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Hepatitis E virus infection among blood donors in Ningbo
Published 2025-01-01“…[Methods] A total of 12 227 blood samples from voluntary blood donors in Ningbo from June 2022 to May 2023 were tested for HEV serology, enzymology, and nucleic acid testing. Furthermore, HEV gene sequencing was performed for genotyping analysis, and donors with reactive nucleic acid testing results were followed up to confirm their infection status. …”
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Case Report: Novel ADA2 variants cause atypical adenosine deaminase 2 deficiency
Published 2025-01-01“…DADA2 was finally confirmed by enzymology and genetic testing, and we believe this is the first reported case of the c.1082-7T>A intronic variant in DADA2, and the RNA studies conducted in this case have been pivotal in assessing its pathogenicity.…”
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Recognition and cleavage of human tRNA methyltransferase TRMT1 by the SARS-CoV-2 main protease
Published 2025-01-01“…We also determined the structure of an Mpro-TRMT1 peptide complex that shows how TRMT1 engages the Mpro active site in an uncommon substrate binding conformation. Finally, enzymology and molecular dynamics simulations indicate that kinetic discrimination occurs during a later step of Mpro-mediated proteolysis following substrate binding. …”
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Effect of Acarbose on High Carohydrate Diet Induced Liver Injury in Largemouth Bass (Micropterus salmoides)
Published 2024-11-01“…Then, largemouth bass with an initial body weight of 7.5 mg/kg was fed with acarbose to explore the therapeutic effects of acarbose on high carbohydrate diet-induced liver injury by using gross pathology, histopathology, enzymology, and flow cytometry. In addition, six candidate Chinese herbal medicines were screened by simulating the sugar control principle of acarbose, and their therapeutic effects on high carbohydrate dietinduced liver injury were preliminarily analyzed.…”
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