Epigenetic Regulatory Mechanisms Associated with Infertility by Sheroy Minocherhomji, Prochi F. Madon, Firuza R. Parikh

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The epigenetic regulatory network of long noncoding RNAs in hepatocellular carcinoma by Zhaoqi Shi, Shengxi Jin, Xiaolong Liu, Mengting Jiang, Yifeng Fang, Parikshit Asutosh Khadaroo, Hui Lin, Xiaoxiao Fan

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Epigenetic regulatory protein chromobox family regulates multiple signalling pathways and mechanisms in cancer by Weiyu Su, Weiwen Wang, Guanghui Zhang, Lianhe Yang

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A multi-omic single-cell landscape reveals transcription and epigenetic regulatory features of t(8;21) AML by Xue-Ping Li, Yan Gao, Bai-Tian Zhao, Yu-Ting Dai, Jia-Ying Mao, Yang Liang, Lu Jiang

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Uncovering the epigenetic regulatory clues of PRRT1 in Alzheimer’s disease: a strategy integrating multi-omics analysis with explainable machine learning by Fang Wang, Ying Liang, Qin-Wen Wang

“…Objective This study employs an innovative approach that integrates multi-omics analysis and explainable machine learning to explore the epigenetic regulatory mechanisms underlying the epigenetic signature of PRRT1 implicated in AD. …”
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Potential mechanisms of epigenetic regulation in diabetic retinopathy from the perspectives of multi-omics by Xin Luo, Daxi Xue

“…A comprehensive DR-related epigenetic regulatory network was constructed, identifying hub genes. …”
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Combinatorial phenethyl isothiocyanate and withaferin A targets multiple epigenetics pathways to inhibit MCF-7 and MDA-MB-231 human breast cancer cells by Mohammad Mijanur Rahman, Trygve O. Tollefsbol

“…Conclusion Overall, our investigation demonstrated that combined PEITC and WA is effective in inhibiting MCF-7 and MDA-MB-231 BC cells by impacting multiple epigenetic regulatory pathways.…”
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SUMO modification of a heterochromatin histone demethylase JMJD2A enables viral gene transactivation and viral replication. by Wan-Shan Yang, Mel Campbell, Pei-Ching Chang

“…Our results revealed that SUMO conjugation mediates an epigenetic regulatory function of JMJD2A and suggests that inhibiting JMJD2A SUMOylation may be a novel avenue for anti-cancer therapy.…”
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Epigenome-wide Association Studies and the Interpretation of Disease -Omics. by Ewan Birney, George Davey Smith, John M Greally

“…The epigenome is especially intriguing as a target for study, as epigenetic regulatory processes are, by definition, heritable from parent to daughter cells and are found to have transcriptional regulatory properties. …”
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CELLULAR GENOME IN PATHOGENESIS OF BASIC DISEASES IN HUMANS (ATHEROSCLEROSIS, AUTOIMMUNE DISEASES, CANCER) by V. A. Kozlov

“…First of all, it concerns epigenetic regulatory mechanisms of gene expression that show virtually identical patterns of changes, i.e., total hypomethylation and reversible hypermethylation of distinct genes. …”
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DNA methylation provides new insights into the epigenetic regulation of Vibrio parahaemolyticus infection in Portunus trituberculatus by Dongfang Sun, Xianfa Zhou, Shaoting Jia, Ping Liu, Jianjian Lv

“…Research on pathogenic mechanism of V. parahaemolyticus in crustaceans has predominantly concentrated on genetics, with limited exploration of epigenetic regulatory mechanisms. Here, to elucidate the epigenetic regulatory mechanisms of crustacean resistance to V. parahaemolyticus infection, we conducted an artificial infection study on P. trituberculatus. …”
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Genetic background and biliary atresia by Jianghua Zhan, Shaowen Liu, Yu Meng, Qianhui Yang, Xingyuan Ke

“…We review advances in the genetic and epigenetic regulatory networks of BA with the aim of providing ideas for future genetic research on this disease.…”
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Emerging Epigenetic Therapeutics and Diagnostics for Autism Spectrum Disorder by Cassie Kao, Kim Kiat Lim, Ee Sin Chen

“…In this review, we summarize recent findings and emerging therapeutics for ASD, with a focus on implications of epigenetic regulatory pathways and factors. We expound the implications of these findings to enable preventive measurements for mothers to reduce the impact of ASD at birth, non-invasive diagnostic tests for early detection, and personalized medicine management. …”
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Role of epigenetics and the high-throughput sensing techniques to detect stress adaptation mechanisms in crop plants: A mini review by Dipan Adhikari, Dipan Adhikari

“…As a result of epigenetic regulatory processes such DNA methylation, histone structural modification, and RNA-based regulatory mechanisms, it is hypothesised that chromatin will alter. …”
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C-Terminal Binding Protein: A Molecular Link between Metabolic Imbalance and Epigenetic Regulation in Breast Cancer by Jung S. Byun, Kevin Gardner

“…In this review, we discuss a novel example of how shifts in the concentration and flux of substrates metabolized and generated during carbohydrate metabolism represent components of a signaling network that can influence epigenetic regulatory events in the nucleus. We refer to this regulatory process as “metabolic transduction” and describe how the C-terminal binding protein (CtBP) family of NADH-dependent nuclear regulators represents a primary example of how cellular metabolic status can influence epigenetic control of cellular function and fate.…”
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The therapeutic potential of mesenchymal stem cells in intestinal diseases: from mechanisms to clinical translation by Jia-Zhi Yang, Li-Yan He, Xian-Zhou Lu

“…Mechanistic insights into MSC-mediated intestinal repair are elucidated, with particular emphasis on emerging evidence suggesting MSC-derived exosomes may modulate ZBP1-associated H3K27 acetylation to attenuate intestinal epithelial apoptosis—a novel epigenetic regulatory axis for gastrointestinal restitution. …”
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ALKBH1: emerging biomarker and therapeutic target for cancer treatment by Ming Zhu Xiao, Jin Yin Fu, Le Tao Bo, Yi Dong Li, Zhong Wei Lin, Zhe Sheng Chen

“…Therefore, this research not only furnishes novel insights but also establishes a foundation for prospective initiatives aimed at cancer prophylaxis and therapeutics that exploit epigenetic regulatory mechanisms.…”
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Epigenetics and Herbs: Potential Therapeutic Strategies for Osteoarthritis of the Knee by Zheng Y, Wang J, Wang L, Zheng Y, Qi W

“…Recent studies have found that TCM can intervene in the epigenetic regulatory network by targeting epigenetic enzymes with active ingredients, non-coding RNA-mediated co-regulation, and epigenetic-metabolic reprogramming. …”
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Prediction of transposable element derived enhancers using chromatin modification profiles. by Ahsan Huda, Eishita Tyagi, Leonardo Mariño-Ramírez, Nathan J Bowen, Daudi Jjingo, I King Jordan

“…These data indicate that human TE-derived sequences are likely to be involved in regulating cell-type specific gene expression on a broad scale and suggest that the enhancer activity of TE-derived sequences is mediated by epigenetic regulatory mechanisms.…”
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Dextromethorphan Suppresses Lipopolysaccharide-Induced Epigenetic Histone Regulation in the Tumor Necrosis Factor-α Expression in Primary Rat Microglia by Yung-Ning Yang, Yu-Chen S. H. Yang, Pei-Ling Wu, Chun-Hwa Yang, Kuang-Che Kuo, San-Nan Yang

“…Dextromethorphan (DM) has been reported to possess neuroprotective effects in lipopolysaccharide- (LPS-) stimulated animals; however, it remains unclear whether epigenetic regulatory mechanisms in microglial cells are involved in such DM-mediated neuroprotective effects. …”
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