Targeting MMP-9 activation after early-life seizures reduces seizure susceptibility and memory deficits in a larval zebrafish model by Christopher Stegmuller, Alfonsina Ramón, Kasulul Melissa Bhuiyan, Nat Berk, Rebecca Han, Faisha Salami, Marina D'Angelo, Jocelyn J. Lippman-Bell

“…Chronic consequences of prolonged early-life seizures (ELS) in humans and rodent models vary, but can include the development of epilepsy (spontaneous, recurrent seizures) and cognitive impairment. …”
Get full text

Estimating the prevalence of hypocalcemia in adults presenting with new-onset seizures: A cross-sectional study by Sharan Bose, K.V. Rajalakshmi, Anantha Kumar P.K., Bhuvaneshwar, Jibin Simon

“…Only about 2% to 3% of patients go on to develop epilepsy. Common metabolic causes include hypoglycemia, hyperglycemia, hyponatremia, hypocalcemia, hypomagnesemia, etc. …”
Get full text

Treatments and outcomes of untreated cerebral cavernous malformations in China: study protocol of a nationwide multicentre prospective cohort study by Shufa Zheng, Fuxin Lin, Qiu He, Zhuyu Gao, Lianghong Yu, Dengliang Wang, Yuanxiang Lin, Dezhi Kang

“…The secondary outcome includes symptomatic haemorrhage, drug refractory epilepsy, focal neurological deficits, morbidity and all-cause mortality during follow-up. …”
Get full text

Schizencephaly in children: A single medical center retrospective study by Po-Cheng Hung, Huei-Shyong Wang, Ming-Liang Chou, Kuang-Lin Lin, Meng-Ying Hsieh, I-Jun Chou, Alex M-C. Wong

“…Eight patients developed refractory epilepsy. The majority of the patients had motor deficits, intellectual disabilities, and language deficits, especially in bilateral clefts. …”
Get full text

Cvill6 and Cvill7: Potent and Selective Peptide Blockers of Kv1.2 Ion Channel Isolated from Mexican Scorpion <i>Centruroides villegasi</i> by Kashmala Shakeel, Muhammad Umair Naseem, Timoteo Olamendi-Portugal, Fernando Z. Zamudio, Lourival Domingos Possani, Gyorgy Panyi

“…These pharmacological properties make Cvill7 a potential candidate to target Kv1.2 gain of function (GOF)-related channelopathies such as epilepsy.…”
Get full text

Inhibitory Effects of Cenobamate on Multiple Human Cardiac Ion Channels and Possible Arrhythmogenic Consequences by Andreea Larisa Mateias, Florian Armasescu, Bogdan Amuzescu, Alexandru Dan Corlan, Beatrice Mihaela Radu

“…Cenobamate is a novel third-generation antiepileptic drug used for the treatment of focal onset seizures and particularly for multi-drug-resistant epilepsy; it acts on multiple targets: GABA_A receptors (EC₅₀ 42–194 µM) and persistent neuronal Na⁺ currents (IC₅₀ 59 µM). …”
Get full text

CONTEXTUAL APPROACH TO LITERARY CRITICISM: DOSTOEVSKY AND PSYCHOANALYSIS by V. G. Kalashnikov

“…Through the systematization of complementary contexts and psychoanalytic interpretation the myth about F. M. Dostoyevsky’s epilepsy as a source of his creativity is discredited; though by recognition of the writer, personal problems and neuroses nevertheless were reflected in his works. …”
Get full text

Comprehensive Evaluation of Neuroprotective Effects of Levetiracetam in C57BL/6J Male Mice Model of Parkinsonism: Preclinical Insights by Neeraj Pandey, VP Karthik, Preetha Selva, Philo Hazeena

“…Introduction: Levetiracetam (LEV), an anticonvulsant used for epilepsy, exhibits neuroprotective effects by stabilising neuronal activity and reducing excitotoxicity. …”
Get full text

Vagus nerve stimulation as a potential treatment for acute asthmatic bronchoconstriction: a systematic review by Elizabeth Di Flumeri, Francine M. Ducharme, Joël St-Pierre, Farbod Niazi, Nathan A. Shlobin, Simon Couillard, Jean-Paul Praud, Alexander G. Weil, Christian Iorio-Morin

“…ObjectiveVagus nerve stimulation (VNS) is a therapeutic option for diseases such as epilepsy and depression. Given that the smooth muscle of the bronchi is innervated by the vagus nerve, VNS could aid in treating pathologies of the respiratory system involving a bronchoconstrictive component. …”
Get full text

A Comprehensive Review of the Pathophysiology of Neonatal Stroke and a Critique of Current and Future Therapeutic Strategies by Victor Mondal, Emily Ross-Munro, Gayathri K. Balasuriya, Ritu Kumari, Md. Munnaf Hossen, Mohammed Ageeli, Kate Firipis, David R. Nisbet, Glenn F. King, Richard J. Williams, Pierre Gressens, Jeanie L. Y. Cheong, Flora Y. Wong, David W. Walker, Mary Tolcos, Bobbi Fleiss

“…Neonatal stroke has significant clinical and socio-economic consequences, leading to cerebral palsy, epilepsy, and a range of motor, sensory, and cognitive impairments. …”
Get full text

Separating Subjective from Objective Food Value in the Human Insula: An Exploratory Study Using Intracranial EEG by Benjamin Hébert-Seropian, Olivier Boucher, Daphné Citherlet, Manon Robert, François Richer, Dang Khoa Nguyen

“…<b>Methods</b>: Eight patients with drug-resistant epilepsy undergoing a pre-surgical evaluation between 2017 and 2023 participated in this study. …”
Get full text

Anti-GAD encephalitis in a child with beta-thalassemia after allogeneic hematopoietic stem cell transplantation by N. V. Bronina, I. O. Schederkina, B. M. Kurmanov, E. A. Burtsev, M. V. Natrusova, G. O. Bronin

“…Anti-GAD-anitibodies are associated with type 1 diabetes mellitus, limbic encephalitis, cerebellar ataxia, temporal autoimmune epilepsy, and rigid man syndrome. We present a rare clinical case of anti-GAD-anitibodies- associated immune encephalitis in a child with beta-thalassemia after allogeneic hematopoietic stem cell transplantation (allo-HSCT).A 3-year-old boy diagnosed with beta-thalassemia underwent allo-HSCT from a 9/10 compatible unrelated donor. …”
Get full text

Vitamin B6, cardiovascular diseases, and diabetes mellitus by A.A. Serhiyenko, T.T. Dolinay, V.B. Sehin, V.A. Serhiyenkо

“…Vitamin B6 deficiency has been linked to a number of clinically significant diseases, including autism, schizophrenia, Alzheimer’s disease, Parkinson’s disease, epilepsy, Down syndrome, DM, and cancer, although the underlying processes remain largely unclear. …”
Get full text

Impact of pathogenic mutations of the GLUT1 glucose transporter on solute carrier dynamics using ComDYN enhanced sampling [version 2; peer review: 2 approved, 1 approved with reser... by K. Anton Feenstra, Akiko Higuchi, Kei Yura, Sanne Abeln, Halima Mouhib

“…Several pathogenic mutations are reported in the glucose transporter subfamily SLC2, causing Glut1-deficiency syndrome (GLUT1DS1, GLUT1DS2), epilepsy (EIG2) and cryohydrocytosis with neurological defects (Dystonia-9). …”
Get full text

Effective Protection Against Status Epilepticus Caused by Lithium–Pilocarpine: Combination of Midazolam and Lacosamide by Cumaali Demirtas, Metehan Akca, Ugur Aykin, Yunus Emre Surmeneli, Hava Yildirim, Mehmet Yildirim

“…ABSTRACT Aim Status epilepticus causes the most severe condition related to epilepsy in terms of high mortality rate. Although status epilepticus treatment guidelines specify a treatment process based on three‐stage monotherapy, effective control cannot yet be achieved in all cases. …”
Get full text

Alcohol consumption and its association with cancer, cardiovascular, liver and brain diseases: a systematic review of Mendelian randomization studies by Naouras Bouajila, Cloé Domenighetti, Henri-Jean Aubin, Mickael Naassila

“…However, there was no evidence to support the protective effects of light to moderate alcohol consumption on cognitive function, Alzheimer's disease, and amyotrophic lateral sclerosis, as reported in observational studies while our review revealed an increased risk of epilepsy and multiple sclerosis. The available studies provided limited results on the link between alcohol consumption and liver disease.ConclusionsDespite the valuable insights into the causal relationship between alcohol consumption and various health outcomes that MR studies provided, it is worth noting that the inconsistent ability of genetic instrumental variables to distinguish between abstainers, light and moderate drinkers makes it difficult to differentiate between U or J-shaped vs. linear relationships between exposure and outcome. …”
Get full text

Profile of neurological manifestations in patients with COVID-19: Review of the literature published during the first six months of the pandemic by Maria Alejandra Daza-Latorre, Carlos Mario Echeverria-Palacio, Sofia Albornoz, Juan Argothy, Lilia Ballesteros-Egurrola, María Camila Ocampo, Juan Felipe Vera

“…Other manifestations such as delirium and epileptic seizures occur more frequently in people with a history of dementia or epilepsy, respectively. Finally, some manifestations such as Guillain-Barré syndrome and stroke may cause several sequelae. …”
Get full text

BK channel activity in skin fibroblasts from patients with neurological disorder by Ria L. Dinsdale, Thomas R. Middendorf, Deborah Disilvestre, David Adams, William Gahl, Ellen F. Macnamara, Lynne Wolfe, Camilo Toro, Cynthia J. Tifft, Andrea L. Meredith

“…N999S was previously shown to produce strong gain-of-function (GOF) changes in homomeric BK channel properties in vitro and is found as a heterozygous allele associated with epilepsy and paroxysmal dyskinesia in humans. Although its pathogenicity has been demonstrated in heterozygous animal models, the GOF classification for N999S has not been validated in a heterozygous patient-derived tissue. …”
Get full text

Pediatric Syncope: An Examination of Diagnostic Processes, Therapeutic Approaches and the Role of the Tilt Test: Insights from an 18-Year Single-Center Experience by Serra Karaca, Doruk Özbingöl, Pelin Karaca Özer, Mustafa Lütfi Yavuz, Kemal Nişli

“…Patients diagnosed with cardiac syncope, epilepsy, or postural orthostatic tachycardia syndrome (POTS) were excluded. …”
Get full text

Development and Validation of an LC–MS/MS Method for Quantifying Gabapentin in Plasma: Application to a Pharmacokinetic Study in Cats by Feifei Zhao, Changcheng Lin, Yunying Wu, Xinyue Luo, Ning Han, Wenguang Xiong, Zhenling Zeng

“…Gabapentin (GBP), a γ-aminobutyric acid analogue used for neuropathic pain and epilepsy, can reduce cat stress and improve veterinary exam compliance. …”
Get full text