Changes in soft and hard tissue of central incisor before and after distal migration of the maxillary dentition in adult patients with different periodontal phenotypes by CHEN Rui, HAN Shuang, AN Qi

“…Methods The study was approved by the hospital ethics committee, and the patients signed the informed consent form. …”
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Performance of HPV E4 and p16INK4a biomarkers in predicting regression of cervical intraepithelial neoplasia grade 2 (CIN2): protocol for a historical cohort study by David Jenkins, Mark H Stoler, Anne Hammer, Torben Steiniche, Lone Kjeld Petersen, Patti E Gravitt, Rikke Kamp Damgaard, Maurits NC de Koning, Wim GV Quint, John Doorbar, Johnny Kahlert

“…Regression will be used as the primary outcome.Ethics and dissemination The study has been approved by the Ethical Committee in Central Denmark Region (1-10-72-60-20) and registered at the Faculty of Health, Aarhus University. …”
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Systematic literature review on Calcium Pyrophosphate Deposition (CPPD) nomenclature: condition elements and clinical states— A Gout, Hyperuricaemia and Crystal-Associated Disease... by Georgios Filippou, Antonella Adinolfi, Emilio Filippucci, Nicola Dalbeth, Robert Terkeltaub, Tristan Pascart, Edoardo Cipolletta, Silvia Sirotti, Charlotte Jauffret, Sara Tedeschi, Daniele Cirillo, Luca Ingrao, Alessandro Lucia

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Understanding the use of the National Early Warning Score 2 in acute care settings: a realist review protocol by Nia Roberts, Geoff Wong, Michelle Treacy, Mandy Odell

“…This initial programme theory presents how the NEWS2 is supposed to work (or not), it will now be developed, tested and refined.Ethics and dissemination Ethical approval is not required for this study as it is secondary research. …”
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Evaluating novel approaches for estimating awake and sleep blood pressure: design of the Better BP Study – a randomised, crossover trial by Paul Muntner, Ligong Chen, Daichi Shimbo, Joseph E Schwartz, Maria Cepeda, Demetria Hubbard, Suzanne Oparil, Byron C Jaeger, Shakia T Hardy, Julia Medina

“…Psychosocial factors, anthropometrics, left ventricular mass index and albumin-to-creatinine ratio are also being assessed.Ethics and dissemination This study was approved by the University of Alabama at Birmingham and the Columbia University Medical Center Institutional Review Boards. …”
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Impact of a pharmaceutical care service for patients with rheumatoid arthritis using a customised mobile device (the PROUD trial): study protocol for a randomised controlled trial by Jung-Yoon Choe, Hwajeong Lee, Yun-Kyoung Song, Seong-Kyu Kim, Ji-Won Kim, Ji-Eun Park, Ju-Eun Lee, Bo-Kyung Moon, Sung-Hoon Park

“…Analysis will be carried out with intent-to-treat and per-protocol principles.Ethics and dissemination The study protocol was reviewed and approved by the Institutional Review Board (IRB) of Daegu Catholic University Medical Center (IRB no. …”
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Randomised controlled trial comparing intraoperative cell salvage and autotransfusion with standard care in the treatment of hip fractures: a protocol for the WHITE 9 study by Mike Murphy, Nicholas Parsons, James Mason, Juul Achten, Duncan Appelbe, Edward Dickenson, Damian Griffin, Katy Mironov, Matthew Wyse, Amrita Athwal, Xavier Luke Griffin, Heather O'Connor

“…Secondary outcomes will include complications, postoperative delirium, residential status, mobility, allogenic blood use, mortality and resource use.Ethics and dissemination NHS ethical approval was provided on 14 August 2019 (19/WA/0197) and the trial registered (ISRCTN15945622). …”
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Relationship between Tai Chi and clinical outcomes in elderly patients with COVID-19: a protocol for systematic review and dose–response meta-analysis by Yang Wang, Na Li, Xiao Peng, Chun Wang, Sheng He, Jinfeng Yang, Yuanpeng Liao

“…The quality of evidence will be assessed by the Grading of Recommendations Assessment, Development and Evaluation, and the risk of bias will be evaluated by using the Physiotherapy Evidence Database Scale.Ethics and dissemination This study will review published data; thus, obtaining ethical approval and consent is unnecessary. …”
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Utility of 5-ALA for resection of CNS tumours other than high-grade gliomas: a protocol for a systematic review by Michael D Jenkinson, Ashwin Venkatesh, Colin Watts, Michael T C Poon, Victoria Wykes, Stephen John Price, Puneet Plaha, Georgios Solomou, Melissa Gough, Conor S Gillespie, Aref-Ali Gharooni, Waqqas Patel

“…The quality of non-randomised studies will be appraised.Ethics and dissemination The study will summarise the available evidence on the effect of the clinical utility of 5-ALA in achieving resection and improving survival and its diagnostic accuracy for tumours of the CNS other than HGG. …”
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Pre-IVF treatment with a GnRH antagonist in women with endometriosis (PREGNANT): study protocol for a prospective, double-blind, placebo-controlled trial by Hugh Taylor, Hao Huang, Lubna Pal, Heping Zhang, Howard J Li, Sandra Carson, Valerie Flores, Jared Robbins, Nanette F Santoro, James H Segars, David Seifer, Steven Young

“…Secondary outcomes include oocyte number, fertilisation rate, embryo morphology and implantation rates, as well as rates of known endometriosis-related obstetrical outcomes (pregnancy-induced hypertension, antepartum haemorrhage, caesarean delivery and preterm birth).Ethics and dissemination The PREGnant trial was approved by the Institutional Review Board at Johns Hopkins University. …”
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Human Papillomavirus, Human Immunodeficiency Virus, and Oral Microbiota Interplay in Nigerian Youth (HOMINY): A Prospective Cohort Study Protocol by Jia Liu, Esosa Osagie, Paul Akhigbe, Nosakhare Idemudia, Ozoemene Obuekwe, Ruxton Adebiyi, Nicolas Schlecht, Yana Bromberg, Fidelis E Eki-Udoko, Nosayaba Osazuwa-Peters, Modupe Oluseun Coker

“…Multiple comparisons will be adjusted using the False Discovery Rate (FDR) correction to control for Type I error.Ethics and dissemination The study was approved by Rutgers State University (Pro2022000949) and the UBTH (ADM/E22/A/VOL. …”
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Investigating male factors and their relationships with reproductive health outcomes: a case-control study protocol for Towards Optimal Fertility, Fathering, and Fatherhood studY (... by Fabian Yap, See Ling Loy, Yin Bun Cheung, Jerry Kok Yen Chan, Keith Godfrey, Chee Wai Ku, Jun Wei Pek, Melissa D/O Tharmalingam Durgahshree, Melinda Chan, Yie Hou Lee

“…Multivariable linear regression will be used to explore relationships between male modifiable exposures and semen parameters.Ethics and dissemination The study protocol has received approval from the Centralised Institutional Review Board of SingHealth (2024/2120), Singapore. …”
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Application of the flipped classroom model based on Bloom’s Taxonomy of Educational Objectives in endodontics education for undergraduate dental students by Yaru Wei, Zhengjun Peng

“…Students’ understanding of ideological and humanistic objectives as well as medical ethics were both significantly improved by 11.4% (t = 2.267, p = 0.009) and 13.9% (t = 2.600, p = 0.014), respectively. …”
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Improving quality and safety in nursing homes and home care: the study protocol of a mixed-methods research design to implement a leadership intervention by Eline Ree, Terese Johannessen, Siri Wiig, Torunn Strømme, Ingunn Aase, Roland Bal, Karina Aase, Marianne Storm, Berit Ullebust, Elisabeth Holen-Rabbersvik, Line Hurup Thomsen, Anne Torhild Sandvik Pedersen, Hester van de Bovenkamp

“…A comparative study of Norway and the Netherlands will establish knowledge of the context dependency of the intervention.Ethics and dissemination The study is approved by the Norwegian Centre for Research Data (2017/52324 and 54855). …”
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ASSOCIATION BETWEEN POLYMORPHISMS IN GENES ENCODING 2′-5′-OLIGOADENYLATE SYNTHETASES AND THE HUMORAL IMMUNE RESPONSE UPON VACCINATION AGAINST TICK-BORNE ENCEPHALITIS by N. S. Yudin, A. V. Igoshin, S. L. Lutova, Ya. Gon, M. I. Voevoda, V. A. Belyavskaya

“…However, excessive vaccination is unjustified in terms of economics and medical ethics. One of the individualized approaches to vaccines is the selection of vaccine doses depending on the expected levels of immune response. …”
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Factors associated with cancer treatment delay: a protocol for a systematic review and meta-analysis by Timothy P Hanna, Elizabeth T Jacobs, Kristin E Morrill, Rogelio Robles-Morales, Melissa Lopez-Pentecost, Raigam J Martínez Portilla, Ahlam A Saleh, Meghan B Skiba, Taylor S Riall, Jessica D Austin, Rachel Hirschey, Lena Spotleson

“…Risk of bias will be assessed independently by two authors using validated tools according to the article’s study design.Ethics and dissemination Formal ethical approval is not required because the work is being carried out on publicly accessible studies. …”
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Patients’ Perspectives on the Preference for the Gender of Medical Professionals in Perioperative Care and Attitudes Toward Anaesthesiologists: A Cross-sectional Study by Usha Devi, Minnu Panditrao, Shilpa Bansal

“…After obtaining approval from the Institutional Ethics Committee (IEC) and patient consent, the study was conducted on 400 patients aged 18 to 85 years who were admitted for elective surgeries in different specialties. …”
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Non-pharmacological interventions for the reduction and maintenance of blood pressure in people with prehypertension: a systematic review protocol by Paul Rutter, Andrew Clegg, Valerio Benedetto, Caroline Watkins, Nefyn Williams, Joseph Spencer, Lucy Hives, Emma P Bray, Cath Harris, Rachel F Georgiou, Nafisa Iqbal

“…Where relevant, the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) will be used to assess the certainty of the evidence found.Ethics and dissemination Ethical approval is not needed. …”
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Strategies to mitigate the impact of the COVID-19 pandemic on child and youth well-being: a scoping review protocol by Jeanna Parsons Leigh, Henry T Stelfox, Perri R Tutelman, Diane L Lorenzetti, Melanie C Anglin, Kirsten M Fiest, Stephana Julia Moss, Emily A FitzGerald, Stacie Smith, Micaela Harley, Kathryn Birnie, Sara J Mizen

“…Data synthesis will be performed according to the convergent integrated approach described by the Joanna Briggs Institute.Ethics and dissemination Ethical approval is not applicable as this review will be conducted on published data. …”
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Efficacy of non-invasive ventilation and oxygen therapy on immunocompromised patients with acute hypoxaemic respiratory failure: protocol for a systematic review and meta-analysis... by Juhong Shi, Gang Liu, Meng Wang, Tao Wang, Yi Li, Yi Yang, Xuezhong Yu, Huadong Zhu, Yong Ma, Zongru Li, Lixi Zhang, Kun He, Jianqiang He

“…Publication bias will be identified with the funnel plot.Ethics and dissemination Ethical approval is not required since it is not carried out in humans. …”
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