Vaccination of mice with Trichinella spiralis C-type lectin elicited the protective immunity and enhanced gut epithelial barrier function. by Bo Ning Wang, Xin Zhuo Zhang, Jin Yi Wu, Zhao Yu Zhang, Pei Kun Cong, Wen Wen Zheng, Shao Rong Long, Ruo Dan Liu, Jing Cui, Zhong Quan Wang

“…Our previous studies showed that recombinant Trichinella spiralis C-type lectin (rTsCTL) mediated larval invasion of enteral mucosal epithelium. The aim of this study was to investigate protective immunity produced by vaccination with rTsCTL and its effect on gut epithelial barrier function in a mouse model.…”
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Long-Term Outcomes of Rheohaemapheresis in the Treatment of Dry Form of Age-Related Macular Degeneration by Jan Studnička, Eva Rencová, Milan Bláha, Pavel Rozsíval, Miriam Lánská, Vladimír Bláha, Jan Němčanský, Hana Langrová

“…We measured the drusenoid pigment epithelium detachment (DPED), best-corrected visual acuity (BCVA), electroretinography (ERG), and rheological parameters. …”
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Radiation decreases bronchial epithelial progenitor function as assessed by organoid formation by Merian E. Kuipers, Dennis K. Ninaber, Krista C.J. van Doorn-Wink, Annelies M. Slats, Pieter S. Hiemstra

“…Abstract Objective Radiation-induced lung injury (RILI) is a serious side-effect of radiotherapy for lung cancer, in which effects on the normal lung epithelium may play a key role. Since these effects are incompletely understood, the aim of the present study was to evaluate the effect of ionizing radiation (IR) on cultured well-differentiated primary bronchial epithelial cells (PBEC) with a focus on cytotoxicity, barrier formation, inflammation and epithelial progenitor function. …”
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Preservation of the Photoreceptor Inner/Outer Segment Junction in Dry Age-Related Macular Degeneration Treated by Rheohemapheresis by Eva Rencová, Milan Bláha, Jan Studnička, Vladimír Bláha, Miriam Lánská, Ondřej Renc, Alexander Stepanov, Věra Kratochvílová, Hana Langrová

“…In our study, we followed 24 patients with dry AMD and drusenoid retinal pigment epithelium detachment (DPED) for a period of more than 2.5 years. …”
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Predicting Outcomes in Esophageal Squamous Cell Carcinoma Using scRNA‐Seq and Bulk RNA‐Seq: A Model Development and Validation Study by Jiaqi Zhang, Shunzhe Song, Yuqing Li, Aixia Gong

“…Results A total of 13 kinds of cell clusters were screened, and the squamous epithelium was identified with the highest score. And 558 differential genes were selected from the single‐cell RNA sequencing (scRNA‐seq) dataset. …”
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Examining the impact of probiotic Lactiplantibacillus pentosus 6MMI on inhibiting biofilm formation, adhesion, and virulence gene expression in Listeria monocytogenes ATCC 19115 by Behrooz Alizadeh Behbahani, Mostafa Rahmati-Joneidabad, Morteza Taki

“…Probiotic bacteria improve human health by secreting pro-microbial substances, balancing intestinal flora, binding to the mucous membrane and epithelium, strengthening the intestinal epithelial barrier, and creating interactions between the gastrointestinal microbiota and the immune system. …”
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Key bacterial vaginosis-associated bacteria influence each other's growth in biofilms in rich media and media simulating vaginal tract secretions by Lúcia G.V. Sousa, Christina A. Muzny, Nuno Cerca

“…BV is characterized by a depletion of lactic acid-producing Lactobacillus species and an increase in strict and facultative anaerobic bacteria that develop a polymicrobial biofilm on the vaginal epithelium. Despite multiple decades of research, the etiology of this infection is still not clear. …”
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Airway β-Defensin-1 Protein Is Elevated in COPD and Severe Asthma by Katherine J. Baines, Thomas K. Wright, Jodie L. Simpson, Vanessa M. McDonald, Lisa G. Wood, Kristy S. Parsons, Peter A. Wark, Peter G. Gibson

“…Elevated β-defensin-1 protein is a feature of COPD and severe asthma regardless of inflammatory phenotype. β-defensin-1 production is dysregulated in the epithelium of patients with COPD and may be an effective biomarker and potential therapeutic target.…”
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Methanolic Extract of Distemonanthus benthamianus (Caesalpiniaceae) Stem Bark Suppresses Ethanol/Indomethacin-Induced Chronic Gastric Injury in Rats by Vanessa Mba Matah Marte, Gilbert Ateufack, Marius Mbiantcha, Albert Donatien Atsamo, Carine Flore Adjouzem, Stéphanie Flore Djuichou Nguemnang, Eric Gonzal Tsafack, William Yousseu Nana, Yacine Karelle Madjo Kouam, Elvira Ngoufack Azanze

“…Histological micrographs show that in the presence of the extract, there is advanced reepithelialization with recovery of the ulcerated epithelium. Thus, the extract of Distemonanthus benthamianus has healing properties against gastric ulcers which are associated with its anti-inflammatory, immunomodulatory, and antioxidant effects.…”
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Time-series single-cell transcriptomic profiling of luteal-phase endometrium uncovers dynamic characteristics and its dysregulation in recurrent implantation failures by Dandan Cao, Yijun Liu, Yanfei Cheng, Jue Wang, Bolun Zhang, Yanhui Zhai, Kongfu Zhu, Ye Liu, Ye Shang, Xiao Xiao, Yi Chang, Yin Lau Lee, William Shu Biu Yeung, Yuanhua Huang, Yuanqing Yao

“…In addition, a time-varying gene set regulating epithelium receptivity is identified, based on which the recurrent implantation failure endometria are stratified into two classes of deficiencies. …”
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Diagnosis and treatment of thyroblastoma: a case report and review of literature by Xiting Chen, Xiting Chen, Lijuan Xiong, Lijuan Xiong, Hongling Liu, Haoqiang Wang, Donghai Cheng, Wei Wang, Wenyuan He, Bo Xie, Juan Zhou

“…This classification was based on the observation that the tumor presents with independent primitive multilineage elements and is frequently associated with DICER1 hotspot mutations.The objective of this study was to explore and investigate the clinicopathologic characteristics, molecular features and treatment strategies of patients with thyroblastoma, followed by a review of the previous relevant literature.MethodsThe clinical manifestations, pathological characteristics, molecular features and treatment strategies of the initial case of thyroblastoma pathologically confirmed in China were analyzed.ResultsThe tumor was revealed to have high invasive potential, rapid disease progression, and primitive multilineage elements of pathology, including immature thyroid epithelium, spindled mesenchymal proliferations, and neuroepithelial blastema. …”
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In vitro evaluation of the immunomodulatory and antibacterial activities of calcitriol (1,25-dihydroxy-vitamin D3) as a potential application for aerobic vaginitis treatment - prel... by Anna Tomusiak-Plebanek, Grażyna Więcek, Edyta Golińska, Magdalena Strus

“…Abstract Background Aerobic vaginitis (AV) is a state of abnormal vaginal microbiota, which is associated with increased numbers of aerobic, enteric bacteria and inflammation of the vaginal epithelium. Anti-microbial treatment combined with anti-inflammatory therapy could be useful in the treatment of this condition. …”
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Adjuntive nicergoline therapy for severe persistent corneal epithelial defects. by Valeria Oliva-Biénzobas, Enrique O. Graue-Hernandez, Guillermo Raul Vera-Duarte, Jesus Cabral-Macías, Juan Serna-Ojeda, Victor Boullosa, Arturo Ramirez-Miranda, Vishal Jhanji, Victor L. Perez, Alejandro Navas

“…Further studies and clinical trials must be conducted to prove safety and efficacy as a treatment for persistent corneal epithelium defects in humans.…”
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Downregulation of S100 Calcium Binding Protein A9 in Esophageal Squamous Cell Carcinoma by Harsh Pawar, Srinivas M. Srikanth, Manoj Kumar Kashyap, Gajanan Sathe, Sandip Chavan, Mukul Singal, H. C. Manju, Kariyanakatte Veeraiah Veerendra Kumar, M. Vijayakumar, Ravi Sirdeshmukh, Akhilesh Pandey, T. S. Keshava Prasad, Harsha Gowda, Rekha V. Kumar

“…This suggests the important role that S100A9 plays in maintaining the differentiated state of epithelium and suggests that its downregulation may be associated with increased susceptibility to tumor formation.…”
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Prophylactic Ozone Administration Reduces Intestinal Mucosa Injury Induced by Intestinal Ischemia-Reperfusion in the Rat by Ozkan Onal, Fahri Yetisir, A. Ebru Salman Sarer, N. Dilara Zeybek, C. Oztug Onal, Banu Yurekli, H. Tugrul Celik, Ayse Sirma, Mehmet Kılıc

“…IR caused an increase in intestinal injury score. The intestinal epithelium maintained its integrity and decrease in intestinal injury score was detected in Ozone + IR group. …”
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Local and Systemic IKKε and NF-κB Signaling Associated with Sjögren’s Syndrome Immunopathogenesis by Weiqian Chen, Jin Lin, Heng Cao, Danyi Xu, Bei Xu, Liqin Xu, Lihuan Yue, Chuanyin Sun, Guolin Wu, Wenbin Qian

“…In minor salivary glands from pSS patients, phosphorylated IKKε (pIKKε), pIκBα, and pNF-κB p65 (p-p65) were highly expressed in ductal epithelium and infiltrating mononuclear cells by immunohistochemistry, compared to healthy individuals. pIKKα/β and pIKKγ were both negative. …”
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Long-Term Effect of Half-Fluence Photodynamic Therapy on Fundus Autofluorescence in Acute Central Serous Chorioretinopathy by Martin Stattin, Stefan Hagen, Daniel Ahmed, Eva Smretschnig, Florian Frommlet, Katharina Krepler, Siamak Ansari-Shahrezaei

“…To evaluate normalized short-wavelength fundus autofluorescence (SW-FAF) imaging changes over time as a predictive parameter for the retinal pigment epithelium (RPE) function in eyes compromised by acute central serous chorioretinopathy (CSCR) after indocyanine green angiography-guided verteporfin (Visudyne®, Novartis Pharma, Basel, Switzerland) photodynamic therapy (PDT) with a half-fluence rate (25 J/cm2). …”
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Tanshinone IIA Sodium Sulfonate Attenuates LPS-Induced Intestinal Injury in Mice by Xin-Jing Yang, Jin-Xian Qian, Yao Wei, Qiang Guo, Jun Jin, Xue Sun, Sheng-Lan Liu, Chun-Fang Xu, Guo-Xing Zhang

“…TSS treatment significantly attenuated small intestinal epithelium injury induced by LPS. LPS-induced release of inflammatory mediators, including TNF-α, IL-1β, and IL-6, were markedly inhibited by TSS. …”
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OCT Biomarkers in Neovascular Age-Related Macular Degeneration: A Narrative Review by Cristian Metrangolo, Simone Donati, Marco Mazzola, Liviana Fontanel, Walter Messina, Giulia D’alterio, Marisa Rubino, Paolo Radice, Elias Premi, Claudio Azzolini

“…The key importance of retinal fluid compartmentalization (intraretinal fluid, subretinal fluid, and subretinal pigment epithelium (RPE) fluid) will be discussed firstly. In the second part, the structural alterations of different retinal layers in various stages of the disease (photoreceptors layer integrity, hyperreflective dots, outer retinal tubulations, subretinal hyperreflective material, and retinal pigment epithelial tears) will be analyzed in detail. …”
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Biological, cytomorphological and karyological heterogeneity of transformed cell lines derived from domestic pig (Sus scrofa L.) organs by B. L. Manin, E. A. Trofimova, V. L. Gavrilova, O. S. Puzankova

“…All transformed cell lines of porcine origin have similar morphology with predominated epithelium-like forms. Some of them – SPEV, А4 С2 , RSK – tend to adopt a spherical shape in suspension. …”
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