Complement 3a receptor 1 on macrophages and Kupffer cells is not required for the pathogenesis of metabolic dysfunction-associated steatotic liver disease by Edwin A Homan, Ankit Gilani, Alfonso Rubio-Navarro, Maya A Johnson, Odin M Schaepkens, Eric Cortada, Renan Pereira de Lima, Lisa Stoll, James C Lo

“…Together with obesity and type 2 diabetes, metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global epidemic. Activation of the complement system and infiltration of macrophages has been linked to progression of metabolic liver disease. …”
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Construction of a Vero cell line expression human KREMEN1 for the development of CVA6 vaccines by Dongqing Zhang, Yuxiang Zou, Jiaying Wu, Longfa Xu, Zhifeng Ke, Yuanyuan Wu, Zhenhong Zhou, Mujin Fang, Ling Chen, Henggang Xu, Jianping Chu, Ningshao Xia, Rui Zhu, Tong Cheng

“…Abstract Coxsackievirus A6 (CVA6) has emerged as a major pathogen causing hand, foot and mouth disease (HFMD) outbreaks worldwide. The CVA6 epidemic poses a new challenge in HFMD control since there is currently no vaccine available against CVA6 infections. …”
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Detection and Phylogenetic Analysis of Alphacoronaviruses in Bat Populations of Rostov and Novosibirsk Regions of Russia, 2021–2023 by Olesia V. Ohlopkova, Igor V. Popov, Ilia V. Popov, Kristina A. Stolbunova, Marina A. Stepanyuk, Alexey D. Moshkin, Aleksei A. Maslov, Ivan A. Sobolev, Aleksey V. Malinovkin, Elizaveta V. Tkacheva, Daria A. Bogdanova, Ekaterina A. Lukbanova, Alexey M. Ermakov, Alexander Y. Alekseev, Svetoslav D. Todorov, Alexander M. Shestopalov

“…Bats are natural reservoirs for many emerging viruses, including coronaviruses that were probably progenitors to human coronaviruses with epidemic and pandemic potential, which highlights the importance of screening studies of bat-derived viruses. …”
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The Potential Proallergenic Activity of Tranzschelia pruni-spinosae and Phragmidium rubi-idaei in vitro Studies by Sztandera-Tymoczek M, Wdowiak-Wróbel S, Świderska U, Palusińska-Szysz M, Szuster-Ciesielska A

“…Monika Sztandera-Tymoczek,1 Sylwia Wdowiak-Wróbel,2 Urszula Świderska,3 Marta Palusińska-Szysz,2 Agnieszka Szuster-Ciesielska1 1Department of Virology and Immunology, Institute of Biological Sciences, Maria Curie-Skłodowska University, Lublin, Poland; 2Department of Genetics and Microbiology, Institute of Biological Sciences, Maria Curie-Skłodowska University, Lublin, Poland; 3Department of Botany, Mycology and Ecology, Institute of Biological Sciences, Maria Curie-Skłodowska University, Lublin, PolandCorrespondence: Agnieszka Szuster-Ciesielska, Department of Virology and Immunology, Institute of Biological Sciences, Maria Curie-Skłodowska University, Akademicka 19, Lublin, 20-033, Poland, Tel +48 81 537 59 43, Email agnieszka.szuster-ciesielska@mail.umcs.plPurpose: Allergic diseases have escalated to epidemic levels worldwide, impacting nearly 30% of the global population. …”
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Factors associated with HIV testing among young women in Tanzania: Insights from the 2022 Tanzanian Demographic and Health Survey using Anderson’s Behavioral Model by Mesfin Abebe, Yordanos Sisay Asgedom, Amanuel Yosef Gebrekidan, Yohannes Addisu Wondimagegne, Habtamu Endashaw Hareru, Tsion Mulat Tebeje

“…Addressing barriers like stigma and improving access to healthcare and information through media and the internet can significantly boost HIV testing rates among young women, aiding the global effort to end the AIDS epidemic by 2030.The Anderson Behavioral Model emphasizes the importance of predisposing, enabling, and need factors in healthcare utilization, which aligns with our findings and underscores the necessity of a multifaceted approach to improve HIV testing rates.…”
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Impact of Mobile Health (mHealth) Use by Community Health Workers on the Utilization of Maternity Care in Rural Malawi: A Time Series Analysis by Kachimanga C, Ng’ambi WF, Kazinga D, Ndarama E, Amulele MA, Munyaneza F, Abejirinde IOO, van den Akker T, Kulinkina AV

“…The models were adjusted for the COVID-19 pandemic, the occurrence of cyclones, and a cholera epidemic. We analyzed data from six eligible health facilities and their respective catchment areas in which CHWs were using YendaNafe, and compared 12 months before and 12 months after its introduction.Results: The use of YendaNafe was associated with a 22% immediate increase in facility-based births (aIRR 1.22, 95% CI 1.12– 1.33, p< 0.001) but not an immediate increase in new ANC visits (aIRR 1.02,95% CI 0.90– 1.14, p=0.77), ANC in the first trimester (aIRR 1.17, 95% CI 0.95– 1.45 p=0.13), or PNC visits (aIRR 1.03, 95% CI 0.79– 1.36, p=0.81). …”
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Preparation of Tragopogon graminifolius-loaded electrospun nanofibers and evaluating its wound healing activity in a rat model of skin scar by Leila Almasi, Elham Arkan, Mohammad Hosein Farzaei, Amin Iranpanah, Cyrus Jalili, Fatemeh Abbaszadeh, Faranak Aghaz, Sajad Fakhri, Javier Echeverría

“…Moreover, in histopathological analysis, PVA/PEO/CS/TG showed a lower presence of inflammatory cells, higher density of dermis collagen fibers, and better regeneration of the epidemic layer. In addition, PVA/PEO/CS/TG elevated plasma antioxidant capacity via increasing catalase while reducing nitrite levels.ConclusionPVA/PEO/CS/TG is a promising wound dressing nanofiber with antioxidant and tissue regeneration potential. …”
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Effects of population aging on quality of life and disease burden: a population-based study by Jun-Yan Xi, Bo-Heng Liang, Wang-Jian Zhang, Bo Yan, Hang Dong, Yuan-Yuan Chen, Xiao Lin, Jing Gu, Yuan-Tao Hao

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Does viral circulation in slums have a global impact? The lesson learned from SARS-CoV-2 circulation in Complexo de favelas da Maré, Rio de Janeiro, Brazil by Monique Cristina dos Santos, Monique Cristina dos Santos, Natalia Fintelman-Rodrigues, Natalia Fintelman-Rodrigues, Aline de Paula Dias da Silva, Aline de Paula Dias da Silva, Rodolfo Leandro Nascimento Silva, Victor Corrêa Seixas, Amanda A. Batista-da-Silva, Amanda A. Batista-da-Silva, Marcelo Alves Ferreira, Patrícia T. Bozza, Fernando A. Bozza, Fernando A. Bozza, Fernando A. Bozza, Thiago Moreno L. Souza, Thiago Moreno L. Souza

“…Thus, enhancing surveillance in slums could be important for future epidemic/pandemic preparedness by connecting virus genetic diversity in this region with its circulation at divergent locations.…”
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The immune landscape and viral shedding of Omicron SARS-CoV-2 variants implicate immune escape by Weilong Zhang, Xiaoyan Gai, Zhonghui Duan, Changjian Yan, Chunyuan Huang, Chaoling Wu, Siping Zheng, Zixiang Lin, Qingtao Zhou, Lili Dai, Ping Yang, Fang Bao, Hongmei Jing, Chao Cai, Yingmin Ma, Yongchang Sun

“…BackgroundThree years into the SARS-CoV-2 pandemic, the virus continues to mutate despite widespread vaccination, posing ongoing challenges for epidemic prevention and control. The relationship between viral shedding and immune escape remains under investigation. …”
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Pre-exposure Prophylaxis Awareness and Endorsement among Adolescents and Young Adults in Tanzania: Insights from the 2022 Demographic and Health Survey by Alpha Johnson Kapola, Rahma Musoke, Glenda Marie Manayon, Hassan Fredrick Fussi, Hafidha Mhando Bakari, Haji Mbwana Ally, Swalehe Mustafa Salim, Zuhura Mbwana Ally, Lynn Moshi, Mariam Salim Mbwana, Habib Omari Ramadhani

“…Targeted interventions focused on adolescents, females, and rural communities are needed to increase PrEP awareness and usage to achieve the Joint United Nations Programme on HIV/Acquired Immune Deficiency Syndrome (AIDS) (UNAIDS) 95–95–95 goals for HIV epidemic control.…”
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Correlation between Glycated Hemoglobin Levels and Knowledge, Attitude, and Practice of Type 2 Diabetic Patients Attending Primary Health Care Centers in Dubai Health Authority by Hind Al Razooqi, Bashayer AlNajjar, Ebrahim AlShamsi, Kaltham Ibrahim, Wadeia Sharief, Hamda Khansaheb, Marwan Zidan

“…Introduction: Type 2 diabetes mellitus (DM) is not only one of the fastest-growing health problems in the world but also a burden that is reaching to epidemic proportion worldwide. Knowledge, attitude, and practice (KAP) significantly impact the outcome of self-management in patients with diabetes, yet the association between KAP of type 2 diabetes and the combined control of the glycated hemoglobin (HbA1c) level to date remains uncertain due to lack in the number of studies. …”
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Comparative efficacy and safety of GLP-1 receptor agonists for weight reduction: A model-based meta-analysis of placebo-controlled trials by Haoyang Guo, Juan Yang, Jihan Huang, Ling Xu, Yinghua Lv, Yexuan Wang, Jiyuan Ren, Yulin Feng, Qingshan Zheng, Lujin Li

“…Aim: Obesity is a global epidemic. The FDA has approved glucagon-like peptide-1 (GLP-1) receptor agonists such as Liraglutide, Semaglutide, and the GLP-1/gastric inhibitory polypeptide (GIP) dual agonist Tirzepatide for the treatment of obesity. …”
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Rationale, design, and methodology of My Body Is Fit and Fabulous at school (MyBFF@school) study: a multi-pronged intervention program to combat obesity among Malaysian schoolchild... by Abdul Halim Mokhtar, Ruziana Mona Wan Mohd Zin, Abqariyah Yahya, Fuziah Md. Zain, Rusidah Selamat, Zahari Ishak, Muhammad Yazid Jalaludin

“…Abstract Background Childhood obesity has increased rapidly in recent years and is now a global epidemic. To combat this, MyBFF@school program, a multi-faceted obesity intervention incorporating physical activity in the form of small-sided games (SSG), nutrition, and psychology components for schoolchildren was designed. …”
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Using photovoice to define “community” in substance use disorder research engaging service users, providers, and policymakers by McGladrey Margaret L, Marisa Booty, Ramona Olvera, Peter Balvanz, Hilary L. Surratt, Shannon Matthews, Susannah Stitzer, Owusua Yamoah, Sylvia Ellison, Kevin Campbell, Amy Farmer, Bethany Gealy, Mike Greenwell, Felicia Harris, Amy Kuntz, Sara Szelagowski, Alexandrea Shouse, Carrie B. Oser

“…Service provider burnout is exacerbated by competition for scarce public investments in addressing the dire need for SUD services amid the opioid epidemic. Community-engaged SUD research can be improved by defining the parameters of communities in explicit, participatory, and reflexive ways and recognizing how disinvestment and stigmatization influence relationships among community members occupying different roles in SUD services.…”
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Testing a Web-Based Interactive Comic Tool to Decrease Obesity Risk Among Racial and Ethnic Minority Preadolescents: Randomized Controlled Trial by May May Leung, Katrina F Mateo, Marlo Dublin, Laura Harrison, Sandra Verdaguer, Katarzyna Wyka

“… BackgroundChildhood obesity prevalence remains high, especially in racial and ethnic minority populations with low incomes. This epidemic is attributed to various dietary behaviors, including increased consumption of energy-dense foods and sugary beverages and decreased intake of fruits and vegetables. …”
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Application of Six Sigma in the management of caregivers of inpatients in Department of Neurology during the COVID-19 outbreak (六西格玛管理法在新型冠状病毒肺炎疫情防控期间神经内科住院患者陪护人员管理中的应用)... by PAN Xi (潘习), XU Lan (徐岚), WANG Zhi (王稚)

“…Results A significant increase in qualification rate was found in the following issues such as the maximum number of the bedside caregiver, number of visitors, investigation and registration of epidemic situation of ward (P＜0. 05) . The rate of caregivers-related conflicts dropped from 16. 99% to 1. 08%, and the rate of caregivers-related complaints dropped from 3. 92% to 0, with a significant difference (P＜0. 01). …”
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Associations of meteorological factors and ambient air pollutants with mumps incidence in Ningxia Hui Autonomous Region: boosted regression tree model analysis by Xianglong LIU, Linlin CHEN, Jiayu YU, Rui GONG, Yaogeng CHEN, Yu ZHAO

“…ObjectiveTo evaluate the associations of meteorological factors and ambient air pollutants with the incidence of mumps in Ningxia Hui Autonomous Region, and to provide a reference for the development of early warning and response systems for mumps epidemic. MethodsData on the daily number of mumps cases in Ningxia Hui Autonomous Region from 2015 to 2019 were obtained from the Notifiable Infectious Disease Surveillance System of the region, and data on meteorological factors (daily mean temperature/relative humidity/atmospheric pressure/wind speed) and air pollutants (daily concentrations of ozone, [O3], sulfur dioxide [SO2], carbon monoxide [CO], nitrogen dioxide [NO2], and particulate matter with aerodynamic diameter < 2.5/10 mum [PM2.5/PM10]) for the same period were obtained from the National Meteorological Science Data Center. …”
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Interventions for the management of post-COVID-19 condition (long COVID): protocol for a living systematic review and network meta-analysis by Paul Garner, Lawrence Mbuagbaw, Jason W Busse, Dena Zeraatkar, Thomas Agoritsas, Ariel Izcovich, Tari Turner, Lyn Turkstra, Roger S McIntyre, Rachel J Couban, Tyler Pitre, Sarah Kirsh, Tanvir Jassal, Michael Ling, Samantha Chakraborty, Signe A Flottorp

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CPEB4 modulates liver cancer progression by translationally regulating hepcidin expression and sensitivity to ferroptosis by M. Eugenia Delgado, Salvador Naranjo-Suarez, Marta Ramírez-Pedraza, Beatriz I. Cárdenas, Carmen Gallardo-Martínez, Alexandra Balvey, Eulalia Belloc, Judit Martín, Mark Boyle, Raúl Méndez, Mercedes Fernandez

“…Background &amp; Aims: Liver cancer is a significant global health issue, with its incidence rising in parallel with the obesity epidemic. The limited therapeutic options available emphasize the need for a better understanding of the molecular pathways involved in its pathogenesis. …”
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