New bitongling regulates gut microbiota to predict angiogenesis in rheumatoid arthritis via the gut-joint axis: a deep neural network approach by Yin Guan, Xiaoqian Zhao, Yun Lu, Yue Zhang, Yan Lu, Yue Wang

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Cross-sectional design and protocol for Artificial Intelligence Ready and Equitable Atlas for Diabetes Insights (AI-READI) by Gerald McGwin, Linda M Zangwill, Nicholas Evans, Shannon McWeeney, Cecilia S Lee, Bhavesh Patel, Jeffrey C Edberg, Cynthia Owsley, Aaron Lee, Cecilia Lee, Sally L Baxter, Michael Snyder, Samantha Hurst, Nicole Ehrhardt, Christopher Chute, Dawn S Matthies, Julia P Owen, Amir Bahmani, Sally Baxter, Edward Boyko, Aaron Cohen, Jorge Contreras, Garrison Cottrell, Virginia de Sa, Jeffrey Edberg, Irl Hirsch, Michelle Hribar, T.Y. Alvin Liu, Bonnie Maldenado, Sara Singer, Bradley Voytek, Joseph Yracheta, Linda Zangwill

“…There are three study sites: Birmingham, Alabama; San Diego, California; and Seattle, Washington.Ethics and dissemination AI-READI aims to establish standards, best practices and guidelines for collection, preparation and sharing of the data for the purposes of AI/ML, including guidance from bioethicists. …”
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Factors Associated with Healthcare-Seeking Behavior among Health Profession Students in Selected Universities in Southwestern Uganda. by Wamaani, Hannington Gamukama, Olum, Ronald, Ajuna, Noble, Atwijukire, Humphrey, Kabami, Jane, Asiimwe, John Baptist

“…The link to the questionnaire was sent to prospective participants via WhatsApp platform or email between September and November 2021. Ethical clearance was obtained from the Mbarara University Research Ethics Committee. …”
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The role of the Hygiene Department of Stephen Bathory University in the development and promotion of Public Health in Vilnius in the years 1922–1939 by Aistis Žalnora

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Top 10 palliative care research priorities in France: a 3-step, mixed-methods protocol (AXEPRO study) by Stéphane Sanchez, Guillaume Economos, Fiona Ecarnot, Cecile Barbaret, Raphaëlle Habert-Dantigny, Héloïse Rouze, Doan Huynh, Roseline Huynh, Caroline Tête, Martin Julier-Costes, Valérie Amouroux-Gorsse, Isabelle Lavault, Justine Bret

“…A multidisciplinary steering committee including board-certified PC physicians, methodologists, nurses, a sociologist, an anthropologist and an information specialist will analyse the data collected in order to delete duplicate questions, do a thematic and population classification of the responses, modify questions using the PICO (patient problem, intervention, comparison and outcome) format and perform a literature review on each question to identify any relevant systematic review.Ethics and dissemination We expect the results to have wide-ranging benefits, for example, by prompting investment in the 10 prioritised research questions. …”
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Effects of a nutrition education intervention on nutrition knowledge and attitude among overweight and obese primary schoolchildren: a cluster randomized controlled trial by Rusidah Selamat, Nur Azlina Abdul Aziz, Junidah Raib, Norlida Zulkafly, WNurul Ashikin W. Mohamad, Ainan Nasrina Ismail, Muhammad Yazid Jalaludin, Fuziah Md. Zain, Zahari Ishak, Abqariyah Yahya, Abdul Halim Mokhtar

“…The intervention program was approved by the Medical Research and Ethics Committee (MREC), Ministry of Health Malaysia and Educational Planning and Research Division (EPRD), Ministry of Education Malaysia. …”
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SAVASTIES ĮGIJIMO BŪDAI. FOUCAULT IR BACHTINAS APIE GYVENIMO ESTETIZACIJĄ by Leszek Koczanowicz

“…Keywords: aesthetic existence, the self, the other, ethics. …”
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Descemet Endothelial Thickness Comparison Trial 1 (DETECT 1): outcome masked, placebo-controlled trial comparing two types of corneal transplant surgeries and effect of rho kinase... by Thomas M Lietman, Jennifer Rose-Nussbaumer, Bennie H Jeng, Benjamin F Arnold, Winston Chamberlain, Charles C Lin, Jennifer Y Li, William Gensheimer, Jameson Clover, Nicole Varnado, Sarah Abdelrahman

“…Dissemination of findings through peer-reviewed publications and national/international meetings will facilitate knowledge translation and guide clinical practice in the field of corneal transplantation.Ethics and dissemination A data and safety monitoring committee (DSMC) has been empaneled by the NEI.All study protocols will be subject to review and approval by WCG IRB as the single IRB of record.This study will comply with the National Institute of Health (NIH) Data Sharing Policy and Policy on the Dissemination of NIH-Funded Clinical Trial Information and the Clinical Trials Registration and Results Information Submission rule. …”
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Family-focused intervention programme to foster adolescent mental health and well-being: protocol for a multicountry cluster randomised factorial trial (FLOURISH Phase 2) by Heather M Foran, Marija Raleva, Nina Heinrichs, Graham Moore, Yulia Shenderovich, Xiang Zhao, Judith Simon, Antonio Piolanti, Viorel Babii, Janina Mueller, Franziska Waller, Dennis Wienand, Swetha Sampathkumar, Ivo Kunovski

“…Statistical analyses will include regression models to assess the main and interaction effects of the intervention components and cost analyses.Ethics and dissemination The study received ethical approval from the University of Klagenfurt in Austria (approval number: 2023–013), the Medical Faculty at St. …”
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Multicultural values: meeting point of two forces in developing Islamic education by Dwi Mariyono

“…Researchers should acknowledge and address their own biases transparently. Ethical considerations: the study may have encountered ethical challenges related to participant consent, confidentiality and cultural sensitivity. …”
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Multilevel determinants of racial/ethnic disparities in severe maternal morbidity and mortality in the context of the COVID-19 pandemic in the USA: protocol for a concurrent triang... by Bankole Olatosi, Jiajia Zhang, Xiaoming Li, Chen Liang, Jihong Liu, Peiyin Hung, Shan Qiao, Berry A Campbell, Myriam E Torres, Neset Hikmet

“…We will use a convergent parallel design which includes a quantitative analysis of data from the 2018–2021 SC Pregnancy Risk Assessment and Monitoring System (unweighted n>2000) and in-depth interviews of 40 postpartum women and 10 maternal care providers to identify distinct mediating pathways.Ethics and dissemination The study was approved by institutional review boards at the University of SC (Pro00115169) and the SC Department of Health and Environmental Control (DHEC IRB.21-030). …”
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Does completion of radical hysterectomy improve oncological outcomes of women with clinical early-stage cervical cancer and intraoperative detection of nodal involvement?: protocol... by Hui Xu, Qing Liu, Yu Xu, Yi Du, Ai Zheng, Cui Hu, Ya Jia, Qianwen Zhang, Yue-Dong He, Shuang-Shuang Cui, Yong Tian, Lin Ran, Fengmei Ke

“…The grade of evidence will be evaluated by two independent members of our team using the Grading of Recommendations, Assessment, Development and Evaluations approach.Ethics and dissemination Ethical approval is not required because there will no primary data collected. …”
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The effect of blue-blocking intraocular lenses on circadian biological rhythm: protocol for a randomised controlled trial (CLOCK-IOL colour study) by Taiji Hasegawa, Kenji Obayashi, Kimie Miyata, Tetsuo Ueda, Norio Kurumatani, Keigo Saeki, Nahoko Ogata, Hiroki Tsujinaka, Mariko Yamashita, Tomo Nishi, Nobuhiro Tone, Naonori Masuda, Yutarou Mizusawa, Masahiro Okamoto, Shinji Maruoka, Masashi Kojima, Toyoaki Matsuura

“…Primary outcomes will be followed until 20 years after surgery, and secondary outcomes will be assessed at baseline and 1 year after surgery.Ethics and dissemination Ethical approval has been obtained from the Institutional Review Board of Nara Medical University (No. 13-032). …”
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Sustainability of healthcare system improvements, programmes and interventions in acute care settings: protocol for a mixed methods systematic review by Franz E Babl, Sandy Middleton, Julie Cowie, Catherine Wilson, Peter Wilson, Pauline Campbell, Emma Tavender, Lisa Kuhn, Nicola Straiton, Victoria Ramsden, Elizabeth McInnes

“…Facilitators and barriers will be mapped to the Consolidated Framework for Sustainability Constructs in Healthcare and a narrative approach will be used to present key findings.Ethics and dissemination No primary data will be collected so formal ethical approval is not required. …”
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Impact of mother’s own milk expression practices and processing treatments on infant health and growth outcomes: a systematic review protocol by Daniel Klotz, Carolyn Smith, Agnieszka Bzikowska-Jura, Marzia Giribaldi, Tanya Cassidy, Laura Cavallarin, Serena Gandino, Karolina Karcz, Chiara Peila, Bartłomiej Walczak, Aleksandra Wesolowska

“…For relevant outcomes, certainty of the evidence will be tested by using the Grading of Recommendations Assessment, Development and Evaluation approach.Ethics and dissemination Ethical approval is not required for this study since no original data will be collected. …”
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Personalised Lung Cancer Screening (PLuS) study to assess the importance of coexisting chronic conditions to clinical practice and policy: protocol for a multicentre observational... by Yi Guo, Dongyu Zhang, Rafael Meza, Jihyoun Jeon, Dejana Braithwaite, Gerard A Silvestri, Michael K Gould, Jiang Bian, Bruno Hochhegger, Shama D Karanth, Christopher G Slatore, Martin Tammemagi, Mattthew Schabath, Meghann Wheeler, Frederic J Kaye

“…To our knowledge, this is the first study to combine observational data and simulation models to estimate the long-term impact of LCS with LDCT.Ethics and dissemination The study was approved by the Kaiser Permanente Southern California Institutional Review Board and VA Portland Health Care System. …”
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Clinical efficacy of a virtual reality tool for the treatment of obesity: study protocol of a randomised controlled trial by Dimitra Anastasiadou, Jose Antonio Ramos-Quiroga, Mel Slater, Bernhard Spanlang, Desiderio Cano Porras, Marta Comas, Andreea Ciudin, Gemma Parramon Puig, Julia Vázquez-De Sebastián, Pilar Lusilla-Palacios

“…Finally, variables related to adherence and satisfaction with the VR tool will be evaluated for the experimental groups.Ethics and dissemination This study was approved by the Research Projects Committee of the Vall d’Hebron University Hospital. …”
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Large-scale evidence generation and evaluation across a network of databases for type 2 diabetes mellitus (LEGEND-T2DM): a protocol for a series of multinational, real-world compar... by Rohan Khera, Yuan Lu, Harlan M Krumholz, Martijn J Schuemie, Ruijun Chen, George Hripcsak, Marc A Suchard, Patrick B Ryan, Anna Ostropolets

“…The study will pursue data-driven, large-scale propensity adjustment for measured confounding, a large set of negative control outcome experiments to address unmeasured and systematic bias.Ethics and dissemination The study ensures data safety through a federated analytic approach and follows research best practices, including prespecification and full disclosure of results. …”
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Study protocol for a randomised controlled trial of a care partner assisted intervention to improve oral health of individuals with mild dementia by Bei Wu, Gary Yu, Brenda L Plassman, Patricia Poole, Shahrzad Siamdoust, Melanie Bunn, Bobbi Burwell, Yaolin Pei, Christine Downey, Danni Gomes, Angela Kamer, A Leak Bryant, Ruth A Anderson

“…The study enrollment started in November 2021, and the data collection will end in Spring 2024.Ethics and dissemination The study has been approved by the Institutional Review Board of the NYU Grossman School of Medicine and Duke University, and is registered at Clinicaltrials.gov. …”
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Risk factors for the delayed discharge from anesthesia intensive care unit: a single-center retrospective study by Yue Qian, Jing Hao, Wei Zhu, Yan Yang, Zhuan-yun Zhang, Lu-yang Zhou, Xiao-ping Gu, Zheng-liang Ma, Yu-e Sun

“…Trial registration The single-center retrospective study was approved by the Ethics Committee of Nanjing Drum Tower Hospital (No. 2021-563-01, Data: 22 November 2021) and registered on the Chinese Clinical Trial Registry (No. …”
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