Influence of Genetic Variants of the N-Methyl-D-Aspartate Receptor on Emotion and Social Behavior in Adolescents by Li-Ching Lee, Ying-Chun Cho, Pei-Jung Lin, Ting-Chi Yeh, Chun-Yen Chang, Ting-Kuang Yeh

“…Considerable evidence has suggested that the epigenetic regulation of N-methyl-D-aspartate (NMDA) glutamate receptors plays a crucial role in neuropsychiatric disorders. …”
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Cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i): Mechanisms of resistance and where to find them by L. Foffano, L. Cucciniello, E. Nicolò, I. Migliaccio, C. Noto, C. Reduzzi, L. Malorni, M. Cristofanilli, L. Gerratana, F. Puglisi

“…Additionally, the importance of dissecting CDK4/6i resistance from endocrine resistance for personalized treatment is increasingly recognized.Liquid biopsy has emerged as a minimally invasive tool for identifying circulating biomarkers of resistance through the integration of multiparametric and dynamic assessments that encompass ctDNA, CTCs, exosomes, and epigenetic ctDNA alterations, representing a promising perspective for the clinical characterization of treatment resistance and guiding post-progression strategies to improve patient outcomes.Aim of this review is summarize potential mechanisms of CDK4/6i resistance, along with the advantages of using liquid biopsy to identify resistance biomarkers in HR+/HER2- MBC patients treated with CDK 4/6 inhibitors.…”
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Brd7 loss reawakens dormant metastasis initiating cells in lung by forging an immunosuppressive niche by Jayanta Mondal, Junfeng Zhang, Feng Qing, Shunping Li, Dhiraj Kumar, Jason T. Huse, Filippo G. Giancotti

“…Abstract Metastasis in cancer is influenced by epigenetic factors. Using an in vivo screen, we demonstrate that several subunits of the polybromo-associated BAF (PBAF) chromatin remodeling complex, particularly Brd7, are required for maintaining breast cancer metastatic dormancy in the lungs of female mice. …”
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<i>Phyllanthus emblica</i> Prevents Adipogenesis by Regulating Histone Acetylation by Seon Kyeong Park, Yu Geon Lee, Jae-In Lee, Min-Sun Kim, Jae-Ho Park, Jin-Taek Hwang, Min-Yu Chung

“…This study aimed to determine the preventive effect of <i>P. emblica</i> on obesity by evaluating the inhibition of adipogenesis and the related regulatory epigenetic mechanisms during 3T3-L1 differentiation. …”
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Molecular and Cellular Pathways Contributing to Joint Damage in Rheumatoid Arthritis by Qinghua Fang, Chun Zhou, Kutty Selva Nandakumar

“…Rheumatoid arthritis is a chronic autoimmune syndrome associated with several genetic, epigenetic, and environmental factors affecting the articular joints contributing to cartilage and bone damage. …”
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Theoretical underpinnings and future research on academic stress in biological and educational perspectives by Wasis Wuyung Wisnu Brata, Hendra Susanto, Siti Zubaidah

“…The review identifies four key theoretical foundations: the neurocognitive aspects of stress and performance, the neurophysiology of stress, epigenetic regulation of stress, and stress and genetic variations. …”
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Fenofibrate Exerts Antitumor Effects in Colon Cancer via Regulation of DNMT1 and CDKN2A by Rui Kong, Nan Wang, Wei Han, Wen Bao, Jie Lu

“…The PPARA agonist, fenofibrate, might serve as an applicable agent for epigenetic therapy of colon cancer patients.…”
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MethylBERT enables read-level DNA methylation pattern identification and tumour deconvolution using a Transformer-based model by Yunhee Jeong, Clarissa Gerhäuser, Guido Sauter, Thorsten Schlomm, Karl Rohr, Pavlo Lutsik

“…Abstract DNA methylation (DNAm) is a key epigenetic mark that shows profound alterations in cancer. …”
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Stress Response and Perinatal Reprogramming: Unraveling (Mal)adaptive Strategies by Laura Musazzi, Jordan Marrocco

“…These changes are likely driven by epigenetic factors that lie at the core of the stress-response reprogramming in individuals with a history of perinatal stress. …”
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CHD7 Regulates Osteogenic Differentiation of Human Dental Follicle Cells via PTH1R Signaling by Caojie Liu, Qiwen Li, Qingyue Xiao, Ping Gong, Ning Kang

“…Chromodomain helicase DNA-binding protein 7 (CHD7) is an ATP-dependent chromatin remodeling enzyme, functioning as chromatin reader to conduct epigenetic modification. Its effect on osteogenic differentiation of human dental follicle cells (hDFCs) remains unclear. …”
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Leveraging AI to automate detection and quantification of extrachromosomal DNA to decode drug responses by Kohen Goble, Aarav Mehta, Damien Guilbaud, Jacob Fessler, Jingting Chen, William Nenad, William Nenad, Christina G. Ford, Oliver Cope, Darby Cheng, William Dennis, Nithya Gurumurthy, Yue Wang, Kriti Shukla, Elizabeth Brunk, Elizabeth Brunk, Elizabeth Brunk, Elizabeth Brunk, Elizabeth Brunk

“…This pipeline is tailored to monitor ecDNA dynamics during drug treatment.ResultsOur approach effectively quantified ecDNA changes, providing a robust framework for analyzing the adaptive responses of cancer cells under therapeutic pressure.DiscussionThe pipeline not only serves as a valuable resource for automating ecDNA detection in metaphase FISH images but also highlights the role of ecDNA in facilitating swift and reversible adaptation to epigenetic remodeling agents such as JQ1.…”
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Biological functions of 5-methylcytosine RNA-binding proteins and their potential mechanisms in human cancers by Tingting Zhao, Zhe Zhang, Zhuo Chen, Guozheng Xu, Yongxi Wang, Fang Wang

“…The 5-methylcytosine (m5C) modification is a crucial epigenetic RNA modification, which is involved in the post-transcriptional regulation of genes. …”
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Pluripotent Stem Cell Metabolism and Mitochondria: Beyond ATP by Jarmon G. Lees, David K. Gardner, Alexandra J. Harvey

“…ESC similarly modulate their metabolism in response to altered metabolite levels, with changes in nutrient availability shown to have a lasting impact on derived cell identity through the regulation of the epigenetic landscape. Further, the preferential use of glucose and anaplerotic glutamine metabolism serves to not only support cell growth and proliferation but also minimise reactive oxygen species production. …”
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From heparan glycobiology to stem cell therapy: a historical perspective by Victor Nurcombe

“…Furthermore, structure-function relationships are presented, which resulted in the recognition that specific sugar-moieties and sulfation states provide a “glycocode” that is analogous to the “genetic code” and the epigenetic “histone code”. Translational avenues include the selection and biochemical tuning of heparan sugars as nanoscale scaffolds that support cell signaling for specific applications in tissue engineering and regenerative medicine. …”
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The Mammary Gland Carcinogens: The Role of Metal Compounds and Organic Solvents by Stephen Juma Mulware

“…The four most predominant mechanisms for metal carcinogenicity include (1) interference with cellular redox regulation and induction of oxidative stress, (2) inhibition of major DNA repair, (3) deregulation of cell proliferation, and (4) epigenetic inactivation of genes by DNA hypermethylation. …”
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Non-coding RNAs and exosomal ncRNAs in colorectal cancer by Yalda Zhoulideh

“…Abstract Colorectal cancer (CRC) is a complex disease with many genetic and epigenetic changes leading to dysregulation of cell signaling pathways. …”
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Implications of intratumoral microbiota in tumor metastasis: a special perspective of microorganisms in tumorigenesis and clinical therapeutics by Lei Zhang, Xichu Duan, Yanhua Zhao, Dejiu Zhang, Yuan Zhang

“…Intratumoral microbiota can modulate tumor progression through multiple mechanisms, including regulating immune responses, inducing genomic instability and gene mutations, altering metabolic pathways, controlling epigenetic pathways, and disrupting cancer-related signaling pathways. …”
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Glioblastoma Multiforme Stem Cells by Irena Dimov, Deasanka Tasic-Dimov, Irena Conic, Vladisav Stefanovic

“…There are promising mounting data on providing new molecular targets and predictive markers of response, leading to more effective therapies of GBM, guided by patient-specific genetic and epigenetic profiling. However, the achievement of efficient GBMSC targeting also requires an adequate understanding of the unique microenvironment, and the relationship with the immune system in the central nervous system (CNS) and CNS tumors. …”
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Non-metric variations in individuals who died during the perinatal period in past populations: recording protocol and comparative data by Caroline Partiot, Dominique Castex, Valérie Delattre, Bruno Maureille, Mark Guillon

“…Non-metric variations, also referred to as "epigenetic variations" or asymptomatic bone variants, are bone or dental phenotypic variants of unknown origin, with no known pathological etiology. …”
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A biallelically active embryonic enhancer dictates GNAS imprinting through allele-specific conformations by Yorihiro Iwasaki, Monica Reyes, Harald Jüppner, Murat Bastepe

“…Abstract Genomic imprinting controls parental allele-specific gene expression via epigenetic mechanisms. Abnormal imprinting at the GNAS gene causes multiple phenotypes, including pseudohypoparathyroidism type-1B (PHP1B), a disorder of multihormone resistance. …”
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