GABAB Receptor: Structure, Biological Functions, and Therapy for Diseases by Weijie Xie, Yuan Li, Xinyue Wang, Elena Blokhina, Evgeny Krupitsky, Marina Vetrova, Ji Hu, Ti‐Fei Yuan, Jue Chen, Hua Wang, Xiangfang Chen

“…ABSTRACT Gamma‐aminobutyric acid (GABA) B receptors (GABABRs) that acts slowly and maintains the inhibitory tone are versatile regulators in the complex nervous behaviors and their involvement in various neuropsychiatric disorders, such as anxiety, epilepsy, pain, drug addiction, and Alzheimer's disease. …”
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Acute gabapentin administration in healthy adults. A double-blind placebo-controlled study using transcranial magnetic stimulation and 7T 1H-MRS by Katherine Dyke, Sophia E. Pépés, Ben Babourina-Brooks, Chen Chen, Soyoung Kim, Hilmar P. Sigurdsson, Amelia Draper, Masud Husain, Parashkev Nachev, Penny Gowland, Peter G. Morris, Stephen R. Jackson

“…Gabapentin (GBP) is one of several drugs developed to increase GABA levels and is routinely prescribed for conditions such as epilepsy and neuralgia. While animal and human studies indicate that GBP can elevate GABA levels, its exact mechanisms of action are not fully understood, although animal studies indicate that GBP does not have a direct effect upon GABAergic receptors.To investigate the impact of acute GBP administration in the human motor system we used two complimentary approaches – transcranial magnetic stimulation (TMS) and magnetic resonance spectroscopy (MRS). …”
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Exploring proposed recommendations for immediate‐use seizure medication: Treating both cluster and prolonged seizures with diazepam nasal spray by Michael Chez, Pavel Klein, Danielle Becker, Jurriaan M. Peters, Enrique Carrazana, Adrian L. Rabinowicz

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Digital Multidomain Lifestyle Intervention for Community-Dwelling Older Adults: A Mixed Methods Evaluation by Renato Mattli, Manuel Weber, Manuel Weber, Manuel Weber, Anja Maria Raab, Anja Maria Raab, Karin Haas, Karin Haas, Albrecht Vorster, Albrecht Vorster, Kai-Uwe Schmitt, Kai-Uwe Schmitt

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Automated Identification of Cyclic Alternating Patterns of Sleep Using Fusion of VGG16 and Vision Transformer by Hardik Telangore, Ashutosh Kumar Jha, Prithviraj Verma, Manish Sharma, Chakka Sabareesh, Ankit A. Bhurane, Hasan S. Mir, U. Rajendra Acharya

“…By utilizing the PhysioNet dataset, encompassing a diverse range of subjects, from healthy individuals to those with various sleep disorders, such as Insomnia, Narcolepsy, Nocturnal Frontal Lobe Epilepsy (NFLE) and Periodic Limb Movement (PLM), our approach seeks to provide comprehensive insights into sleep patterns and disorders. …”
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Pharmacokinetic Interactions of Phenosanic Acid with Valproic Acid and Carbamazepine in Dogs by M. V. Karlina, V. M. Kosman, V. G. Makarov, M. N. Makarova, S. V. Morozov, E. E. Gushchina, N. V. Zhuravskaya

“…Phenosanic acid prevents convulsions, reduces the frequency of epileptic seizures, and improves cognitive, intellectual and mnestic functions in patients with epilepsy. Therefore, phenosanic acid-based medicinal products are promising candidates for inclusion in combination antiepileptic therapy. …”
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Stakeholders’ perspectives on implementing and integrating patient-reported outcome measures (PROMs) in health systems - insights from Alberta, Canada by Fatima Al Sayah, Hilary Short, Arto Ohinmaa, Stafford Dean, Brenda Hubley, Markus Lahtinen, Jeffrey A. Johnson

“…Methodology Key stakeholders from various roles were interviewed, including PROMs programs, health system improvement, data analytics, clinical practice, evaluation, health economics, and research, from diverse clinical areas, including cancer, primary care, epilepsy, rehabilitation, arthroplasty, cardiovascular surgery, and rheumatology. …”
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The Impact of Secondary Orthopedic Complications on the Quality of Life in Children with Cerebral Palsy by Vladimir А. Novikov, Valery V. Umnov, Dmitry S. Zharkov, Dmitry V. Umnov, Olga V. Barlova, Stanislav V. Ivanov, Alina R. Mustafaeva, Ulyana A. Svinina

“…The impact of concomitant disorders, such as epilepsy, also negatively affects the perception of quality of life by children and their parents. …”
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Extracutaneous Lesions in Patients with Focal Scleroderma of Craniofacial Localization: a Retrospective Cross-Sectional Study by Nikolay N. Murashkin, Alexander I. Materikin, Roman V. Epishev, Maria A. Leonova, Leonid A. Opryatin, Dmitry V. Fedorov, Roman A. Ivanov, Alena A. Savelova, Ekaterina S. Pavlova, Anastasiya U. Ufimtseva

“…The study has revealed correlation indicating that the presence of epilepsy in CLS is associated with changes in the brain structure according to MRI (hyperintensive signal at T2-weighted image and FLAIR) (p=0,022). …”
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Clinical significance of the determination of antibodies to the NR2 subunit of glutamate N-methyl-D-aspartate receptors (aNMDAR) in patients with systemic lupus erythematosus and a... by T. A. Lisitsyna, A. B. Borisova, T. M. Reshetnyak, D. Yu. Veltishchev, M. E. Diatroptov, A. S. Avdeeva, K. S. Nurbaeva, A. A. Abramkin, E. L. Nasonov

“…Patients with elevated aNMDAR concentrations had a statistically significantly higher (p<0.05) probability of detecting neurological manifestations such as acute/transient cerebrovascular accident/epilepsy (odds ratio (OR) – 9.0), as well as bipolar affective disorder (OR=14.0), and statistically not significantly – schizotypal disorder (OR=3.8) and moderate cognitive impairment (organic type) (OR=2.15). …”
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Neonatal Hypoglycemia and Neurodevelopmental Outcomes—An Updated Systematic Review and Meta-Analysis by Shivashankar Diggikar, Paula Trif, Diana Mudura, Arun Prasath, Jan Mazela, Maria Livia Ognean, Boris W. Kramer, Radu Galis

“…No difference in the incidence of epilepsy, motor impairment, emotional-behavioral problems, or hearing impairment were noted. …”
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Confusion and seizures: is a CT head always required? by Mohamed Salah Fayed, Isbah Munir, Moez Nayyar

“…It is not recommended to perform a CT head in patients with epilepsy who present with a typical seizure.1,2 CT head has a low yield in patients presenting with confusion without neurological symptoms.3 Despite the published guidelines, the overuse of CT head remains an ongoing concern.4 We aimed to identify patients who are most likely to benefit from a CT head. …”
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Impact of Absence Seizures on Physical Activity Levels in Children: A Cross-Sectional Study by Martina Gnazzo, Valentina Baldini, Marco Carotenuto, Giulia Pisanò, Giovanni Messina, Fiorenzo Moscatelli, Maria Ruberto

“…However, children with neurological conditions such as childhood absence seizures (CAE), a type of epilepsy characterized by brief episodes of impaired consciousness, may face barriers to participating in regular physical activities. …”
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Long‐term treatment with carbamazepine restores cognitive abilities in a mouse model of KCNQ2 developmental and epileptic encephalopathy by Jordane Louis, Natalia Doudka, Marie‐Solenne Félix, Adeline Spiga Ghata, Camille Espanet, Romain Guilhaumou, Mathieu Milh, Laurent Villard

“…It was performed in a mouse model of a severe form of genetic epilepsy. The results showed that a chronic treatment with CBZ effectively reduced seizures. …”
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Animals traded for traditional medicine in Ghana: their zootherapeutic uses and implications for biodiversity conservation by Evans Paul Kwame Ameade, Daniel Korley Attuquayefio, Francis Gbogbo, Joseph Adusei-Sarkodie, Benjamin Yeboah Ofori, Stephen Gbedema, Emmanuel Adom

“…Majority of the vendors (59.1%) indicated that their clients use the animal parts for medicinal purposes mainly for skin diseases, epilepsy and fractures, while clients of 28.2% of the vendors use the animal parts for spiritual or mystical purposes, such as protection against spiritual attacks, spiritual healing and money rituals. …”
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Exploring postictal recovery with acetaminophen or nimodipine: A randomized‐controlled crossover trial by Julia C. M. Pottkämper, Joey P. A. J. Verdijk, Sven Stuiver, Eva Aalbregt, Freek tenDoesschate, Esmée Verwijk, Martin Schmettow, Guido A. vanWingen, Michel J. A. M. vanPutten, Jeannette Hofmeijer, Jeroen A. vanWaarde

“…Abstract Objective The postictal state is underrecognized in epilepsy. Animal models show improvement of postictal symptoms and cerebral perfusion with acetaminophen or nimodipine. …”
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Tissue-specific mitochondrial DNA, MT-TF, pathogenic variants in mitochondrial myopathies by Sylvia Rose, Aurélien Trimouille, Didier Lacombe, Edoardo Malfatti, Zahra Assouline, Julie Steffann, Isabelle Desguerre, Arnold Munnich, Agnès Rötig, Giulia Barcia

“…We report four patients from three families with mitochondrial myopathy associated with ptosis, sensorineural hearing loss, epilepsy, tubulointerstitial nephropathy and cardiomyopathy. …”
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Rare homozygous CNPY3 variant causing autosomal recessive developmental and epileptic encephalopathy 60: A case report by Nohela Rehman, Zohra Hasan Ali, Mahrukh Nasir, Salman Kirmani

“…Introduction: Epilepsy is one of the most common neurological disorders, affecting around 50 million people globally. …”
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Prediction Models for Risk of Cardiorespiratory Morbidity/Mortality and Fracture Among Young Adults With Cerebral Palsy by Daniel G. Whitney, Edward A. Hurvitz

“…The following predictors were included: age, sex, intellectual disabilities, epilepsy and four serum biomarkers (creatinine, glucose, calcium, carbon dioxide) from the clinical Basic/Comprehensive Metabolic Panel assay. …”
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Fetal and neonatal cardiac tumor diagnosed as Tuberous Sclerosis associated rhabdomyomas resulting from novel pathogenic missense variant detected in TSC2 gene: A case report by Aya Kawasaki, MD, Hidefumi Tonoki, MD, PhD, Osamu Sasaki, MD, PhD, Yoko Matsushita, MD, PhD, Michiko Watari, MD, PhD, Nobuhiro Takahashi, MD, Satoko Fujieda, MD

“…Multiple fetal cardiac tumors were detected on ultrasonography at 24 weeks, gestation with no other manifestation. Neither epilepsy nor mental retardation was seen after birth. …”
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