Genetic analysis of ocular tumour-associated genes using large genomic datasets: insights into selection constraints and variant representation in the population by Jose S Pulido, Mandeep S Sagoo, Omar A Mahroo, Alexander Tanner

“…We explored these parameters in ocular tumour-associated genes.Methods A curated list of ocular tumour-associated genes was assessed using the genomic databases Genome Aggregation Database (gnomAD) and DatabasE of genomiC varIation and Phenotype in Humans using Ensembl Resources (DECIPHER) and compared with breast and lung cancer-associated gene lists. …”
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Distinguishing classes of neuroactive drugs based on computational physicochemical properties and experimental phenotypic profiling in planarians. by Danielle Ireland, Christina Rabeler, Sagar Rao, Rudy J Richardson, Eva-Maria S Collins

“…We used principal coordinate analysis or uniform manifold approximation and projection, each coupled with linear discriminant analysis, and two types of machine learning models-artificial neural net ensembles and support vector machines. Classification based on physicochemical properties had comparable accuracy to classification based on planarian profiling, especially with the machine learning models that all had accuracies of 90-100%. …”
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Correlation of precisely fabricated geometric characteristics of DNA-origami nanostructures with their cellular entry in human lens epithelial cells by Yexuan Guo, Tianze Xiong, Hong Yan, Rui Xue Zhang

“…To investigate cellular internalization of nanostructures in hLECs, herein, DNA nanotechnology was exploited to precisely fabricate four distinct, mass-controlled DNA-origami nanostructures (DONs) through computer-aided design. Ensembled DONs included the rods, ring, triangle, and octahedron with defined geometric parameters of accessible surface area, effective volume, compactness, aspect ratio, size and vertex number. …”
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Modeling performances of maize cultivars under current and future climate scenarios in southern central Ethiopian rift valley by Daniel Markos, Walelign Worku, Girma Mamo

“…Later, we simulated the growth and yield of maize using twenty multimodel climate ensembles across RCP 4.5 and 8.5 during early, medium and late century across Shamana, Bilate, Hawassa and Dilla clusters using DSSATv4.8 model. …”
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Emerging Risk to Dengue in Asian Metropolitan Areas Under Global Warming by Cheng Jing, Guojie Wang, Kristie L. Ebi, Buda Su, Xiaoming Wang, Dong Chen, Tong Jiang, Zbigniew W. Kundzewicz

“…We project the geographic distribution of Aedes and associated changes in populations exposed to dengue in Asian metropolitan areas under warming scenarios from 1.5°C to 5.0°C above pre‐industrial temperatures, using multi‐model ensembles. With global warming, the southern part of the Arabian Peninsula, the coast of the Arabian Sea in southern Iran, southern Pakistan in West Asia, the Korean Peninsula, most of the Japanese islands, and parts of North China in East Asia are projected to become suitable for dengue transmission. …”
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Epigene functional diversity: isoform usage, disordered domain content, and variable binding partners by Leroy Bondhus, Aileen A. Nava, Isabelle S. Liu, Valerie A. Arboleda

“…Conclusions Here we identify significant differences in isoform usage, disordered domain content, and variable binding partners between human epigenes and non-epigenes using various functional genomics datasets from Ensembl, ENCODE, GTEx, HPO, LINCS L1000, and BrainSpan. …”
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Genomic regions of Solanum tuberosum L. associated with the tuber eye depth by I. V. Totsky, I. V. Rozanova, A. D. Safonova, A. S. Batov, Yu. A. Gureeva, A. V. Kochetov, E. K. Khlestkina

“…DNA sections containing SNPs linked to the tuber’s eye depth were studied in the SolTub_3.0 potato genome assembly (https:// plants.ensembl.org/). KASP markers were developed based on the data obtained. …”
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Comparison of SNP Genotypes Related to Proliferative Vitreoretinopathy (PVR) across Slovenian and European Subpopulations by Xhevat Lumi, Mateja M. Jelen, Daša Jevšinek Skok, Emanuela Boštjančič, Metka Ravnik-Glavač, Marko Hawlina, Damjan Glavač

“…Genotype distributions of 42 SNPs among 96 Slovenian healthy controls were investigated and compared to genotype frequencies in 503 European individuals (Ensembl database) and their subpopulations. Furthermore, a case-control status was simulated to evaluate effects of allele frequency changes on statistically significant results in gene-association studies investigating functional polymorphisms. …”
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Imputation of missing land carbon sequestration data in the AR6 Scenarios Database by R. Prütz, R. Prütz, R. Prütz, R. Prütz, S. Fuss, S. Fuss, S. Fuss, J. Rogelj, J. Rogelj, J. Rogelj

“…We discuss the limitations of our approach, the use of our datasets for secondary assessments of AR6 scenario ensembles, and how this approach compares to other recent AR6 data reanalyses.…”
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Comment acquérir une compétence d’oral spontané en situation d’apprentissage institutionnalisée by Günter Schmale

“…Les structures servant de base à l’apprentissage-acquisition par l’apprenant sont décrites en tant que “constructions lexicogrammaticales”, i.e. de structures syntaxiques plus ou moins pourvues lexicalement, que les apprenants mémorisent en tant qu’ensembles holistiques à employer tels quels. Au niveau didactique, il importe, dans une perspective “constructiviste” de créer un environnement pédagogique qui permet l’apprentissage et la subséquente acquisition durable et opérationnelle des “constructions” adéquates. …”
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Increasing vulnerability of an endemic Mediterranean-climate conifer to changing climate and fire regime by Frank W. Davis, Anne-Marie Parkinson, Max A. Moritz, Max A. Moritz, Isaac W. Park, Carla M. D’Antonio

“…We also modeled the distribution of Quercus chrysolepis (CLO), a widespread oak that can be co-dominant with BDF and that can limit fire spread and reduce crown fire risk to BDF compared to the risk from surrounding chaparral vegetation. Ensembles of MAXENT and General Boosted Models were produced for a 2.1 million ha model domain encompassing BDF’s 672,000 ha range for the period 1981–2010, and were projected to 2040–2069 and 2070–2099 using three climate models (warmer-wetter, warmer, and hotter-drier) under a high emission scenario (IPCC 5th Assessment, RCP 8.5). …”
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Les vestiges fauniques de la rue Lecointre à Reims/Durocortorum : une carrière utilisée comme dépotoir by Frédéric Poupon

“…The answer is likely to be found in the monumental ensembles near the quarry, such as the polygonal temple and the amphitheater, located, respectively, 50 and 120 m from the quarry. …”
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Reims antique, acquis et perspectives by Magalie Cavé, Philippe Rollet, Régis Bontrond

“…Construction of the important ensembles of monumental decoration can be dated between the 1st c. …”
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La ferme à enclos quadrangulaire du Bois des Olivettes à Roncourt (Moselle) : une catégorie d’établissement romain largement diffusée dans la vallée mosellane by Gaël Brkojewitsch, Brice Chevaux

“…Within these farmsteads, several forms co-exist, from simple constructions composed of perishable earthen and wooden materials, built within plots of land encircled by ditches, to much more structured ensembles, forming genuine small-scale agropastoral operations. …”
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Les textiles dans les tombes gauloises à dépôt de crémation en vase métallique : usages pratiques, mises en scène et perspectives anthropologiques (seconde moitié du vie s.-ve s. a... by Elsa Desplanques

“…Archaeological and literary comparisons open up enriching avenues of reflection concerning the polysemy of these funerary ensembles. The choices highlighted by these European-wide analyses and comparisons underscore the fact that individuals embraced a practice and imbued it with a meaning that was both generic and well-rooted in local cultural and religious contexts.…”
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Dépôts et pratiques symboliques dans l’établissement aristocratique gaulois de Varennes-sur-Seine, la Justice (Seine-et-Marne) by Jean-Marc Séguier, Ginette Auxiette, Fabien Pilon

“…The study of sanctuaries, funerary ensembles and the re-examination of written sources provide a rich corpus for documenting the symbolic universe of Late Iron Age communities. …”
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