Depleting parenchymal border macrophages alleviates cerebral edema and neuroinflammation following status epilepticus by Renbao Lin, Rui Luo, Xinyue Yu, Junjie Zou, Xiaowei Huang, Yanwu Guo

“…Cerebral edema caused by SE is unavoidable and may exacerbate epilepsy. Recent studies have identified cerebrospinal fluid (CSF) as a crucial fluid source of initial cerebral edema following ischemic stroke and cardiac arrest. …”
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Transtornos neurológicos mais frequentes: contribuição para a definição de temas do conteúdo programático do curso de neurologia, para a graduação médica The most frequent neurolog... by JOÃO ELIEZER FERRI-DE-BARROS, JOSÉ CARLOS ESTEVES VEIGA, ANTONIO VITOR MARTINS PRIANTE, CESAR AUGUSTO CARDOSO, FÁBIO LUIZ ALVES, MARINA FERRI-DE-BARROS, ROSALIA MATERA TURRINI, SÍLVIA DANIELA SCARPEL OLIVEIRA, SILVINO FONTANA JUNIOR

“…The most frequent diagnosis in institutions were listed: alcoholism, cerebrovascular disease, coma, cranial trauma, dementia, dizziness, epilepsy, facial paralysis, faint, headache, hemiplegia or paraplegia, meningitis, others paralysis, periferical neuropathy and psychiatric disordes. …”
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Uncovering the molecular targets of phytocannabinoids: mechanistic insights from inverse molecular docking fingerprint approaches by Vid Ravnik, Marko Jukič, Marko Jukič, Veronika Furlan, Uroš Maver, Uroš Maver, Jan Rožanc, Urban Bren, Urban Bren, Urban Bren

“…The major cannabinoids Δ-9-THC and CBD are well-studied, with approved palliative and therapeutic applications such as appetite stimulation, antiemetic therapy, pain management and epilepsy treatment. However, Δ-9-THC’s psychotropic effects limit its broader use. …”
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Clinical confocal laser endomicroscopy for imaging of autofluorescence signals of human brain tumors and non-tumor brain by Marlen Reichenbach, Sven Richter, Roberta Galli, Matthias Meinhardt, Katrin Kirsche, Achim Temme, Dimitrios Emmanouilidis, Witold Polanski, Insa Prilop, Dietmar Krex, Stephan B. Sobottka, Tareq A. Juratli, Ilker Y. Eyüpoglu, Ortrud Uckermann

“…Fresh samples were obtained from routine surgeries (glioblastoma n = 6, meningioma n = 6, brain metastases n = 10, pituitary adenoma n = 2, non-tumor from surgery for the treatment of pharmacoresistant epilepsy n = 2). Additionally, in situ intraoperative label-free CLE was performed in three cases. …”
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Intracerebral hemorrhage (ICH) in easternmost Finland 2021–2023 by Jussi O.T. Sipilä, Jari Toivanen, Juha Pääkkönen, Liisu Balk, Mohamed Hassan, Matti Heikkinen, Albina Kettunen, Ayla Mehdiyeva, Anna Maija Saukkonen, Johanna Willman, Anne-Mari Kantanen

“…In multivariate analyses, diabetes was associated with mortality [hazard ratio: 3.50, 95% confidence interval (CI): 1.02–11.95], and age was associated with functional outcome in three-month follow-up (odds ratio: 1.060, 95% CI: 1.015–1.107). New-onset epilepsy was diagnosed in three patients (6%) during the follow-up (mean: 1.84 years). …”
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Longitudinal multimodal MRI analysis of lecanemab treatment in mild cognitive impairment: a pilot study of structural, perfusion, and microstructural changes by Toshiya Takahashi, Dinh Ha Duy Thuy, Shingo Takenaka, Sayaka Ono, Maya Fukui, Yasushi Okada, Tomohiko Asada, Kan Niimi, Kaku Kimura, Akio Ikeda, Ryosuke Takahashi, Riki Matsumoto, Hidenao Fukuyama

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Effectiveness, cost-effectiveness and safety of gabapentin versus placebo as an adjunct to multimodal pain regimens in surgical patients: protocol of a placebo controlled randomise... by Chris A Rogers, Lucy Culliford, Maria Pufulete, Sarah Baos, Mark Edwards, Sarah Wordsworth, Elizabeth A Stokes, Holly Mckeon, Gianluca Casali, Aiman Alzetani, Reyad Abbadi, Nilesh Chauhan, Laura Collett, Samantha E de Jesus, Nicholas Goddard, Jennifer Lamb, Mat Molyneux, Ben Gibbison

“…Introduction Gabapentin is an antiepileptic drug currently licensed to treat epilepsy and neuropathic pain but has been used off-label to treat acute postoperative pain. …”
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Parent carer and disabled young people’s perspectives on the impacts of changes to service provision for children and young people in England during the COVID-19 pandemic: a qualit... by Lindsay Pennington, Catherine Exley, Dawn Teare, Jeremy R Parr, Christopher Morris, Shona Haining, Ge Yu, Amanda Allard, Philip Heslop, Sara Carr, Hannah Merrick, Helen Driver, Lily Potts, Vicki Grahame, Lesley Platts, Kulwinder Bola

“…Children had a range of diagnoses, including autism, attention deficit hyperactivity disorder, cerebral palsy, genetic conditions and epilepsy. Nine young people (aged 8–16 years; eight males, one female) were interviewed; two individually, three in a focus group and four with their parent carer.Results Four themes were identified: (1) communication of service changes, (2) access to services during the pandemic, (3) impacts of service changes and (4) learning for future emergencies and resetting services. …”
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Prospective study of safety, immunogenicity, and efficacy of inactivated COVID-19 vaccine in tuberous sclerosis complex children on sirolimus by Sufang Lin, Xia Zhao, Lin Li, Qiru Su, Weiwei Long, Xiaoqin Tian, Jinghua Ye, Bixia Yuan, Yan Hu, Jianxiang Liao, Hongbing Zhang

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Kir6.1, a component of an ATP-sensitive potassium channel, regulates natural killer cell development by Natalie Samper, Lilja Hardardottir, Delphine M. Depierreux, Soomin C. Song, Ayano Nakazawa, Ivan Gando, Tomoe Y. Nakamura, Andrew M. Sharkey, Carla R. Nowosad, Stefan Feske, Francesco Colucci, William A. Coetzee, William A. Coetzee, William A. Coetzee

“…Most current strategies use cytokines or antibodies to enhance NK-cell function, but none use ion channel modulators, which are widely used in clinical practice to treat hypertension, diabetes, epilepsy, and other conditions. Little is known about ion channels in NK cells. …”
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Maternally inherited genetic variants of CADPS2 are present in Autism Spectrum Disorders and Intellectual Disability patients by Elena Bonora, Claudio Graziano, Fiorella Minopoli, Elena Bacchelli, Pamela Magini, Chiara Diquigiovanni, Silvia Lomartire, Francesca Bianco, Manuela Vargiolu, Piero Parchi, Elena Marasco, Vilma Mantovani, Luca Rampoldi, Matteo Trudu, Antonia Parmeggiani, Agatino Battaglia, Luigi Mazzone, Giada Tortora, IMGSAC, Elena Maestrini, Marco Seri, Giovanni Romeo

“…We identified a novel intragenic deletion of maternal origin in two siblings with mild ID and epilepsy in the CADPS2 gene, encoding for a synaptic protein involved in neurotrophin release and interaction with dopamine receptor type 2 (D2DR). …”
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Febrile temperature-regulated TRPV1 in CD4+ T cells mediates neuroinflammation in complex febrile seizures by Shuo Kong, Xianglei Jia, Xin Liang, Yu Chen, Jingyi Liang, Yan Zhang, Ningyang Wu, Song Su, Taoxiang Chen, Xiaohua He, Jun Yin, Song Han, Wanhong Liu, Yuanteng Fan, Jian Xu, Biwen Peng

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Pontas positivas occipitais transitórias no eletrencefalograma de pacientes epilépticos submetidos a privação do sono Sleep occipital positive transient spikes seen at EEG of epile... by Gilson Edmar Gonçalves e Silva

“…Every patient included in this study had epilepsy clinically diagnosed and all EEG without abnormalities. …”
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Semiology and neurophysiology of clonic seizures in children: a retrospective study by Qiao Hu, Yuanyuan Luo, Tingsong Li, Siqi Hong, Ping Yuan, Li Jiang

“…Neurophysiological profiling identified a mean EEG–EMG discharge latency of 115.88 msec. Notably, epilepsy represented the primary underlying etiology (83.83%), distinguishing pediatric clonic seizures from adult populations where structural lesions predominate.ConclusionThe lateralizing value, seizure-onset zone and EEG seizure pattern in childhood clonic seizures exhibited consistency with those observed in adults. …”
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Foco epileptógeno parassagital com reversão de fase no vertex: correlações clínico-eletrencefalográficas Parasagittal epileptogenic focus with a phase reversal at the vertex: clini... by Décio Mega, Michel P. Lison

“…Those discharges can be similar to the primary bilateral synchronism found in the P.M. epilepsy and can be characterized by three fundamental aspects: a) irregularity of discharges; b) a single phase reversal at the midline; c) asymmetry at the vertex region. 4) From the clinical point of view the adversive (45%) and akinetic seizures (18%) were the most frequently found. 5. …”
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NEUROPSYCHIATRIC DISORDERS IN JUVENILE-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS: RESULTS FROM A RETROSPECTIVE STUDY by M. I. Kaleda, I. P. Nikishina, S. I. Glukhova, N. Yu. Stepanenko

“…Among the neuropsychiatric disorders, there were headaches (28.9%), cognitive impairment (28.9%), cerebrovascular disease (35.5%), distal sensory polyneuropathy (20%), epilepsy syndrome (15.5%), anxiety disorders (11.1%), psychoses (8.9%), myelopathy (6.7%), and chorea (4.4%). …”
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Clinical Manifestations, Outcomes, and Etiologies of Perinatal Stroke in Taiwan: Comparisons between Ischemic, and Hemorrhagic Stroke Based on 10-year Experience in A Single Instit... by Chien-Chung Lee, Jainn-Jim Lin, Kuang-Lin Lin, Wai-Ho Lim, Kai-Hsiang Hsu, Jen-Fu Hsu, Ren-Huei Fu, Ming-Chou Chiang, Shih-Ming Chu, Reyin Lien

“…Acute seizure manifestation was associated with poststroke epilepsy in infants with PHS but not in infants with PAIS (86% vs. 0%, p=0.005). …”
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Effect of long-term transcutaneous auricular vagus nerve stimulation in multiple system atrophy-cerebellar subtype: a case report by Zhao-Di Wang, Zhao-Di Wang, Xiao-Ping Cheng, Zhen-Yi Liu, Di Wu, Jun Ni, Chuan-Juan Chen, Chuan-Juan Chen, Xin-Yuan Chen, Xin-Yuan Chen

“…In recent years, it has been established that taVNS has significant therapeutic effects on epilepsy, depression, migraine, insomnia, and other diseases. …”
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Role of Tropomodulins in brain physiology and pathology by Chuan Hong, Xiaopeng Liu, Zhou Zhou, Yuan Xing, Zixuan Cao, Yan-Zhong Chang, Guofen Gao

“…Dysregulation of Tmods has been demonstrated in several neurodegenerative and neuropsychiatric diseases, such as Alzheimer's disease, epilepsy, Down syndrome, and addictive behaviors. Currently, compared to cancer and cardiovascular diseases, the roles and mechanisms of altered Tmod expression in neurological diseases remain poorly understood. …”
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Analysis of Regions of Homozygosity: Revisited Through New Bioinformatic Approaches by Susana Valente, Mariana Ribeiro, Jennifer Schnur, Filipe Alves, Nuno Moniz, Dominik Seelow, João Parente Freixo, Paulo Filipe Silva, Jorge Oliveira

“…<b>Results:</b> These resources were applied for the genetic characterization of two siblings with epilepsy, myoclonus and dystonia, pinpointing the <i>CSTB</i> gene as disease-causing. …”
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