Immunomodulatory Effect of Phage Depolymerase Dep_kpv74 with Therapeutic Potential Against K2-Hypervirulent <i>Klebsiella pneumoniae</i> by Nikolay V. Volozhantsev, Maria A. Makarova, Alena S. Kartseva, Marina V. Silkina, Valentina M. Krasilnikova, Egor A. Denisenko, Alexander I. Borzilov, Victoria V. Firstova

“…Previously, the therapeutic effectiveness of phage-encoded depolymerase Dep_kpv74 in a mouse model of <i>K. pneumoniae</i>-induced thigh soft tissue infection was reported. …”
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Research on Traffic Accident Severity Level Prediction Model Based on Improved Machine Learning by Jiming Tang, Yao Huang, Dingli Liu, Liuyuan Xiong, Rongwei Bu

“…In the experiment, effective preprocessing measures were taken for problems such as data imbalance, missing values, the encoding of categorical variables, and the standardization of numerical features. …”
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First Report of SNPs Detection in TMEM154 Gene in Sheep from Poland and Their Association with SRLV Infection Status by Magdalena Materniak-Kornas, Katarzyna Piórkowska, Katarzyna Ropka-Molik, Adrianna Dominika Musiał, Joanna Kowalik, Anna Kycko, Jacek Kuźmak

“…Recent reports revealed several candidates, including gene encoding transmembrane protein 154 (TMEM154). Several single nucleotide polymorphisms (SNPs) are found within this gene in sheep of different breeds, but only some can be considered as resistant markers. …”
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Deep learning based decision-making and outcome prediction for adolescent idiopathic scoliosis patients with posterior surgery by Kai Chen, Xiao Zhai, Ziqiang Chen, Haojue Wang, Mingyuan Yang, Changwei Yang, Yushu Bai, Ming Li

“…Four deep learning models were designed, including Multi-Layer Perceptron model, Encoder-Decoder model, CNN-LSTM Attention model and Deep FM model. …”
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Identification and expression analysis of P-type ATPase IIIA subfamily in Puccinia Striiformis f. sp. tritici by Yingjie Sun, Hong Tao, Hong Han, Yiping Zou, Yingyu Xue, Shiwen Chen, Fei Tao

“…Results Six PMA genes were identified in the genome of P. striiformis f. sp. tritici (CYR34 race). The PMA proteins encoded by these genes ranged in length from 811 to 960 amino acids (aa). …”
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SWEET transporters of Medicago lupulina in the arbuscular-mycorrhizal system in the presence of medium level of available phosphorus by A. A. Kryukov, A. O. Gorbunova, T. R. Kudriashova, O. B. Ivanchenko, M. F. Shishova, A. P. Yurkov

“…Using the selected model system, differences in the expression levels of 11 genes encoding SWEET transporters in the roots of the host plant were evaluated during the development of or in the absence of symbiosis of M. lupulina with R. irregularis at various stages of the host plant development in the presence of medium level of phosphorus available for plant nutrition in the substrate. …”
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Poldip2/Nox4 Mediates Lipopolysaccharide-Induced Oxidative Stress and Inflammation in Human Lung Epithelial Cells by Yueguo Wang, Zhenxing Ding, Youhui Tu, Xu Wu, Wenying Zhang, Shuang Ji, Jilong Shen, Li Zhang, Huimei Wu, Guanghe Fei

“…The small interfering RNA (siRNA) or plasmid targeting Nox4 was used to downregulate or upregulate Nox4, and the lentiviral vector encoding Poldip2 was used to downregulate or upregulate Poldip2. …”
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Regulatory T cell-like response to SARS-CoV-2 in Jamaican fruit bats (Artibeus jamaicensis) transduced with human ACE2. by Bradly Burke, Savannah M Rocha, Shijun Zhan, Miles Eckley, Clara Reasoner, Amin Addetia, Juliette Lewis, Anna Fagre, Phillida A Charley, Juergen A Richt, Susan R Weiss, Ronald B Tjalkens, David Veesler, Tawfik Aboellail, Tony Schountz

“…Bats were then intranasally inoculated with a replication-defective adenovirus encoding human ACE2 and 5 days later challenged with SARS-CoV-2. …”
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Chlamydia trachomatis Growth and Cytokine mRNA Response in a Prostate Cancer Cell Line by Ivan M. Petyaev, Naylia A. Zigangirova, Elena Y. Morgunova, Nigel H. Kyle, Elena D. Fedina, Yuriy K. Bashmakov

“…Furthermore, propagation of C. trachomatis in CWR-R1 cells leads to enhanced transcription of interleukin-6 and fibroblast growth factor-2, genes encoding two important proinflammatory cytokines implicated in the molecular mechanisms of chemoresistance of prostate cancer and its ability to metastasize. …”
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Evaluation of the Frequency of HLA-DQ2/DQ8 Genes Among Patients with Celiac Disease and Those on a Gluten-Free Diet by Marek K. Kowalski, Danuta Domżał-Magrowska, Ewa Małecka-Wojciesko

“…All subjects underwent a genetic analysis assessing the presence of histocompatibility antigens HLA-DQ2.2, -DQ2.5, and -DQ8, along with the assessment of alleles encoding the α and β subunits of the antigens, according to European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) guidelines from 2020, using the EUROarray technique at EUROIMMUNE^®. …”
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Single Nucleotide Polymorphisms in TLR4 Affect Susceptibility to Tuberculosis in Mexican Population from the State of Veracruz by Enrique Ortega, Sujhey Hernández-Bazán, Beatriz Sánchez-Hernández, Ileana Licona-Limón, Javier Fuentes-Dominguez

“…In this work, we performed a case-control study to determine if common single nucleotide polymorphisms (SNPs) in genes encoding TLRs 1, 2, 4, 6, and 10 are associated with susceptibility to develop active tuberculosis in population from the state of Veracruz, Mexico. …”
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Genetic Background and Phenotypic Aspects of Light-Induced Carotenoid Biosynthesis in <i>Isosphaeraceae</i> Planctomycetes by Anastasia A. Ivanova, Igor Y. Oshkin, Aleksandr A. Ashikhmin, Olga V. Danilova, Svetlana N. Dedysh

“…The biosynthesis of C30 carotenoids via squalene, as evidenced by the presence of <i>hpnCDE</i> and <i>crtNPQO</i> gene clusters, was encoded in genomes of all pigmented <i>Singulisphaera</i>, <i>Aquisphaera</i>, and <i>Paludisphaera</i> species. …”
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How do staff work in NHS hospital operations management meetings to support resilience in everyday service delivery? A qualitative study by L. Sutton, C. Tarrant, J. Willars, T. Coats, M. Simmonds, D. Mclean, A. Boyle, K. Dreesbeimdiek, S. Richter, A. Oyedijo, D. Roland

“…Review of centralised data, formally encoded and recorded in numerical form, played an important role, but staff also drew on local intelligence to make sense of and adapt to often pressurised situations. …”
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CFO-CR: Carrier Frequency Offset Methodology for High-Rate Common Randomness Generation by Prashanth Kumar Herooru Sheshagiri, Martin Reisslein, Juan A. Cabrera, Frank H. P. Fitzek

“…Our evaluations with single-carrier software-defined radios, for which we make measurement traces publicly available, indicate that high-rate CR generation should observe (probe) the CFO and employ a Savitzky Golay low-pass filter with a low cut-off frequency for noise reduction in conjunction with multi-bit quantization, Gray code encoding, and a shuffling based randomization. We provide insights into the tradeoffs between the reconciliation cost for correcting bit discrepancies and the CR generation parameters. …”
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The extremely halotolerant black yeast Hortaea werneckii - a model for intraspecific hybridization in clonal fungi by Polona Zalar, Jerneja Zupančič, Cene Gostinčar, Janja Zajc, G. Sybren de Hoog, Filomena De Leo, Armando Azua-Bustos, Nina Gunde-Cimerman

“…Due to the limited number of phylogenetically informative characters in the ribosomal DNA dataset, the partial genes encoding for β-tubulin (BTB) and mini-chromosome maintenance protein (MCM7) were also sequenced. …”
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Leveraging two-dimensional pre-trained vision transformers for three-dimensional model generation via masked autoencoders by Muhammad Sajid, Kaleem Razzaq Malik, Ateeq Ur Rehman, Tauqeer Safdar Malik, Masoud Alajmi, Ali Haider Khan, Amir Haider, Seada Hussen

“…We employ the adept 2D information to direct a 3D masking-based autoencoder, which uses an encoder-decoder architecture to rebuild the masked point tokens through self-supervised pre-training. …”
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Stage-specific function of sphingolipid synthases in African trypanosomes by Norton Heise, Carolina M. Koeller, Mohamed Sharif, James D. Bangs

“…It has four paralogous genes encoding sphingolipid synthases (TbSLS1–4). TbSLS1 is a dedicated IPC synthase, TbSLS2 is a dedicated EPC synthase, and TbSLS3 and TbSLS4 are bifunctional SM/EPC synthases. …”
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Comparative analysis of lactaptin activity when produced in bacterial or eukaryotic expression systems by O. A. Koval, O. Y. Volkova, A. A. Gorchakov, S. V. Kulemzin, A. V. Tkachenko, A. A. Nushtaeva, E. V. Kuligina, V. A. Richter, A. V. Taranin

“…Using lentiviral vector pCDH as a backbone, two constructs, pEL1 and pEL2, encoding secreted forms of lactaptin that differ in their signal sequences were created. …”
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Emergence of a blaNDM-5-carrying extensively drug-resistant Enterobacter cloacae ST1718 in Saudi Arabia: Insights from comprehensive genome analysis by Ibrahim A. Al-Zahrani, Thamer M. Brek

“…The strain was found to harbor IncFIB(pECLA) and IncX3 plasmid replicons, with the latter encoding the blaNDM-5 gene. The IncX3 plasmid was identified as a significant contributor to the dissemination of the blaNDM-5 gene among Enterobacterale species The coexistence of blaNDM-5 and other carbapenem-hydrolyzing enzymes explains the reduced efficacy of β-lactam drugs in ECloa-JZ71. …”
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Effect of the host-specific toxin SnTOX3 from Stagonospora nodorum on ethylene signaling pathway regulation and redox-state in common wheat by S. V. Veselova, G. F. Burkhanova, T. V. Nuzhnaya, S. D. Rumyantsev, I. V. Maksimov

“…The most important factors of Stagonospora nodorum virulence include numerous fungal necrotrophic effectors (NEs) encoded by SnTox genes. They interact with the matching products of host susceptibility genes (Snn). …”
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