One-stage versus two-stage video-assisted thoracic surgery for synchronous bilateral pulmonary nodules: protocol for a single center, non-randomized clinical trial (OTVATS-1) by Yu Han, Weixun Zhang, Peihang Xu, Zhoujunyi Tian, Yang Hao, Jin Zhang, Tai Ren, Chaoyang Liang

“…Trail registration This study underwent review by the Ethics Committee of China-Japan Friendship Hospital under No. 2023-KY-061-1. …”
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Routine Multimodal Antiemesis Including Low-Dose Perphenazine in an Ambulatory Surgery Unit of a University Hospital: A 10-Year History by Brian A. Williams, Michael L. Kentor, Susan J. Skledar, Steven L. Orebaugh, Manuel C. Vallejo

“…In settings where droperidol is still routinely used and deemed acceptable by local scientific ethics committees, we believe that oral perphenazine 8 mg should be compared head to head with droperidol 0.625–1.25 mg in patients receiving coadministered dexamethasone and 5-HT3 antagonists in order to determine differences in synergistic efficacy, if any. …”
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Analysis of the correlations between changes in posterior segment and anterior chamber segment after implantable collamer lens implantation in highly myopic patients by Yifei Peng, Lu Xiong, Haokun Qu, Yang Liu, Zheng Wang

“…Trial registration The study was approved by the ethics committee of Aier Eye Hospital, Jinan University (No. …”
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Determining the Feasibility of Ambulance-Based Randomised Controlled Trials in Patients with Ultra-Acute Stroke: Study Protocol for the “Rapid Intervention with GTN in Hypertensive... by Sandeep Ankolekar, Gillian Sare, Chamila Geeganage, Michael Fuller, Lynn Stokes, Nikola Sprigg, Ruth Parry, A. Niroshan Siriwardena, Philip M. W. Bath

“…The trial has all relevant ethics and regulatory approvals and recruitment started on February 15, 2010. …”
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Co-design for stroke intervention development: Results of a scoping review. by Hardeep Singh, Natasha Benn, Agnes Fung, Kristina M Kokorelias, Julia Martyniuk, Michelle L A Nelson, Heather Colquhoun, Jill I Cameron, Sarah Munce, Marianne Saragosa, Kian Godhwani, Aleena Khan, Paul Yejong Yoo, Kerry Kuluski

“…Limitations, challenges and potential strategies for recruitment, participant-engagement, contextual and logistical and ethics of co-designed interventions were described.…”
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Effects of prophylactic antibiotic administration and antibiotic timing on culture results and clinical outcomes of paediatric musculoskeletal infection: a protocol for a randomise... by Chao You, Yibiao Zhou, Zhiyong Liu, Chao Deng, Yongjie Xia, Dechao Wu, Liangfu Xie, Bing E, Jingming Han

“…Statistical comparisons between the different patient groups regarding the confounding and outcome variables will be conducted using independent t-tests, Mann-Whitney U tests, χ2 tests and Fisher’s exact tests as appropriate with the significance level set to 5% (p<0.05).Ethics and dissemination This study has received ethical approval. …”
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Enhanced Neuroprotective Effects of Coadministration of Tetrandrine with Glutathione in Preclinical Model of Parkinson’s Disease by Xiang-Yun Li, Guang-Hai Mei, Qiang Dong, Yu Zhang, Zhuang-Li Guo, Jing-Jing Su, Yu-Ping Tang, Xue-Hong Jin, Hou-Guang Zhou, Yan-Yan Huang

“…Levels in the redox system, dopamine (DA) metabolism, dopaminergic neuronal survival, and apoptosis of the substantia nigra (SN) and striatum, as well as the rotational behavior of animals were examined after a 50-day administration of GSH + Tet (or GSH) and/or L-3,4-dihydroxyphenylalanine (L-dopa) to PD rats. Ethics Committee of Huashan Hospital, Fudan University approved the protocol (number SYXK2009-0082). …”
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Digital multiple health behaviour change intervention targeting online help seekers: protocol for the COACH randomised factorial trial by Hanna Henriksson, Pontus Henriksson, Marie Löf, Preben Bendtsen, Marcus Bendtsen, Katarina Åsberg, Oskar Lundgren, Jenny Blomqvist

“…Multilevel regression models will be used to analyse behavioural outcomes collected at 2 months and 4 months postrandomisation.Ethics and dissemination Approved by the Swedish Ethical Review Authority on 2021-08-11 (Dnr 2021-02855). …”
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Obstacles and opportunities for care collaboration through the utilisation of a preventive care process for frail older adults: a study protocol for a mixed methods study design by Åsa Larsson Ranada, Elisabet Rothenberg, Helle Wijk, Martina Karin Boström, Pia Skott, Anette Erichsen

“…This model can be tested and upscaled to achieve a more effective and equitable healthcare system.Ethics and dissemination The study has been approved by the Swedish ethical review authority. …”
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Effects of falls prevention interventions on falls outcomes for hospitalised adults: protocol for a systematic review with meta-analysis by Anne-Marie Hill, Meg E Morris, David L Carey, Susan C Slade

“…The results will be presented textually, with flow charts, summary tables, statistical analysis (and meta-analysis where possible) and narrative summaries.Ethics and dissemination Ethical approval is not required. …”
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Randomised, pragmatic, waitlist controlled trial of cannabis added to prescription opioid support on opioid dose reduction and pain in adults with chronic non-cancer pain: study pr... by A Eden Evins, Ellie Grossman, Julia Jashinski, Aurora Quaye, Corinne Cather, Kevin Potter, David A Schoenfeld, Jodi M Gilman

“…We will record adverse events.Ethics and dissemination This study has ethical approval by the Massachusetts General Brigham Institutional Review Board (#2021P000871). …”
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Epidemiology and Control of diabetes - tuberculosis comorbidity in Eswatini: protocol for the prospective study of tuberculosis patients on predictive factors, treatment outcomes a... by Diederick E Grobbee, Kerstin Klipstein-Grobusch, Kennedy Otwombe, Victor Williams, Alinda Vos

“…Key informant interviews from healthcare workers will be analysed using content analysis.Ethics and dissemination This research has been approved by the Eswatini Health and Human Research Review Board and participant confidentiality will be maintained. …”
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Mixed-methods study to examine the response of opioid addiction treatment programmes to COVID-19: a study protocol by Sugy Choi, Rhea Naik, Kamila Kiszko, Charles Neighbors, Thomas D’Aunno

“…We will then employ qualitative methods and interview 200 key informants (ie, programme director, clinical supervisor, counsellor and medical director) to develop an understanding of the quantitative findings by examining organisational characteristics of programmes (n=25) representative of those that rank in the top quartile of clinical practice measures as well as programmes that performed worst on these measures (n=25).Ethics and dissemination The study has been approved by the Institutional Review Board of NYU Langone Health (#i21-00573). …”
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Public perceptions on the application of artificial intelligence in healthcare: a qualitative meta-synthesis by Jing Gao, Xinyu Chen, Xiaolian Jiang, Chenxi Wu, Huiqiong Xu, Dingxi Bai

“…However, several policy and regulatory issues such as credibility, sharing of responsibility and ethics have raised concerns in the use of AI. It is therefore necessary to understand the general public’s views on medical AI. …”
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Successful open defecation-free intervention in low- and middle-income countries: a qualitative synthesis systematic review protocol by Vera Yulyani, Iswanto Iswanto, Daniel Daniel, Fitrina Mahardani Kusumaningrum, Fatwa Sari Tetra Dewi

“…Since the data used will not contain individual patient information, ethical approval is unnecessary.PROSPERO registration number CRD42023408851.…”
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Understanding personality pathology in a clinical sample of youth: study protocol for the longitudinal research project ‘APOLO’ by Nagila Koster, Igor Lusin, Paul T van der Heijden, Odilia M Laceulle, Marcel A G van Aken

“…This study has been approved by the ethical review committee of the Utrecht University Faculty for Social and Behavioural Sciences (FETC17-092). …”
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Defining New Research Questions and Protocols in the Field of Traumatic Brain Injury through Public Engagement: Preliminary Results and Review of the Literature by Shumaila Hasan, Aswin Chari, Mario Ganau, Chris Uff

“…To gauge acceptance of this, and as per the guidelines set out by the National Research Ethics Service, we conducted a survey of TBI and non-TBI patients admitted to our Trauma ward and their families. 100 responses were collected between December 2017 and July 2018, incorporating two redesigns in response to patient feedback. 75.0% of respondents said that they would consent to a brain biopsy performed at the time of insertion of an intracranial pressure (ICP) bolt. 7.0% replied negatively and 18.0% did not know. 70.0% would consent to insertion of a jugular bulb catheter to obtain paired intracranial venous samples and peripheral samples for analysis of biomarkers. …”
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Evaluating and mapping the evidence that screening for diabetic foot disease meets the criteria for population-wide screening: a scoping review by Patricia M Kearney, Claire M Buckley, Sean F Dinneen, Caroline McIntosh, Paul Kavanagh, Lauren Connell, Jennifer A Pallin

“…Articles, published in English since 2000, reporting on the impact of the diabetes-related foot ulcers, effectiveness of treatment available for those identified as being at risk, reliability of screening tests for screening for the at-risk foot and the effectiveness, cost-effectiveness, safety and ethics of diabetes-related foot screening programmes were included.Data extraction and synthesis Data were extracted by one reviewer, with data extraction headings relating to the principles of screening. …”
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Rockwood Clinical Frailty Scale as a predictor of adverse outcomes among older adults undergoing aortic valve replacement: a protocol for a systematic review by Rose Galvin, Ahmed Gabr, Catherine Peters, Margaret O'Connor, Aoife Leahy, Elaine Shanahan, Tadhg Prendiville, Laura Quinlan, Anastasia Saleh, Ivan Casserly

“…The quality of the evidence will be determined using the Grading of Recommendations, Assessment, Development and Evaluation tool.Ethics and dissemination Ethical approval is not required for this study as no primary data will be collected. …”
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Exploring the epidemiology of disseminated intravascular coagulation: protocol for the DANish Disseminated Intravascular Coagulation (DANDIC) Cohort Study by Henrik Toft Sørensen, Kasper Adelborg, Jecko Thachil, Anne-Mette Hvas, Simon Flæng, Søren Nygaard, Asger Granfeldt

“…Register-based studies require no ethical approval in Denmark. The results will be disseminated in international peer-reviewed journals.…”
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