The success of the tumor immunotherapy: neutrophils from bench to beside by Meng Zhu, Ru Jia, Xiaojie Zhang, Pingwei Xu

“…They play double “edge-sward” by either supporting or suppressing the tumor growth, including driving angiogenesis, extracellular matrix remodeling to promote tumor growth, participating in antitumor adaptive immunity, or killing tumor cells directly to inhibit the tumor growth. …”
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Role of macrophage in intervertebral disc degeneration by Yiming Dou, Yiming Zhang, Yang Liu, Xun Sun, Xinyu Liu, Bin Li, Qiang Yang

“…Macrophages construct the inflammatory microenvironment of the intervertebral disc and are involved in regulating intervertebral disc cell activities, extracellular matrix metabolism, intervertebral disc vascularization, and innervation, profoundly influencing the progression of disc degeneration. …”
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Molecular and pathological identification of ovine pulmonary adenomatosis at Mosul city abattoirs by Osama Z. Jiad, Ahmed M. Al-Saidya

“…Histological analysis showed nodular tumor areas (proliferative pulmonary nodules) were composed of carcinomatous cells supplementary with an adequate amount of extracellular matrix, characteristic columnar and cuboidal metaplasia, as well as hyperplasia of pulmonary cells, especially the pneumocytes (type II), an epithelial cell (secretory types) in the pulmonary alveoli, Non-ciliated Clara cells as well as the epithelial lining of the terminal bronchioles. …”
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Exploring the Crosstalk between Inflammation and Epithelial-Mesenchymal Transition in Cancer by Indranil Chattopadhyay, Rangarao Ambati, Rohit Gundamaraju

“…Tumor cells undergo invasion and metastasis through epithelial-to-mesenchymal cell transition (EMT) by activation of alterations in extracellular matrix (ECM) protein-encoding genes, enzymes responsible for the breakdown of ECM, and activation of genes that drive the transformation of the epithelial cell to the mesenchymal type. …”
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Proteomic profiling of iPSC and tissue-derived MSC secretomes reveal a global signature of inflammatory licensing by Margeaux Hodgson-Garms, Matthew J. Moore, Mikaël M. Martino, Kilian Kelly, Jessica E. Frith

“…Overall, resting secretomes were defined by extracellular matrix (ECM) and pro-regenerative proteins, while licensed secretomes were enriched in chemotactic and immunomodulatory proteins. iMSC and UC.MSC secretomes contained proteins indicating proliferative potential and telomere maintenance, whereas adult tissue-derived secretomes contained fibrotic and ECM-related proteins. …”
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Hyaluronan and Collagen in Human Hypertrophic Cardiomyopathy: A Morphological Analysis by Martin Hellström, Anna Engström-Laurent, Stellan Mörner, Bengt Johansson

“…The hypertrophic cardiomyopathy (HCM) disease process is not only limited to cardiomyocyte abnormalities but also engages the extracellular matrix. Hyaluronan (HA) and its receptor CD44 are involved in cellular growth and tissue proliferation but have so far been less studied in myocardial hypertrophy. …”
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Comparison of Wide Conjunctival Flap and Conjunctival Autografting Techniques in Pterygium Surgery by Lokman Aslan, Murat Aslankurt, Adnan Aksoy, Murat Özdemir, Erdem Yüksel

“…A stromal overgrowth of fibroblast and blood vessels is accompanied by an inflammatory cell infiltrate and abnormal extracellular matrix accumulation. The surgical excision is the main treatment method of pterygium, but recurrence is the most common postoperative complication. …”
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Human epicardial organoids from pluripotent stem cells resemble fetal stage with potential cardiomyocyte- transdifferentiation by Fanwen Wang, Xinle Zou, Huilin Zheng, Tianci Kong, Duanqing Pei

“…Single-cell RNA seq unveils the heterogeneity and multipotency exhibited by epicardium-derived-cells and fetal-like epicardium. Meanwhile, extracellular matrix and growth factors secreted by epicardial organoid mimics the ecology of subepicardial space between the epicardium and cardiomyocytes. …”
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Turnover of Focal Adhesions and Cancer Cell Migration by Makoto Nagano, Daisuke Hoshino, Naohiko Koshikawa, Toshifumi Akizawa, Motoharu Seiki

“…Cells are usually surrounded by the extracellular matrix (ECM), and adhesion of the cells to the ECM is a key step in their migration through tissues. …”
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Genotypic and Phenotypic Assessment of Hyaluronidase among Type Strains of a Select Group of Staphylococcal Species by Mark E. Hart, Morgan J. Hart, Anna J. Roop

“…Hyaluronidases degrade hyaluronic acid, a major polysaccharide of the extracellular matrix of tissues, and are considered important for virulence in a number of Gram-positive and -negative bacteria. …”
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KIF26B and CREB3L1 Derived from Immunoscore Could Inhibit the Progression of Ovarian Cancer by Shanshan Cong, Yao Fu, Xibo Zhao, Qiuyan Guo, Tian Liang, Di Wu, Jing Wang, Guangmei Zhang

“…We identified two hub gene modules related to the immunoscore of OV and found that these genes in the modules were related to the extracellular matrix and viral infections. At the same time, we also discovered six hub genes related to the immunity of OV. …”
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Chondroitin 6-Sulfation Regulates Perineuronal Net Formation by Controlling the Stability of Aggrecan by Shinji Miyata, Hiroshi Kitagawa

“…Perineuronal nets (PNNs) are lattice-like extracellular matrix structures composed of chondroitin sulfate proteoglycans (CSPGs). …”
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CTRP9 Mitigates the Progression of Arteriovenous Shunt-Induced Pulmonary Artery Hypertension in Rats by Hua Guan, Xiaofeng Yang, Tao Shi, Yongjian Zhang, Aoqi Xiang, Yongxin Li

“…CTRP9 attenuated the pulmonary vascular remodeling in the shunt group by decreasing the mPAP and RVSP, which was associated with suppressed inflammation, apoptosis, and extracellular matrix injury. In addition, CTRP9 dramatically increased the phosphorylation of AKT and p38-MAPK in the lung tissues of shunt-operated animals. …”
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Effect of Age and Diabetes on the Response of Mesenchymal Progenitor Cells to Fibrin Matrices by A. Stolzing, H. Colley, A. Scutt

“…These niches are composed of niche cells, stem cells, and extracellular matrix. When blood vessels are damaged, a fibrin clot forms as part of the wound healing response. …”
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PTEN Gene: A Model for Genetic Diseases in Dermatology by Corrado Romano, Carmelo Schepis

“…The negative regulation of cell interactions with the extracellular matrix could be the way PTEN phosphatase acts as a tumor suppressor. …”
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The Extracellular Environment of the CNS: Influence on Plasticity, Sprouting, and Axonal Regeneration after Spinal Cord Injury by Shmma Quraishe, Lindsey H. Forbes, Melissa R. Andrews

“…In this review, we have focused on two components of the neuronal extracellular environment, which are important in regulating CNS plasticity including the extracellular matrix (ECM) and myelin. The ECM consists of chondroitin sulfate proteoglycans (CSPGs) and tenascins, which are organized into unique structures called perineuronal nets (PNNs). …”
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Mimicking Neural Stem Cell Niche by Biocompatible Substrates by Citlalli Regalado-Santiago, Enrique Juárez-Aguilar, Juan David Olivares-Hernández, Elisa Tamariz

“…The circumscribed areas where the NSCs are located contain the secreted proteins and extracellular matrix components that conform their niche. …”
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COSMC-Regulated O-Glycosylation: A Bioinformatics-Driven Biomarker Identification for Stratifying Glioblastoma Stem Cell Subtypes by Sara Sadat Aghamiri, Rada Amin

“…Additionally, elevated Cosmc correlated with extracellular matrix (ECM) pathways and stromal cell populations, such as perivascular fibroblasts. …”
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Cardiac Progenitor Cells and the Interplay with Their Microenvironment by Arianna Mauretti, Sergio Spaans, Noortje A. M. Bax, Cecilia Sahlgren, Carlijn V. C. Bouten

“…We focus on the interaction between CPCs and supporting cells, extracellular matrix, mechanical stimuli, and soluble factors. …”
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Aloin Regulates Matrix Metabolism and Apoptosis in Human Nucleus Pulposus Cells via the TAK1/NF-κB/NLRP3 Signaling Pathway by Taiqiu Chen, Pengfei Li, Jincheng Qiu, Wenjun Hu, Shaoguang Li, Huihong Shi, Xianjian Qiu, Dongsheng Huang, Wenjie Gao, Anjing Liang

“…We found that aloin had a curative effect on extracellular matrix metabolism and apoptosis in TNF-alpha- (TNF-α-) treated NPCs by inhibiting oxidative stress and the proinflammatory factor expression. …”
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