Epidemiological trends and predictions of urinary tract infections in the global burden of disease study 2021 by Yining He, Jing Zhao, Lanhui Wang, Chao Han, Ruxue Yan, Peiqi Zhu, Tianyang Qian, Siyao Yu, Xiaolin Zhu, Weiming He

“…Tropical Latin America and low–middle SDI regions exhibited the highest ASIR, ASPR, ASDR, and ASDAR, while East Asia showed the lowest. ASDR and ASDAR decreased with higher SDI levels. …”
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Month-to-Month Variability of Autumn Sea Ice in the Barents and Kara Seas and Its Relationship to Winter Air Temperature in China by Chuhan Lu, Kaili Li, Shaoqing Xie, Zhaomin Wang, Yujing Qin

“…This regional tropospheric warming results in a higher barotropic positive height anomaly over the Ural Mountains, and then more active cold advection from the high latitude affects East Asia.…”
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Estimating the impact of the Mongol expansion upon the gene pool of Tuvans by L. D. Damba, Е. V. Balanovskaya, M. K. Zhabagin, Y. М. Yusupov, Y. V. Bogunov, Z. M. Sabitov, A. T. Agdzhoyan, N. A. Korotkova, M. B. Lavryashina, B. B. Mongush, U. N. Kavai-ool, O. P. Balanovsky

“…All the results derived – “genetic portraits”, the matrix of genetic distances, the dendrogram and the multidimensional scaling plot, which mirror the genetic connections between Tuvinian clans and populations of South Siberia and East Asia, demonstrated the prominent similarity of the Tuvinian gene pools with populations from and Khakassia and Altai. …”
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Global, regional, and national burden of early-onset colorectal cancer from 1990 to 2021: a systematic analysis based on the global burden of disease study 2021 by Yang Meng, Zongbiao Tan, Junhai Zhen, Di Xiao, Liwei Cai, Weiguo Dong, Changzheng Chen

“…Over the same period, the death rate decreased from 2.98/100000 to 2.30/100000 (AAPC = − 0.84), whereas the disability-adjusted life-year (DALY) decreased from 148.46/100000 to 115.42/100000 (AAPC = − 0.82). In 2021, East Asia and China had the highest burden of EOCRC regionally and nationally. …”
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The extract of the immature fruit of Poncirus trifoliata induces apoptosis in colorectal cancer cells via mitochondrial autophagy by Sun-Young Kim, Ho-Keun Yi, Bong-Sik Yun, Dae-Yeol Lee, Pyung Han Hwang, Hae-Ryong Park, Min Sun Kim

“…The immature fruits of Poncirus trifoliate are used as a medicine for the treatment of gastrointestinal disorders, inflammation, and allergies in East Asia. However, their effect on colon cancer cells remains unclear. …”
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Phenolic and Iridoid Glycosides from <i>Leonurus cardiaca</i> L. and Their Effects on the α, δ, and γ Subtypes of the PPAR System—Including the Discovery of the Novel Phenylethanoi... by Kenny Kuchta, Nobuyasu Matsuura, Tung Huu Nguyen, Christian Rusch, Munekazu Iinuma, Yukihiro Shoyama, Hans Wilhelm Rauwald

“…<i>Leonurus cardiaca</i> L. is known in Europe for its cardioactivity—also in interrelation with known risk factors of the metabolic syndrome—just as <i>L. japonicus</i> Houtt. in East Asia; however, up to now, no active constituents could be identified. …”
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The Global Burden of Migraine: A 30-Year Trend Review and Future Projections by Age, Sex, Country, and Region by Lingkang Dong, Wenqi Dong, Yuchen Jin, Yumeng Jiang, Zhuangzhuang Li, Dongzhen Yu

“…Regionally, high SDI regions having the highest age-standardized rate (ASR) and low SDI regions having the lowest ASR in DALYs. East Asia and Latin America exhibited the most significant increases in migraine burden, whereas Southeast Asia exhibited the most pronounced decrease. …”
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Phylogeography and genetic diversity of Ulmus elongata (Ulmaceae), a Tertiary relict tree with extremely small populations (PSESP) by Yakun Wang, Xiankun Wang, Junyuan Wu, Jun Yang, Yanpei Liu, Peng Guo, Fude Shang, Nan Lin

“…A notable phylogeographic structure was identified in U. elongata, comprising eight distinct haplogroups (N ST = 0.917, G ST = 0.876, p < 0.05), which was attributed to the global cooling in the East Asia and Quaternary climate oscillations. Conclusions Overall, our study using Ulmus elongata as a representative supported the hypothesis that plants belonging to Tertiary relict species and PSESP simultaneously exhibits significantly lower genetic diversity compared to those are either Tertiary relict species or PSESP individually. …”
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Genome‐wide association study of tuberculosis in the western Chinese Han and Tibetan population by Hao Bai, Mengyuan Song, Shikun Lei, Lin Jiao, Xuejiao Hu, Tao Wu, Jiajia Song, Tangyuheng Liu, Wu Peng, Zhenzhen Zhao, Zirui Meng, Binwu Ying

“…Furthermore, we conducted an imputation‐based meta‐analysis on another two East Asia cohorts to replicate our findings. We identified one independent locus harbored by the human leukocyte antigen (HLA) class II genes that was genome‐wide significantly associated with TB (lead SNP rs111875628 with a p‐value of 2.20 × 10−9). …”
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In vitro degradation of non-starch polysaccharide residues in the digesta of broilers offered wheat-soy or maize-soy diets by feed enzymes by E. Kim, N.K. Morgan, A.F. Moss, A. Solbak, L. Li, P. Ader, M. Choct

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Global regional and national burden of intracerebral hemorrhage between 1990 and 2021 by Zhao-wei Wang, Mei-ping Wan, Jia-hui Tai, Yong Wang, Min-yi Yin

“…Our novel geographic analysis revealed East Asia bearing the highest burden, with Eastern Europe showing the highest age-standardized rates. …”
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Rabies re-emergence after long-term disease freedom (Amur Oblast, Russia) by A. D. Botvinkin, I. D. Zarva, I. V. Meltsоv, S. A. Chupin, E. M. Poleshchuk, N. G. Zinyakov, S. V. Samokhvalov, I. V. Solovey, N. V. Yakovleva, G. N. Sidorov, I. A. Boyko, V. G. Yudin, E. I. Andaev, A. Ye. Metlin

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Genomic insights into ecological adaptation of oaks revealed by phylogenomic analysis of multiple species by Tian-Rui Wang, Xin Ning, Si-Si Zheng, Yu Li, Zi-Jia Lu, Hong-Hu Meng, Bin-Jie Ge, Gregor Kozlowski, Meng-Xiao Yan, Yi-Gang Song

“…Here we used a newly sequenced genome of Quercus gilva, an evergreen oak species from East Asia, with 18 published Fagales genomes to determine how Fagaceae genomes have evolved, identify genomic footprints of ecological adaptability in oaks in general, as well as between evergreen and deciduous oaks. …”
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Profiling of the Major Phenolic Compounds and Their Biosynthesis Genes in Sophora flavescens Aiton by Jeongyeo Lee, Jaeeun Jung, Seung-Hyun Son, Hyun-Bi Kim, Young-Hee Noh, Sung Ran Min, Kun-Hyang Park, Dae-Soo Kim, Sang Un Park, Haeng-Soon Lee, Cha Young Kim, Hyun-Soon Kim, Hyeong-Kyu Lee, HyeRan Kim

“…Sophorae Radix (Sophora flavescens Aiton) has long been used in traditional medicine in East Asia due to the various biological activities of its secondary metabolites. …”
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The autoimmune disease risk variant NCF1-His90 is associated with a reduced risk of tuberculosis in women by Xinjun Hu, Shasha Li, Renliang Huang, Ziwei Fu, Chenyu Ma, Zheng Cheng, Hongjun Hu, Qiaomiao Zhou, Frank Petersen, Xinhua Yu, Xinhua Yu, Junfeng Zheng

“…Given the high prevalence of this autoimmune disease risk variant in East Asia, we hypothesized that it may confer an evolutionary advantage by providing protection against infectious diseases.MethodsTo test this hypothesis, we investigated whether the NCF1 rs201802880 variant offers a protective effect against tuberculosis (TB), a historically significant and deadly infectious disease. …”
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Unleashing the potential of geostationary satellite observations in air quality forecasting through artificial intelligence techniques by C. Zhang, X. Niu, H. Wu, Z. Ding, K. L. Chan, J. Kim, T. Wagner, C. Liu, C. Liu, C. Liu

“…., the Geostationary Environment Monitoring Spectrometer (GEMS), offers hourly measurements of atmospheric trace gas pollutants at high spatial resolution over East Asia. In this study, we successfully incorporate geostationary satellite observations into a neural network model (GeoNet) to forecast full-coverage surface nitrogen dioxide (NO<span class="inline-formula">₂</span>) concentrations over eastern China at 4 h intervals for the next 24 h. …”
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Identification of Intracranial Germ Cell Tumors Based on Facial Photos: Exploratory Study on the Use of Deep Learning for Software Development by Yanong Li, Yixuan He, Yawei Liu, Bingchen Wang, Bo Li, Xiaoguang Qiu

“… BackgroundPrimary intracranial germ cell tumors (iGCTs) are highly malignant brain tumors that predominantly occur in children and adolescents, with an incidence rate ranking third among primary brain tumors in East Asia (8%-15%). Due to their insidious onset and impact on critical functional areas of the brain, these tumors often result in irreversible abnormalities in growth and development, as well as cognitive and motor impairments in affected children. …”
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Heterogeneity in Seed Samples from Vineyards and Natural Habitats Along the Eurasian <i>Vitis vinifera</i> Range: Implications for Domestication and Hybridization by Diego Rivera, Javier Valera, David Maghradze, Maia Kikvadze, Anna Nebish, Rafael Ocete, Carlos Álvar Ocete, Claire Arnold, Emilio Laguna, Francisco Alcaraz, Diego José Rivera-Obón, Gianni Lovicu, Massimino Farci, Concepción Obón

“…A domestication gradient is evident, with higher domestication rates in the South Caucasus compared to Western Europe and East Asia. The results demonstrate the significance of these mixed populations as repositories of genetic diversity, underscoring their conservation value, particularly considering the negative impact of habitat alterations, especially in riparian forests due to major public works.…”
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Detection of genetic sex using a qPCR-based method in the bigfin reef squid (Sepioteuthis lessoniana) by Yi-Chien Lee, Li-Lun Tang, Yu-Chen Yeh, Hau-Wen Li, Huei-Mien Ke, Cheng-Ju Yang, Chun-I Chiang, Chia-Hui Wang, Yung-Che Tseng, Ching-Fong Chang, Isheng Jason Tsai, Guan-Chung Wu

“…The bigfin reef squid (Sepioteuthis lessoniana) is a valuable commercial species, especially in East Asia. While small-scale cultivation exists, efforts to achieve large-scale aquaculture are underway. …”
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Burden of NASH related liver cancer from 1990 to 2021 at the global, regional, and national levels by Shuang Li, Shuang Li, Shuangjiang Li, Linjing Guan, Mingjuan Li, Jiahui Zhao, Min Wu, Qiuyun Li, Hui Li, Guoqing Ouyang, Guangdong Pan, Guangdong Pan

“…In 2021, there were 42,291 new cases, 40,925 deaths, and 995,475 DALYs attributed to NRLC. East Asia, South Asia, and Southeast Asia reported the highest absolute case numbers, while Western, Southern, and Eastern Sub-Saharan Africa exhibited the highest ASRs. …”
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