterization by Rebecca Wißmann, Petros Martirosian, Marina Danalache, Gerd Grözinger, Fritz Schick, Stefanie Elser

“…This is contributed by natural cell-cell interactions that occur within spheroids, leading to the subsequent development of extracellular matrix. The assessment of cell spheroids with conventional microscopy is destructive, requiring sectioning that damages their micro-structures. …”
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