Targeted inhibition of ferroptosis in bone marrow mesenchymal stem cells by engineered exosomes alleviates bone loss in smoking-related osteoporosis by Yao Wang, Lin Sun, Zhenglin Dong, Tianyu Zhang, Leining Wang, Yihui Cao, Hui Xu, Chenglei Liu, Bo Chen

“…Using genetic engineering techniques, we introduced α-1,3-fucosyltransferase 6 (Fut6), a key protein involved in prostate cancer bone metastasis, and identified exosomes expressing Fut6 (F6-exo) with bone-targeting capabilities. Additionally, we modified these exosomes with a bone-targeting peptide, (AspSerSer)6, to synthesize F6-(DSS)6-exo. …”
Get full text

Leishmania mexicana: Novel Insights of Immune Modulation through Amastigote Exosomes by Laura Enedina Soto-Serna, Mariana Diupotex, Jaime Zamora-Chimal, Adriana Ruiz-Remigio, José Delgado-Domínguez, Rocely Buenaventura Cervantes-Sarabia, Adriana Méndez-Bernal, Alma Reyna Escalona-Montaño, María Magdalena Aguirre-García, Ingeborg Becker

“…We here show that exosomes of L. mexicana amastigotes (aExo) contain the virulence proteins gp63 and PP2C. …”
Get full text

An Investigation of the Enolization and Isomeric Products Distribution in the Water Promoted Aldol Reaction of Tropinone and Granatanone by Ryszard Lazny, Artur Ratkiewicz, Krzysztof Brzezinski, Aneta Nodzewska, Katarzyna Sidorowicz

“…The exo,anti/exo,syn-diastereoselectivity of water promoted direct aldol reactions of tropinone and granatanone (pseudopelletierine) is strongly dependent on the amount of water added and aromatic aldehyde used. …”
Get full text

Myofibroblast-derived exosomes enhance macrophages to myofibroblasts transition and kidney fibrosis by Wenqiang Yu, Jinfang Song, Shuangquan Chen, Jiayi Nie, Chujun Zhou, Jiamin Huang, Hua Liang

“…Mice treatment with myofibroblast-derived exosomes (Myo-Exo) exhibited severe fibrotic lesion and more abundant MMT cells in kidneys with folic acid (FA) injury, which was negated by TANK-banding kinase-1 inhibitor. …”
Get full text

Changes in Circulating BDNF in relation to Sex, Diet, and Exercise: A 12-Week Randomized Controlled Study in Overweight and Obese Participants by M. Glud, T. Christiansen, L. H. Larsen, B. Richelsen, J. M. Bruun

“…Body weight was reduced in all intervention groups (p<0.006). Exercise (EXO group) induced a 22% reduction in circulating BDNF in men (p=0.037) and women (p=0.080). …”
Get full text

Exosomal miR-141-3p from PDLSCs Alleviates High Glucose-Induced Senescence of PDLSCs by Activating the KEAP1-NRF2 Signaling Pathway by Min Liu, Rui Chen, Yunxuan Xu, Jiawen Zheng, Min Wang, Ping Wang

“…PDLSC-Exos were cocultured with senescent PDLSCs to further explore the role of PDLSC-Exos in cellular senescence and determine the differences in cellular oxidative stress levels after PDLSC-Exo treatment. …”
Get full text

Comparative transcriptomic and phenotypic analysis of monoclonal and polyclonal Populus deltoides genotypes by Macy Gosselaar, Macy Gosselaar, Mark A. Arick, Chuan-Yu Hsu, Heidi Renninger, Courtney M. Siegert, Waqar Shafqat, Daniel G. Peterson, Austin Himes

“…RNA sequencing revealed upregulation of key genes such as exocyst subunit exo70 family protein H7 (EXO70H7), NDH-dependent cyclic electron flow 5 (NDF5), and expansin-like A3 (EXLA3). …”
Get full text

De l’os, de l’ennemi et du divin. Réflexions sur quelques pratiques funéraires tupi-guarani by Olivier Allard

“…If the greatest contrast is that between vengeful exo-cannibalism and the cult of bones, there is also, within the former, a culturally determined gradation in the treatment of the bones during consumption of the corpse.…”
Get full text

Entre la parole et l’image : le système mythopoétique marubo by Pedro de Niemeyer Cesarino

“…The transformation and composition relationships of the previous schemes constitute a specialized mythological and poetic knowledge, characterized by transmission and acquisition processes that are connected to the exo-centered Amerindian cosmologies.…”
Get full text

Signal and modulating role of enzymes of digestive glands by G. F. Korotko

“…They carry out also signaling role in modulation of exo- and endocrine secretions of digestive glands and motor activity of gastro-intestinal tract. …”
Get full text

PCOT: An open‐source toolkit for multispectral image processing by James Finnis, Helen C. Miles, Ariel Ladegaard, Matt Gunn

“…It is in active development in support of the ExoMars mission and intended to be used on data from the Rosalind Franklin rover, but it has much greater potential for use beyond this specific context. …”
Get full text

Small Mars Mission Architecture Study by Claire E. Parfitt, Adam G. McSweeney, Lisa De Backer, Csilla Orgel, Andrew J. Ball, Michael Khan, Sanjay Vijendran

“…While the vast majority of ESA’s funding for Mars exploration in the 2020s is planned to be invested in ExoMars and Mars Sample Return, there is an interest to assess the possibility of implementing a small mission to Mars in parallel with, or soon after, the completion of the MSR programme. …”
Get full text

Antimicrobial Activities of Stigmasterol from Piper crocatum In Vitro and In Silico by Seftiana Lestari, Dikdik Kurnia, Tri Mayanti, Leny Heliawati

“…The study findings indicate that the stigmasterol compound exhibits antibacterial and antifungal properties against pathogenic oral microorganisms in vitro as well as in silico against the crucial antibacterial enzymes MurA and PBP in addition to the pivotal antifungal enzyme exo-β-1,3-glucanase and lanosterol-14-α-demethylase. …”
Get full text

Support Services Provided by a Child and Youth Care Centre (CYCC) to Adolescent Witnesses of Domestic Violence by Shahana Rasool, Suzanne Swart

“…These support services are explored in terms of four inter-dependent levels including the micro, meso, exo and macro levels of the Ecological Theory, as described by Bronfenbrenner (1979). …”
Get full text

Mesenchymal Stem Cell-derived Exosomes: Novel Therapeutic Approach for Inflammatory Bowel Diseases by Cheng-mei Tian, Mei-feng Yang, Hao-ming Xu, Min-zheng Zhu, Yuan Zhang, Jun Yao, Li-sheng Wang, Yu-jie Liang, De-feng Li

“…The anti-inflammatory and immunomodulatory activities of mesenchymal stem cell (MSC)-derived Exos (MSC-Exos) provide a rationale for novel cell-free therapies for inflammatory bowel disease (IBD). …”
Get full text

Lemon-derived nanoparticle-functionalized hydrogels regulate macrophage reprogramming to promote diabetic wound healing by Enyou Jin, Yusheng Yang, Shengjie Cong, Dengke Chen, Ruixiong Chen, Jun Zhang, Yanjun Hu, Weini Chen

“…Our GelMA-DAS-Lemon Exosomes hydrogel (GelMA/DAS/Exo hydrogel) patch represents a potentially valuable option for repairing diabetic wounds in clinical applications. …”
Get full text

Molecular basis for azetidine-2-carboxylic acid biosynthesis by Tim J. Klaubert, Jonas Gellner, Charles Bernard, Juliana Effert, Carine Lombard, Ville R. I. Kaila, Helge B. Bode, Yanyan Li, Michael Groll

“…AZE synthases catalyse the intramolecular 4-exo-tet cyclisation of S-adenosylmethionine (SAM), yielding a highly strained heterocycle. …”
Get full text

Synthesis and crystal structure of 5,10-bis(phenylsulfonyl)tetrahydrodibenzopentalene by Toshiki Sakami, Hikaru Watanabe, Takuma Sato, Yasuhiro Okuda, Kan Wakamatsu, Haruo Akashi, Akihiro Orita

“…Additionally, a pair of phenylsulfonyl groups were observed at the exo positions relative to the V-shaped array.…”
Get full text

Direct imaging of exoplanets: Legacy and prospects by Chauvin, Gael

“…On the timescale of a human Life, we may well be witnessing the first discovery of an exoplanet and the first detection of indices of life in the atmosphere of a nearby exo-Earth!…”
Get full text

BPI-ANCA Provides Additional Clinical Information to Anti-Pseudomonas Serology: Results from a Cohort of 117 Swedish Cystic Fibrosis Patients by Ulrika Lindberg, Malin Carlsson, Thomas Hellmark, Mårten Segelmark

“…IgA BPI-ANCA was compared with assays for antibodies against alkaline protease (AP), Elastase (ELA), and Exotoxin A (ExoA). Lung function and patient outcome, alive, lung transplanted, or dead, were registered. …”
Get full text