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Hypothalamic AMPK as a Regulator of Energy Homeostasis
Published 2016-01-01“…Here we explore the factors that affect hypothalamic AMPK activity and give the underlying mechanisms for the role of central AMPK in energy homeostasis together with the physiological effects of hypothalamic AMPK on energy balance restoration.…”
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Dendrobium species regulate energy homeostasis in neurodegenerative diseases: a review
Published 2023-11-01Subjects: Get full text
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Function of Dicer with regard to Energy Homeostasis Regulation, Structural Modification, and Cellular Distribution
Published 2020-01-01“…The close relationship between Dicer levels and fluctuations of nutrient availability suggests that the protein participates in the regulation of systemic energy homeostasis. Through miRNAs, Dicer regulates the hypothalamic melanocortin-4 system and central autophagy promoting energy expenditure. …”
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Resistance to the Beneficial Metabolic Effects and Hepatic Antioxidant Defense Actions of Fibroblast Growth Factor 21 Treatment in Growth Hormone-Overexpressing Transgenic Mice
Published 2015-01-01“…Fibroblast growth factor 21 (FGF21) modulates a diverse range of biological functions, including glucose and lipid metabolism, adaptive starvation response, and energy homeostasis, but with limited mechanistic insight. …”
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Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation
Published 2010-01-01“…The peroxisome proliferator-activated receptors (PPARs) are central regulators of fat metabolism, energy homeostasis, proliferation, and inflammation. The three PPAR subtypes, PPAR𝛼, 𝛽/𝛿, and 𝛾 activate overlapping but also very different target gene programs. …”
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Fever
Published 2010-01-01“…We also show how fever research provided new insights into temperature and energy homeostasis, and into treatment of infection and inflammation.…”
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The Mla pathway promotes Vibrio cholerae re-expansion from stationary phase
Published 2025-02-01“…Our findings suggest that the defects in cellular energy homeostasis that emerge in the absence of the Mla pathway underlie its importance in maintaining V. cholerae culturability.…”
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Sex Differences in Energy Metabolism Need to Be Considered with Lifestyle Modifications in Humans
Published 2011-01-01“…Moreover, elucidating the regulatory role of hormones in energy homeostasis is important for understanding the pathogenesis of obesity and perhaps in the future may lead to ways to reduce body fat with less energy restriction.…”
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Contribution of Neuroinflammation to the Pathogenesis of Cancer Cachexia
Published 2015-01-01“…Robust data indicate that, during cancer, functional modifications within brain areas regulating energy homeostasis contribute to the onset of anorexia, reduced food intake, and increased catabolism of muscle mass and adipose tissue. …”
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Peroxisome Proliferator-Activated Receptors in Lung Cancer
Published 2007-01-01“…Their discovery in the 1990s provided insights into the cellular mechanisms involved in the control of energy homeostasis; the regulation of cell differentiation, proliferation, and apoptosis; and the modulation of important biological and pathological processes related to inflammation, among others. …”
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Adropin: a key player in immune cell homeostasis and regulation of inflammation in several diseases
Published 2025-01-01“…Adropin is a secreted peptide encoded by the energy homeostasis-associated gene (ENHO), located chromosome 9p13.3, with a conserved amino acid sequence across humans and mice. …”
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Extra Fructose in the Growth Medium Fuels Lipogenesis of Adipocytes
Published 2014-01-01“…Apart from toxic action on liver cells, adipocytes might be stimulated to take up extra fructose and generate new lipid vesicles, further dysregulating energy homeostasis.…”
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The Role of Peroxisome Proliferator-Activated Receptors in Colorectal Cancer
Published 2012-01-01“…Some nuclear hormone receptors play an important role in regulating nutrient metabolism and energy homeostasis. Among these receptors, special attention has been focused on the role of peroxisome proliferator-activated receptors (PPARs) in colorectal cancer, because PPARs are involved in regulation of lipid and carbohydrate metabolism. …”
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The hypothalamus as the central regulator of energy balance and its impact on current and future obesity treatments
Published 2025-01-01“…The signals then proceed to third- and fourth-order neurons that activate complex responses aimed at maintaining whole-body energy homeostasis. During the last 30 years, since the identification of leptin in 1994, there has been a great advance in the unveiling of the hypothalamic and extra-hypothalamic neuronal networks that control energy balance. …”
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Drosophila melanogaster as an alternative animal model in fat metabolism studies
Published 2024-07-01“…It is discovered that Drosophila accommodates a range of cell types and organs which entail lipid metabolism and related energy homeostasis similar to those of mammals. Fat storage in Drosophila occurs in the form of lipid droplets carrying cholesterol and triacylglycerol which are accumulated primarily in the fat body – the analogous Drosophila organ to mammalian adipose tissue. …”
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PPAR𝜸 and Oxidative Stress: Con(𝜷) Catenating NRF2 and FOXO
Published 2012-01-01“…Peroxisome-proliferator activator receptor γ (PPARγ) is a nuclear receptor of central importance in energy homeostasis and inflammation. Recent experimental pieces of evidence demonstrate that PPARγ is implicated in the oxidative stress response, an imbalance between antithetic prooxidation and antioxidation forces that may lead the cell to apoptotic or necrotic death. …”
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Adropin as an indicator of T2DM and its complications
Published 2022-11-01“…As a secreted peptide, adropin is identified as a useful regulator associated with insulin sensitivity and energy homeostasis. It has the potential for regulating metabolic diseases including obesity and T2DM. …”
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Peroxisome Proliferator-Activated Receptor γ and PGC-1α in Cancer: Dual Actions as Tumor Promoter and Suppressor
Published 2018-01-01“…PPARγ coactivator-1α (PGC-1α), initially identified as a PPARγ-interacting protein, is an important regulator of diverse metabolic pathways, such as oxidative metabolism and energy homeostasis. The role of PGC-1α in diabetes, neurodegeneration, and cardiovascular disease is particularly well known. …”
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A mouse model of Bardet-Biedl Syndrome has impaired fear memory, which is rescued by lithium treatment.
Published 2021-04-01“…Primary cilia are microtubule-based organelles present on most cells that regulate many physiological processes, ranging from maintaining energy homeostasis to renal function. However, the role of these structures in the regulation of behavior remains unknown. …”
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