Prevalence of Mental Health Disorders and Predictors of Substance Use Disorders among Hospitalized Patients at the Sierra Leone Psychiatric Teaching Hospital, Freetown, Sierra Leon... by Mary Sinnah, Anna Jammeh, Solomon Sogbeh, Amara Sheriff, Eric Ikoona, Gebrekrstos Negash Gebru

“…Of the 3,241 patients, SUDs accounted for 1,966 (60.7%), psychosis 804 (24.8%), bipolar disorder 293 (9.0%), depression 109 (3.4%), epilepsy 12 (0.4%), and other conditions 57 (1.7%). …”
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Xq12q13.2 duplication detected in a child in selective exome screening by A. A. Dokshukina, Je. Shubina, D. N. Maslennikov, I. O. Sadelov, E. R. Tolmacheva, S. V. Ionushene, T. A. Bairova, L. V. Rychkova, D. Yu. Trofimov, D. N. Degtyarev

“…Similar duplications have been described in the literature in three patients with congenital malformations, epilepsy and psychomotor retardation. Early diagnosis of such a copy number variation disorder before the appearance of severe clinical signs of the disease will allow determining the prognosis and tactics of observation and treatment of the patient.Conclusion. …”
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Astrocytic AEG-1 drives neuroinflammation and enhances seizure susceptibility by Yuzhou Chen, Yunbo Yu, Jinhao Kou, Honggang Qi, Canyu Zhang, Feiyu Wang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Xiufang Liu, Chenchen Zhang, Guangming Gan, Jie Sun, Xinjian Zhu

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Impact of albendazole treatment on the symptom profile of neurocysticercosis patients 14–16 years following diagnosis by Lucila Vilela, Zachary Shahn, Arturo Carpio, W. Luis Yepez, Daniela Di Capua, Alex Jaramillo, W. Allen Hauser, Karina Quinde-Herrera, Elizabeth A. Kelvin

“…Eleven participants with no live parasites at last imaging (8 with residual calcifications) had seizures post-trial, which may be unprovoked and an indication of epilepsy risk. Research is urgently needed to improve NCC treatment to mitigate long-term outcomes.…”
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Lack of the human choline transporter‐like protein SLC44A2 causes hearing impairment and a rare red blood phenotype by Bérengère Koehl, Cédric Vrignaud, Mahmoud Mikdar, Thankam S Nair, Lucy Yang, Seyve Landry, Guy Laiguillon, Claudine Giroux‐Lathuile, Sophie Anselme‐Martin, Hanane El Kenz, Olivier Hermine, Narla Mohandas, Jean Pierre Cartron, Yves Colin, Olivier Detante, Raphaël Marlu, Caroline Le Van Kim, Thomas E Carey, Slim Azouzi, Thierry Peyrard

“…Interestingly, the first‐ever reported SLC44A2‐deficient individuals suffer from progressive hearing impairment, recurrent arterial aneurysms, and epilepsy. Furthermore, SLC44A2null individuals showed no significant platelet aggregation changes and do not suffer from any apparent hematological disorders. …”
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Functional divergence of the two Elongator subcomplexes during neurodevelopment by Monika Gaik, Marija Kojic, Megan R Stegeman, Tülay Öncü‐Öner, Anna Kościelniak, Alun Jones, Ahmed Mohamed, Pak Yan Stefanie Chau, Sazia Sharmin, Andrzej Chramiec‐Głąbik, Paulina Indyka, Michał Rawski, Anna Biela, Dominika Dobosz, Amanda Millar, Vann Chau, Aycan Ünalp, Michael Piper, Mark C Bellingham, Evan E Eichler, Deborah A Nickerson, Handan Güleryüz, Nour El Hana Abbassi, Konrad Jazgar, Melissa J Davis, Saadet Mercimek‐Andrews, Sultan Cingöz, Brandon J Wainwright, Sebastian Glatt

“…Here, we identify ELP4 and ELP6 variants in patients with developmental delay, epilepsy, intellectual disability, and motor dysfunction. …”
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Medicare Savings for Seizure Drugs by Adopting the Mark Cuban Cost Plus Drug Company Model by Smith T, Young A, O'Brien C, Duncan J, Rashid M, Magee T, Fitzgerald K, Vassar M

“…Tim Smith,1 Alec Young,1 Cameron O’Brien,1 Jacob Duncan,1 Matthew Rashid,1 Trevor Magee,1 Kyle Fitzgerald,1 Matt Vassar1,2 1Office of Medical Student Research, Oklahoma State University Center for Health Sciences, Tulsa, OK, USA; 2Department of Psychiatry and Behavioral Sciences, Oklahoma State University Center for Health Sciences, Tulsa, OK, USACorrespondence: Cameron O’Brien, Oklahoma State University Center for Health Sciences, 1111 W 17th St, Tulsa, OK, 74107, USA, Tel +918-582-1972, Email obriencameron99@gmail.comBackground: Epilepsy is a lifelong diagnosis, often requiring pharmacologic management. …”
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Review and metabolomic profiling of unsolved case reveals newly reported autosomal dominant congenital disorder of glycosylation, type Iw formerly thought to only be an autosomal r... by Kimberly M. Ezell, Yutaka Furuta, Devin Oglesbee, Eniko K. Pivnick, David Rinker, Jonathan H. Sheehan, Rory J. Tinker, Rizwan Hamid, Joy D. Cogan, Lynette Rives, Serena Neumann, Brian Corner, Mary Koziura, John A. Phillips, III

“…This report describes a 17-year-old male who was referred to the Undiagnosed Diseases Network (UDN) with a history of macrocephaly, failure to thrive, short stature, epilepsy, autism, attention-deficit/hyperactivity disorder, mild developmental delay, intermittent hypotonia, dysmorphic features, and mildly enlarged aortic root. …”
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High-gamma and beta bursts in the left supramarginal gyrus can differentiate verbal memory states and performance by Shennan Aibel Weiss, Nicolás Sawczuk, Daniel Y. Rubinstein, Michael R. Sperling, Katrina Wendel-Mitoraj, Päivi Österman, René Dumay-Roscher, Charles B. Mikell, Sima Mofakham, Kelly Coulehan, Petar M. Djuric, Diego Fernandez Slezak, Juan Esteban Kamienkowski

“…Given the roles of high-gamma and beta bursts in cognition and memory, this proof-of-concept study investigated whether these signals within the LSMG could classify memory state and performance.MethodsUsing secondary data from 103 epilepsy patients undergoing presurgical iEEG evaluation, we analyzed 141 delayed verbal free recall experiments. …”
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Relationship between executive function and dual-task walking in people with Parkinson's disease by Jun-Hong Zhou, Ray-Yau Wang, Yo-Tsen Liu, Yo-Tsen Liu, Yo-Tsen Liu, Yo-Tsen Liu, Shih-Jung Cheng, Shih-Jung Cheng, Hsin-Hsuan Liu, Hsin-Hsuan Liu, Yea-Ru Yang

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Antidepressant effect of Crossopteryx febrifuga trunk bark aqueous extract on chronic stress-induced depression-related behaviors in male and female rats by Daniel Ndavoumta, Harquin Simplice Foyet, Guillaume Woumitna Camdi, Serge Hermann Defo Tchinda, Hervé Hervé Abaïssou Ngatanko, Roland Nhouma Rebe, Kalib Kodji, Dieudonné Abengue Weinkai, Elisabeth Ngo Bum

“…Crossopteryx febrifuga is widely used in traditional medicine to treat fever, pain, epilepsy, and depression. This study aimed at evaluating the antidepressant effect of C. febrifuga aqueous extract (CF) using the chronic physical restriction stress (CRS) model on male and female rats. …”
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Traumatismos dentarios en niños con retraso mental de la provincia Holguín by Yunaydis Tamayo Avila, Niurka Sara Cruz Besil, Yuleika Nuñez Rojas

“…ABSTRACT   Introduction: the high prevalence of dental injuries has been found in patients with mental disturbances relate to factor as unbalanced walking, aver crowed of persons in institutions and concomitant epilepsy in some cases. Objective:  to characterize the dental injuries in children with mental retardation, in Holguin municipality, in the period from January to June of 2012. …”
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Multimodal single-cell profiling reveals neuronal vulnerability and pathological cell states in focal cortical dysplasia by Isabella C. Galvão, Manuela Lemoine, Lauana A. Messias, Patrícia A.O.R.A. Araújo, Jaqueline C. Geraldis, Clarissa L. Yasuda, Marina K.M. Alvim, Enrico Ghizoni, Helder Tedeschi, Fernando Cendes, Fabio Rogerio, Iscia Lopes-Cendes, Diogo F.T. Veiga

“…Summary: Focal cortical dysplasia (FCD) is a neurodevelopmental condition characterized by malformations of the cerebral cortex that often cause drug-resistant epilepsy. In this study, we performed multi-omics single-nuclei profiling to map the chromatin accessibility and transcriptome landscapes of FCD type II, generating a comprehensive multimodal single-nuclei dataset comprising 61,525 cells from 11 clinical samples of lesions and controls. …”
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Spatiotemporal dynamics of reading Kana (syllabograms) and Kanji (morphograms) by Kazuto Katsuse, Kazuo Kakinuma, Shin-Ichiro Osawa, Shoko Ota, Hana Kikuchi, Ai Kawamura, Kazushi Ukishiro, Kazuyo Tanji, Nobuko Kawakami, Chifumi Iseki, Shigenori Kanno, Yuichiro Shirota, Masashi Hamada, Tatsushi Toda, Hidenori Endo, Nobukazu Nakasato, Kyoko Suzuki

“…Using high-gamma power analysis from electrocorticography recordings in 14 patients with epilepsy and subdural implants, we examined the spatiotemporal neural dynamics of Kana and Kanji reading. …”
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Abstract 164: Chronic Total Occlusion of the Bilateral Internal Carotid Arteries, Vertebral Arteries and Basilar Artery by Luis Paixao, Derek Holder, Brendan Eby

“…Results A 58‐year‐old man who is independent for ADLs/iADLs with a history of prior ischemic strokes (first stroke at 40 years old) with residual left‐sided weakness and dysarthria, hypertension, hyperlipidemia, prior blood clots (previously on warfarin), post‐stroke epilepsy, and never smoker presented as a code stroke to the emergency department after waking that morning with worsening of his residual left‐sided weakness and dysarthria. …”
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Breastfeeding initiation and duration: links to physical, mental and behavioural health in US children aged 3–5 years by Xin Wang, Lei Shi, Li Cai, Li-Zi Lin, Qiang Feng, Ning Pan, Kang-You Li, Sai-Jun Huang, Yingqian Chen, An-Qi Ren, Xu-Chu Weng

“…Any breastfeeding initiation and duration, physical (asthma, allergies, arthritis, cerebral palsy, diabetes, epilepsy or seizure disorder, heart conditions or severe headaches), mental (anxiety or depression) and behavioural (Tourette syndrome, attention-deficit/hyperactivity disorder or behavioural/conduct problems) health conditions were measured using parent-reported questionnaires.Results Any breastfeeding was significantly associated with lower odds of behavioural health conditions (OR=0.76, 95% CI: 0.58 to 0.99) and marginally with mental health conditions (OR=0.70, 95% CI: 0.48 to 1.02, p=0.067). …”
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A pediatric case of anti-GABABR encephalitis: case report and literature review by Junxian Fu, Kairu Jia, Tianxia Li, Zhidong Qiao, Yuexin Jia, Xiaofan Yang, Hao Pan, Lu Zhao, Peirong Li, Manjie Zan, Guanglu Yang

“…Main symptoms include epilepsy in adults (78.24%) and sleep disorders (26.67%) and involuntary limb movements (33.33%) in children. …”
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Clinical features and risk factors for severe influenza in children: A study from multiple hospitals in Shanghai by Yu Shi, Weiming Chen, Mei Zeng, Guomei Shen, Chengjun Sun, Gongbao Liu, Hairong Gong, Chuanqing Wang, Mengmeng Ge, Jin Xu, Libo Wang, Aizhen Lu, Guoping Lu, Xiaowen Zhai

“…Clinical symptoms such as fever, cough, gastrointestinal symptoms, coma and epilepsy were higher in the severe group. Complications such as pneumorrhagia, heart failure, septic shock, acute renal failure and influenza-associated encephalitis were higher in the severe influenza group than the death group. …”
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Directional hand movement can be classified from insular cortex SEEG signals using recurrent neural networks and high-gamma band features by Xiecheng Shao, Ryan S. Chung, Jonathon M. Cavaleri, Roberto Martin Del Campo-Vera, Miguel Parra, Shivani Sundaram, Selena Zhang, Ashwitha Surabhi, Ryan J. McGinn, Charles Y. Liu, Spencer S. Kellis, Brian Lee

“…Seven participants with medication-resistant epilepsy underwent stereo electroencephalographic (SEEG) implantation of depth electrodes for seizure monitoring in the insula. …”
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Significantly Increased Aqueous Solubility of Piperine via Nanoparticle Formulation Serves as the Most Critical Factor for Its Brain Uptake Enhancement by Li J, Leung SSY, Chan EHY, Jiang C, Ho ETY, Zuo Z

“…., Hong Kong SAR, Tel +852 3943 6832, Fax +852 2603 5295, Email joanzuo@cuhk.edu.hkIntroduction: Piperine, the major component in Piper retrofractum and Piper nigrum, had potential therapeutic effects on central nervous system diseases such as Alzheimer’s disease, Parkinson’s disease, epilepsy and fragile X-associated tremor/ataxia syndrome. …”
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