Fructose-Induced Carbonyl/Oxidative Stress in S. cerevisiae: Involvement of TOR by Bohdana V. Valishkevych, Ruslana A. Vasylkovska, Liudmyla M. Lozinska, Halyna M. Semchyshyn

“…The TOR (target of rapamycin) signaling pathway first described in the budding yeast Saccharomyces cerevisiae is highly conserved in eukaryotes effector of cell growth, longevity, and stress response. …”
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Protein Machineries Involved in the Attachment of Heme to Cytochrome c: Protein Structures and Molecular Mechanisms by Carlo Travaglini-Allocatelli

“…To accomplish this task, prokaryotic and eukaryotic cells have evolved distinctive protein machineries composed of different proteins. …”
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Mechanistic studies on regulation of the activity of GPI-anchored serine protease testisin by WAN Jiahui, ZHOU Aiwu

“…Objective·To explore the activation methods and activity regulation mechanisms of the testisin zymogen in vitro, laying a foundation for further research on the physiological functions of testisin in organisms.Methods·The eukaryotic expression plasmid for the mouse-derived testisin (mTN) zymogen was constructed through full-gene synthesis and subsequently transfected into eukaryotic HEK293S cells for expression. …”
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Decreased SynMuv B gene activity in response to viral infection leads to activation of the antiviral RNAi pathway in C. elegans. by Ashwin Seetharaman, Himani Galagali, Elizabeth Linarte, Mona H X Liu, Jennifer D Cohen, Kashish Chetal, Ruslan Sadreyev, Alex J Tate, Taiowa A Montgomery, Gary Ruvkun

“…RNA interference (RNAi) mediates antiviral defense in many eukaryotes. Caenorhabditis elegans mutants that disable RNAi are more sensitive to viral infection. …”
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A shallow-water oxygen minimum zone in an oligotrophic Tonian basin by Yunpeng Sun, Wei Wang, Xianguo Lang, Chengguo Guan, Qing Ouyang, Ke Pang, Guangjin Li, Yongliang Hu, Hongyi Shi, Xianye Zhao, Chuanming Zhou

“…Abstract The Tonian Period (1000–720 Ma) bore witness to the transition from a prokaryote-dominated marine ecosystem to one characterized by the proliferation of eukaryotes. This fundamental shift has generally been attributed to evolving marine redox states. …”
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Evolutionary plasticity and functional repurposing of the essential metabolic enzyme MoeA by Daniela Megrian, Mariano Martinez, Pedro M. Alzari, Anne Marie Wehenkel

“…Abstract MoeA, also known as gephyrin in higher eukaryotes, is an enzyme essential for molybdenum cofactor (Moco) biosynthesis and involved in GABA and GlyR receptor clustering at the synapse in animals. …”
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Effects of Taxon Sampling in Reconstructions of Intron Evolution by Mikhail A. Nikitin, Vladimir V. Aleoshin

“…Introns comprise a considerable portion of eukaryotic genomes; however, their evolution is understudied. …”
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Metagenome-assembled-genomes recovered from the Arctic drift expedition MOSAiC by William Boulton, Asaf Salamov, Igor V. Grigoriev, Sara Calhoun, Kurt LaButti, Robert Riley, Kerrie Barry, Allison A. Fong, Clara J. M. Hoppe, Katja Metfies, Kersten Oetjen, Sarah Lena Eggers, Oliver Müller, Jessie Gardner, Mats A. Granskog, Anders Torstensson, Marc Oggier, Aud Larsen, Gunnar Bratbak, Andrew Toseland, Richard M. Leggett, Vincent Moulton, Thomas Mock

“…This dataset presents a catalogue of MAGs recovered from a set of 73 samples from MOSAiC, including 2407 prokaryotic and 56 eukaryotic MAGs, as well as annotations of a near complete eukaryotic MAG using the Joint Genome Institute (JGI) annotation pipeline. …”
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The Transcriptional Network Structure of a Myeloid Cell: A Computational Approach by Jesús Espinal-Enríquez, Daniel González-Terán, Enrique Hernández-Lemus

“…Understanding the general principles underlying genetic regulation in eukaryotes is an incomplete and challenging endeavor. …”
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R-loops acted on by RNase H1 influence DNA replication timing and genome stability in Leishmania by Jeziel D. Damasceno, Emma M. Briggs, Marija Krasilnikova, Catarina A. Marques, Craig Lapsley, Richard McCulloch

“…Abstract Genomes in eukaryotes normally undergo DNA replication in a choreographed temporal order, resulting in early and late replicating chromosome compartments. …”
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Structural insights into how Cas9 targets nucleosomes by Reina Nagamura, Tomoya Kujirai, Junko Kato, Yutaro Shuto, Tsukasa Kusakizako, Hisato Hirano, Masaki Endo, Seiichi Toki, Hiroaki Saika, Hitoshi Kurumizaka, Osamu Nureki

“…Abstract The CRISPR-associated endonuclease Cas9 derived from prokaryotes is used as a genome editing, which targets specific genomic loci by single guide RNAs (sgRNAs). The eukaryotes, the target of genome editing, store their genome DNA in chromatin, in which the nucleosome is a basic unit. …”
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Spatial and temporal variation of Antarctic microbial interactions: a study around the west Antarctic Peninsula by Swan L. S. Sow, Willem H. van de Poll, Rachel Eveleth, Jeremy J. Rich, Hugh W. Ducklow, Patrick D. Rozema, Catherine M. Luria, Henk Bolhuis, Michael P. Meredith, Linda A. Amaral-Zettler, Julia C. Engelmann

“…Results We report on the seasonal diversity, taxonomic overview, as well as predicted inter-and intra-domain causal effects (interactions) of the bacterial and microbial eukaryotic communities close to the Palmer station and at the Rothera time-series site between July 2013 and April 2014. …”
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REGULATORY TRANSCRIPTION FACTORS MAY PARTICIPATE IN POST-INITIATION CONTROL OF TRANSCRIPTION by V. M. Merkulov, T. I. Merkulova

“…Sequence-specific (regulatory) transcription factors selectively regulate the transcription levels of different sets of eukaryotic genes depending on cell type, developmental stage, and external signals. …”
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CTCF, Cohesin, and Chromatin in Human Cancer by Sang-Hyun Song, Tae-You Kim

“…It is becoming increasingly clear that eukaryotic genomes are subjected to higher-order chromatin organization by the CCCTC-binding factor/cohesin complex. …”
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Identification of Key Genes and Pathways Involved in Circulating Tumor Cells in Colorectal Cancer by Ruijun Pan, Chaoran Yu, Yanfei Shao, Hiju Hong, Jing Sun, Zhou Zhang, Peiyong Li, Minhua Zheng

“…The top 10 hub genes were included, including eukaryotic translation elongation factor 2 (EEF2), ribosomal protein S2 (RPS2), ribosomal protein S5 (RPS5), ribosomal protein L3 (RPL3), ribosomal protein S3 (RPS3), ribosomal protein S14 (RPS14), ribosomal protein SA (RPSA), eukaryotic translation elongation factor 1 alpha 1 (EEF1A1), ribosomal protein S15a (RPS15A), and ribosomal protein L4 (RPL4). …”
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Dissection of Ire1 functions reveals stress response mechanisms uniquely evolved in Candida glabrata. by Taiga Miyazaki, Hironobu Nakayama, Yohsuke Nagayoshi, Hiroshi Kakeya, Shigeru Kohno

“…Proper protein folding in the endoplasmic reticulum (ER) is vital in all eukaryotes. When misfolded proteins accumulate in the ER lumen, the transmembrane kinase/endoribonuclease Ire1 initiates splicing of HAC1 mRNA to generate the bZIP transcription factor Hac1, which subsequently activates its target genes to increase the protein-folding capacity of the ER. …”
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Detection of host-derived sphingosine by Pseudomonas aeruginosa is important for survival in the murine lung. by Annette E LaBauve, Matthew J Wargo

“…These sphingolipids not only play a structural role in lipid membranes, but some are also intracellular and intercellular signaling molecules important in normal eukaryotic cell functions as well as orchestrating immune responses. …”
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A glimpse into the biogeography, seasonality, and ecological functions of arctic marine Oomycota by Brandon T. Hassett, Marco Thines, Anthony Buaya, Sebastian Ploch, R. Gradinger

“…Oomycota are a group of fungal-like organisms that comprise a major clade of eukaryotic life and are parasites of fish, agricultural crops, and algae. …”
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Plant expression systems for production of recombinant pharmaceutically important proteins by E. V. Deineko, A. A. Zagorskaya

“…Plant cells combine the advantages of the eukaryotic system of protein production and the simplicity and cheapness of the bacterial, and the use of plants for the production of recombinant proteins is an economically important and promising direction. …”
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Plant diversity and transcriptional variability assessed by retrotransposon-based molecular markers by R. N. Kalendar, K. S. Aizharkyn, O. N. Khapilina, A. A. Amenov, D. S. Tagimanova

“…Retrotransposons are a major component of all eukaryotic genomes, which makes them suited as molecular markers. …”
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