Cost–utility and budget impact analysis of tocilizumab for the treatment of refractory systemic juvenile idiopathic arthritis in Thailand by Nitichen Kittiratchakool, Disorn Kulpokin, Chonticha Chanjam, Soamarat Vilaiyuk, Sirirat Charuvanij, Gun Phongsamart, Parichat Khaosut, Manasita Tanya, Ratanavadee Nanagara, Sira Nantapaisarn, Pattara Leelahavarong

“…Objectives This study aimed to analyse the cost–utility and budget impact of adding tocilizumab to the standard treatment for patients with refractory systemic juvenile idiopathic arthritis (sJIA) in Thailand.Design Economic evaluation using a decision-analytical model.Setting Thailand.Participants Patients with refractory sJIA who were ≥2 years old.Methods The use of tocilizumab as an add-on therapy to standard treatment was compared with standard treatment alone. …”
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Young, Empowered & strong (YES): a study protocol paper for a randomized controlled trial of an mHealth symptom monitoring and self-management intervention for adolescent and young... by Kate E Dibble, Shoshana M Rosenberg, Craig Snow, Gregory J Kirkner, Nabihah Tayob, Magnolia Contreras, Noel D Roma, Cecilia R DeGraffinreid, Timiya S Nolan, Dawn L Hershman, Michelle Naughton, Ann H Partridge

“…., fertility, genetics, relationships, economic attainment). Improved attention to concerns and symptoms may improve symptom management and quality of life. …”
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Seasonal Changes in the Elemental Composition of Five Valuable Fish Species (<i>Sparidae</i>) from Bozcaada, North Aegean Sea: A Health Risk and Nutritional Benefit Assessment by İlknur Yuvka, Ali Rıza Kosker, Mustafa Durmus, Yılmaz Ucar, Yesim Ozogul

“…This study investigates the seasonal variations in the elemental composition of five economically valuable <i>Sparidae</i> fish species from Bozcaada, North Aegean: red seabream (<i>Pagrus major</i>), gilthead seabream (<i>Sparus aurata</i>), saddled seabream (<i>Oblada melanura</i>), white seabream (<i>Diplodus sargus</i>), and common dentex (<i>Dentex dentex</i>), with a focus on both essential minerals and toxic metals. …”
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Targeting and editing the second exon of bmp6 gene results in a silver carp with reduced intramuscular bones by Shuang Niu, Xiaohui Li, Cui Feng, Zewen Zhang, Hang Sha, Xiangzhong Luo, Guiwei Zou, Hongwei Liang

“…Intermuscular bones (IBs) are needle-like bones frequently observed within the muscle septa of cyprinid fish, which adversely affects fish palatability and economic value. The deletion of bmp6 has been shown to lead the absence of IBs in fish, without affecting normal growth. …”
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Impact of Physical Features on Visual Walkability Perception in Urban Commercial Streets by Using Street-View Images and Deep Learning by Gonghu Huang, Yiqing Yu, Mei Lyu, Dong Sun, Bart Dewancker, Weijun Gao

“…Therefore, promoting the development of a high-quality walking environment in commercial districts is crucial for fostering urban economic growth and the creation of livable cities. …”
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Systematic review of the impact of non-alcoholic fatty liver disease on mortality and adverse clinical outcomes for individuals with chronic kidney disease by Paul Roderick, Julie Parkes, Theresa Hydes, Ryan Buchanan, Oliver J Kennedy, Simon Fraser

“…This should be a focus for future research as both conditions continue to rise in prevalence and have end-stage events associated with significant health and economic costs.PROSPERO registration number CRD42020166508.…”
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From across the globe – traumatic injuries are an international concern at the US-Mexico border wall by Allison E Berndtson, Jay Doucet, Todd W Costantini, Laura Haines, Sarah Lagan, Laura Adams, Jarrett Santorelli, Gabriella Waters

“…Introduction Socio-economic and political events of recent years have caused a significant increase in immigrants attempting to illegally cross the United States (US)-Mexico border. …”
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Data-driven insights into pre-slaughter mortality: Machine learning for predicting high dead on arrival in meat-type ducks by Chalita Jainonthee, Phutsadee Sanwisate, Panneepa Sivapirunthep, Chanporn Chaosap, Raktham Mektrirat, Sudarat Chadsuthi, Veerasak Punyapornwithaya

“…Elevated rates of DOA frequently signify substandard welfare conditions and might stem from multiple causes, resulting in diminished productivity and economic losses. This study included 18,643 truckload entries from 45 farms, encompassing a total of 23,191,809 meat-type ducks sent to a single slaughterhouse in Eastern Thailand between January 2019 and December 2023. …”
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Remote sensing-based maize growth process parameters revel the maize yield: a comparison of field- and regional-scale by Minghan Cheng, Xiuliang Jin, Chenwei Nie, Kaihua Liu, Tianao Wu, Yuping Lv, Shuaibing Liu, Xun Yu, Yi Bai, Yadong Liu, Lin Meng, Xiao Jia, Yuan Liu, Lili Zhou, Fei Nan

“…Abstract The accurate estimation of regional crop yields holds significant importance for optimizing subsequent resource allocation and maximizing economic returns in agriculture. Crop yield can be effectively estimated by assessing the overall growth status through long-term remote sensing observations. …”
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Ecological security driving mechanisms and optimization of zoning in Chinese urban agglomerations: A case study of the central plains urban agglomeration by Jinyuan Zhang, Xuning Qiao, Yongju Yang, Liang Liu, Yalong Li, Shengnan Zhao

“…In light of mounting ecological security challenges, including disparities in ecological efficiency and growing constraints from resource and environmental limitations, the CPUA urgently requires achieving a balance and mutually beneficial relationship between economic growth and ecological protection. This study examines 271 counties within the CPUA, utilizing both objective and subjective weighting methods to assess ecological security from a three-dimensional perspective, encompassing ecosystem health, landscape ecological risk, and ecosystem services over the period from 2000 to 2020. …”
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Evaluation of ecological geological environment carrying capacity and analysis of driving mechanisms based on normal cloud model and geodetector model by Rongkun Dai, Changlai Xiao, Xiujuan Liang, Lin Jia, Yi Jia, Jiarui Yao, Weifei Yang, Jiang Zhang, Linzuo Zhang, Weifeng Li

“…The findings demonstrate that: (1) The overall EGECC in the Luoyang region of the YRB fluctuates upward, with the eastern area displaying more favorable conditions compared to the western region. (2) Over these twenty-two years, the geological environment system experienced initial deterioration followed by improvement, the ecological environment system remained relatively stable, and social and economic development continuously strengthened. (3) Landform types, elevation, human activity impact index, population density, and geological disaster susceptibility are the main driving elements for the assessment of the ecological geological environment system. …”
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Comprehensive agrobiological assessment and analysis of genetic relationships of promising walnut varieties of the Nikitsky Botanical Gardens by Yu. V. Plugatar, I. I. Suprun, S. Yu. Khokhlov, I. V. Stepanov, E. A. Al-Nakib

“…On the basis of the performed phenotypic assessment, the study sample, which included 31 varieties, was divided into several groups according to the main phenotypic traits, such as frost and drought resistance, the start of the growing season, the ripening period, the weight and type of flowering, the weight of the fruit, and the thickness of the endocarp. Varieties with economically valuable traits that can be recommended as promising as initial parental forms in breeding work for resistance to abiotic stress factors have been identified, as well as varieties with increased productivity and large fruit sizes. …”
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Serological Evidence of Infectious Laryngotracheitis Infection and Associated Risk Factors in Chickens in Northwestern Ethiopia by Mastewal Birhan, Ashenafi Syoum, Saddam Mohammed Ibrahim, Tewodros Fentahun, Addisu Mohammed, Nega Berhane, Molalegne Bitew, Esayas Gelaye, Malede Birhan Atanaw, Belayneh Getachew, Bereket Dessalegn, Anmaw Shite Abat, Kassahun Berrie, Kassaye Adamu, Takele Abayneh

“…Infectious laryngotracheitis (ILT) is a disease of high economic consequence to the poultry sector. Gallid herpesvirus 1 (GaHV-1), a.k.a infectious laryngotracheitis virus (ILTV), under the genus Iltovirus, and the family Herpesviridae, is the agent responsible for the disease. …”
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Effects of cassava pellets and enzymes addition on growth performance, meat quality, serum biochemical indices and cecum microbiota of broilers by Dan Yue, Ying Lu, Jin Zhao, Xiaoming He, Junhong Zhu, Jiawei Liang, Weidong Deng

“…The addition of 10 % cassava pellets to the diet improved the growth performance and meat quality of broilers from 1 to 21 days of age and enhanced the microbial composition, providing valuable insights for optimizing broiler diets and improving economic returns.…”
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Professional Barriers in Energy Efficiency Retrofits—A Solution Based on Information Flow Modeling by Xilong Liao, Chun Wang, Baiyi Li, Baizhan Li, Chenqiu Du

“…The analysis uncovers that the primary obstacles to energy-saving renovations are categorized into technical, economic, environmental, and other barriers. These barriers are characterized by a high degree of specialization, the inadequate integration of information, and limited collaboration among stakeholders. …”
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Sex-specific associations between estimated glucose disposal rate and cognitive decline in middle-aged and older adults in China: a longitudinal cohort study by Chun Luo, Shuang Han, Xiaoying Shen, Hao Wu, Jianqing Zhou, Bingyang Liu

“…Given the high prevalence of dementia and its substantial economic burden in China, large-scale longitudinal studies are essential to elucidate the complex relationship between IR and cognitive function.MethodsThis longitudinal cohort study included 8,734 middle-aged and older adults (median age: 58 years; 53.6% females) from the China Health and Retirement Longitudinal Study (CHARLS), followed from 2011 to 2018. …”
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Prevalence of Helicobacter pylori infection and its Associated Risk Factors among symptomatic Residents of Sulaimani city, Kurdistan region, Iraq, 2020 by Seerwan Hama Rashid Ali, Sabiha Sharif Salih, Taib Ahmed Hama Sour, Goran Mohammad Raouf, Araz Latif Rahim

“…There are many factors involved in the H pylori reinfection, such as the epidemiology of H. pylori infection, condition of the live, development of economical state, and health conditions. The Objectives of this study were to estimate the incidence and determine the risk factors of infection by H. pylori bacteria in dyspeptic patients in Sulaimani city. …”
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EV Hybrid Battery With Integrated Multilevel Neutral-Point-Clamped Interfacing and Lossless Intermodule State-of-Charge Balancing by Gabriel Garcia-Rojas, Sergio Busquets-Monge, Alber Filba-Martinez, Turev Sarikurt, Salvador Alepuz, Josep Bordonau

“…On the other hand, the use of a custom cell for each vehicle, optimized for its particular requirements, is not economically viable. Instead, hybrid batteries, combining only two battery cell chemistries, with distinct particular strengths, such as high specific energy or high specific power, offer an opportunity to cover a wide range of vehicle battery specifications while avoiding oversizing and dispersion in the cells to be employed. …”
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Photosynthetic characteristics of Paris polyphylla var. chinensis in response to different light intensities and soil water contents by Yaling Zhang, Yaling Zhang, Rong Xu, Rong Xu, Rong Xu, Zhaozhao Wang, Juan Zhang, Xinghao Tang, Yu Chen, Xiao-Li Yan, Lu-Ping Qu, Lu-Ping Qu

“…This is associated with a decrease in the light response curve, indicating that low soil moisture inhibits the growth of P. polyphylla and increases the likelihood of irreversible light damage, so the optimum soil moisture content for P. polyphylla should be above 20%.DiscussionConsidering the economic benefits and the growth and health of P. polyphylla in artificial cultivation, it is recommended that shade be controlled at around 50% while maintaining soil moisture between 40% and 60% of water content.…”
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QTL Mapping of Traits Associated with Dual Resistance to the African Stem Borer (Busseola fusca) and Spotted Stem Borer (Chilo partellus) in Sorghum (Sorghum bicolor) by Phyllis W. Muturi, Mary Mgonja, Patrick Rubaihayo, James K. Mwololo

“…The African stem borer Busseola fusca Fuller (Noctuidae) and the spotted stem borer Chilo partellus Swinhoe (Crambidae), are among the most economically important insect pests of sorghum. The two borers can cause 15% - 80% grain yield loss in sorghum. …”
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