Development and validation of a model to predict cognitive impairment in traumatic brain injury patients: a prospective observational studyResearch in context by Xiaofang Yuan, Qingrong Xu, Fengxia Du, Xiaoxia Gao, Jing Guo, Jianan Zhang, Yehuan Wu, Zhongkai Zhou, Youjia Yu, Yi Zhang

“…Among the 48 potential predictors, the following 6 variables were significant independent predictive factors and were included in the net risk score: age (odds ratio (OR) = 1.06, 95% confidence interval (CI): 1.03–1.08, P = 0.00), years of education (OR = 0.80, 95% CI: 0.70–0.93, P = 0.00), pulmonary infection status (OR = 4.64, 95% CI: 1.41–15.27, P = 0.01), epilepsy status (OR = 4.79, 95% CI: 1.09–21.13, P = 0.04), cerebrospinal fluid leakage status (OR = 5.57, 95% CI: 1.08–28.75, P = 0.04), and the Helsinki score (OR = 1.53, 95% CI: 1.28–1.83, P = 0.00). …”
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Ketogenic diet and β-hydroxybutyrate in osteoporosis: current progress and controversy by Changfang Luo, Changfang Luo, Changfang Luo, Changfang Luo, Zhuojun Dai, Zhuojun Dai, Zhuojun Dai, Zhuojun Dai, Wanhong He, Wanhong He, Wanhong He, Wanhong He, Yanqiu He, Yanqiu He, Yanqiu He, Yanqiu He, Ping Yang, Ping Yang, Ping Yang, Ping Yang, Mengting Huang, Mengting Huang, Mengting Huang, Mengting Huang, Junle Li, Junle Li, Junle Li, Junle Li, Yong Xu, Yong Xu, Yong Xu, Yong Xu, Wei Huang, Wei Huang, Wei Huang, Wei Huang

“…The ketogenic diet has been broadly used in the treatment of epilepsy, diabetes, obesity, and certain neoplasms by triggering ketone bodies, mainly BHB. …”
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A phase II double-blind multicentre, placebo-controlled trial to assess the efficacy and safety of alpelisib (BYL719) in paediatric and adult patients with Megalencephaly-CApillary... by Jean-Marc Treluyer, Benedicte Demeer, Laurence Faivre, Marc Bardou, Nathalie Boddaert, Paul Kuentz, Florence Petit, Christine Francannet, Pierre Vabres, Nadia Bahi-Buisson, Estelle Colin, Laurent Guibaud, Romaric Loffroy, Maxime Luu, Caroline Racine, Aurore Garde, Philippe Khau Van Kien, Aurore Curie, Nawale Hadouiri, Aurélie Espitalier, Agnès Maurer, Maud Carpentier, Adélaide Rega, Mouna Chebbi, Julie Charligny, Guillaume Canaud, Camille Fleck, Amelie Cransac, Elise Boucher-Brischoux, Adélaïde Brosseau-Beauvir, Florian Cherik, Alice Phan, Michaela Semeraro, Marion Nys, Charles Joris Roux, Alinoë Lavillaureix, Isabelle Maruani

“…Secondary objectives are safety, VABS improvement at 6 months, impact on the quality of life, epilepsy and hypotonia. 20 patients aged 2 to 40 years with an MCAP diagnosis and neurodevelopmental disorders of various degrees, will be followed monthly in local centres, centrally assessed (clinical, biological, neuropsychological and functional evaluation) at baseline and every 6 months. …”
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Application of compound lidocaine cream for preemptive analgesia in placement of stereotactic head frames for Gamma Knife treatment (复方利多卡因乳膏超前镇痛在伽玛刀治疗固定立体定位头架中的应用)... by WU XunXin (吴逊欣), LI Dongna (李冬娜), ZENG Dongyu (曾冬玉)

“…Conclusion Applying 5% compound lidocaine cream to the nail position before stereotactic head frame fixation for Gamma Knife treatment can produce good preemptive analgesic effect, reduce the risk of syncope and epilepsy caused by pain during head frame installation, and increase the comfort in the treatment process. …”
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Pulmonary vascular malformations in genetic epileptic encephalopathy: A rare, fatal case report by N. Garancini, M. Ghezzi, A. Farolfi, V. Guaia, G. Canali, V. Fabiano, G.V. Zuccotti, E. D'Auria

“…Mutations of KCNT1 gene, encoding for a sodium-gated potassium channel, are causative of a wide spectrum of epilepsies and neurodevelopmental disorders; cardiovascular involvement also seems to be significant, with cardiac arrhythmia and, less frequently, the development of Systemic to Pulmonary Collateral Arteries (SPCAs) has been reported. …”
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Pnömoni Tanılı Çocuk Hastanın Gordon’un Fonksiyonel Sağlık Örüntülerine Göre Hemşirelik Bakımı: Olgu Sunumu by Raziye Çelen, Hüseyin Emre Tosun

“…Olgu Sunumu: Sekiz yaşında olan hidrosefali ve epilepsi tanılı bir erkek çocuk hastada dört gün süren öksürük, hafif ateş ve nefes darlığı şikayetleri vardı. …”
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A Novel MEGNet for Classification of High-Frequency Oscillations in Magnetoencephalography of Epileptic Patients by Jun Liu, Siqi Sun, Yang Liu, Jiayang Guo, Hailong Li, Yuan Gao, Jintao Sun, Jing Xiang

“…Epilepsy is a neurological disease, and the location of a lesion before neurosurgery or invasive intracranial electroencephalography (iEEG) surgery using intracranial electrodes is often very challenging. …”
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SEEG-Based Bilateral Seizure Network Analysis for Neurostimulation Treatment by Genchang Peng, Mehrdad Nourani, Jay Harvey

“…Epilepsy patients with drug-resistant seizures emanating from two or more distinct regions of left and right hemispheres are the primary candidates for neurostimulation treatment. …”
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Neuronal cell type specific roles for Nprl2 in neurodevelopmental disorder-relevant behaviors by Brianne Dentel, Lidiette Angeles-Perez, Abigail Y. Flores, Katherine Lei, Chongyu Ren, Andrea Pineda Sanchez, Peter T. Tsai

“…Loss of function in the subunits of the GTPase-activating protein (GAP) activity toward Rags-1 (GATOR1) complex, an amino-acid sensitive negative regulator of the mechanistic target of rapamycin complex 1 (mTORC1), is implicated in both genetic familial epilepsies and Neurodevelopmental Disorders (NDDs) (Baldassari et al., 2018). …”
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