Naturally Occurring Canine Invasive Urinary Bladder Cancer: A Complementary Animal Model to Improve the Success Rate in Human Clinical Trials of New Cancer Drugs by Christopher M. Fulkerson, Deepika Dhawan, Timothy L. Ratliff, Noah M. Hahn, Deborah W. Knapp

“…Therapies aimed at specific genetic and epigenetic targets in cancer cells as well as expanded development of immunotherapies are placing increased demands on animal models. …”
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A Review of Fish Anomalies in Türkiye’s Waters by İsmail Reis, Sercan Yapıcı, Hasan Cerim, Özgen Yılmaz

“…According to the literature, possible factors causing anomalies can be discussed under four general headings; environmental (anthropogenic factors, industrial activities, industrial chemicals, trace elements, pollution, light intensity, pesticide usage), biological (endocrine system, genetic, teratological cases, epigenetic, nutritional problems, parasitic or physiologic reasons, oxidative stress, pigment deficiency), ecological (attacked by carnivores, competition, changes in water parameters), and fishery-related (ghost fishing). …”
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Mechanism of Inflammation in Age-Related Macular Degeneration by Francesco Parmeggiani, Mario R. Romano, Ciro Costagliola, Francesco Semeraro, Carlo Incorvaia, Sergio D’Angelo, Paolo Perri, Paolo De Palma, Katia De Nadai, Adolfo Sebastiani

“…Risk factors of AMD are heterogeneous, mainly including increasing age and different genetic predispositions, together with several environmental/epigenetic factors, that is, cigarette smoking, dietary habits, and phototoxic exposure. …”
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A Novel Heterozygous De Novo MORC2 Missense Variant Causes an Early Onset and Severe Neurodevelopmental Disorder by Daniel Arbide, Nour Elkhateeb, Ewa Goljan, Carolina Perez Gonzalez, Anna Maw, Soo-Mi Park

“…Microrchidia CW-type zinc finger protein 2 (MORC2) is an ATPase-containing nuclear protein which regulates transcription through chromatin remodelling and epigenetic silencing. MORC2 may have a role in the development of neurones, and dominant variants in this gene have recently been linked with disorders including Charcot-Marie-Tooth type 2Z disease, spinal muscular atrophy and, more recently, a neurodevelopmental syndrome consisting of developmental delay, impaired growth, dysmorphic facies, and axonal neuropathy (DIGFAN), presenting with hypotonia, microcephaly, brain atrophy, intellectual disability, hearing loss, faltering growth, and craniofacial dysmorphism. …”
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Role of Sex Hormones in the Development and Progression of Hepatitis B Virus-Associated Hepatocellular Carcinoma by Maurizio Montella, Giovanni D’Arena, Anna Crispo, Mario Capunzo, Flavia Nocerino, Maria Grimaldi, Antonio Barbieri, Anna Maria D’Ursi, Mario Felice Tecce, Alfonso Amore, Massimiliano Galdiero, Gennaro Ciliberto, Aldo Giudice

“…Additionally, sex hormones can also affect HBV-related hepatocarcinogenesis by inducing epigenetic changes such as the regulation of mRNA levels by microRNAs (miRNAs), DNA methylation, and histone modification in liver tissue. …”
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Genome-Wide Analysis of DNA Methylation in Human Amnion by Jinsil Kim, Mitchell M. Pitlick, Paul J. Christine, Amanda R. Schaefer, Cesar Saleme, Belén Comas, Viviana Cosentino, Enrique Gadow, Jeffrey C. Murray

“…To investigate the importance of epigenetic events in this tissue in the physiology and pathophysiology of pregnancy, we performed genome-wide DNA methylation profiling of human amnion from term (with and without labor) and preterm deliveries. …”
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The role of KLF4 in human primordial germ cell development by Sun-Min Lee, Merrick Pierson Smela, M. Azim Surani

“…Cut-and-run and transcriptomic analyses reveal that KLF4 represses somatic markers involved in neuronal and endodermal differentiation while promoting the expression of genes associated with PGC specification, such as PAX5, and epigenetic regulators, including DNMT3L and REST. KLF4 targets in hPGCLCs showed significant co-enrichment of motifs for SP and STAT factors, which are known to regulate cell cycle and migration genes. …”
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A scATAC-seq atlas of stasis zone in rat skin burn injury wound process by Ruikang Li, Jiashan Li, Shuai Liu, Xinya Guo, Jianyu Lu, Tao Wang, Tao Wang, Junjie Chen, Yue Zheng, Yue Yuan, Jiaxin Du, Jiaxin Du, Bolin Zhu, Bolin Zhu, Xiaoyu Wei, Pengcheng Guo, Longqi Liu, Longqi Liu, Xun Xu, Xi Dai, Runzhi Huang, Xin Liu, Xin Liu, Xiaoyan Hu, Shiwei Wang, Shizhao Ji

“…To understand the intricate cellular and epigenetic changes occurring within this critical zone, we utilized single-cell assay for transposase-accessible chromatin sequencing (scATAC-seq) to profile over 31,500 cells from both healthy rat skin and the stasis zone at nine different time points after a burn injury. …”
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The putative role of immune-inflammatory mechanisms in nociplastic pain pathways: a narrative review by Mariateresa Giglio, Alberto Corriero, Angela Preziosa, Giustino Varrassi, Filomena Puntillo

“…The challenge for the future will be to identify the exact role of inflammation and immunity, the cause of this activation, and its link to other pathogenetic factors of nociplastic pain, such as diet or microbiota alteration, social and phycological factors, together with a genetic and epigenetic predisposition.…”
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Alleviation of liver fibrosis by inhibiting a non-canonical ATF4-regulated enhancer program in hepatic stellate cells by Li-Xian Yang, Chuangye Qi, Si Lu, Xiang-Shi Ye, Parnaz Merikhian, Du-Yu Zhang, Tao Yao, Jiang-Sha Zhao, Ying Wu, Yongshi Jia, Bo Shan, Jinghai Chen, Xiaozhou Mou, Jia You, Wenbo Li, Yu-Xiong Feng

“…Here, we identify that ATF4, a master transcription factor in ER stress response, promotes liver fibrosis by facilitating a stress response-independent epigenetic program in hepatic stellate cells (HSCs). …”
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Altered Immune Regulation in Type 1 Diabetes by András Zóka, Györgyi Műzes, Anikó Somogyi, Tímea Varga, Barbara Szémán, Zahra Al-Aissa, Orsolya Hadarits, Gábor Firneisz

“…Genomewide association studies have helped to understand the congenital susceptibility, and hand-in-hand with the immunological research novel paths of immune dysregulation were described in central tolerance, apoptotic pathways, or peripheral tolerance mediated by regulatory T-cells. Epigenetic factors are contributing to the immune dysregulation. …”
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Mapping naturally presented T cell antigens in medulloblastoma based on integrative multi-omics by Julia Velz, Lena K. Freudenmann, Gioele Medici, Marissa Dubbelaar, Malte Mohme, David R. Ghasemi, Jonas Scheid, Daniel J. Kowalewski, Angelica B. Patterson, Anna M. Zeitlberger, Katrin Lamszus, Manfred Westphal, Matthias Eyrich, Martina Messing-Jünger, Andreas Röhrig, Harald Reinhard, Kévin Beccaria, Rogeiro B. Craveiro, Beat M. Frey, Martin Sill, Sven Nahnsen, Marie Gauder, Konstantina Kapolou, Manuela Silginer, Tobias Weiss, Hans-Georg Wirsching, Patrick Roth, Michael Grotzer, Niklaus Krayenbühl, Oliver Bozinov, Luca Regli, Hans-Georg Rammensee, Elisabeth J. Rushing, Felix Sahm, Juliane S. Walz, Michael Weller, Marian C. Neidert

“…Integration of immunopeptidomics, transcriptomics, and epigenetic data leads to the identification of a large set of actionable targets that can be further used for the translation into the clinical setting by facilitating the informed design of immunotherapeutic approaches to children with medulloblastoma.…”
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Methylation Marks of Blood Leukocytes of Native Hucul Mares Differentiated in Age by T. Ząbek, E. Semik-Gurgul, T. Szmatoła, A. Gurgul, A. Fornal, M. Bugno-Poniewierska

“…In the recent years, the research on aging includes studies of age-related epigenetic effects observed on the DNA methylation level. …”
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Emerging Marine Nematodes as Model Organisms: Which Species for Which Question? by Federica Semprucci, Eleonora Grassi, Adele Cocozza di Montanara, Roberto Sandulli, Elisa Baldrighi

“…These tiny organisms provide valuable insights into phenomena such as developmental plasticity, epigenetic regulation, and adaptive responses to environmental stress. …”
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Twist-Induced Epithelial-to-Mesenchymal Transition Confers Specific Metabolic and Mitochondrial Alterations by Haleigh N. Parker, Kayla L. Haberman, Tolulope Ojo, Juli Watkins, Adhwaitha Nambiar, Kayla Morales, Bernd Zechmann, Joseph H. Taube

“…Cells undergo significant epigenetic and phenotypic change during the epithelial-to-mesenchymal transition (EMT), a process observed in development, wound healing, and cancer metastasis. …”
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Emerging Role of Histone Acetyltransferase in Stem Cells and Cancer by Daniela Trisciuoglio, Marta Di Martile, Donatella Del Bufalo

“…In this context, different hematological and solid tumors are characterized by deregulation of the protein acetylation pattern as a result of genetic or epigenetic changes. The imbalance between acetylation and deacetylation of histone or nonhistone proteins is also involved in the modulation of the self-renewal and differentiation ability of stem cells, including cancer stem cells. …”
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Possible impact of use of a ketogenic diet in pregnancy on the fetus: Review of animal and human studies by Agata Miłosz, Justyna Michalczyk, Iwona Morawik, Klaudia Długoborska, Monika Gesek

“…In addition, it may lead to epigenetic changes in the fetus that affect the child's health and functioning in adulthood [2]. …”
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Implications of noncoding RNAs for cancer therapy: Are we aiming at the right targets? by Amil Shah

“…It now appears that dual epigenetic regulatory systems exist in higher eukaryotic cells: a ncRNA network that governs essential cell functions, like cell fate decision and maintenance of homeostasis, and a protein-based system that presides over core physiological processes, like cell division and genomic maintenance. …”
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Spatial stochastic models of cancer: Fitness, migration, invasion by Natalia L. Komarova

“…Cancer progression is driven by genetic and epigenetic events giving rise to heterogeneity of cellphenotypes, and by selection forces that shape the changingcomposition of tumors. …”
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Facioscapulohumeral muscular dystrophy: a review of pathogenesis, clinical symptoms, and treatment by T. Mikalauskas, B. Burnytė

“…The first type is characterised by a reduction in D4Z4 repeats, while the second type is characterised by mutations in genes encoding epigenetic regulators such as SMCHD1. In recent years, significant progress has been made in understanding the pathogenesis, clinical features, and progression of the disease, but there is still no specific treatment due to the obstacles in the development of gene therapy. …”
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