Showing 57,001 - 57,020 results of 59,424 for search '"Engineering"', query time: 0.23s Refine Results
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    Advancements in bioengineered and autologous skin grafting techniques for skin reconstruction: a comprehensive review by Jillian Dean, Cosima Hoch, Barbara Wollenberg, Justin Navidzadeh, Bhagvat Maheta, Anisha Mandava, Samuel Knoedler, Khalil Sherwani, Helena Baecher, Alina Schmitz, Michael Alfertshofer, Max Heiland, Kilian Kreutzer, Steffen Koerdt, Leonard Knoedler

    Published 2025-01-01
    “…Bioengineered skin grafts (BSGs) aim to address these drawbacks through advanced tissue engineering and biomaterial science. This study conducts a systematic review to describe the benefits and shortcomings of BSGs and ASGs across wound healing efficacy, tissue integration, immunogenicity, and functional outcomes focusing on wound re-epithelialization, graft survival, and overall aesthetic outcomes. …”
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    INBRX-120, a CD8α-targeted detuned IL-2 that selectively expands and activates tumoricidal effector cells for safe and durable in vivo responses by Jason Ho, Chelsie Macedo, Garrett Cyprus, Rajay Pandit, Anya Polovina, Nadja Kern, Abrahim Hussain, Sae Jeong Ahn, William Crago, Emily Rowell, Florian J Sulzmaier, John C Timmer, Brendan P Eckelman

    Published 2023-01-01
    “…Despite promising activity in a subset of patients, wider therapeutic utility of IL-2 (aldesleukin) has been hampered by severe dose-limiting toxicities, the expansion of immunosuppressive regulatory T cells and a poor pharmacokinetic (PK) profile. Recent engineering efforts, including non-α IL-2 variants, have lowered the toxicity profile, but have yet to induce meaningful antitumor activity in a wider patient population.Methods We engineered INBRX-120, a CD8α-targeted Cisleukin™ molecule consisting of an affinity tuned IL-2 (IL2-x) connected to two high affinity CD8α-specific single domain antibodies via an effector-silenced Fc domain. …”
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  12. 57012
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    Conversion of placental hemogenic endothelial cells to hematopoietic stem and progenitor cells by Guixian Liang, Shicheng Liu, Chunyu Zhou, Mengyao Liu, Yifan Zhang, Dongyuan Ma, Lu Wang, Jing-Dong J. Han, Feng Liu

    Published 2025-01-01
    “…In the embryo, hematopoietic stem cells (HSCs) arise from hemogenic endothelial (HE) cells lining the major arteries in vivo. In this work, by engineering vascular niche endothelial cells (VN-ECs), we generated functional HSPCs in vitro from ECs at various sites, including the aorta-gonad-mesonephros (AGM) region and the placenta. …”
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    Combining Unity with machine vision to create low latency, flexible and simple virtual realities by Yuri Ogawa, Raymond Aoukar, Richard Leibbrandt, Jake S. Manger, Zahra M. Bagheri, Luke Turnbull, Chris Johnston, Pavan K. Kaushik, Jaxon Mitchell, Jan M. Hemmi, Karin Nordström

    Published 2025-01-01
    “…We created a novel virtual reality arena combining machine vision with the gaming engine Unity. For tethered flight, we enhanced an existing multi‐modal virtual reality arena, MultiMoVR, but tracked wing movements using DeepLabCut‐live (DLC‐live). …”
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