Abstract 016: Endovascular Coiling of a Left L3 Radicular Artery Mycotic Aneurysm by William H Roberts, Brian A Tong, Dan‐Victor Giurgiutiu

“…The most commonly affected vessels include the aorta, iliac, visceral, femoral, brachial, and cerebral arteries, often occurring in the setting of bacteremia, direct invasion from local infection, septic emboli from infective endocarditis, or arterial trauma.¹⁻³ However, there is limited existing documentation of mycotic aneurysms of the spinal vasculature.² Furthermore, knowledge regarding the management of paraspinal mycotic aneurysms and the efficacy of endovascular repair of these lesions is scarce.⁴ Methods We present a 51‐year‐old male with a past medical history of diabetes mellitus, end‐stage renal disease on hemodialysis (T/T/S), hypertension, congestive heart failure, peripheral arterial disease s/p right bilateral knee amputation, coronary artery disease, and epilepsy that presented with a 2‐week duration of severe low back pain with associated left upper and lower extremity numbness, subjective fevers, generalized weakness, diffuse abdominal pain, nausea and vomiting. …”
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Sturge-Weber Syndrome: A comprehensive review of clinical features, optimized diagnosis and management strategies by Katarzyna Naja, Alicja Kapciak, Julia Górny, Adrianna Świerzyńska, Artur Hawajski, Natalia Jankowska, Oliwia Kamieniecka, Jakub Zwardoń, Weronika Mazur, Natalia Pawelec

“…Neurological complications, particularly epilepsy, are a major concern, often necessitating pharmacological or surgical interventions. …”
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Exploring the diverse phenotypes of anti-GAD 65 encephalitis, diagnosis and treatment challenges by Octaviana Adriana Dulamea, Anca Adriana Arbune, Andreea Andronache, Lorenzo Giovanni Zurini, Daniela Anghel

“…She was diagnosed 11 months after the onset with limbic encephalitis with anti-GAD65 antibodies, left temporal focal epilepsy with nocturnal seizures and mild cognitive decline. …”
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Antiepileptic Effects of Lacosamide Loaded Polymers Implanted Subdurally in GAERS by Sebastien H. Bauquier, Jonathan L. Jiang, Zhilian Yue, Alan Lai, Yu Chen, Simon E. Moulton, Karen J. McLean, Sara Vogrin, Amy J. Halliday, Gordon Wallace, Mark J. Cook

“…The current experiment investigated the ability of coaxial electrospun poly(D,L-lactide-co-glycolide) (PLGA) biodegradable polymer implants loaded with the antiepileptic drugs (AED) lacosamide to reduce seizures following implantation above the motor cortex in the Genetic Absence Epilepsy Rat from Strasbourg (GAERS). In this prospective, randomized, masked experiments, GAERS underwent surgery for implantation of skull electrodes (n=6), skull electrodes and blank polymers (n=6), or skull electrodes and lacosamide loaded polymers (n=6). …”
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Comprehensive assessment reveals numerous clinical and neurophysiological differences between MECP2‐allelic disorders by Davut Pehlivan, Chengjun Huang, Holly K. Harris, Christine Coquery, Aditya Mahat, Mirjana Maletic‐Savatic, Laurence Mignon, Sukru Aras, Daniel G. Glaze, Charles S. Layne, Leonardo Sahelijo, Huda Y. Zoghbi, Matthew J. McGinley, Bernhard Suter

“…MRL individuals exhibited large amplitude whole body tremor, midline stereotypies (vs. hand flapping at sides in MDS), earlier neuromotor regression, and earlier onset but less commonly refractory epilepsy. In the neurophysiological domain, we observed several marked differences in sleep physiology between MDS/MRL and typically developing (TD) individuals including reduced sleeping time, increased delta power during rapid eye movement (REM) sleep, decreased occipital alpha and increased brain‐wide delta power during wakefulness, and reduced spindle density and duration. …”
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The clinical spectrum associated with ERCC5 mutations: Is there a relationship between phenotype and genotype? by Jinpeng Zhang, Jiannan Ma, Yuanyuan Luo, Siqi Hong, Li Jiang, Tianyi Li

“…In addition, patients with the XP/CS phenotype were more prone to appearance abnormalities, deafness, and epilepsy, and cheilitis and tumors were more common in patients with the XP phenotype, but the differences were not significant. …”
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Síndrome peri-sylviana: estudo de uma família brasileira com ênfase na modalidade de transmissão genética e espectro clínico Perisylvian syndrome: report of one Brazilian family wi... by Eliane P. Herrera, Iara L. Brandão-Almeida, Catarina A. Guimarães, Ecila P. M. Oliveira, Maria Augusta Montenegro, Fernando Cendes, Iscia Lopes-Cendes, Carlos A.M. Guerreiro, Simone R.V. Hage, Marilisa M. Guerreiro

“…All of them had developmental language disorder. Epilepsy, motor deficit and pseudobulbar signs (such as drooling) were detected in one child who had diffuse PMG along the Sylvian fissure. …”
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Limbic Encephalitis in Taiwanese Children and Adolescence: A Single Center Study by I-Jun Chou, Huei-Shyong Wang, Jainn-Jim Lin, Chang-Fu Kuo, Kuang-Lin Lin, Min-Liang Chou, Po-Cheng Hung, Meng-Ying Hsieh, Yun-Tong Lin

“…They had persistent neuropsychiatric symptoms and 90% developed refractory epilepsy, despite six patients having been treated with methylprednisolone pulse therapy or intravenous immunoglobulin (IVIG) at the acute stage. …”
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Novel TBC1D8B variant causes neonatal nephrotic syndrome combined with acute kidney injury by Yuanyuan Xu, Chao Dai, Jing He, Yaping Liang, Ying Zhu, Fang Deng, Chang Wang, Danqun Jin

“…Results The child, at 1 month, showed severe edema and proteinuria and unexplained coma with epilepsy. Ultrasound examination revealed multiple organ enlargement, and MRI showed nonspecific high diffusion-weighted imaging signal characteristics in the splenium of the corpus callosum. …”
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PATIENTS WITH NEUROLOGICAL DISEASES: RATIONALE FOR PHARMACOECONOMIC EVALUATION OF COST OPTIMIZATION FOR MANAGEMENT WITH NEURON-SPECIFIC PROTEINS ASSESSMENT AS MARKERS OF INCREASED... by D. V. Blinov

“…becoming increasingly widespread evaluation of the blood-brain barrier (BBB) resistance to predict severity and outcome of epilepsy, stroke, traumatic brain injury (TBI) and other neurological disorders by assessment of neuron-specific proteins (NSP)  concentration in biological fluids. …”
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CSF Tau Is a Biomarker of Hippocampal Injury in Cryptogenic New‐Onset Refractory Status Epilepticus by Yihui Goh, Yoonhyuk Jang, Soo Jean Shin, Soo Hyun Ahn, Su Yee Mon, Yoon Hee Shin, Kon Chu, Sang Kun Lee, Soon‐Tae Lee

“…CSF from 21 patients with other neurological diseases (atypical parkinsonism, postural orthostatic hypotension syndrome, epilepsy, and cerebellar ataxia) was used as controls. …”
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Early epileptic encephalopathy associated with SCN2A mutations: clinical and genetic description of eight novel patients by E. L. Dadali, F. A. Konovalov, I. A. Akimova, A. A. Sharkov, G. E. Rudenskaya, S. V. Mikhaylova, S. A. Korostelev

“…Identification of the mutated genes causing EEE and further study of their function are important for selection of therapeutic approach to epilepsy treatment.…”
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Temporal patterns of multiple long-term conditions in individuals with intellectual disability living in Wales: an unsupervised clustering approach to disease trajectories by Rania Kousovista, Georgina Cosma, Emeka Abakasanga, Ashley Akbari, Francesco Zaccardi, Gyuchan Thomas Jun, Reza Kiani, Satheesh Gangadharan

“…For females ≥ 45 years, two clusters were identified: the first cluster was predominantly defined by circulatory (34.1%), while the second cluster by digestive (25.9%) and musculoskeletal (21.9%) system conditions. Mental illness, epilepsy, and reflux disorders were prevalent across all groups.DiscussionThis study reveals complex multimorbidity patterns in individuals with ID, highlighting age and sex differences. …”
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Sleep disturbance as a marker of postpartum psychosis risk: a prospective actigraphy study by Chiara Petrosellini, Sofia H. Eriksson, Nicholas Meyer, Edwin Antony, Olivia Protti, Lucinda Donaldson, Vincent van Hees, Aviva Petrie, Andrew McQuillin, Dimitrios Siassakos

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Title not available by Paulo Breno Noronha Liberalesso, Eliana Garzon, Elza M.T. Yacubian, Américo C. Sakamoto

“…Seven (46.7%) patients were diagnosed with previous symptomatic focal epilepsy. More than one etiology was identified in 40.0% of the cases. …”
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From Bedside to Desktop: A Data Protocol for Normative Intracranial EEG and Abnormality Mapping by Heather Woodhouse, Sarah Gascoigne, Gerard Hall, Callum Simpson, Nathan Evans, Gabrielle Schroeder, Peter Taylor, Yujiang Wang

“…Briefly, we take as input the icEEG recordings and neuroimaging data from people with epilepsy who are undergoing evaluation for resective surgery. …”
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A Hybrid 2D/3D Approach for Neural Differentiation Into Telencephalic Organoids and Efficient Modulation of FGF8 Signaling by Michele Bertacchi, Gwendoline Maharaux, Michèle Studer

“…Disruption of this developmental balance can lead to brain malformations, which underlie a range of complex neurodevelopmental disorders, including epilepsy, autism, and intellectual disabilities. Studying the early stages of human brain development, whether under normal or pathological conditions, remains challenging due to ethical and technical limitations inherent to working with human fetal tissue. …”
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Prevalence of communicable, non-communicable diseases, disabilities and related risk factors in Khyber Pakhtunkhwa Pakistan: Findings from the Khyber Pakhtunkhwa Integrated Populat... by Ziaul Haq, Saima Afaq, Muhammad Ibrahim, Zala, Muhammad Asim

“…<h4>Objectives</h4>The objective of this study was to present the demographic characteristics and the burden of locally-specific CDs (hepatitis B and C, TB, AIDS), NCDs (diabetes, renal diseases, asthma, epilepsy, coronary heart diseases, cancer, hypertension, cholesterol, thalassemia), and disabilities (congenital, post-disease, post-injury, paralysis) stratified by sex, age and setting in the Khyber Pakhtunkhwa province of Pakistan.…”
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Healthcare utilization and disease burden in children with metachromatic leukodystrophy in Germany by Christiane Kehrer, Andrea Bevot, Pascal Martin, Christa Raabe, Saskia Gregor, Ingeborg Krägeloh-Mann, Samuel Groeschel

“…Results Nearly all patients showed spasticity, truncal hypotonia and dysphagia, and about half of the patients developed epilepsy. Most children required special education; none finished regular school. …”
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Impact of a training program for community health officers on neurological disorders: insights from the Karnataka brain health initiative by Mohammed Farhan Ansari, Deenadayalan Boopalan, Ganagarajan Inbaraj, Sarath Govindaraj, Rajani Parthasarathy, Girish N Rao, Rehan Shahed, Faheem Arshad, Suvarna Alladi, the Karnataka Brain Health Initiative (KaBHI) Consortium

“…A total of 295 CHOs participated in a two-hour training program delivered by expert neurologists, covering headache, epilepsy, stroke, and dementia through lectures, discussions, and case-based scenarios. …”
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