Justifying the structure of the improved mechanism for manual control of motor vehicles’ pedals by Vitaliy Korendiy, Nazarii Fedunyshyn, Vasyl Kozub

“…The results obtained can be utilized by researchers and engineers to enhance manual control mechanisms for vehicle pedals and in the practical implementation processes. …”
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Intercellular TIMP-1-CD63 signaling directs the evolution of immune escape and metastasis in KRAS-mutated pancreatic cancer cells by Chu-An Wang, Ya-Chin Hou, Yi-Kai Hong, Yu-Jing Tai, Chieh Shen, Pei-Chi Hou, Jhao-Lin Fu, Cheng-Lin Wu, Siao Muk Cheng, Daw-Yang Hwang, Yung-Yeh Su, Yan-Shen Shan, Shaw-Jenq Tsai

“…Methods Single-cell RNA sequencing and analysis of primary PDAC tumors were conducted. Genetically engineered pancreas-specific Kras-mutated, dual specificity phosphatase-2 (Dusp2) knockout mouse models were established. …”
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HOTSSea v1: a NEMO-based physical Hindcast of the Salish Sea (1980–2018) supporting ecosystem model development by G. Oldford, G. Oldford, T. Jarníková, V. Christensen, M. Dunphy

“…With the aim of addressing these gaps, we present the Hindcast of the Salish Sea (HOTSSea) v1, a 3D physical oceanographic model developed using the Nucleus for European Modelling of the Ocean (NEMO) ocean engine, with temporal coverage from 1980–2018. We used an experimental approach to incrementally assess sensitivity to atmospheric and ocean reanalysis products used for boundary forcings and to the horizontal discretisation of the model grid (<span class="inline-formula">∼</span> 1.5 km). …”
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Combined delivery of IL12 and an IL18 mutant without IL18BP-binding activity by an adenoviral vector enhances tumor specific immunity by Yan Cheng, Renjie Luo, Erguang Li

“…These results show that adenovirus armed with engineered cytokines boosts tumor specific immunity and antitumor effect.…”
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Equity in Basic Medical Education accreditation standards: a scoping review protocol by Usman Mahboob, Muhammad Irfan, Neelofar Shaheen, Ahsan Sethi

“…A systematic literature search, from inception to May 2024, will be conducted across search engines and databases including Google Scholar, PubMed, Web of Science, Wiley Online Library and ProQuest, in collaboration with a qualified librarian. …”
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Music Theory, Historically-Informed Performance, and The Significance of Cities by Adam Krims

“…It isolates the feature of wind/string balance, widely touted at the time as an advantage of the HIP approach, and measures them at key points of the movement; the resulting similarities of two of the recordings, both from London-based performers, and their pronounced divergence from the third, featuring East-Coast American performers, suggests the possibility that music workers (performers, but also engineers, producers, etc.) informed each others’ aesthetic preference and priorities, whether implicitly or explicitly. …”
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Integrated Transcriptomic and Targeted Metabolomic Analysis Reveals the Key Genes Involved in Triterpenoid Biosynthesis of <i>Ganoderma lucidum</i> by Xiaolan Xu, Chunxia Li, Fangjing Wu, Shuangshuang Zhao, Tiqiang Chen, Haihong You, Yijie Lin, Xiaoxing Zou

“…In addition, interestingly, some flavonoids and phenolic compounds, which have been reported in plants, were also detected in <i>G. lucidum</i>, indicating that it has the potential to be engineered into a strain capable of synthesizing flavonoid compounds. …”
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Assessing cell lines with inducible depletion of cohesin and condensins components through analysis of metaphase chromosome morphology by A. M. Yunusova, A. V. Smirnov, I. E. Pristyazhnuk, T. A. Shnaider, E. K. Maltseva, S. D.  Afonnikova, O. A. Gusev, N.  R. Battulin

“…A crucial aspect of development of cell lines engineered for inducible protein depletion is the selection of cell clones with efficient  auxin-dependent degradation of the protein of interest. …”
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PRMT5 inhibition has a potent anti-tumor activity against adenoid cystic carcinoma of salivary glands by Vasudha Mishra, Alka Singh, Michael Korzinkin, Xiangying Cheng, Claudia Wing, Viktoria Sarkisova, Ashwin L. Koppayi, Alexandra Pogorelskaya, Oksana Glushchenko, Manu Sundaresan, Venkat Thodima, Jack Carter, Koichi Ito, Peggy Scherle, Anna Trzcinska, Ivan Ozerov, Everett E. Vokes, Grayson Cole, Frank W. Pun, Le Shen, Yuxuan Miao, Alexander T. Pearson, Mark W. Lingen, Bruce Ruggeri, Ari J. Rosenberg, Alex Zhavoronkov, Nishant Agrawal, Evgeny Izumchenko

“…Results Using a comprehensive AI-powered engine for target identification, PRMT5 was predicted among potential therapeutic target candidates for ACC. …”
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Multimodal Imaging of Patients With Gliomas Confirms C-MET PET as a Complementary Marker to MRI for Noninvasive Tumor Grading and Intraindividual Follow-Up After Therapy by Kai R. Laukamp MD, Florian Lindemann PhD, Matthias Weckesser MD, Volker Hesselmann MD, Sandra Ligges PhD, Johannes Wölfer MD, Astrid Jeibmann MD, Bastian Zinnhardt PhD, Thomas Viel PhD, Michael Schäfers MD, Werner Paulus MD, Walter Stummer MD, Otmar Schober PhD, MD, Andreas H. Jacobs MD

“…The computer software “visualization and analysis framework volume rendering engine (Voreen)” was used for analysis of extent and intersection of tumor compartments. …”
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Detection of Bartonella spp. in foxes' populations in Piedmont and Aosta Valley (NW Italy) coupling geospatially-based techniques by Annalisa Viani, Tommaso Orusa, Sara Divari, Stella Lovisolo, Stefania Zanet, Riccardo Orusa, Enrico Borgogno-Mondino, Enrico Bollo

“…To investigate the relationship between environmental factors and Bartonella infection, data from NASA USGS Landsat missions (TOA collection) from 2011 to 2022 were processed using Google Earth Engine. The Tasseled Cap Wetness Index (TCW), an indicator of landscape moisture, was calculated for each meteorological season. …”
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Experiences of internationally educated nurses working with older adults: A scoping review protocol. by Kristina M Kokorelias, Marianne Saragosa, Reham Abdelhalim, Eleni Philippopoulos, Ann Vo

“…Grey literature will be searched using Google search engines, targeted websites and consultation with content experts. …”
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Signals of propaganda-Detecting and estimating political influences in information spread in social networks. by Alon Sela, Omer Neter, Václav Lohr, Petr Cihelka, Fan Wang, Moti Zwilling, John Phillip Sabou, Miloš Ulman

“…Their methods include the use of synchronized or individual bots, multiple accounts operated by one social media management tool, or different manipulations of search engines and social network algorithms, all aiming to promote their ideology. …”
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Mapeo semiautomático de áreas quemadas en Chimborazo-Ecuador utilizando medias compuestas de dNBR con umbrales ajustados by César Cisneros-Vaca, Julia Calahorrano, María Abarca, Mery Manzano

“…Se utilizó las colecciones de imágenes de Landsat 7 y Landsat 8 corregidas atmosféricamente y disponibles en la plataforma Google Earth Engine (GEE). Para delimitar las áreas quemadas se calculó medias compuestas de índices normalizados de áreas quemadas (NBR) en GEE y se evaluaron los umbrales de la diferencia de índices normalizados de quema (dNBR) más adecuados por encima de los cuales se delimita la quema para el herbazal de páramo. …”
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Principles of organization and structure of the management system of a holding type company by A. Borovikov, O. Smolyakov

“…The experience of improving the management systems of a number of really active groups of companies and diversified enterprises (including the sector of aviation and rocket engine building) focused on both scientific and technical, and production and commercial business, has been taken into account. …”
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An adenoviral vector encoding an inflammation-inducible antagonist, HMGB1 Box A, as a novel therapeutic approach to inflammatory diseases by Kari Ann Shirey, John Joseph, Lynda Coughlan, Haye Nijhuis, Alan W. Varley, Jorge C. G. Blanco, Stefanie N. Vogel

“…We anticipate that this strategy will apply to the treatment of multiple diseases in which HMGB1-mediated signaling is a central driver of inflammation.IMPORTANCEMany inflammatory diseases are mediated by the action of a host-derived protein, HMGB1, on Toll-like receptor 4 (TLR4) to elicit an inflammatory response. We have engineered a non-replicative AdV vector that produces HMGB1 Box A, an antagonist of HMGB1-induced inflammation, under the control of an endogenous complement component C3 (C3) promoter sequence, that is inducible by LPS and influenza in vitro and ex vivo in macrophages (Mϕ) and protects mice and cotton rats therapeutically against infection with mouse-adapted and human non-adapted influenza strains, respectively, in vivo. …”
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Network analysis reveals potential mechanisms that determine the cellular identity of keratinocytes and corneal epithelial cells through the Hox/Gtl2-Dio3 miRNA axis by Yanjie Guo, Weini Wu, Haoyu Chen, Xueqi Wang, Yi Zhang, Shuaipeng Li, Xueyi Yang

“…As a result of this shared origin, corneal epithelial cells may exhibit the same characteristics as the skin epidermis in pathological situations, while keratinocytes are ideal seed cells for tissue-engineered corneas. However, how the identities of keratinocytes and corneal epithelial cells are determined is currently unclear. …”
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A novel USP4 inhibitor that suppresses colorectal cancer stemness by promoting β-catenin and Twist1 degradation by Fengtian Li, Yi Zhou, Xinyue Lin, Yaxin Zhang, Qingyong Hu, Enen Zhao, Huali Li, Xingyan Pan, Feng Shu, Kun Zhang, Chengmei Huang, Na Tang, Wenting Liao

“…Treatment with U4-I05 also inhibited tumor metastasis and extended survival in a genetically engineered CRC mouse model. Conclusions This study identifies U4-I05 as a USP4 inhibitor with significant therapeutic efficacy against CRC, offering a promising avenue for the development of new treatments targeting cancer stemness and chemotherapy resistance. …”
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Monoallelic variants resulting in substitutions of MAB21L1 Arg51 Cause Aniridia and microphthalmia. by Hildegard Nikki Hall, Hemant Bengani, Robert B Hufnagel, Giuseppe Damante, Morad Ansari, Joseph A Marsh, Graeme R Grimes, Alex von Kriegsheim, David Moore, Lisa McKie, Jamalia Rahmat, Catia Mio, Moira Blyth, Wee Teik Keng, Lily Islam, Meriel McEntargart, Marcel M Mannens, Veronica Van Heyningen, Joe Rainger, Brian P Brooks, David R FitzPatrick

“…These mutations occurred de novo in 3/5 families, with the remaining families being compatible with autosomal dominant inheritance. Mice engineered to carry the p.Arg51Leu change showed a highly-penetrant optic disc anomaly in heterozygous animals with severe microphthalmia in homozygotes. …”
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Dual Role of Bacteria in Carcinoma: Stimulation and Inhibition by Suad A Al-Hilu, Wisam H Al-Shujairi

“…Therefore, the world has turned to an alternative solution, which is the use of genetically engineered microorganisms; thus, the use of living bacteria targeting cancerous cells is the unique option to overcome these challenges. …”
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