Predicting the impact of missense mutations on an unresolved protein’s stability, structure, and function: A case study of Alzheimer’s disease-associated TREM2 R47H variant by Joshua Pillai, Kijung Sung, Chengbiao Wu

“…We believe that the in-silico mutagenesis methods described here can be applied broadly to evaluate the ever-growing numbers of protein mutations/variants discovered in human genetics study for their potential in diseases, ultimately facilitating personalized medicine.…”
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Technical efficiency of public hospitals in east Africa: a systematic review and meta-analysis by Anteneh Lamesgen, Bekalu Endalew, Aysheshim Belaineh Haimanot, Tigabu Kidie Tesfie, Elyas Melaku Mazengia, Mulat Belay Simegn, Werkneh Melkie Tilahun, Molla Yigzaw Birhanu, Lakew Asmare, Habtamu Geremew, Muluye Gebrie Mengie

“…Abstract Background Hospitals usually encounter human, capital, and financial resource constraints which alerts the efficient use of allocated resources more than ever. Health system managers are required to identify inefficient hospitals and the drivers of the inefficiencies. …”
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Modifiable Risk Factors Including Self-Perceived Stress for Breast Cancer in Hong Kong: A Case-Control Study of 10 757 Subject by Winnie Yeo, Lok-Wa Yuen, Kelvin Kam-Fai Tsoi, Emily Ying-Yang Chan, Carol C Kwok, Inda Soong, Ting-Ying Ng, Joanne Chiu, Miranda Chan, Sharon Wing-Wai Chan, Ting-Ting Wong, Yolanda Ho-Yan Chan, Lawrence Pui-Ki Li, Chun-Chung Yau, Wai-Ka Hung, Polly Suk-Yee Cheung

“…Self-perceived high stress level (adjusted odd ratios [AOR]= 3.44; 95% confidence intervals [CI] = 3.13-3.78), dairy-rich diet (AOR = 3.33; 95% CI = 2.01-5.52), delayed child-bearing (AOR = 2.23; 95% CI = 1.79-2.79), meat-rich diet (AOR = 1.77; 95% CI = 1.54-2.04), ever use of oral contraceptives (AOR = 1.34; 95% CI = 1.22-1.47), nulliparity (AOR = 1.21; 95% CI = 1.08-1.35), and being overweight/obese (AOR = 1.21; 95% CI = 1.10-1.32) were found to be associated with an increased risk of breast cancer. …”
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Estimated cumulative incidence of intervention by children's social care services to age 18: a whole-of-England administrative data cohort study using the child in need census by Matthew A Jay, Patricio Troncoso, Andy Bilson, Dave Thomson, Richard Dorsett, Rachel Pearson, Bianca De Stavola, Ruth Gilbert

“…Government should monitor the cumulative incidence of ever receiving CSC support with a view to addressing upstream health and social determinants. …”
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Enhancement of CD8+T cell cytotoxicity activity by IFN-α implies alternative pathologic role in systemic lupus erythematosus by Chen-xing Zhang, You-ying Mao, Yu-pin Tan, Mei-yu Zhang, Kang Shao, Shu-jun Wang, Ping Ji, Jia-yuan Wang, Lei Yin, Ying Wang

“…Up to date, however, no research has ever investigated the effect of IFN-α on CD8+T cells, which might be implicated in the pathogenesis of SLE. …”
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The association of HIV status and depressive symptoms in the Ndlovu Cohort study by Li Xiang Y. den Boer, Karine Scheuermaier, Hugo A. Tempelman, Roos E. Barth, Walter L. J. M. Devillé, Roel A. Coutinho, Diederick E. Grobbee, Francois Venter, Alinda G. Vos-Seda, Kerstin Klipstein-Grobusch

“…Logistic regression analysis on the relationship between HIV status and depressive symptoms was used while adjusting for age, sex, level of education, employment status, income, and ever smoking. The study included 1,927 participants; 46% were PLHIV and 239 (12.5%) had depressive symptoms. …”
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Impact of witnessing abuse of their mother and childhood trauma on men's perpetration of intimate partner violence in the cross-sectional UN multi-country study on men and violence... by Rachel Jewkes, Ruchira Tabassum Naved, Naeema Abrahams, Nwabisa Shai, Leane Ramsoomar, Bianca Dekel, Andrew Gibbs, Jani Nöthling, Samantha Willan, Esnat Chirwa

“…Methods: In nine sites, from six countries, data were collected in a two-stage, randomly-selected household survey, with one man aged 18–49 years interviewed per house. 8379 interviews were completed with ever partnered men in Bangladesh, Cambodia, China, Indonesia, Papua New Guinea (Bougainville) and Sri Lanka. …”
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Sustained Impairment in Cardiopulmonary Exercise Capacity Testing in Patients after COVID-19: A Single Center Experience by Georg Evers, Arik Bernard Schulze, Irina Osiaevi, Kimon Harmening, Richard Vollenberg, Rainer Wiewrodt, Rudin Pistulli, Matthias Boentert, Phil-Robin Tepasse, Juergen R. Sindermann, Ali Yilmaz, Michael Mohr

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Estimated baseline density of a spotted hyaena population in a post-war landscape by Willem D. Briers-Louw, Tamar A. Kendon, Matthew S. Rogan, Alison J. Leslie, Drew Bantlin, Emma Evers, David Gaynor, Peter Lindsey, João Almeida, Vincent N. Naude

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Prevalence and factors associated with adverse pregnancy outcomes in South Africa: Evidence from the 2016 Demographic and Health Survey by L Mpolokeng, A Musekiwa

“…Contrarily, adverse pregnancy outcomes were lower with each additional child delivered or ever born (aOR 0.66, 95% CI 0.58 - 0.75). Conclusions. …”
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RCE-IFE: recursive cluster elimination with intra-cluster feature elimination by Cihan Kuzudisli, Burcu Bakir-Gungor, Bahjat Qaqish, Malik Yousef

“…The computational and interpretational difficulties caused by the ever-increasing dimensionality of biological data generated by new technologies pose a significant challenge. …”
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The Effect of Annealing in a Magnetic Field on the Microstructures and Magnetic Properties of (Nd_0.8RE_0.2)_2.2Fe₁₂Co₂B (RE = L... by Xiaohua Tan, Xuanbo Shi, Shiqi Zhang, Hui Xu

“…The development of high-performance and cost-effective Nd-Fe-B permanent magnets is crucial to meet the ever-growing requirements of renewable and clean energy applications. …”
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Estimating ocean heat content from the ocean thermal expansion parameters using satellite data by V. P. Kondeti, S. Palanisamy

“…In addition, the first-ever attempt to estimate the ocean thermal expansion component (i.e., TSL) from satellite data was successful, and the model-derived TSL can be used to obtain high-end sea level rise products in the global ocean.…”
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Reflections on the Yoruba Past: Toyin Falola on Isaac Delano by Wale Oyedeji

“…It became prominently popular from the beginning of African’s contact with Europeans and Arabs, and this, ever since then, has attracted deepened engagement by African scholars whose primary intention was to defend their cultural legacy. …”
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Determinants of family planning services uptake among women within the reproductive age in the Yendi municipality in Northern Ghana by Iddrisu Sulemana, Collins Gbeti, Maxwell Dalaba, Adadow Yidana, Gifty Apiung Aninanya

“…More than half of the respondents (54.3%) said they had ever used a family planning method and almost half of them said they were still using a family planning method. …”
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Ethical education: Ways of moral consciousness development (understanding experience through Tyumen ethical and philosophical tradition) by E. N. Yarkova, A. G. Ivanov, Ya. V. Maltsev

“…The methodology of ethical education is an ever-relevant topic of research. This is due to the fact that the person’s moral consciousness is an extremely subtle matter; the ways of its development are complex and non-linear. …”
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Perspectives of People with Type 2 Diabetes Mellitus Towards a Decision Aid Assessing Preferences of Glucose-Lowering Drugs: The Dilemma of Choosing by Roldan Munoz S, Mol PGM, de Vries F, van Dijk PR, Hillege H, Postmus D, de Vries ST

“…A qualitative study using semi-structured interviews was conducted among Dutch patients with T2D who were or had ever been under pharmacological treatment for T2D. …”
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Folic acid supplementation during preconception period in sub-Saharan African countries: A systematic review and meta-analysis. by Mekuriaw Nibret Aweke, Elsa Awoke Fentie, Muluken Chanie Agimas, Lemlem Daniel Baffa, Ever Siyoum Shewarega, Aysheshim Kassahun Belew, Esmael Ali Muhammad, Berhanu Mengistu

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A brief instrument measuring the water, sanitation and hygiene domain of menstrual health among women who inject drugs. by Alhelí Calderón-Villarreal, Lourdes Johanna Avelar Portillo, Daniela Abramovitz, Shira Goldenberg, Shawn Flanigan, Penelope J E Quintana, Alicia Harvey-Vera, Carlos F Vera, Gudelia Rangel, Steffanie A Strathdee, Georgia L Kayser

“…The sample included people who inject drugs (PWID) who had ever menstruated in their lifetime and were 18+ during 2020-2021. …”
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Unilateral Toxic Anterior Segment Syndrome Resulting in Cataract and Urrets-Zavalia Syndrome after Sequential Uneventful Implantation of a Posterior Chamber Phakic Toric Intraocula... by Kepa Balparda, Claudia Marcela Vanegas-Ramirez, Johny Márquez-Tróchez, Tatiana Herrera-Chalarca

“…To date, to the best of the authors’ knowledge, no article has ever described the simultaneous occurrence of TASS and UZS in a patient after P-IOL implantation. …”
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