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641
RIP mutated ITS genes in populations of Ophiocordyceps sinensis and their implications for molecular systematics
Published 2020-09-01“…This is a process that detects and mutates repetitive DNA and frequently leads to epigenetic silencing, and these mutations have been interpreted as pseudogenes. …”
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642
Circulating LncRNA Is Potentially Up-regulated in Coronary Artery Disease
Published 2018-12-01“…Recent studies have revealed that aberrantly regulated long non-coding RNA (lncRNA) as one of the main classes of cellular transcript plays a key regulatory role in transcriptional and epigenetic pathways. Recent reports have demonstrated that circulating lncRNAs in the blood can be potential biomarkers for CAD. …”
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643
Cashmere cyclic growth affected by different photoperiods alters DNA methylation patterns
Published 2024-12-01“…Whole-genome bisulfite sequencing was used to study epigenetic differences in hair follicles from Inner Mongolia Albas cashmere goats during long and short photoperiods. …”
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644
Investigating DNA Methylation of Solute Carrier Genes in Colorectal Cancer: A Comprehensive Analysis Using Microarray and Bioinformatics Tools
Published 2023-12-01“…Results: This study decoded the epigenetic landscape of SLC genes in CRC, promising innovative therapeutic strategies and improved patient outcomes to combat this prevalent malignancy. …”
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645
State of the art and new directions using DNA and other molecular markers in forensic entomology
Published 2024-12-01“…Furthermore, as new types of DNA markers and methods, including those based on epigenetic phenomena, continue to be developed for human and other forensic applications, the incorporation of these new technologies into forensic entomology will further enhance the capacity of professionals in this field to provide timely and valuable information to crime investigators.…”
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646
The Role of Noncoding RNA in Airway Allergic Diseases through Regulation of T Cell Subsets
Published 2022-01-01“…Mounting evidence suggested that epigenetic alterations were strongly associated with the progression and severity of allergic diseases. …”
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647
A Systems Biology Overview on Human Diabetic Nephropathy: From Genetic Susceptibility to Post-Transcriptional and Post-Translational Modifications
Published 2016-01-01“…We performed a systematic analysis of the most relevant studies investigating genetic susceptibility and specific transcriptomic, epigenetic, proteomic, and metabolomic patterns in order to summarize the most significant traits associated with the disease onset and progression. …”
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648
Trachoma and Ocular Chlamydial Infection in the Era of Genomics
Published 2015-01-01“…We focus on the contribution of host and pathogen genetic variation, bacterial ecology of the conjunctiva, and host epigenetic imprinting including small RNA regulation by both host and pathogen in the development of ocular pathology. …”
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649
Dopamine Neurons in the Ventral Tegmental Area: An Autopsy Case of Disorganized Type of Schizophrenia
Published 2011-01-01“…The mechanisms underlying the morphological characteristics of DA neurons of the brains with schizophrenia should be elucidated epigenetically as well as genetically.…”
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650
Dietary, Metabolic, and Potentially Environmental Modulation of the Lysine Acetylation Machinery
Published 2010-01-01“…A number of scientific studies support the notion that external stimuli regulate an individual's epigenomic profile. Epigenetic changes play a key role in defining gene expression patterns under both normal and pathological conditions. …”
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651
Nutrigenomic regulation of sensory plasticity
Published 2023-03-01“…OGT also cooperates with the epigenetic silencer Polycomb Repressive Complex 2.1 (PRC2.1) to decrease chromatin accessibility and repress transcription in the high-sugar diet. …”
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652
Redox Signaling in Diabetic Nephropathy: Hypertrophy versus Death Choices in Mesangial Cells and Podocytes
Published 2015-01-01“…Main topics this review is addressing are biomarkers of oxidative stress in diabetic nephropathy, the sources of reactive oxygen species (mitochondria, NADPH-oxidases, hyperglycemia, and inflammation), and the redox-sensitive signaling networks (protein kinases, transcription factors, and epigenetic regulators). Molecular switches deciding on the renal cells fate in diabetic nephropathy are presented, such as hypertrophy versus death choices in mesangial cells and podocytes. …”
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653
Mitochondrial DNA: A New Predictor of Diabetic Kidney Disease
Published 2020-01-01“…The occurrence and development of DKD is closely related to epigenetic changes and the interaction between mtDNA, ROS, inflammatory factors, and endothelial damage, which continuously aggravates kidney. …”
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654
Periconceptional Folate Deficiency and Implications in Neural Tube Defects
Published 2012-01-01“…Nutritional deficiencies are preventable etiological and epigenetic factors causing congenital abnormalities, first cause of infant mortality. …”
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655
DNA Methylation in Prostate Cancer: Clinical Implications and Potential Applications
Published 2025-01-01“…Among emerging biomarker, DNA methylation, an epigenetic process, is increasingly being studied in carcinogenesis. …”
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656
A Pilot Proteomic Analysis of Huntington’s Disease by Functional Capacity
Published 2025-01-01“…<b>Background:</b> The molecular biology of Huntington’s Disease (HD) has grown substantially, with pathological considerations extending to genetic modifiers, epigenetic changes, transcriptomics, the proteome, and the metabolome. …”
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657
Side-stepping the guardian of the genome: current cancer therapeutics targeting mutant p53
Published 2025-01-01“…These agents can broadly be classified into six categories: the viral approach, direct modifiers of the p53 pathway, epigenetic modifiers of the p53 pathway, synthetic lethal agents, structural reactivators, and immune activating vaccines. …”
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658
Research progress of DNA methylation in the screening of cervical cancer and precancerous lesions
Published 2025-01-01“…DNA methylation is a common epigenetic modification and is considered to be closely related to the occurrence and development of tumors. …”
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659
INTESTINAL MICROBIOME - A LEADING FACTOR IN HUMAN HEALTH AND DISEASES
Published 2018-08-01“…Based on modern molecular, genetic, epigenetic microbiologic and biochemical studies it is, on the one hand, possible to identify disease-related point mutations and single nucleotide polymorphisms within genome-wide association analyses (GWAS). …”
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660
Gut Microbiota Secondary Metabolites: Key Roles in GI Tract Cancers and Infectious Diseases
Published 2025-01-01“…Recent research has highlighted the significant role of these metabolites, particularly short-chain fatty acids, indoles, and bile acids, in modulating immune responses, impacting epigenetic mechanisms, and contributing to disease processes. …”
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