Structure–Activity Relationship Studies in a Series of 2-Aryloxy-<i>N</i>-(pyrimidin-5-yl)acetamide Inhibitors of SLACK Potassium Channels by Nigam M. Mishra, Brittany D. Spitznagel, Yu Du, Yasmeen K. Mohamed, Ying Qin, C. David Weaver, Kyle A. Emmitte

“…Epilepsy of infancy with migrating focal seizures (EIMFS) is a rare, serious, and pharmacoresistant epileptic disorder often linked to gain-of-function mutations in the <i>KCNT1</i> gene. …”
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Pulmonary vascular malformations in genetic epileptic encephalopathy: A rare, fatal case report by N. Garancini, M. Ghezzi, A. Farolfi, V. Guaia, G. Canali, V. Fabiano, G.V. Zuccotti, E. D'Auria

“…Mutations of KCNT1 gene, encoding for a sodium-gated potassium channel, are causative of a wide spectrum of epilepsies and neurodevelopmental disorders; cardiovascular involvement also seems to be significant, with cardiac arrhythmia and, less frequently, the development of Systemic to Pulmonary Collateral Arteries (SPCAs) has been reported. …”
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Sobressalto patológico: aspectos clínicos e eletrencefalográficos Startle seizures: clinical and electroencephalographic studies by Frederico Dahne Kliemann, Nelson Pires Ferreira

“…The situation of the disease among reflex epilepsies is revised.…”
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Dev intrakranial lipom olgu sunumu ve literatürün gözden geçirilmesi by Can Yaldız, Davut Ceylan, Özlem Kıtıki Kaçıra, Tibet Kaçıra

“…En sık semptom baş ağrısıdır. Bununla birlikte epilepsi, hemipleji gözlenebilir. Bu benign karekterdeki kitlelere BBT ve kraniyal magnetik rezonans(MRG) görüntüleme ile tanı konulabilir. …”
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Proton magnetic spectroscopy agreed better with magnetic resonance image to lateralization of epileptogenic zone than with surface electroencephalography by Ricardo Andre Amorim Leite, Maria Concepcion Garcia Otaduy, Gilson Edmar Goncalves e Silva, Maria Lucia Brito Ferreira, Maria de Fatima Vasco Aragao

“…Objective To analyze the agreement rate of proton magnetic spectroscopy with magnetic resonance image (MRI) and surface electroence-phalography (EEG) in extratemporal neocortical epilepsies. Methods A cross-sectional study, type series of cases included 33 patients, age range 13–59 years old, of both gender, presenting structural alteration identified by MRI (75.8%) or by neurophysiologic techniques (72.7%). …”
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Unraveling genetic etiologies in complex pediatric neurological diseases: A genetic investigation using whole exome sequencing. by Zainab Gaouzi, Aziza Belkhayat, Zahra Chebihi Takki, Hind Lachraf, Idrissa Diawara, Yamna Kriouile

“…WES revealed a diagnostic yield of 45%, identifying conditions such as intellectual disabilities, hereditary metabolic disorders and epilepsies. It also uncovered neurodevelopmental and neurodegenerative disorders, neuromuscular diseases, and genetic syndromes. …”
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Mental deterioration in lafora's disease by A. Cukiert, M.M. Vilela, H.B. Scapolan, B. H. W. Lefèvre, L. Marques-Assis

“…Lafora's disease is included among the progressive myoclonic epilepsies. Despite the fact that dementia is a constant finding in this disease only a few papers have studied the timing of riental deterioration. …”
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Musical hallucination associated with hearing loss by T G Sanchez, S C M Rocha, K A B Knobel, M A Kii, R M R Santos, C B Pereira

“…Concerning the cortical area involved in musical hallucination, there is evidence that the excitatory mechanism of the superior temporal gyrus, as in epilepsies, is responsible for musical hallucination. …”
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Otizm Spektrum Bozukluğunda Refleks Tabanlı Motor ve Gelişimsel Problemler: Fear Paralysis ve Moro by Murat Eliöz, Ekrem Akbuğa

“…Ayrıca OSB, dispraksi, epilepsi, alerjiler, serebral palsi, disleksi gibi sorunlara yol açabilmekte veya eşlik edebilmektedirler. …”
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Peran Vektor Anopheles sp. dan Faktor Risiko Host dalam Kejadian Malaria Serebral serta Dampaknya terhadap Fungsi Otak Manusia di Wilayah Endemis by Budiyanti Mulyaningsih, Tien Zubaidah

“…Dampak neurologis yang umum meliputi gangguan kognitif, epilepsi, dan defisit motorik, dengan prevalensi komplikasi jangka panjang pada survivor mencapai 10–24%. …”
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Targeting shared molecular etiologies to accelerate drug development for rare diseases by Galliano Zanello, Macarena Garrido‐Estepa, Ana Crespo, Daniel O'Connor, Rima Nabbout, Christina Waters, Anthony Hall, Maurizio Taglialatela, Chun‐Hung Chan, David A Pearce, Marc Dooms, Philip John Brooks

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AMPA GluA1-flip targeted oligonucleotide therapy reduces neonatal seizures and hyperexcitability. by Nicole M Lykens, David J Coughlin, Jyoti M Reddi, Gordon J Lutz, Melanie K Tallent

“…Importantly, GR1 demonstrated anti-seizure properties and reduced post-seizure hyperexcitability in neonatal mice, highlighting its drug candidate potential for treating epilepsies and other neurological diseases involving network hyperexcitability.…”
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SEEG-Based Bilateral Seizure Network Analysis for Neurostimulation Treatment by Genchang Peng, Mehrdad Nourani, Jay Harvey

“…Epilepsy patients with drug-resistant seizures emanating from two or more distinct regions of left and right hemispheres are the primary candidates for neurostimulation treatment. …”
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Novel Lipid Formulation Increases Absorption of Oral Cannabidiol (CBD) by Edward Chesney, Ndabezinhle Mazibuko, Dominic Oliver, Amedeo Minichino, Ayşe Doğa Lamper, Lucy Chester, Thomas J. Reilly, Millie Lloyd, Matilda Kråkström, Alex M. Dickens, Matej Orešič, Eric Lynch, Gregory Stoloff, Mitul A. Mehta, Philip McGuire

“…<b>Background</b>: Cannabidiol (CBD) is an approved treatment for childhood epilepsies and a candidate treatment for several other CNS disorders. …”
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The impact of REM-sleep behavior disorder on people with Parkinson’s disease and their partners by Eva M. Prins, Angelique Pijpers, Noortje Verbeek, Sirwan K. L. Darweesh, Angelika D. Geerlings, Marjan J. Meinders, Bastiaan R. Bloem, Karin D. van Dijk, Lisanne J. Dommershuijsen

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DEPDC5 regulates the strength of excitatory synaptic transmission by interacting with ubiquitin-specific protease 46 by Maria Sabina Cerullo, Caterina Canevari, Antonella Marte, Alexandre Bacq, Antonio De Fusco, Marina Maletic, Stéphanie Baulac, Fabio Benfenati

“…Loss-of-function mutations in human DEPDC5 are the most common cause of lesional or non-lesional focal epilepsies associated with mTOR hyperactivation. Depdc5 silencing in mature neurons leads to excitation/inhibition imbalance and increased excitatory synapse strength. …”
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Efficacy and tolerability of perampanel as add‐on therapy in Dravet syndrome: A prospective real‐world study by Han Wang, Hong Chen, Xin Ding, Xueyan Cao, Jiahui Mai, Huafang Zou, Dongfang Zou, Yanwei Zhu, Jianxiang Liao, Dezhi Cao

“…Perampanel, as a novel anti‐seizure medication approved for focal and generalized epilepsies as add‐on therapy, showed sufficient efficacy and a satisfactory safety and tolerability profile in this study.…”
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Tratamento medicamentoso de 1217 pacientes epilépticos. II: estudo em relação à idade de início, ao tempo de doença e à freqüência das crises Drug treatment of 1217 epileptic patie... by Luís Marques-Assis

“…Since some initial forms, even when submitted to early treatment, had bad evolution, the presence of imponderable and unpredictable factors exercting negative influences in the prognosis of the epilepsies is admissible.…”
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Neuronal cell type specific roles for Nprl2 in neurodevelopmental disorder-relevant behaviors by Brianne Dentel, Lidiette Angeles-Perez, Abigail Y. Flores, Katherine Lei, Chongyu Ren, Andrea Pineda Sanchez, Peter T. Tsai

“…Loss of function in the subunits of the GTPase-activating protein (GAP) activity toward Rags-1 (GATOR1) complex, an amino-acid sensitive negative regulator of the mechanistic target of rapamycin complex 1 (mTORC1), is implicated in both genetic familial epilepsies and Neurodevelopmental Disorders (NDDs) (Baldassari et al., 2018). …”
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Auditory evoked delta brushes involve stimulus-specific cortical networks in preterm infants by Anna Kaminska, Dorothée Arzounian, Victor Delattre, Jacques Laschet, Jean-François Magny, Shushanik Hovhannisyan, Mostafa Mokhtari, Antoine Manresa, Anne Boissel, Lisa Ouss, Lucie Hertz-Pannier, Catherine Chiron, Fabrice Wendling, Yves Denoyer, Mathieu Kuchenbuch, Jessica Dubois, Roustem Khazipov

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