Metabolic reprogramming and immunological changes in the microenvironment of esophageal cancer: future directions and prospects by Zhi-Xun Guo, Jia-Li Ma, Jin-Qiu Zhang, Ling-Ling Yan, Ying Zhou, Xin-li Mao, Xin-li Mao, Xin-li Mao, Shao-Wei Li, Shao-Wei Li, Shao-Wei Li, Xian-Bin Zhou, Xian-Bin Zhou, Xian-Bin Zhou

“…Metabolic reprogramming in tumors frequently coincides with aberrant immune function alterations, and extensive research has demonstrated that perturbations in energy metabolism within the tumor microenvironment influence the occurrence and progression of esophageal cancer. …”
Get full text

Characterization of the Collagen Extraction Manufacturing Process Using Markov Chains and Artificial Neural Networks by Rosa Trasvina-Osorio, Sergio Alonso-Romero, Juan de Anda-Suarez, Valentin Calzada-Ledesma, Javier Yanez-Mendiola, Luis Fernando Villanueva-Jimenez, Erick Rojas-Mancera

“…The product of this research is a four-dimensional predictive model that estimates the yield with decreasing material, energy resources, and the time required for the collagen extraction process from the skin waste of tilapia. …”
Get full text

Acid-Unlocked Two-Layer Ca-Loaded Nanoplatform to Interfere With Mitochondria for Synergistic Tumor Therapy by Zheng Y, Williams GR, Hu R, Tong S, Xu J, Wang T, Zhang Y, Wu J, Li F, Cai Y, Zhu LM

“…Yilu Zheng,1 Gareth R Williams,2 Ran Hu,1 Sen Tong,3 Jianxiang Xu,1 Tong Wang,1 Yanyan Zhang,1 Junzi Wu,3 Fan Li,4 Yingyu Cai,4 Li-Min Zhu1 1College of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai, 201620, People’s Republic of China; 2UCL School of Pharmacy, University College London, London, WC1N 1AX, UK; 3The Key Laboratory of Microcosmic Syndrome Differentiation, Education Department of Yunnan, Yunnan University of Chinese Medicine, Kunming, 650500, People’s Republic of China; 4Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, People’s Republic of ChinaCorrespondence: Yingyu Cai, Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, People’s Republic of China, Email yingyu.cai@shgh.cn Li-Min Zhu, College of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai, 201620, People’s Republic of China, Email lzhu@dhu.edu.cnBackground: The development of selective formulations able to target and kill tumor cells without the application of external energy has shown great promise for anti-tumor therapy.Methods: Here, we report a “nanobomb” that explosively increases Ca content within cells. …”
Get full text

The moderating effect of self-efficacy on the relationship between parents and children and academic participation, considering the mediating variable of learning adaptation among... by meysam karamipour, samaneh mataji, rezvaneh kazem nezhad, maryam esfandyari

“…The current research is applicable in terms of purpose, and descriptive-correlative in terms of nature and method. …”
Get full text

Presenting a model of ecotourism and sustainable tourism development with an emphasis on foreign exchange and economic development of Qeshm Island by Naser Rajabi, Vahid Reza Mirabi, Khosro Moradi Shahdadi

“…AbstractThe purpose of the current research is to provide a model of ecotourism and sustainable tourism development with an emphasis on foreign exchange and economic development of Qeshm Island. …”
Get full text

WRF-Chem simulations of snow nitrate and other physicochemical properties in northern China by X. Wang, X. Wang, T. Che, T. Che, X. Ruan, S. Yue, S. Yue, J. Wang, J. Wang, C. Zhao, C. Zhao, C. Zhao, L. Geng, L. Geng, L. Geng

“…<p>Snow is a key component of the cryosphere and has significant impacts on surface energy balance, hydrology, atmospheric circulation, etc. …”
Get full text

Constraints on Relativistic Jets from the Fast X-Ray Transient 210423 Using Prompt Radio Follow-up Observations by Dina Ibrahimzade, R. Margutti, J. S. Bright, P. Blanchard, K. Paterson, D. Lin, H. Sears, A. Polzin, I. Andreoni, G. Schroeder, K. D. Alexander, E. Berger, D. L. Coppejans, A. Hajela, J. Irwin, T. Laskar, B. D. Metzger, J. C. Rastinejad, L. Rhodes

Get full text

Adaptive Path Following and Locomotion Optimization of Snake-Like Robot Controlled by the Central Pattern Generator by Zhengcai Cao, Dong Zhang, Biao Hu, Jinguo Liu

“…To optimize the locomotion efficiency, it takes energy consumption and forward velocity into account to investigate the optimal locomotion parameters of snake-like robots controlled by a central pattern generator (CPG) controller. …”
Get full text

Impact of childhood maltreatment on adolescents’ mental health– a longitudinal study based on dual-factor model by Qingji Zhang, Yeman Tu, Shunyu Yao, Qingdi Zhang, Jiangnan Liu, Peng Quan

Get full text

DISPERSION RELATIONS IN BILAYER GRAPHENE AT FINITE TEMPERATURE by Nguyen Van Men

“…Recently, graphene, a perfect two-dimensional structure, has attracted a large amount of interest from researchers due to its unique properties and possible applications in a variety of technological fields. …”
Get full text

Toward sustainable desalination: a patent analysis of technology-development trajectories by Kyungsun Lee, Wendy Jepson

“…Research and development (R&D) in desalination has enabled innovations and expanded global water-supply capacity to enhance water security. …”
Get full text

Influence of Genetics, Immunity and the Microbiome on the Prognosis of Inflammatory Bowel Disease (IBD Prognosis Study): the protocol for a Copenhagen IBD Inception Cohort Study by Johan Burisch, Lene Terslev, Mikkel Østergaard, Annette Bøjer Jensen, Frank Krieger Jensen, Flemming Bendtsen, Charlotte Wiell, Mohamed Attauabi, Klaus Theede, Viktoria Fana, Hartwig Roman Siebner, Henrik S Thomsen, Jakob M Møller, Simon Francis Thomsen, Gorm Roager Madsen, Anne Vibeke Wewer, Rune Wilkens, Johan Ilvemark, Nora Vladimirova, Sanja Bay Hansen, Yousef Jesper Wirenfeldt Nielsen, Helene Andrea Sinclair Ingels, Trine Boysen, Jacob T Bjerrum, Christian Jakobsen, Maria Dorn-Rasmussen, Sabine Jansson, Yiqiu Yao, Ewa Anna Burian, Frederik Trier Møller, Kristina Bertl, Andreas Stavropoulos, Jakob B Seidelin

Get full text

Associations between accurate measures of adiposity and fitness, blood proteins, and insulin sensitivity among South Asians and Europeans by Pik Fang Kho, Pik Fang Kho, Laurel Stell, Shirin Jimenez, Shirin Jimenez, Daniela Zanetti, Daniela Zanetti, Daniela Zanetti, Daniel J. Panyard, Kathleen L. Watson, Ashish Sarraju, Ashish Sarraju, Ming-Li Chen, Ming-Li Chen, Lars Lind, John R. Petrie, Khin N. Chan, Holly Fonda, Kyla Kent, Kyla Kent, Jonathan N. Myers, Jonathan N. Myers, Jonathan N. Myers, Latha Palaniappan, Latha Palaniappan, Latha Palaniappan, Fahim Abbasi, Themistocles L. Assimes, Themistocles L. Assimes, Themistocles L. Assimes, Themistocles L. Assimes

Get full text

Impact of mineral dust on the global nitrate aerosol direct and indirect radiative effect by A. Milousis, K. Klingmüller, A. P. Tsimpidi, J. F. Kok, M. Kanakidou, M. Kanakidou, M. Kanakidou, A. Nenes, A. Nenes, V. A. Karydis

Get full text

Kinetics, modelling and optimization of Shea butter transesterification via clay doped ionic liquid catalyst by Nwosu-Obieogu Kenechi, Ude Callistus Nonso, Onukwuli Dominic Okechukwu, Ezeugo Joseph

“…Developing a cost effective and sustainable fuel from inedible oils and enhancing transesterification process via heterogeneous catalyst with high selectivity prompted this research. The study focuses on evaluating the kinetics, modelling, and optimization of shea butter biodiesel using a clay-doped ionic liquid catalyst. …”
Get full text

Digestibility of pre-treated cassava peel as feed ingredient for Nile tilapia by , Mulyasari, Feri Kurniawati, Mia Setiawati

“…ABSTRACT   This research aimed at determining digestibility coefficient of cassava peel(Manihot utilissima) after immersion in 3% (w/v) NaOH for three days, fermentation using combined fungi of 10% Trichoderma viride and Phanerochaete chrysosporium for seven days, and fermentation using 15% (w/w) Bacillus megaterium for five days as feed ingredients for Nile tilapia Oreochromis niloticus. …”
Get full text

Associations between oxidation balance score and abdominal aortic calcification, and the mediating role of glycohemoglobin: a nationally representative cross-sectional study from N... by Heqian Liu, Yifei Wu, Zhenyu Liu, Hongzhi Ren, Ya Wu, Ya Wu, Yong Liu, Yong Liu, Yong Liu

Get full text

The Relationship Between Screen Time, Sleep and Obesity by Dominika Lewandowska, Dominika Rosińska-Lewandoska, Zofia Podraza, Dominika Strep, Julia Grabowska, Jakub Rosiński, Zofia Głowniak, Maciej Kwiatkowski, Izabela Kwiatkowska, Malwina Soja

“…Public health strategies and educational campaigns are essential to raise awareness and promote healthier screen habits. Future research should focus on longitudinal studies and scalable …”
Get full text

Experimental Study on the Influence of Buried Geothermal Pipes on the Temperature Field of Concrete Roads by Yan Tan, Jun Song, Zhi Chen, Henglin Xiao

“…Ensuring that the road surface temperature is above 0°C, the heating system is turned on intermittently to save energy. The research provides theoretical support for preventing road snow and freezing.…”
Get full text

Accurate estimation of Jujube leaf chlorophyll content using optimized spectral indices and machine learning methods integrating geospatial information by Nigela Tuerxun, Sulei Naibi, Jianghua Zheng, Renjun Wang, Lei Wang, Binbin Lu, Danlin Yu

“…Leaf chlorophyll content (LCC) is vital for photosynthesis and ecosystem functioning; it influences carbon, water, and energy exchanges while serving as an indicator of photosynthetic activity and nitrogen levels in precision agriculture. …”
Get full text