Cyanidin-3-O-Glucoside Modulates the In Vitro Inflammatory Crosstalk between Intestinal Epithelial and Endothelial Cells by Daniela Ferrari, Francesco Cimino, Deborah Fratantonio, Maria Sofia Molonia, Romina Bashllari, Rossana Busà, Antonella Saija, Antonio Speciale

“…Intestinal epithelium represents a protective physical barrier and actively contributes to the mucosal immune system. …”
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Correlation of Macular Focal Electroretinogram with Ellipsoid Zone Extension in Stargardt Disease by Edoardo Abed, Giorgio Placidi, Luigi Calandriello, Marco Piccardi, Francesca Campagna, Matteo Bertelli, Angelo Maria Minnella, Maria Cristina Savastano, Benedetto Falsini

“…This disease is characterized by a progressive accumulation of lipofuscin in the outer retina and subsequent loss of photoreceptors and retinal pigment epithelium. The aim of this study was to evaluate the relationship between cone photoreceptor function and structure in STGD1. …”
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Differential infectivity by the oral route of Trypanosoma cruzi lineages derived from Y strain. by Cristian Cortez, Rafael M Martins, Renan M Alves, Richard C Silva, Luciana C Bilches, Silene Macedo, Vanessa D Atayde, Silvia Y Kawashita, Marcelo R S Briones, Nobuko Yoshida

“…Both molecules are involved in lysosome exocytosis-dependent host cell invasion, but exhibit differential gastric mucin-binding capacity, a property critical for parasite migration toward the gastric mucosal epithelium. Upon oral infection of mice, the number of Y30 and Y82 parasites in gastric epithelial cells differed widely.…”
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PSMA antibody, humanized PSMA.CAR10.3, or Cetuximab increases prostate cancer localization of NF-κB p50-deficient immature myeloid cells (p50-IMC) and phagocytosis by their macroph... by Mohammad A. Alzubi, Theresa Barberi, Alan D. Friedman

“…Nevertheless, this study indicates the potential clinical utility of adding a tumor-directing antibody or CAR, including the novel, fully humanized PSMA.CAR10.3, to proinflammatory p50-IMC to optimize the activation of anti-tumor immunity in prostate cancer and other malignancies, and understanding PSMA toxicity in normal but not malignant prostate epithelium may reveal a novel therapeutic opportunity.…”
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Faktor Risiko Non Viral Pada Karsinoma Nasofaring by Sukri Rahman, Bestari Jaka Budiman, Histawara Subroto

“…Purpose: To find non viral factors that may increase the incidence of nasopharyngel carcinoma in order to prevent and avoid non-viral factors Literature: Nasopharyngeal carcinoma is a malignant tumor that causes nasopharyngeal epithelium associated with viral and non-viral factors such as cigarette smoke, salt fish, formaldehyde, genetic, wood smoke ,wood dust, ear nose throat chronic infections, alcohol, and traditional medicine. …”
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Pleiotropic effects of mutant huntingtin on retinopathy in two mouse models of Huntington's disease by Hui Xu, Anakha Ajayan, Ralf Langen, Jeannie Chen

“…In addition, we present novel findings that mHTT disrupts cell polarity in the photoreceptor cell layer and the retinal pigment epithelium (RPE). Furthermore, we show that the RPE cells from R6/1 mice contain mHTT nuclear inclusions, adding to the list of non-neuronal cells with mHTT aggregates and pathology. …”
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Corneal Epithelial Thickness Mapping in Healthy Population Corneas Using MS-39 Anterior Segment Optical Coherence Tomography by AlTurki HS, Alsubhi SS, Alhazmi A, Alhadlag A, Albalawi NS, Alzoman MA, Aljasir M, Alsubaie M, Aljindan M, Alsomali A

“…Hissah Saleh AlTurki,1 Shahad Salah Alsubhi,1 Asma Alhazmi,1 Abdulrahman Alhadlag,2 Nada Saleh Albalawi,3 Musab Abdulaziz Alzoman,1 Mohammed Aljasir,1 Majed Alsubaie,1 Mohanna Aljindan,4 Abdulaziz Alsomali5 1Ophthalmology Department, Dhahran Eye Specialist Hospital, Dhahran, Saudi Arabia; 2Surgery Department, College of Medicine, Shaqra University, Riyadh, Saudi Arabia; 3Ophthalmology Department, King Salman Armed Forces Hospital, Tabuk, Saudi Arabia; 4Ophthalmology Department, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; 5Ophthalmology Department, College of Medicine, King Faisal University, Alahsa, Saudi ArabiaCorrespondence: Shahad Salah Alsubhi, Ophthalmology Department, Dhahran Eye Specialist Hospital, 32413, Hassan Alaslami, Ash Shati Ash Sharqi District, Dhahran, Saudi Arabia, Email Shahadsalah@hotmail.comPurpose: The corneal epithelium is the outermost layer of the cornea. It plays a vital role in both normal and pathological conditions of the eye surface and serves as a protective layer. …”
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The effect of replacing red algae on histomorphology and enzymes of digestive tract of Nile tilapia, Oreochromis niloticus by Sanaz Kord, Rahim Abdi, Isaac Zamani, Rhima Peyghan

“…Results: Histological examination in the mid-esophagus, anterior, middle, and posterior parts of the intestine showed that the highest number of mucous cells, the highest thickness of the epithelium and muscle layer, as well as the highest height and thickness of the esophageal villi were observed in the group receiving the diet containing 9% red algae. …”
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Shear Stress Promotes Arterial Endothelium-Oriented Differentiation of Mouse-Induced Pluripotent Stem Cells by Yan Huang, Xiaofang Chen, Jifei Che, Qi Zhan, Jing Ji, Yubo Fan

“…In addition, Notch1 was significantly upregulated, and the Notch ligand Delta-like 4 was activated in response to shear stress, while inhibition of Notch signaling by DAPT remarkably abolished the shear stress-induced arterial epithelium differentiation. Taken together, our results indicate that exposure to appropriate shear stress facilitated the differentiation of mouse iPSCs towards arterial ECs via Notch signaling pathways, which have potential applications for both disease modeling and regenerative medicine.…”
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The effects of coenzyme q10 on testes of rats with diabetes induced by streptozotocin by Tuğba Özaydın, Yasemin Öznurlu, Emrah Sur

“…Mean seminiferous tubular diameter (STD), height of germinal epithelium (GEH) and PCNA index were significantly reduced in diabetes groups in comparison with control, oil, CoQ₁₀ and diabetes+CoQ₁₀ groups (p<0.05). …”
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Gap Junctions Are Involved in the Rescue of CFTR-Dependent Chloride Efflux by Amniotic Mesenchymal Stem Cells in Coculture with Cystic Fibrosis CFBE41o- Cells by Annalucia Carbone, Roberto Zefferino, Elisa Beccia, Valeria Casavola, Stefano Castellani, Sante Di Gioia, Valentina Giannone, Manuela Seia, Antonella Angiolillo, Carla Colombo, Maria Favia, Massimo Conese

“…Cx43 downregulation determined also a decrease in transepithelial resistance and an increase in paracellular permeability as compared with control cocultures, implying that GJIC may regulate CFTR expression and function that in turn modulate airway epithelium tightness. These results indicate that GJIC is involved in the correction of CFTR chloride channel activity upon the acquisition of an epithelial phenotype by hAMSCs in coculture with CF cells.…”
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The Therapeutic Effects and Possible Mechanism of Pranoprofen in Mouse Model of Corneal Alkali Burns by Minting Chen, Abdirahman Abdinasir Gureeye, Yacouba Cissé, Lang Bai

“…Sodium fluorescein staining showed obvious corneal structure disorders, poor corneal epithelium continuity, and a larger corneal epithelial defect area in the saline group (10.33±+−0.57) as opposed to the pranoprofen group (8.33 ± 0.57） (p<0.05). …”
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Molecular evidence for the efficacy of PBM therapy in the treatment of oral lichen planus by Maria Zaharieva Mutafchieva, Milena Nenkova Draganova, Plamen Ivanov Zagorchev, Reem Hanna, Georgi Tomchev Tomov

“…An enhance in Ki-67 immunoreactivity was revealed predominantly in the atrophic-erosive epithelium. Conclusion: PBM is an effective treatment modality for OLP patients. …”
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The assessment of chemical composition and biological activity of faba bean pods as a potential feed additive utilized in piglets nutrition by Inna Vlasova, Philip Krüsselmann, Yuliia Kostenko, Maciej Obrębski, Sebastian Granica, Wilfried Vahjen, Jürgen Zentek, Marcin Równicki, Jakub P. Piwowarski

“…The extract had low cytotoxicity (IC50 = 432.6 µg/mL) against IPEC-J2 – cells derived from porcine jejunal epithelium. The results indicate that FBP ‘Bizon’ is a valuable source of bioactive compounds with antibacterial properties, without adverse effects on porcine enzymes or IPEC-J2 cells, supporting its potential as a sustainable feed in piglet nutrition, in line with circular economy concepts.…”
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Comparative evaluation of localized genotoxicity between the field of focus and scatter following exposure to cone beam computed tomography using buccal mucosal micronuclei assay:... by Rajeswari Sreeenivas, Algi Nadil, Priya Thomas, Giju George Baby, Deepu George Mathew, Pooja Latti, Jiss George

“…Materials and methods: To establish the genotoxic and cytotoxic impacts of CBCT radiation on the mucosa and its effects on the basal cell layer of the epithelium, the research enlisted 35 subjects aged 18 to 60 years. …”
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Ocular Findings in Infants with Microcephaly Caused by Presumed Congenital Infection by Zika Virus in Sergipe by Marco Valadares, Anne Carolyne Lelis Oliveira Pedroso, Alessandro Santana, Angela Maria da Silva, Isabela Soares Costa, Maria Luiza Doria Almeida, Roque Pacheco de Almeida

“…Findings in the posterior segment occurred in 29 (46.8%) patients, including atrophy of the retinal pigmentary epithelium in 15 (24.2%) patients, chorioretinal scars in 14 (22.6%) patients, retinal coloboma in 6 (9.7%) patients, and punctate retinal hemorrhage in 1 (1.6%) patient. …”
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Virgin coconut oil lessens trichloroacetic acid assault on the stomach and intestine of rats via enhancement of Nrf2 but inhibition of TNF-α, IL1β/NF-kB signalling pathway by OO Oladokun, KO Ajeigbe, MA Adelakun

“…Focal disruption of the gastric pit, derangement of surface epithelium, and sloughing of the surface epithelial barrier of the intestinal villi occasioned by TCA were all assuaged by VCO. …”
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Immunopathological Changes of Streptococcus pneumoniae Causing Respiratory Infection in Lambs by Abbas A Hamzah, Zainab I Ibrahim

“…Histopathologically, severe erosion and necrosis in the trachea and bronchus epithelium, along with inflammation in adjacent mucosa and submucosa, accompanied by focal inflammatory infiltration and emphysema in the lung by day 6 post-exposure, were observed. …”
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Semen extender triggers a mild physiological inflammatory response in the uterus without disrupting sperm-uterine immune crosstalk in vitro in cattle by Malinda HULUGALLA, Alireza MANSOURI, Elham WAEHAMA, Ihshan AKTHAR, Akio MIYAMOTO

“…Immunofluorescence analyses confirmed the upregulation of the strong inflammatory marker TNF alongside TLR2 and the downregulation of NOD1 in the uterine epithelium, similar to the effects observed with sperm. …”
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The role of olfactory transport in the penetration of manganese oxide nanoparticles from blood into the brain by A. V. Romashchenko, M. B. Sharapova, К. N. Morozova, E. V. Kiseleva, K. E. Kuper, D. V. Petrovskii

“…A comparative analysis of the results showed that the transport of Mn3O4-NPs from the nasal cavity to the brain is more efficient than their local permeation through BBB into CNS from the bloodstream, for example with the accumulation of Mn3O4NPs in the dentate gyrus of the hippocampus, and through the capture and transport of NPs from the blood by olfactory epithelium cells. Also, experiments with the administration of chlorpromazine, a specific inhibitor of clathrin-dependent endocytosis, and methyl-β-cyclodextrin, inhibitor of the lipid rafts involved in the capture of substances by endothelium cells, showed differences in the mechanisms of NP uptake from the nasal cavity and from the bloodstream. …”
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